Pathology Tables for Peer Review
The National Toxicology Program
NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 13:47:04 Control vs Stop Study Facility: Battelle Columbus Laboratory Chemical CAS #: 87-86-5 Lock Date: 07/13/95 Cage Range: All Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death 25021 Terminal Sacrifice Removal Date Range: All Treatment Groups: Include 001 0 PPM Include 002 0 PPM Include 009 1000 PPM Include 010 1000 PPM Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 13:47:04 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 5| DAY ON TEST | 0| 6| 9| 3| 3| 4| 3| 3| 3| 2| 3| 1| 4| 3| 4| 3| 4| 4| 0| 4| 3| 3| 6| 9| 7| | 4| 3| 6| 8| 9| 4| 9| 9| 9| 3| 8| 5| 0| 8| 5| 9| 0| 0| 5| 0| 8| 9| 1| 8| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| | 1| 2| 3| 7| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X| __________________________________________________________________________| Mesentery | + + + | Leukemia Mononuclear | | Schwannoma Malignant, Metastatic, | | Uterus | X | __________________________________________________________________________| Oral Mucosa | + | Pharyngeal, Squamous Cell Papilloma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Tongue | + | Squamous Cell Papilloma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + M + + + +| Adenoma | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| Pars Distalis, Adenoma | X X X X X X X X X X X X | Pars Intermedia, Adenoma | | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 13:47:04 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 5| DAY ON TEST | 0| 6| 9| 3| 3| 4| 3| 3| 3| 2| 3| 1| 4| 3| 4| 3| 4| 4| 0| 4| 3| 3| 6| 9| 7| | 4| 3| 6| 8| 9| 4| 9| 9| 9| 3| 8| 5| 0| 8| 5| 9| 0| 0| 5| 0| 8| 9| 1| 8| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| | 1| 2| 3| 7| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | C-Cell, Adenoma | X | C-Cell, Carcinoma | X | Follicular Cell, Adenoma | | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Carcinoma | X | Leukemia Mononuclear | X | Bilateral, Carcinoma | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Polyp Stromal | X X | Schwannoma Malignant, Metastatic, | | Uterus | X | __________________________________________________________________________| Vagina | + + | Schwannoma Malignant, Metastatic, | | Uterus | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + +| Inguinal, Leukemia Mononuclear | X | Lumbar, Leukemia Mononuclear | | Mediastinal, Leukemia Mononuclear | X X X X X| Renal, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X| __________________________________________________________________________| Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 13:47:04 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 5| DAY ON TEST | 0| 6| 9| 3| 3| 4| 3| 3| 3| 2| 3| 1| 4| 3| 4| 3| 4| 4| 0| 4| 3| 3| 6| 9| 7| | 4| 3| 6| 8| 9| 4| 9| 9| 9| 3| 8| 5| 0| 8| 5| 9| 0| 0| 5| 0| 8| 9| 1| 8| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 0 PPM | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| | 1| 2| 3| 7| 9| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Fibroadenoma | X X X X X X X X X X X | Fibroadenoma, Multiple | X X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Fibrosarcoma | | Subcutaneous Tissue, Leukemia | | Mononuclear | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Carcinoma | | Leukemia Mononuclear | X X X X X X X X X| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X| _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 13:47:04 __________________________________________________________________________________________________________________________________ | 3| 7| 6| 7| 7| 5| 4| 5| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| | DAY ON TEST | 9| 3| 4| 3| 4| 6| 7| 0| 8| 4| 3| 3| 9| 3| 3| 3| 2| 4| 3| 3| 3| 4| 4| 3| 6| | | 1| 9| 8| 8| 0| 9| 5| 7| 5| 0| 8| 8| 8| 9| 8| 9| 0| 0| 8| 9| 1| 0| 3| 8| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 0 PPM | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| L | | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X | 14 | __________________________________________________________________________|____________| Mesentery | + + + + + | 8 | Leukemia Mononuclear | X X | 2 | Schwannoma Malignant, Metastatic, | | | Uterus | | 1 | __________________________________________________________________________|____________| Oral Mucosa | | 1 | Pharyngeal, Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 3 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Tongue | | 1 | Squamous Cell Papilloma | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 6 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 7 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 7 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | M + + + + + + + + + + + + + M + + + + + + + + + +| 46 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 5 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 13:47:04 __________________________________________________________________________________________________________________________________ | 3| 7| 6| 7| 7| 5| 4| 5| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| | DAY ON TEST | 9| 3| 4| 3| 4| 6| 7| 0| 8| 4| 3| 3| 9| 3| 3| 3| 2| 4| 3| 3| 3| 4| 4| 3| 6| | | 1| 9| 8| 8| 0| 9| 5| 7| 5| 0| 8| 8| 8| 9| 8| 9| 0| 0| 8| 9| 1| 0| 3| 8| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 0 PPM | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| L | | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Adenoma | X | 1 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 6 | Pars Distalis, Adenoma | X X X X X X X X X X| 22 | Pars Intermedia, Adenoma | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | C-Cell, Adenoma | X X | 3 | C-Cell, Carcinoma | X | 2 | Follicular Cell, Adenoma | X | 1 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X | 4 | Carcinoma | | 1 | Leukemia Mononuclear | X | 2 | Bilateral, Carcinoma | X | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | Polyp Stromal | X X X X | 6 | Schwannoma Malignant, Metastatic, | | | Uterus | | 1 | __________________________________________________________________________|____________| Vagina | | 2 | Schwannoma Malignant, Metastatic, | | | Uterus | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + +| 35 | Inguinal, Leukemia Mononuclear | X | 2 | Lumbar, Leukemia Mononuclear | X | 1 | Mediastinal, Leukemia Mononuclear | X X | 7 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 6 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 13:47:04 __________________________________________________________________________________________________________________________________ | 3| 7| 6| 7| 7| 5| 4| 5| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| | DAY ON TEST | 9| 3| 4| 3| 4| 6| 7| 0| 8| 4| 3| 3| 9| 3| 3| 3| 2| 4| 3| 3| 3| 4| 4| 3| 6| | | 1| 9| 8| 8| 0| 9| 5| 7| 5| 0| 8| 8| 8| 9| 8| 9| 0| 0| 8| 9| 1| 0| 3| 8| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 0 PPM | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| L | | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Renal, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 6 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 9 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X | 15 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 | Leukemia Mononuclear | X X | 4 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | X | 1 | Fibroadenoma | X X X X X| 16 | Fibroadenoma, Multiple | X X X X X X | 9 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Fibroma | X | 2 | Subcutaneous Tissue, Fibrosarcoma | X | 1 | Subcutaneous Tissue, Leukemia | | | Mononuclear | X | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 3 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | | 2 | Alveolar/Bronchiolar Carcinoma | X | 1 | Leukemia Mononuclear | X X X X X | 14 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 7 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 13:47:04 __________________________________________________________________________________________________________________________________ | 3| 7| 6| 7| 7| 5| 4| 5| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| | DAY ON TEST | 9| 3| 4| 3| 4| 6| 7| 0| 8| 4| 3| 3| 9| 3| 3| 3| 2| 4| 3| 3| 3| 4| 4| 3| 6| | | 1| 9| 8| 8| 0| 9| 5| 7| 5| 0| 8| 8| 8| 9| 8| 9| 0| 0| 8| 9| 1| 0| 3| 8| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 0 PPM | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| L | | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 1| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 11 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X | 15 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 13:47:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 3| 7| 5| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| DAY ON TEST | 3| 3| 4| 4| 6| 3| 1| 0| 3| 3| 1| 3| 8| 3| 9| 0| 0| 0| 0| 4| 3| 4| 6| 5| 4| | 8| 9| 0| 0| 5| 9| 6| 0| 8| 8| 4| 9| 4| 9| 0| 1| 4| 8| 3| 7| 8| 0| 8| 2| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1000 PPM | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 7| 8| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyoma | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Sarcoma Stromal, Metastatic, Uterus | X | __________________________________________________________________________| Mesentery | + + | Leukemia Mononuclear | X | Fat, Sarcoma Stromal, Metastatic, | | Uterus | X | __________________________________________________________________________| Oral Mucosa | + | Pharyngeal, Squamous Cell Carcinoma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Sarcoma Stromal, Metastatic, Uterus | X | Acinus, Adenoma | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Tongue | | Squamous Cell Papilloma | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Pheochromocytoma Benign | | _____________________________________________________________________________________________________________________| Page 9 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 13:47:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 3| 7| 5| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| DAY ON TEST | 3| 3| 4| 4| 6| 3| 1| 0| 3| 3| 1| 3| 8| 3| 9| 0| 0| 0| 0| 4| 3| 4| 6| 5| 4| | 8| 9| 0| 0| 5| 9| 6| 0| 8| 8| 4| 9| 4| 9| 0| 1| 4| 8| 3| 7| 8| 0| 8| 2| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1000 PPM | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 7| 8| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Parathyroid Gland | + M + + + M M + + + + + M + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Pars Distalis, Adenoma | X X X X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Bilateral, C-Cell, Adenoma | X | C-Cell, Adenoma | X X | C-Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X | Carcinoma | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Polyp Stromal | X X X X | Sarcoma Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + M + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + | Deep Cervical, Carcinoma, Metastatic,| | Thyroid Gland | | Mediastinal, Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Sarcoma Stromal, Metastatic, Uterus | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 10 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 13:47:04 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 3| 7| 5| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7| DAY ON TEST | 3| 3| 4| 4| 6| 3| 1| 0| 3| 3| 1| 3| 8| 3| 9| 0| 0| 0| 0| 4| 3| 4| 6| 5| 4| | 8| 9| 0| 0| 5| 9| 6| 0| 8| 8| 4| 9| 4| 9| 0| 1| 4| 8| 3| 7| 8| 0| 8| 2| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 1000 PPM | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 7| 8| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Fibroadenoma | X X X X X X | Fibroadenoma, Multiple | X X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibrosarcoma | X | Subcutaneous Tissue, Leukemia | | Mononuclear | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Cranial Nerve, Squamous Cell | | Carcinoma, Metastatic, Oral | | Mucosa | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Clitoral Gland| | Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma, Metastatic, | | Oral Mucosa | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 13:47:04 __________________________________________________________________________________________________________________________________ | 7| 0| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| | DAY ON TEST | 3| 1| 7| 3| 4| 3| 3| 3| 2| 3| 4| 1| 1| 0| 7| 3| 4| 3| 4| 0| 3| 9| 3| 3| 4| | | 9| 1| 1| 8| 0| 9| 8| 9| 4| 8| 0| 9| 9| 0| 2| 8| 0| 9| 0| 4| 8| 2| 9| 8| 0| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L | | 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 8| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leiomyoma | X | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X | 11 | Sarcoma Stromal, Metastatic, Uterus | | 1 | __________________________________________________________________________|____________| Mesentery | + + + + | 6 | Leukemia Mononuclear | X | 2 | Fat, Sarcoma Stromal, Metastatic, | | | Uterus | | 1 | __________________________________________________________________________|____________| Oral Mucosa | + | 2 | Pharyngeal, Squamous Cell Carcinoma | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | Sarcoma Stromal, Metastatic, Uterus | | 1 | Acinus, Adenoma | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Tongue | + | 1 | Squamous Cell Papilloma | X | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 7 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 12 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 13:47:04 __________________________________________________________________________________________________________________________________ | 7| 0| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| | DAY ON TEST | 3| 1| 7| 3| 4| 3| 3| 3| 2| 3| 4| 1| 1| 0| 7| 3| 4| 3| 4| 0| 3| 9| 3| 3| 4| | | 9| 1| 1| 8| 0| 9| 8| 9| 4| 8| 0| 9| 9| 0| 2| 8| 0| 9| 0| 4| 8| 2| 9| 8| 0| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L | | 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 8| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 8 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 8 | Pheochromocytoma Benign | X | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + I + + + + +| 45 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 5 | Pars Distalis, Adenoma | X X X X X X X | 18 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Bilateral, C-Cell, Adenoma | X | 2 | C-Cell, Adenoma | X X X | 5 | C-Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X X | 5 | Carcinoma | X | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 4 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | Polyp Stromal | X X | 6 | Sarcoma Stromal | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + +| 30 | Deep Cervical, Carcinoma, Metastatic,| | | Thyroid Gland | X | 1 | Mediastinal, Leukemia Mononuclear | X X | 8 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 6 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 13 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 13:47:04 __________________________________________________________________________________________________________________________________ | 7| 0| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| | DAY ON TEST | 3| 1| 7| 3| 4| 3| 3| 3| 2| 3| 4| 1| 1| 0| 7| 3| 4| 3| 4| 0| 3| 9| 3| 3| 4| | | 9| 1| 1| 8| 0| 9| 8| 9| 4| 8| 0| 9| 9| 0| 2| 8| 0| 9| 0| 4| 8| 2| 9| 8| 0| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L | | 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 8| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 10 | Sarcoma Stromal, Metastatic, Uterus | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X | 11 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibroadenoma | X X X X | 10 | Fibroadenoma, Multiple | X X | 5 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Fibrosarcoma | | 1 | Subcutaneous Tissue, Leukemia | | | Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Leukemia Mononuclear | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 2 | Cranial Nerve, Squamous Cell | | | Carcinoma, Metastatic, Oral | | | Mucosa | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Clitoral Gland| X | 1 | Leukemia Mononuclear | X X X X | 10 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Carcinoma, Metastatic, | | | Oral Mucosa | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 14 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 13:47:04 __________________________________________________________________________________________________________________________________ | 7| 0| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| | DAY ON TEST | 3| 1| 7| 3| 4| 3| 3| 3| 2| 3| 4| 1| 1| 0| 7| 3| 4| 3| 4| 0| 3| 9| 3| 3| 4| | | 9| 1| 1| 8| 0| 9| 8| 9| 4| 8| 0| 9| 9| 0| 2| 8| 0| 9| 0| 4| 8| 2| 9| 8| 0| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| L | | 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 6| 8| 0| 1| 2| 3| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Eye | + | 2 | __________________________________________________________________________|____________| Harderian Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 10 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X | 11 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 15 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 13:47:04 _____________________________________________________________________________________________________________________ | 6| 6| 5| 7| 5| 7| 6| 5| 6| 7| 7| 7| 5| 6| 3| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| DAY ON TEST | 4| 0| 6| 1| 6| 3| 1| 7| 4| 3| 3| 0| 3| 9| 9| 3| 1| 7| 6| 8| 3| 2| 0| 3| 3| | 6| 0| 1| 5| 4| 3| 9| 6| 5| 6| 6| 3| 5| 5| 6| 6| 5| 9| 3| 4| 6| 4| 2| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | Mesothelioma Malignant | | __________________________________________________________________________| Mesentery | + + + | Leukemia Mononuclear | X | Mesothelioma Malignant | | Fat, Sarcoma | | __________________________________________________________________________| Oral Mucosa | + | Pharyngeal, Squamous Cell Papilloma | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | | Acinus, Adenoma | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | | __________________________________________________________________________| Tongue | + | Squamous Cell Papilloma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Pheochromocytoma Malignant | X | Pheochromocytoma Complex | X | Pheochromocytoma Benign | X X X| Bilateral, Pheochromocytoma Benign | X X X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 16 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 13:47:04 _____________________________________________________________________________________________________________________ | 6| 6| 5| 7| 5| 7| 6| 5| 6| 7| 7| 7| 5| 6| 3| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| DAY ON TEST | 4| 0| 6| 1| 6| 3| 1| 7| 4| 3| 3| 0| 3| 9| 9| 3| 1| 7| 6| 8| 3| 2| 0| 3| 3| | 6| 0| 1| 5| 4| 3| 9| 6| 5| 6| 6| 3| 5| 5| 6| 6| 5| 9| 3| 4| 6| 4| 2| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Pars Distalis, Adenoma | X X X X X X X X X X X| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | C-Cell, Adenoma | X X X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Coagulating Gland | + + | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | | Leukemia Mononuclear | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Mesothelioma Malignant | | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + | Lumbar, Leukemia Mononuclear | | Mediastinal, Leukemia Mononuclear | X X X X X X | Mediastinal, Sarcoma, Metastatic, | | Mesentery | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 17 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 13:47:04 _____________________________________________________________________________________________________________________ | 6| 6| 5| 7| 5| 7| 6| 5| 6| 7| 7| 7| 5| 6| 3| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| DAY ON TEST | 4| 0| 6| 1| 6| 3| 1| 7| 4| 3| 3| 0| 3| 9| 9| 3| 1| 7| 6| 8| 3| 2| 0| 3| 3| | 6| 0| 1| 5| 4| 3| 9| 6| 5| 6| 6| 3| 5| 5| 6| 6| 5| 9| 3| 4| 6| 4| 2| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | Mesothelioma Malignant | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | | Squamous Cell Papilloma | X X | Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Fibroma, | | Multiple | | Subcutaneous Tissue, Fibrosarcoma | | Subcutaneous Tissue, Fibrous | | Histiocytoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Vertebra, Hemangiosarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | Renal Tubule, Adenoma | X | __________________________________________________________________________| Urinary Bladder | M + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 13:47:04 _____________________________________________________________________________________________________________________ | 6| 6| 5| 7| 5| 7| 6| 5| 6| 7| 7| 7| 5| 6| 3| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| DAY ON TEST | 4| 0| 6| 1| 6| 3| 1| 7| 4| 3| 3| 0| 3| 9| 9| 3| 1| 7| 6| 8| 3| 2| 0| 3| 3| | 6| 0| 1| 5| 4| 3| 9| 6| 5| 6| 6| 3| 5| 5| 6| 6| 5| 9| 3| 4| 6| 4| 2| 6| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 8| _____________________________________________________________________________________________________________________| Transitional Epithelium, Papilloma | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 13:47:04 __________________________________________________________________________________________________________________________________ | 5| 6| 6| 7| 7| 6| 4| 7| 6| 7| 7| 4| 7| 6| 7| 6| 6| 7| 6| 6| 6| 3| 7| 6| 6| | DAY ON TEST | 9| 8| 8| 3| 3| 9| 3| 3| 6| 3| 2| 2| 3| 9| 3| 4| 4| 3| 9| 0| 1| 9| 2| 7| 0| | | 3| 1| 4| 6| 6| 8| 5| 3| 0| 7| 9| 0| 7| 8| 7| 7| 3| 7| 0| 0| 7| 6| 2| 5| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 PPM | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L | | 9| 0| 1| 2| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 4| 5| 6| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X| 24 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________|____________| Mesentery | + + + + + + + + + + + +| 15 | Leukemia Mononuclear | X X X | 4 | Mesothelioma Malignant | X | 1 | Fat, Sarcoma | X | 1 | __________________________________________________________________________|____________| Oral Mucosa | | 1 | Pharyngeal, Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | Mesothelioma Malignant | X | 1 | Acinus, Adenoma | X X | 2 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________|____________| Tongue | | 1 | Squamous Cell Papilloma | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X| 12 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X| 12 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X| 12 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 20 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 13:47:04 __________________________________________________________________________________________________________________________________ | 5| 6| 6| 7| 7| 6| 4| 7| 6| 7| 7| 4| 7| 6| 7| 6| 6| 7| 6| 6| 6| 3| 7| 6| 6| | DAY ON TEST | 9| 8| 8| 3| 3| 9| 3| 3| 6| 3| 2| 2| 3| 9| 3| 4| 4| 3| 9| 0| 1| 9| 2| 7| 0| | | 3| 1| 4| 6| 6| 8| 5| 3| 0| 7| 9| 0| 7| 8| 7| 7| 3| 7| 0| 0| 7| 6| 2| 5| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 PPM | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L | | 9| 0| 1| 2| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 4| 5| 6| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Complex | | 1 | Pheochromocytoma Benign | X X X X | 7 | Bilateral, Pheochromocytoma Benign | X X | 7 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + M +| 47 | Adenoma | | 1 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X| 13 | Pars Distalis, Adenoma | X X X X X X X | 18 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | C-Cell, Adenoma | X | 5 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Coagulating Gland | | 2 | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X X | 4 | Carcinoma | X | 1 | Leukemia Mononuclear | X X | 2 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 2 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | Mesothelioma Malignant | X | 1 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X | 34 | Interstitial Cell, Adenoma | X X| 8 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 21 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 13:47:04 __________________________________________________________________________________________________________________________________ | 5| 6| 6| 7| 7| 6| 4| 7| 6| 7| 7| 4| 7| 6| 7| 6| 6| 7| 6| 6| 6| 3| 7| 6| 6| | DAY ON TEST | 9| 8| 8| 3| 3| 9| 3| 3| 6| 3| 2| 2| 3| 9| 3| 4| 4| 3| 9| 0| 1| 9| 2| 7| 0| | | 3| 1| 4| 6| 6| 8| 5| 3| 0| 7| 9| 0| 7| 8| 7| 7| 3| 7| 0| 0| 7| 6| 2| 5| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 PPM | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L | | 9| 0| 1| 2| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 4| 5| 6| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X | 9 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + +| 34 | Lumbar, Leukemia Mononuclear | X | 1 | Mediastinal, Leukemia Mononuclear | X X X X X X X X X X | 16 | Mediastinal, Sarcoma, Metastatic, | | | Mesentery | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X| 13 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X| 19 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X| 24 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X | 7 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 | Fibroadenoma | X X X | 5 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basal Cell Adenoma | X | 1 | Squamous Cell Papilloma | | 2 | Subcutaneous Tissue, Fibroma | X | 1 | Subcutaneous Tissue, Fibroma, | | | Multiple | X| 1 | Subcutaneous Tissue, Fibrosarcoma | X X | 2 | Subcutaneous Tissue, Fibrous | | | Histiocytoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Vertebra, Hemangiosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X| 5 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 22 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 13:47:04 __________________________________________________________________________________________________________________________________ | 5| 6| 6| 7| 7| 6| 4| 7| 6| 7| 7| 4| 7| 6| 7| 6| 6| 7| 6| 6| 6| 3| 7| 6| 6| | DAY ON TEST | 9| 8| 8| 3| 3| 9| 3| 3| 6| 3| 2| 2| 3| 9| 3| 4| 4| 3| 9| 0| 1| 9| 2| 7| 0| | | 3| 1| 4| 6| 6| 8| 5| 3| 0| 7| 9| 0| 7| 8| 7| 7| 3| 7| 0| 0| 7| 6| 2| 5| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 PPM | 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| L | | 9| 0| 1| 2| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 4| 5| 6| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X| 25 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Carcinoma | X | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X| 24 | Renal Tubule, Adenoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 | Leukemia Mononuclear | X X X | 4 | Mesothelioma Malignant | X | 1 | Transitional Epithelium, Papilloma | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X X| 25 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 23 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 13:47:04 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 3| 6| DAY ON TEST | 6| 3| 3| 3| 3| 1| 5| 1| 3| 3| 3| 3| 3| 1| 3| 9| 3| 3| 3| 1| 3| 0| 3| 6| 7| | 5| 6| 6| 6| 6| 1| 0| 5| 6| 6| 6| 6| 6| 4| 6| 8| 6| 6| 6| 3| 6| 8| 6| 0| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyoma | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | Polyp Adenomatous | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | Mesothelioma Malignant | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | Carcinoma, Metastatic, Intestine | | Small, Jejunum | X | Mesothelioma Malignant | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Mesothelioma Malignant | | __________________________________________________________________________| Mesentery | + + + + + + + + + | Mesothelioma Malignant | X | __________________________________________________________________________| Oral Mucosa | | Squamous Cell Papilloma | | Gingival, Squamous Cell Carcinoma, | | Metastatic, Nose | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | __________________________________________________________________________| Tongue | + | Squamous Cell Papilloma | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| Page 24 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 13:47:04 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 3| 6| DAY ON TEST | 6| 3| 3| 3| 3| 1| 5| 1| 3| 3| 3| 3| 3| 1| 3| 9| 3| 3| 3| 1| 3| 0| 3| 6| 7| | 5| 6| 6| 6| 6| 1| 0| 5| 6| 6| 6| 6| 6| 4| 6| 8| 6| 6| 6| 3| 6| 8| 6| 0| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X X X X X | Bilateral, Pheochromocytoma Benign | X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Pars Distalis, Adenoma | X X X X X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X X| Follicular Cell, Adenoma | X | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X X X | __________________________________________________________________________| Preputial Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| Adenoma | X X X | Carcinoma | | Leukemia Mononuclear | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X X | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X X X| Interstitial Cell, Adenoma | X X X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + +| Mediastinal, Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 25 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 13:47:04 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 3| 6| DAY ON TEST | 6| 3| 3| 3| 3| 1| 5| 1| 3| 3| 3| 3| 3| 1| 3| 9| 3| 3| 3| 1| 3| 0| 3| 6| 7| | 5| 6| 6| 6| 6| 1| 0| 5| 6| 6| 6| 6| 6| 4| 6| 8| 6| 6| 6| 3| 6| 8| 6| 0| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Leukemia Mononuclear | X X X | Mesothelioma Malignant | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Mesothelioma Malignant | | __________________________________________________________________________| Thymus | + + + + + + + M + + + + + + + + + + + + + + + + M| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | | Keratoacanthoma | X X X | Keratoacanthoma, Multiple | X | Trichoepithelioma | X | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Fibrosarcoma | | Subcutaneous Tissue, Schwannoma | | Malignant | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Astrocytoma Malignant | | Leukemia Mononuclear | X | Oligodendroglioma Malignant | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Harderian | | Gland | | Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | M | __________________________________________________________________________| Harderian Gland | | _____________________________________________________________________________________________________________________| Page 26 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 13:47:04 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 6| 7| 7| 7| 3| 6| DAY ON TEST | 6| 3| 3| 3| 3| 1| 5| 1| 3| 3| 3| 3| 3| 1| 3| 9| 3| 3| 3| 1| 3| 0| 3| 6| 7| | 5| 6| 6| 6| 6| 1| 0| 5| 6| 6| 6| 6| 6| 4| 6| 8| 6| 6| 6| 3| 6| 8| 6| 0| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1000 PPM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 6| 7| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Renal Tubule, Adenoma | | Renal Tubule, Oncocytoma Benign | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Mesothelioma Malignant | X X X | _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 13:47:04 __________________________________________________________________________________________________________________________________ | 7| 5| 2| 7| 7| 6| 7| 7| 6| 7| 7| 4| 7| 7| 6| 7| 6| 7| 6| 5| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 9| 6| 3| 3| 9| 3| 3| 8| 3| 0| 6| 3| 0| 7| 3| 8| 2| 6| 0| 3| 3| 3| 3| 3| | | 6| 2| 5| 6| 6| 8| 6| 6| 4| 6| 2| 0| 6| 2| 7| 6| 0| 5| 1| 2| 6| 6| 6| 6| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 1000 PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L | | 8| 9| 0| 2| 3| 5| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 | Leiomyoma | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 | Mesothelioma Malignant | | 1 | Polyp Adenomatous | | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma | | 1 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 | Carcinoma | X | 1 | Carcinoma, Metastatic, Intestine | | | Small, Jejunum | | 1 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X| 15 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________|____________| Mesentery | + + + + + + | 15 | Mesothelioma Malignant | X X X | 4 | __________________________________________________________________________|____________| Oral Mucosa | + + | 2 | Squamous Cell Papilloma | X | 1 | Gingival, Squamous Cell Carcinoma, | | | Metastatic, Nose | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | X X X | 4 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | X | 2 | __________________________________________________________________________|____________| Tongue | | 1 | Squamous Cell Papilloma | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 4 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 28 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 13:47:04 __________________________________________________________________________________________________________________________________ | 7| 5| 2| 7| 7| 6| 7| 7| 6| 7| 7| 4| 7| 7| 6| 7| 6| 7| 6| 5| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 9| 6| 3| 3| 9| 3| 3| 8| 3| 0| 6| 3| 0| 7| 3| 8| 2| 6| 0| 3| 3| 3| 3| 3| | | 6| 2| 5| 6| 6| 8| 6| 6| 4| 6| 2| 0| 6| 2| 7| 6| 0| 5| 1| 2| 6| 6| 6| 6| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 1000 PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L | | 8| 9| 0| 2| 3| 5| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | Leukemia Mononuclear | X X X | 5 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 5 | Pheochromocytoma Malignant | X X | 3 | Pheochromocytoma Benign | X X X X X X X | 12 | Bilateral, Pheochromocytoma Benign | X | 4 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 47 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 5 | Pars Distalis, Adenoma | X X X X X X X| 16 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Adenoma | | 4 | Follicular Cell, Adenoma | X | 2 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | + | 2 | Mesothelioma Malignant | X | 2 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | X X X X X X | 9 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X | 4 | Carcinoma | X X | 2 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | X | 2 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | X X | 3 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | X X X | 5 | Bilateral, Interstitial Cell, Adenoma| X X X X X X X X X X X X X X X X X X| 38 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 29 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 13:47:04 __________________________________________________________________________________________________________________________________ | 7| 5| 2| 7| 7| 6| 7| 7| 6| 7| 7| 4| 7| 7| 6| 7| 6| 7| 6| 5| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 9| 6| 3| 3| 9| 3| 3| 8| 3| 0| 6| 3| 0| 7| 3| 8| 2| 6| 0| 3| 3| 3| 3| 3| | | 6| 2| 5| 6| 6| 8| 6| 6| 4| 6| 2| 0| 6| 2| 7| 6| 0| 5| 1| 2| 6| 6| 6| 6| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 1000 PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L | | 8| 9| 0| 2| 3| 5| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Interstitial Cell, Adenoma | X X X X | 7 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 5 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + | 28 | Mediastinal, Leukemia Mononuclear | X X X | 6 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 6 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 6 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X| 14 | Mesothelioma Malignant | X X | 2 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X X | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Fibroadenoma | | 2 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basal Cell Adenoma | X X | 2 | Keratoacanthoma | X X X | 6 | Keratoacanthoma, Multiple | | 1 | Trichoepithelioma | X | 2 | Subcutaneous Tissue, Fibroma | | 1 | Subcutaneous Tissue, Fibrosarcoma | X | 1 | Subcutaneous Tissue, Schwannoma | | | Malignant | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Mesothelioma Malignant | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Astrocytoma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 30 NTP Experiment-Test: 89002-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97 Route: DOSED FEED Time: 13:47:04 __________________________________________________________________________________________________________________________________ | 7| 5| 2| 7| 7| 6| 7| 7| 6| 7| 7| 4| 7| 7| 6| 7| 6| 7| 6| 5| 7| 7| 5| 7| 7| | DAY ON TEST | 3| 9| 6| 3| 3| 9| 3| 3| 8| 3| 0| 6| 3| 0| 7| 3| 8| 2| 6| 0| 3| 3| 3| 3| 3| | | 6| 2| 5| 6| 6| 8| 6| 6| 4| 6| 2| 0| 6| 2| 7| 6| 0| 5| 1| 2| 6| 6| 6| 6| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 1000 PPM | 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| L | | 8| 9| 0| 2| 3| 5| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | Leukemia Mononuclear | | 1 | Oligodendroglioma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Harderian | | | Gland | X | 1 | Leukemia Mononuclear | X X X X X X X X X| 15 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Carcinoma | X X X X | 5 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + + | 3 | __________________________________________________________________________|____________| Harderian Gland | + | 1 | Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X| 14 | Renal Tubule, Adenoma | X X| 2 | Renal Tubule, Oncocytoma Benign | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 | Mesothelioma Malignant | X | 2 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X| 15 | Mesothelioma Malignant | X X X X X X | 9 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 31 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------
Web page last updated on November 11, 2004