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Pathology Tables for Peer Review
Pathology Tables for Peer Review
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NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 CORE STUDY Facility: Battelle Columbus Laboratory Chemical CAS #: 93-15-2 Lock Date: 09/17/96 Cage Range: All Reasons For Removal: 25022 Accidently Killed 25018 Dosing Accident 25019 Moribund Sacrifice 25020 Natural Death 25021 Terminal Sacrifice Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 5| 4| 7| 7| 5| 6| 7| 6| 6| 6| 7| 7| 7| 5| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 4| 3| 0| 9| 4| 3| 4| 1| 4| 3| 3| 3| 9| 1| 5| 0| 3| 8| 3| 3| 3| 2| 3| 3| | 9| 8| 0| 0| 8| 1| 1| 4| 6| 1| 1| 0| 1| 8| 7| 5| 9| 0| 3| 0| 1| 1| 4| 0| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 MG/KG | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X X X X X X X X| Clear Cell Focus | X X | Eosinophilic Focus | X X X X X X| Hepatodiaphragmatic Nodule | X X X | Mixed Cell Focus | X X X X | Bile Duct, Hyperplasia | 1 1 1 1 1 1| Hepatocyte, Hypertrophy | 2 | Oval Cell, Hyperplasia | 1 | Periportal, Degeneration, Fatty | 2 | __________________________________________________________________________| Mesentery | + + + + + | Artery, Inflammation, Chronic | 4 | Fat, Necrosis | 3 3 2 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 4 1 1 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Submandibular Gland, Cytoplasmic | | Alteration | 2 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis, Diffuse | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 | Ulcer | 1 1 | __________________________________________________________________________| Tongue | + | Hyperkeratosis, Focal | 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Mucoid | | Myocardium, Degeneration | 1 2 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1| Valve, Fibrosis | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 5| 4| 7| 7| 5| 6| 7| 6| 6| 6| 7| 7| 7| 5| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 4| 3| 0| 9| 4| 3| 4| 1| 4| 3| 3| 3| 9| 1| 5| 0| 3| 8| 3| 3| 3| 2| 3| 3| | 9| 8| 0| 0| 8| 1| 1| 4| 6| 1| 1| 0| 1| 8| 7| 5| 9| 0| 3| 0| 1| 1| 4| 0| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 MG/KG | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Hyperplasia, Focal | 1 1 2 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 1 3 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Parathyroid Gland | + + + + + M + M + + + + + + + + + + + M + + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 3 3 | Cyst | 3 3 | Pars Distalis, Hyperplasia, Focal | 1 2 1 | Rathke's Cleft, Cyst | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 3 2 2 2 2 1 1 2 2 3 3 3 2 2 2 1| Follicle, Cyst | 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Hyperplasia, Focal | 3 | Necrosis, Focal | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 3 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Cystic | 1 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 | Hyperplasia | 2 2 2 1| Myeloid Cell, Hyperplasia | 3 | __________________________________________________________________________| Lymph Node | | Pancreatic, Erythrophagocytosis | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Erythrophagocytosis | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 1| __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 5| 4| 7| 7| 5| 6| 7| 6| 6| 6| 7| 7| 7| 5| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 4| 3| 0| 9| 4| 3| 4| 1| 4| 3| 3| 3| 9| 1| 5| 0| 3| 8| 3| 3| 3| 2| 3| 3| | 9| 8| 0| 0| 8| 1| 1| 4| 6| 1| 1| 0| 1| 8| 7| 5| 9| 0| 3| 0| 1| 1| 4| 0| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0 MG/KG | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| | 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Dilatation | 3 2 2 3 4 3 2 3 1 4 3 1 1| Galactocele | 1 1 4 2 2 1 3 1 | Hyperplasia, Focal | 1 1 3 1 1 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Dermis, Subcutaneous Tissue, Fibrosis| 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 1 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrocephalus | 2 3| Hypothalamus, Degeneration | 2 1 2 3| Medulla, Degeneration | 3 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | 2 | Inflammation, Granulomatous | 1 | Alveolar Epithelium, Hyperplasia, | | Focal | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 1 1 1 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Cataract | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | | Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2 2 1| Renal Tubule, Pigmentation, | | Lipofuscin | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 4| 6| 6| 7| 7| 5| 7| 7| 4| 7| 5| 7| 7| 6| 2| | DAY ON TEST | 3| 3| 1| 3| 0| 5| 9| 3| 3| 5| 5| 1| 4| 3| 3| 6| 3| 3| 0| 3| 9| 3| 1| 7| 4| | | 0| 1| 9| 0| 3| 9| 8| 1| 0| 3| 9| 9| 1| 0| 1| 9| 1| 0| 7| 1| 7| 0| 1| 9| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| L | | 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X X X X X X X X X X X X X X| 36 | Clear Cell Focus | X | 3 | Eosinophilic Focus | X X X X | 10 | Hepatodiaphragmatic Nodule | X X X X | 7 | Mixed Cell Focus | X X | 6 | Bile Duct, Hyperplasia | 1 2 2 1 2 | 11 1.3| Hepatocyte, Hypertrophy | | 1 2.0| Oval Cell, Hyperplasia | | 1 1.0| Periportal, Degeneration, Fatty | | 1 2.0| __________________________________________________________________________|____________| Mesentery | + | 6 | Artery, Inflammation, Chronic | | 1 4.0| Fat, Necrosis | 3 | 5 2.6| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | 1 1 1 1 1 1 | 10 1.5| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Submandibular Gland, Cytoplasmic | | | Alteration | | 1 2.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperkeratosis, Diffuse | 3 | 1 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 1 1 | 3 1.0| Ulcer | 2 | 3 1.3| __________________________________________________________________________|____________| Tongue | | 1 | Hyperkeratosis, Focal | | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Mucoid | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 4| 6| 6| 7| 7| 5| 7| 7| 4| 7| 5| 7| 7| 6| 2| | DAY ON TEST | 3| 3| 1| 3| 0| 5| 9| 3| 3| 5| 5| 1| 4| 3| 3| 6| 3| 3| 0| 3| 9| 3| 1| 7| 4| | | 0| 1| 9| 0| 3| 9| 8| 1| 0| 3| 9| 9| 1| 0| 1| 9| 1| 0| 7| 1| 7| 0| 1| 9| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| L | | 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Myocardium, Degeneration | 1 1 3 1 2 1 1 2 1 2 1 1 1 1 1 1 | 35 1.2| Valve, Fibrosis | | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 1 1 1 1 1 1 1 1 1 | 13 1.1| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 1 | 4 1.8| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + M + + M + + + + +| 44 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 4 | 4 3.3| Cyst | 3 | 3 3.0| Pars Distalis, Hyperplasia, Focal | 2 2 1 1 2 1 2 1 | 11 1.5| Rathke's Cleft, Cyst | 3 | 1 3.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 2 1 2 1 2 2 1 1 4 1 2 2 1 1 2 | 32 1.9| Follicle, Cyst | | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 | Cyst | 3 3 | 2 3.0| Hyperplasia, Focal | 1 | 2 2.0| Necrosis, Focal | 3 | 1 3.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 2 3.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Cystic | | 2 1.5| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 2 | 2 2.0| Hyperplasia | | 4 1.8| Myeloid Cell, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Lymph Node | + + | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 4| 6| 6| 7| 7| 5| 7| 7| 4| 7| 5| 7| 7| 6| 2| | DAY ON TEST | 3| 3| 1| 3| 0| 5| 9| 3| 3| 5| 5| 1| 4| 3| 3| 6| 3| 3| 0| 3| 9| 3| 1| 7| 4| | | 0| 1| 9| 0| 3| 9| 8| 1| 0| 3| 9| 9| 1| 0| 1| 9| 1| 0| 7| 1| 7| 0| 1| 9| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| L | | 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Pancreatic, Erythrophagocytosis | 1 | 1 1.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erythrophagocytosis | | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 1 | 3 1.3| __________________________________________________________________________|____________| Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 1 1 1 3 3 3 3 3 1 1 2 3 4 1 | 27 2.3| Galactocele | 3 2 | 10 2.0| Hyperplasia, Focal | 2 2 2 | 8 1.6| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dermis, Subcutaneous Tissue, Fibrosis| | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperostosis | | 1 1.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydrocephalus | 2 3 | 4 2.5| Hypothalamus, Degeneration | 2 1 4 3 3 | 9 2.3| Medulla, Degeneration | | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Acute | | 1 2.0| Inflammation, Granulomatous | | 1 1.0| Alveolar Epithelium, Hyperplasia, | | | Focal | 1 | 2 1.5| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 1 2 1 | 8 1.4| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | Cataract | 4 | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 4| 6| 7| 7| 6| 4| 6| 6| 7| 7| 5| 7| 7| 4| 7| 5| 7| 7| 6| 2| | DAY ON TEST | 3| 3| 1| 3| 0| 5| 9| 3| 3| 5| 5| 1| 4| 3| 3| 6| 3| 3| 0| 3| 9| 3| 1| 7| 4| | | 0| 1| 9| 0| 3| 9| 8| 1| 0| 3| 9| 9| 1| 0| 1| 9| 1| 0| 7| 1| 7| 0| 1| 9| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| L | | 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis | 3 | 1 3.0| Nephropathy | 1 1 1 1 1 1 1 2 1 1 2 2 1 1 1 | 35 1.2| Renal Tubule, Pigmentation, | | | Lipofuscin | 3 | 1 3.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 3| 5| 7| 4| 6| 7| 6| 6| 6| 7| 6| 7| 7| DAY ON TEST | 8| 2| 3| 6| 0| 3| 3| 1| 1| 4| 5| 3| 4| 6| 3| 5| 9| 3| 1| 0| 6| 3| 0| 3| 3| | 3| 0| 1| 4| 3| 0| 1| 8| 7| 6| 0| 1| 7| 9| 1| 0| 4| 1| 1| 9| 5| 0| 6| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 37 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + M + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X X X X X X X X X X X| Clear Cell Focus | X X X X X | Eosinophilic Focus | X X X X X X X X | Hepatodiaphragmatic Nodule | X | Mixed Cell Focus | X X X | Necrosis, Focal | 1 | Bile Duct, Hyperplasia | 1 1 1 2 | Centrilobular, Degeneration, Fatty | 3 2 4 | Hepatocyte, Hypertrophy | 1 1 2 2 | Oval Cell, Hyperplasia | 1 1 1 1 1 2 | __________________________________________________________________________| Mesentery | + + + + | Fat, Necrosis | 2 1 2 1 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 2 1| __________________________________________________________________________| Salivary Glands | + + + M + + + + + + + + + + + + + + + + + + + + +| Submandibular Gland, Cytoplasmic | | Alteration | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | 3 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 2 1 1 1 1 1 1 3 2 1 3 1 2 2 1 2 2 2 1 1 1| Ulcer | 3 2 1 | Neuroendocrine Cell, Hyperplasia | 1 1 | __________________________________________________________________________| Tongue | | Hyperkeratosis, Focal | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrium, Thrombosis | | Myocardium, Degeneration | 1 1 1 2 2 1 2 2 1 1 1 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 3| 5| 7| 4| 6| 7| 6| 6| 6| 7| 6| 7| 7| DAY ON TEST | 8| 2| 3| 6| 0| 3| 3| 1| 1| 4| 5| 3| 4| 6| 3| 5| 9| 3| 1| 0| 6| 3| 0| 3| 3| | 3| 0| 1| 4| 3| 0| 1| 8| 7| 6| 0| 1| 7| 9| 1| 0| 4| 1| 1| 9| 5| 0| 6| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 37 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Hyperplasia, Focal | 1 1 2 1 | Necrosis | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 1 3 1 1 3 | Infarct | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + M + + + + M M + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Cyst | 3 3 | Pars Distalis, Hyperplasia, Diffuse | 4 | Pars Distalis, Hyperplasia, Focal | 3 1 2 1 1| __________________________________________________________________________| Thyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| Inflammation, Focal, Suppurative | 1 | C-Cell, Hyperplasia | 1 1 2 3 3 2 3 4 2 2 2 2 2 2 1 | Follicular Cell, Hyperplasia, Focal | 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + M + + + + + + + + + M + + + + M + M +| Cyst | | Hyperplasia, Focal | | Inflammation, Chronic | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 3 3 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Vagina | + | Infiltration Cellular, | | Polymorphonuclear | 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 2 1 1 2 1 2 2| Inflammation, Granulomatous | 1 | Necrosis | | Myeloid Cell, Hyperplasia | 4 2 | __________________________________________________________________________| Lymph Node | + + + | Pancreatic, Necrosis | 4 | __________________________________________________________________________| Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 3| 5| 7| 4| 6| 7| 6| 6| 6| 7| 6| 7| 7| DAY ON TEST | 8| 2| 3| 6| 0| 3| 3| 1| 1| 4| 5| 3| 4| 6| 3| 5| 9| 3| 1| 0| 6| 3| 0| 3| 3| | 3| 0| 1| 4| 3| 0| 1| 8| 7| 6| 0| 1| 7| 9| 1| 0| 4| 1| 1| 9| 5| 0| 6| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 37 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hematopoietic Cell Proliferation | 1 2 4 2 4 4| Inflammation, Granulomatous | | Necrosis | | __________________________________________________________________________| Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 2 1 3 2 4 2 3 2 3 2 2 2| Galactocele | 2 3 3 2 2 3 | Hyperplasia, Cystic | 4 4 | Hyperplasia, Focal | 4 2 1| Hyperplasia, Lobular | 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | | Osteopetrosis | | __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrocephalus | 1 2 1 2 3 | Hypothalamus, Degeneration | 1 2 4 4 4 1 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 4 | Alveolar Epithelium, Hyperplasia, | | Focal | 1 | Interstitium, Inflammation, Chronic | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Squamous | | Inflammation, Suppurative | 1 1 1 2 | __________________________________________________________________________| Trachea | + + + M + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydronephrosis | 3 | Infarct | 2 | Nephropathy | 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 6| 6| 7| 5| 7| 7| 7| 7| 7| 6| 6| 7| 3| 5| 7| 4| 6| 7| 6| 6| 6| 7| 6| 7| 7| DAY ON TEST | 8| 2| 3| 6| 0| 3| 3| 1| 1| 4| 5| 3| 4| 6| 3| 5| 9| 3| 1| 0| 6| 3| 0| 3| 3| | 3| 0| 1| 4| 3| 0| 1| 8| 7| 6| 0| 1| 7| 9| 1| 0| 4| 1| 1| 9| 5| 0| 6| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 37 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Renal Tubule, Accumulation, Hyaline | | Droplet | | Renal Tubule, Pigmentation, | | Lipofuscin | 3 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 6| 7| 4| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 5| 7| | DAY ON TEST | 3| 3| 3| 8| 3| 3| 3| 1| 3| 4| 8| 3| 3| 3| 3| 1| 3| 7| 3| 3| 2| 3| 3| 2| 3| | | 0| 0| 0| 8| 1| 1| 0| 1| 0| 3| 3| 0| 0| 1| 1| 8| 0| 3| 0| 0| 4| 1| 7| 0| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 37 MG/KG | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X X | 4 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | 3 | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X X X X X X X X X X X| 36 | Clear Cell Focus | X X X X X | 10 | Eosinophilic Focus | X X X X X X X X X X X X| 20 | Hepatodiaphragmatic Nodule | X | 2 | Mixed Cell Focus | X | 4 | Necrosis, Focal | | 1 1.0| Bile Duct, Hyperplasia | 1 1 2 1 1 2 1 | 11 1.3| Centrilobular, Degeneration, Fatty | | 3 3.0| Hepatocyte, Hypertrophy | 3 2 3 2 3 2 2 1 3| 13 2.1| Oval Cell, Hyperplasia | 1 2 1 1 3 1 1 1 1 | 15 1.3| __________________________________________________________________________|____________| Mesentery | + | 5 | Fat, Necrosis | 2 | 5 1.6| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | 1 2 3 1 1 1 1 1 3 | 11 1.5| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 | Submandibular Gland, Cytoplasmic | | | Alteration | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 48 2.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Ulcer | | 2 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 2 2 2 2 1 2 2 2 1 1 2 1 1 1 2 2 2 1 1| 41 1.6| Ulcer | 2 | 4 2.0| Neuroendocrine Cell, Hyperplasia | 1 1 1 | 5 1.0| __________________________________________________________________________|____________| Tongue | + | 1 | Hyperkeratosis, Focal | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 6| 7| 4| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 5| 7| | DAY ON TEST | 3| 3| 3| 8| 3| 3| 3| 1| 3| 4| 8| 3| 3| 3| 3| 1| 3| 7| 3| 3| 2| 3| 3| 2| 3| | | 0| 0| 0| 8| 1| 1| 0| 1| 0| 3| 3| 0| 0| 1| 1| 8| 0| 3| 0| 0| 4| 1| 7| 0| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 37 MG/KG | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Atrium, Thrombosis | 2 2 | 2 2.0| Myocardium, Degeneration | 1 1 2 1 2 2 1 1 1 1 2 1 1 | 30 1.3| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 1 1 1 2 2 1 1 | 11 1.3| Necrosis | 4 3 | 2 3.5| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 1 3 1 | 9 1.8| Infarct | 4 | 1 4.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + M + +| 45 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 1 | 2 1.5| Cyst | | 2 3.0| Pars Distalis, Hyperplasia, Diffuse | | 1 4.0| Pars Distalis, Hyperplasia, Focal | 2 3 3 1 1 2 3 1 1 1 2 2| 17 1.8| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Focal, Suppurative | | 1 1.0| C-Cell, Hyperplasia | 1 2 4 1 1 2 2 1 2 2 2 2 1 1 3 1 2 2 | 33 1.9| Follicular Cell, Hyperplasia, Focal | | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | Cyst | 3 | 1 3.0| Hyperplasia, Focal | 3 2 3 | 3 2.7| Inflammation, Chronic | 3 | 1 3.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 3 3 3 | 7 3.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Vagina | +| 2 | Infiltration Cellular, | | | Polymorphonuclear | | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 6| 7| 4| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 5| 7| | DAY ON TEST | 3| 3| 3| 8| 3| 3| 3| 1| 3| 4| 8| 3| 3| 3| 3| 1| 3| 7| 3| 3| 2| 3| 3| 2| 3| | | 0| 0| 0| 8| 1| 1| 0| 1| 0| 3| 3| 0| 0| 1| 1| 8| 0| 3| 0| 0| 4| 1| 7| 0| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 37 MG/KG | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hyperplasia | 1 3 2 2 1 2 | 15 1.7| Inflammation, Granulomatous | 1 | 2 1.0| Necrosis | 2 | 1 2.0| Myeloid Cell, Hyperplasia | | 2 3.0| __________________________________________________________________________|____________| Lymph Node | + + | 5 | Pancreatic, Necrosis | | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 2 1 | 3 1.7| Hematopoietic Cell Proliferation | 2 | 7 2.7| Inflammation, Granulomatous | 2 3 | 2 2.5| Necrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 3 3 1 1 1 3 2 3 1 2 | 22 2.2| Galactocele | 3 2 2 1| 10 2.3| Hyperplasia, Cystic | | 2 4.0| Hyperplasia, Focal | 1 2 2 2| 7 2.0| Hyperplasia, Lobular | | 1 3.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperostosis | 2 | 1 2.0| Osteopetrosis | 3| 1 3.0| __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydrocephalus | 2 2 3 3 | 9 2.1| Hypothalamus, Degeneration | 4 3 3 4 2 3 | 12 2.9| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | | 1 4.0| Alveolar Epithelium, Hyperplasia, | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 6| 7| 4| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 5| 7| | DAY ON TEST | 3| 3| 3| 8| 3| 3| 3| 1| 3| 4| 8| 3| 3| 3| 3| 1| 3| 7| 3| 3| 2| 3| 3| 2| 3| | | 0| 0| 0| 8| 1| 1| 0| 1| 0| 3| 3| 0| 0| 1| 1| 8| 0| 3| 0| 0| 4| 1| 7| 0| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 37 MG/KG | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Focal | 2 1 | 3 1.3| Interstitium, Inflammation, Chronic | | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Squamous | 1 | 1 1.0| Inflammation, Suppurative | 1 3 1 1 2 1| 10 1.4| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydronephrosis | 2| 2 2.5| Infarct | 1 2 | 3 1.7| Nephropathy | 1 1 2 2 1 2 3 2 1 1 1 1 1 1 1 1 1 1 1 1 2| 42 1.2| Renal Tubule, Accumulation, Hyaline | | | Droplet | 4 | 1 4.0| Renal Tubule, Pigmentation, | | | Lipofuscin | | 1 3.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 5| 7| 5| 7| 7| 7| 7| DAY ON TEST | 3| 0| 9| 3| 3| 1| 2| 0| 3| 1| 8| 3| 3| 3| 2| 7| 2| 3| 4| 0| 1| 3| 2| 3| 1| | 1| 9| 0| 1| 0| 7| 7| 2| 1| 3| 3| 1| 1| 0| 5| 6| 9| 1| 1| 3| 5| 0| 1| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 75 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + M + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + M + + + + + + + + + +| Basophilic Focus | X X X X X X X X X X X X X| Clear Cell Focus | X X X| Degeneration, Cystic, Focal | 1 | Eosinophilic Focus | X X X X X X X X X X X X| Hepatodiaphragmatic Nodule | X X | Mixed Cell Focus | X X X X X X X X | Necrosis, Focal | 1 | Bile Duct, Hyperplasia | 2 2 1 2 1 1 1 1 | Centrilobular, Necrosis | | Hepatocyte, Hypertrophy | 3 3 3 3 3 | Oval Cell, Hyperplasia | 2 1 1 1 1 1 1 2 1| __________________________________________________________________________| Mesentery | + + | Inflammation, Chronic | 1 | Fat, Necrosis | 2 | __________________________________________________________________________| Oral Mucosa | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 3 | Acinus, Atrophy | 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + M + + + + + + + + + +| Submandibular Gland, Cytoplasmic | | Alteration | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 2 3 2 2 1 2 2 2 2 2 3 1 1 2 2 3 2 3 2 2| Mineralization | 2 | Ulcer | 2 2 | Neuroendocrine Cell, Hyperplasia | 1 3 3 1 1 4 1 2| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + M + + + + + + + + + +| Atrium, Thrombosis | | Myocardium, Degeneration | 1 1 2 1 2 1 1 1 1 1 1 1 1 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 5| 7| 5| 7| 7| 7| 7| DAY ON TEST | 3| 0| 9| 3| 3| 1| 2| 0| 3| 1| 8| 3| 3| 3| 2| 7| 2| 3| 4| 0| 1| 3| 2| 3| 1| | 1| 9| 0| 1| 0| 7| 7| 2| 1| 3| 3| 1| 1| 0| 5| 6| 9| 1| 1| 3| 5| 0| 1| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 75 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 1 1 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 3 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| Bilateral, Hyperplasia | 2 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Cyst | 3 2 3 | Pars Distalis, Hyperplasia, Focal | 1 1 1 2 2 2 3| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| C-Cell, Hyperplasia | 2 2 2 2 2 2 2 2 1 3 4 2 3 2 2 3| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| Cyst | 3 | Hyperplasia, Focal | 1 | Inflammation, Suppurative | 3 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 3 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Endometrium, Degeneration | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 3 2 | Hyperplasia | 1 1 2 2 2 2 2 3| Erythroid Cell, Hyperplasia | | __________________________________________________________________________| Lymph Node | + | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 2 1 | Hematopoietic Cell Proliferation | 3 3 2 2 | Inflammation, Focal, Suppurative | 2 | Inflammation, Granulomatous | | Lymphoid Follicle, Hyperplasia | 3 | __________________________________________________________________________| Thymus | + + + M + + + + + + + + + + M + + + + + + + + + +| Atrophy | 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 5| 7| 5| 7| 7| 7| 7| DAY ON TEST | 3| 0| 9| 3| 3| 1| 2| 0| 3| 1| 8| 3| 3| 3| 2| 7| 2| 3| 4| 0| 1| 3| 2| 3| 1| | 1| 9| 0| 1| 0| 7| 7| 2| 1| 3| 3| 1| 1| 0| 5| 6| 9| 1| 1| 3| 5| 0| 1| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 75 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 3 2 2 3 2 1 2 2 2 2 2 2 2 2 3| Galactocele | 2 2 3 2 | Hyperplasia, Cystic | 4 | Hyperplasia, Focal | 2 2 2 2 1 1| Inflammation, Suppurative | 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | | Dermis, Necrosis | 3 | Dermis, Subcutaneous Tissue, Fibrosis| 3| Hair Follicle, Atrophy, Focal | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 4 2 3 | Osteopetrosis | 3 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrocephalus | | Hypothalamus, Degeneration | 3 1 4 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + M + + + + + + + + + +| Inflammation, Acute | 4 | Inflammation, Granulomatous | | Alveolar Epithelium, Hyperplasia, | | Focal | 1 1 1| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 2 1 1 1 1 1 1 1| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + M + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Cataract | 4 | Degeneration | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | 2 | Inflammation, Focal, Suppurative | 3 | Nephropathy | 1 1 2 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1 1| Renal Tubule, Pigmentation, | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 7| 6| 6| 7| 7| 7| 6| 7| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 5| 7| 5| 7| 7| 7| 7| DAY ON TEST | 3| 0| 9| 3| 3| 1| 2| 0| 3| 1| 8| 3| 3| 3| 2| 7| 2| 3| 4| 0| 1| 3| 2| 3| 1| | 1| 9| 0| 1| 0| 7| 7| 2| 1| 3| 3| 1| 1| 0| 5| 6| 9| 1| 1| 3| 5| 0| 1| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 75 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Lipofuscin | 3 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 6| 7| 7| 6| 5| 5| 7| 6| 4| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5| | DAY ON TEST | 8| 3| 3| 3| 9| 3| 3| 7| 9| 5| 3| 7| 4| 3| 3| 1| 3| 3| 3| 9| 2| 1| 3| 3| 2| | | 3| 7| 1| 0| 0| 0| 1| 6| 5| 7| 0| 6| 4| 1| 0| 2| 0| 0| 0| 7| 4| 4| 0| 0| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 75 MG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Basophilic Focus | X X X X X X X X X X X X X X X X | 29 | Clear Cell Focus | X X X X X X X X X | 12 | Degeneration, Cystic, Focal | | 1 1.0| Eosinophilic Focus | X X X X X X X X X X X X X X X | 27 | Hepatodiaphragmatic Nodule | X X X X | 6 | Mixed Cell Focus | X X X X X X X X X X X | 19 | Necrosis, Focal | | 1 1.0| Bile Duct, Hyperplasia | 2 1 2 1 1 1 1 1 1 | 17 1.3| Centrilobular, Necrosis | 3 | 1 3.0| Hepatocyte, Hypertrophy | 2 3 2 3 4 4 2 3 4 3 4 | 16 3.1| Oval Cell, Hyperplasia | 3 2 2 1 1 3 1 2 1 1 | 19 1.5| __________________________________________________________________________|____________| Mesentery | + | 3 | Inflammation, Chronic | | 1 1.0| Fat, Necrosis | 2 | 2 2.0| __________________________________________________________________________|____________| Oral Mucosa | + | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | | 1 3.0| Acinus, Atrophy | 1 1 1 1 1 1 1 | 8 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Submandibular Gland, Cytoplasmic | | | Alteration | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 49 2.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 2 2 2 3 3 3 4 1 1 2 2 2 1 2 1 1 3 2 3 2 2 3 3 2| 45 2.1| Mineralization | | 1 2.0| Ulcer | 1 2 | 4 1.8| Neuroendocrine Cell, Hyperplasia | 2 2 2| 11 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 6| 7| 7| 6| 5| 5| 7| 6| 4| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5| | DAY ON TEST | 8| 3| 3| 3| 9| 3| 3| 7| 9| 5| 3| 7| 4| 3| 3| 1| 3| 3| 3| 9| 2| 1| 3| 3| 2| | | 3| 7| 1| 0| 0| 0| 1| 6| 5| 7| 0| 6| 4| 1| 0| 2| 0| 0| 0| 7| 4| 4| 0| 0| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 75 MG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrium, Thrombosis | 4 | 1 4.0| Myocardium, Degeneration | 1 1 1 1 1 2 2 2 1 1 1 1 | 26 1.2| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 1 1 1 1 | 7 1.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 1 | 4 1.8| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + M M + + + M M M + + + + + M M + + M + + + + +| 41 | Bilateral, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 2 | 2 1.5| Cyst | 3 | 4 2.8| Pars Distalis, Hyperplasia, Focal | 2 1 2 2 3 1 1| 14 1.7| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | C-Cell, Hyperplasia | 3 2 1 2 2 2 4 1 3 1 1 2 2 2| 30 2.1| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | 3 | 2 3.0| Hyperplasia, Focal | | 1 1.0| Inflammation, Suppurative | | 1 3.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 | Cyst | | 2 3.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 | Endometrium, Degeneration | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 | Fibrosis | | 2 2.5| Hyperplasia | 2 2 3 | 11 2.0| Erythroid Cell, Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 6| 7| 7| 6| 5| 5| 7| 6| 4| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5| | DAY ON TEST | 8| 3| 3| 3| 9| 3| 3| 7| 9| 5| 3| 7| 4| 3| 3| 1| 3| 3| 3| 9| 2| 1| 3| 3| 2| | | 3| 7| 1| 0| 0| 0| 1| 6| 5| 7| 0| 6| 4| 1| 0| 2| 0| 0| 0| 7| 4| 4| 0| 0| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 75 MG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 1 2 | 5 1.6| Hematopoietic Cell Proliferation | 3 2 | 6 2.5| Inflammation, Focal, Suppurative | | 1 2.0| Inflammation, Granulomatous | 2 | 1 2.0| Lymphoid Follicle, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + M + M + + + + + + + + + + +| 46 | Atrophy | | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 3 4 2 3 2 3 1 4 2 2 1 2 2 4 3 3 1 4 3| 34 2.4| Galactocele | 3 2 3 | 7 2.4| Hyperplasia, Cystic | 2 | 2 3.0| Hyperplasia, Focal | 1 3 1 | 9 1.7| Inflammation, Suppurative | | 1 3.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | 3 | 1 3.0| Dermis, Necrosis | | 1 3.0| Dermis, Subcutaneous Tissue, Fibrosis| | 1 3.0| Hair Follicle, Atrophy, Focal | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperostosis | 1 2| 5 2.4| Osteopetrosis | 2 | 2 2.5| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydrocephalus | 3 4 2 | 3 3.0| Hypothalamus, Degeneration | 1 3 2 | 6 2.3| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Acute | 1 | 2 2.5| Inflammation, Granulomatous | 1 | 1 1.0| Alveolar Epithelium, Hyperplasia, | | | Focal | 1 1 1 1 | 7 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 6| 6| 7| 7| 6| 7| 7| 6| 5| 5| 7| 6| 4| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5| | DAY ON TEST | 8| 3| 3| 3| 9| 3| 3| 7| 9| 5| 3| 7| 4| 3| 3| 1| 3| 3| 3| 9| 2| 1| 3| 3| 2| | | 3| 7| 1| 0| 0| 0| 1| 6| 5| 7| 0| 6| 4| 1| 0| 2| 0| 0| 0| 7| 4| 4| 0| 0| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 75 MG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 2 1 1 2 1 | 14 1.2| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 2 | Cataract | | 1 4.0| Degeneration | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infarct | | 1 2.0| Inflammation, Focal, Suppurative | | 1 3.0| Nephropathy | 1 1 1 1 1 2 2 1 1 2 1 1 1 2 1 1 1 1 1 1 | 41 1.2| Renal Tubule, Pigmentation, | | | Lipofuscin | 3 2 2| 4 2.5| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 5| 7| 7| 4| 6| 5| 6| 6| 5| 4| 7| 5| 7| 6| 6| 6| 6| 6| 5| 5| 6| 5| 6| 6| 5| DAY ON TEST | 3| 3| 3| 8| 4| 5| 6| 0| 7| 8| 3| 0| 2| 9| 3| 0| 5| 7| 9| 4| 2| 7| 0| 1| 2| | 4| 0| 1| 3| 1| 3| 0| 9| 6| 3| 0| 8| 4| 4| 2| 0| 2| 9| 0| 8| 0| 2| 5| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 150 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | Ulcer | 3 | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoid Tissue, Hyperplasia | 2 | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + M + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X | Clear Cell Focus | X X X X | Degeneration, Cystic, Focal | 3 1 1 | Eosinophilic Focus | X X X X X X X X X X X X X X X | Hepatodiaphragmatic Nodule | X X | Mixed Cell Focus | X X X X X| Bile Duct, Hyperplasia | 1 1 2 2 1 1 2 2 2 2 1 | Centrilobular, Necrosis | | Hepatocyte, Hypertrophy | 1 4 4 3 2 3 4 3 3 3 3 2 2 4 | Oval Cell, Hyperplasia | 2 2 2 3 2 3 2 2 1 3 2 3 2 3 1 2 2 | __________________________________________________________________________| Mesentery | + | Fat, Necrosis | 2 | __________________________________________________________________________| Pancreas | + + + M + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 1 1 | __________________________________________________________________________| Salivary Glands | + + + M + + + + + + + + + + + + + + + + + + + + +| Submandibular Gland, Cytoplasmic | | Alteration | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + A + + + + + A + + + + + + + + + + + + + + +| Atrophy | 2 3 4 2 3 2 2 1 2 3 4 2 3 3 4 3 2 3 2 3| Neuroendocrine Cell, Hyperplasia | 3 1 3 2| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + M + + + + + + + + + + + + + + + + + + + + +| Myocardium, Degeneration | 1 1 1 1 1 1 1 1 2 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + M + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 3 1 | Necrosis | 1 | __________________________________________________________________________| Adrenal Medulla | + + + M + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 5| 7| 7| 4| 6| 5| 6| 6| 5| 4| 7| 5| 7| 6| 6| 6| 6| 6| 5| 5| 6| 5| 6| 6| 5| DAY ON TEST | 3| 3| 3| 8| 4| 5| 6| 0| 7| 8| 3| 0| 2| 9| 3| 0| 5| 7| 9| 4| 2| 7| 0| 1| 2| | 4| 0| 1| 3| 1| 3| 0| 9| 6| 3| 0| 8| 4| 4| 2| 0| 2| 9| 0| 8| 0| 2| 5| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 150 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Hyperplasia, Focal | 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + M M + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 3 | Pars Distalis, Hyperplasia, Focal | 1 2 1 2 2 1 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 2 2 2 1 3 1 2 2 1 2 3 2 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 | __________________________________________________________________________| Ovary | + + + M + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Cervix, Hyperplasia, Focal | 3 | __________________________________________________________________________| Vagina | + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 1 | Hyperplasia | 1 1 1 2 1 2 2 2 2 | Necrosis | 4 | __________________________________________________________________________| Lymph Node | + + + + | Pancreatic, Hyperplasia | 4 | Renal, Ectasia | 1 | __________________________________________________________________________| Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +| Necrosis | 4 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +| Inflammation, Granulomatous | | Necrosis | 4 | __________________________________________________________________________| Spleen | + + + M + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 2 2 | Hematopoietic Cell Proliferation | 3 2 | Inflammation, Granulomatous | | Red Pulp, Necrosis | 3 3 | __________________________________________________________________________| Thymus | + + + M + + + + + + M + + + + + + + M + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 5| 7| 7| 4| 6| 5| 6| 6| 5| 4| 7| 5| 7| 6| 6| 6| 6| 6| 5| 5| 6| 5| 6| 6| 5| DAY ON TEST | 3| 3| 3| 8| 4| 5| 6| 0| 7| 8| 3| 0| 2| 9| 3| 0| 5| 7| 9| 4| 2| 7| 0| 1| 2| | 4| 0| 1| 3| 1| 3| 0| 9| 6| 3| 0| 8| 4| 4| 2| 0| 2| 9| 0| 8| 0| 2| 5| 1| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 150 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Dilatation | 4 4 2 1 2 2 3 4 1 1 2 1| Galactocele | 2 | Hyperplasia, Focal | 1 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hair Follicle, Atrophy, Focal | 4 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 3 3 3 2 | __________________________________________________________________________| Skeletal Muscle | + | Degeneration, Focal | 3 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion, Focal | 1 | Hydrocephalus | 3 2 2 | Cerebellum, Necrosis, Focal | 3 | Hypothalamus, Degeneration | 3 1 3 | Pons, Degeneration | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + M + + + + + + + + + + + + + + + + + + + + +| Alveolar Epithelium, Hyperplasia, | | Focal | 1 1| __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | __________________________________________________________________________| Lacrimal Gland | + | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + M + + + + + + + + + + + + + + + + + + + + +| Nephropathy | 1 2 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1 1| Renal Tubule, Pigmentation, | | Lipofuscin | 3 2 3 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 5| 6| 7| 7| 7| 6| 6| 7| | DAY ON TEST | 6| 1| 7| 3| 3| 2| 0| 2| 3| 3| 9| 1| 3| 4| 3| 2| 4| 8| 0| 0| 1| 3| 2| 7| 3| | | 7| 1| 6| 1| 0| 3| 3| 4| 0| 0| 1| 1| 1| 7| 1| 0| 1| 9| 9| 2| 7| 0| 0| 9| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 150 | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 1 | Ulcer | | 1 3.0| __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 2 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoid Tissue, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Basophilic Focus | X X X X X X X X | 17 | Clear Cell Focus | | 4 | Degeneration, Cystic, Focal | 1 | 4 1.5| Eosinophilic Focus | X X X X X X X X X X X X X X X X | 31 | Hepatodiaphragmatic Nodule | | 2 | Mixed Cell Focus | X X X X | 9 | Bile Duct, Hyperplasia | 2 2 1 1 1 2 1 1 1 2 2 | 22 1.5| Centrilobular, Necrosis | 1 | 1 1.0| Hepatocyte, Hypertrophy | 3 4 3 4 3 4 4 4 4 3 4 2 | 26 3.2| Oval Cell, Hyperplasia | 2 2 2 3 2 1 3 3 2 1 3 2 3 2 2 2 3 2 | 35 2.2| __________________________________________________________________________|____________| Mesentery | + + | 3 | Fat, Necrosis | 2 2 | 3 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acinus, Atrophy | 1 1 1 1 | 6 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Submandibular Gland, Cytoplasmic | | | Alteration | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 49 2.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Atrophy | 2 3 2 2 2 3 2 2 2 2 2 2 2 1 3 2 2 3 3| 39 2.4| Neuroendocrine Cell, Hyperplasia | 2 2 2 4 1 | 9 2.2| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Myocardium, Degeneration | 1 1 1 1 1 1 1 1 1 1| 20 1.1| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 5| 6| 7| 7| 7| 6| 6| 7| | DAY ON TEST | 6| 1| 7| 3| 3| 2| 0| 2| 3| 3| 9| 1| 3| 4| 3| 2| 4| 8| 0| 0| 1| 3| 2| 7| 3| | | 7| 1| 6| 1| 0| 3| 3| 4| 0| 0| 1| 1| 1| 7| 1| 0| 1| 9| 9| 2| 7| 0| 0| 9| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 150 | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia, Focal | 1 1 1 1 1 1 1| 9 1.2| Necrosis | | 1 1.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia, Focal | 3 4 | 3 2.7| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + +| 46 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 2 2.5| Pars Distalis, Hyperplasia, Focal | 1 2 1 1 1 2 1 1| 15 1.4| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 2 2 1 1 1 2 1 2 2 1 1 2 1 1 3 1| 32 1.6| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + M + + + + + + + + + M M + + M + + + + +| 46 | Cyst | | 1 3.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | 3 | 2 3.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cervix, Hyperplasia, Focal | | 1 3.0| __________________________________________________________________________|____________| Vagina | + | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 2 | 2 1.5| Hyperplasia | 1 1 2 2 1 2 1 2 2 2 1| 20 1.6| Necrosis | 2 | 2 3.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + | 10 | Pancreatic, Hyperplasia | | 1 4.0| Renal, Ectasia | | 1 1.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Necrosis | | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Granulomatous | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 5| 6| 7| 7| 7| 6| 6| 7| | DAY ON TEST | 6| 1| 7| 3| 3| 2| 0| 2| 3| 3| 9| 1| 3| 4| 3| 2| 4| 8| 0| 0| 1| 3| 2| 7| 3| | | 7| 1| 6| 1| 0| 3| 3| 4| 0| 0| 1| 1| 1| 7| 1| 0| 1| 9| 9| 2| 7| 0| 0| 9| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 150 | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Necrosis | | 1 4.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Fibrosis | 1 2 1 1 2 2 2 1 2| 12 1.7| Hematopoietic Cell Proliferation | | 2 2.5| Inflammation, Granulomatous | 2 | 1 2.0| Red Pulp, Necrosis | | 2 3.0| __________________________________________________________________________|____________| Thymus | + + + + + + + M + + + + + + + + + + + + + + + + +| 46 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 4 4 1 4 3 3 3 3 | 20 2.6| Galactocele | 3 2 2 4 3 | 6 2.7| Hyperplasia, Focal | | 2 1.5| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hair Follicle, Atrophy, Focal | | 1 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperostosis | | 4 2.8| __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Degeneration, Focal | | 1 3.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion, Focal | | 1 1.0| Hydrocephalus | 1 3 3 1 3 | 8 2.3| Cerebellum, Necrosis, Focal | | 1 3.0| Hypothalamus, Degeneration | 3 3 4 2 | 7 2.7| Pons, Degeneration | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Alveolar Epithelium, Hyperplasia, | | | Focal | 1 | 3 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 1 1 | 3 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 5| 6| 7| 7| 7| 6| 6| 7| | DAY ON TEST | 6| 1| 7| 3| 3| 2| 0| 2| 3| 3| 9| 1| 3| 4| 3| 2| 4| 8| 0| 0| 1| 3| 2| 7| 3| | | 7| 1| 6| 1| 0| 3| 3| 4| 0| 0| 1| 1| 1| 7| 1| 0| 1| 9| 9| 2| 7| 0| 0| 9| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A | 150 | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Ear | | 1 | __________________________________________________________________________|____________| Lacrimal Gland | | 1 | __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Nephropathy | 1 1 2 1 2 1 2 1 2 2 1 2 2 1 1 1 1 1 1 2 1 2 1 1 3| 44 1.3| Renal Tubule, Pigmentation, | | | Lipofuscin | | 3 2.7| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 5| 6| 6| 3| 7| 7| 2| 6| 4| 7| 7| 6| 6| 5| 4| 7| 6| 6| 6| 7| 6| 6| 6| 5| 7| DAY ON TEST | 7| 6| 9| 3| 3| 3| 8| 3| 7| 3| 3| 2| 2| 1| 5| 3| 4| 1| 7| 3| 0| 5| 4| 6| 0| | 1| 0| 4| 1| 1| 0| 1| 7| 7| 0| 0| 0| 0| 9| 9| 0| 2| 1| 9| 0| 9| 9| 1| 0| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| MG/KG | 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 6| 8| 9| 0| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X | Clear Cell Focus | X X X X | Degeneration, Cystic, Focal | 2 2 1 2 2 2 1 2 1 1 3 1 2| Eosinophilic Focus | X X X X X X X X X X X X X X X X X X X X X| Hepatodiaphragmatic Nodule | | Inflammation, Granulomatous | 1 | Mixed Cell Focus | X X X X X | Necrosis, Focal | 2 | Bile Duct, Cyst | | Bile Duct, Hyperplasia | 1 2 2 1 2 2 1 1 1 2 2 2 2 1 1 4| Centrilobular, Necrosis, Acute | | Hepatocyte, Hypertrophy | 3 4 3 4 4 3 3 4 1 4 3 4 3 3 4 2 2 | Oval Cell, Hyperplasia | 3 2 2 3 1 2 2 1 1 2 1 3 1 3 3 3 2 3 2 | __________________________________________________________________________| Mesentery | + + | Fat, Fibrosis | 3 | Fat, Necrosis | 2 | __________________________________________________________________________| Oral Mucosa | + | Hyperplasia, Focal | 1 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | Acinus, Atrophy | 1 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Submandibular Gland, Cytoplasmic | | Alteration | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 3 1 4 2 2 3 3 4 3 1 1 2 3 2 2| Ulcer | 2 1 | Neuroendocrine Cell, Hyperplasia | 2 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Aorta, Mineralization | 4 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Myocardium, Degeneration | 1 1 1 1 1 2 1 1 1 1 1 1 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 5| 6| 6| 3| 7| 7| 2| 6| 4| 7| 7| 6| 6| 5| 4| 7| 6| 6| 6| 7| 6| 6| 6| 5| 7| DAY ON TEST | 7| 6| 9| 3| 3| 3| 8| 3| 7| 3| 3| 2| 2| 1| 5| 3| 4| 1| 7| 3| 0| 5| 4| 6| 0| | 1| 0| 4| 1| 1| 0| 1| 7| 7| 0| 0| 0| 0| 9| 9| 0| 2| 1| 9| 0| 9| 9| 1| 0| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| MG/KG | 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 6| 8| 9| 0| 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 1 1 1 | Bilateral, Hyperplasia | 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 4 4 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + + + + + M| Hyperplasia | 3 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + A +| Angiectasis | | Cyst | 3 | Pars Distalis, Hyperplasia, Focal | 2 1 1 1 | Pars Intermedia, Hyperplasia, Focal | 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 1 1 2 2 1 2 1 1 1 1 1 3 2 1 2 2| Follicle, Cyst | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 3 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Endometrium, Hyperplasia, Cystic | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 1 | Hyperplasia | 2 2 2 2 2 2 2 2 | __________________________________________________________________________| Lymph Node | + + + | Renal, Inflammation, Granulomatous | 2 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 1 1 1 1 1 2 2 2 | Hematopoietic Cell Proliferation | 2 2 2 2 2| __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + M + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 5| 6| 6| 3| 7| 7| 2| 6| 4| 7| 7| 6| 6| 5| 4| 7| 6| 6| 6| 7| 6| 6| 6| 5| 7| DAY ON TEST | 7| 6| 9| 3| 3| 3| 8| 3| 7| 3| 3| 2| 2| 1| 5| 3| 4| 1| 7| 3| 0| 5| 4| 6| 0| | 1| 0| 4| 1| 1| 0| 1| 7| 7| 0| 0| 0| 0| 9| 9| 0| 2| 1| 9| 0| 9| 9| 1| 0| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 300 | 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| MG/KG | 2| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 6| 8| 9| 0| 1| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Dilatation | 2 3 1 2 | Galactocele | 2 3 2 | Hyperplasia, Focal | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 4 2 | Hyperostosis | 1 3 | __________________________________________________________________________| Skeletal Muscle | | Fibrosis | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrocephalus | 2 2 3 1 1 2| Hypothalamus, Degeneration | 2 2 3 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Granulomatous | 1 1 | Alveolar Epithelium, Hyperplasia, | | Focal | 1 1 | Interstitium, Inflammation, Chronic | | Interstitium, Mineralization | 2 4 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy | 2 3 1 2 3 1 1 2 3 1 2 1 3 3 4 1 2 1 4 2 1 3| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 7| 7| 1| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 2| 7| | DAY ON TEST | 3| 1| 8| 7| 0| 3| 2| 0| 4| 5| 3| 3| 3| 3| 0| 3| 3| 3| 2| 2| 6| 3| 0| 8| 2| | | 1| 1| 3| 9| 3| 1| 4| 9| 1| 3| 0| 0| 1| 1| 3| 1| 0| 1| 8| 4| 5| 0| 9| 8| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 300 | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| L | MG/KG | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X | 10 | Clear Cell Focus | X X X | 7 | Degeneration, Cystic, Focal | 1 2 2 2 2 1 3 3 1 2 1 2 2 2 3 3 | 29 1.9| Eosinophilic Focus | X X X X X X X X X X X X X X X X | 37 | Hepatodiaphragmatic Nodule | X X X | 3 | Inflammation, Granulomatous | | 1 1.0| Mixed Cell Focus | X X | 7 | Necrosis, Focal | | 1 2.0| Bile Duct, Cyst | 3 3 | 2 3.0| Bile Duct, Hyperplasia | 2 1 1 2 1 2 2 2 2 3 2 3 2 2 | 30 1.8| Centrilobular, Necrosis, Acute | 3 | 1 3.0| Hepatocyte, Hypertrophy | 4 2 3 2 4 4 4 4 4 4 4 2 3 4 | 31 3.3| Oval Cell, Hyperplasia | 2 1 1 2 4 1 2 2 4 2 3 3 3 1 2 | 34 2.1| __________________________________________________________________________|____________| Mesentery | + | 3 | Fat, Fibrosis | | 1 3.0| Fat, Necrosis | 2 | 2 2.0| __________________________________________________________________________|____________| Oral Mucosa | | 1 | Hyperplasia, Focal | | 1 1.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 2 | 1 2.0| Acinus, Atrophy | 1 1 | 4 1.3| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Submandibular Gland, Cytoplasmic | | | Alteration | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 49 2.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Glandular | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | 1 2 3 2 3 2 1 2 3 2 1 2 2 3 2 2 1| 33 2.2| Ulcer | 1 | 3 1.3| Neuroendocrine Cell, Hyperplasia | 1 | 3 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 7| 7| 1| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 2| 7| | DAY ON TEST | 3| 1| 8| 7| 0| 3| 2| 0| 4| 5| 3| 3| 3| 3| 0| 3| 3| 3| 2| 2| 6| 3| 0| 8| 2| | | 1| 1| 3| 9| 3| 1| 4| 9| 1| 3| 0| 0| 1| 1| 3| 1| 0| 1| 8| 4| 5| 0| 9| 8| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 300 | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| L | MG/KG | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Aorta, Mineralization | | 1 4.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Myocardium, Degeneration | 1 1 1 1 1 1 1 1 1 1 1 2 1 1| 27 1.1| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 1 1 | 5 1.0| Bilateral, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 4 3 2 | 6 3.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + M + + M +| 45 | Hyperplasia | 2 1 | 3 2.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | 1 1 | 2 1.0| Cyst | 3 1 | 3 2.3| Pars Distalis, Hyperplasia, Focal | 3 1 | 6 1.5| Pars Intermedia, Hyperplasia, Focal | | 1 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + M +| 48 | C-Cell, Hyperplasia | 1 2 2 1 2 2 4 2 1 1 2 2 3 1 2| 32 1.7| Follicle, Cyst | | 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + M + + + + M + + + + + + + + + + + +| 48 | Hyperplasia, Focal | 2 | 1 2.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 3 | 4 3.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Endometrium, Hyperplasia, Cystic | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 2 2 2 | 4 1.8| Hyperplasia | 2 2 3 2 3 2 2 1 1 1 2 1 1 1 2 1 2| 25 1.8| __________________________________________________________________________|____________| Lymph Node | + + + | 6 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 7| 7| 1| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 2| 7| | DAY ON TEST | 3| 1| 8| 7| 0| 3| 2| 0| 4| 5| 3| 3| 3| 3| 0| 3| 3| 3| 2| 2| 6| 3| 0| 8| 2| | | 1| 1| 3| 9| 3| 1| 4| 9| 1| 3| 0| 0| 1| 1| 3| 1| 0| 1| 8| 4| 5| 0| 9| 8| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 300 | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| L | MG/KG | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Renal, Inflammation, Granulomatous | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + M +| 48 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 1 1 2 2 2 2 1 | 15 1.5| Hematopoietic Cell Proliferation | 3 1 2 2 2 2 2 | 12 2.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 1 3 2 2 3 2 | 10 2.1| Galactocele | 3 3 | 5 2.6| Hyperplasia, Focal | 1 1 | 2 1.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 1 | 3 2.3| Hyperostosis | | 2 2.0| __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | Fibrosis | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydrocephalus | 2 1 2 | 9 1.8| Hypothalamus, Degeneration | 3 3 | 5 2.6| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Granulomatous | | 2 1.0| Alveolar Epithelium, Hyperplasia, | | | Focal | 1 1 1 | 5 1.0| Interstitium, Inflammation, Chronic | 1 | 1 1.0| Interstitium, Mineralization | | 2 3.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 1 | 3 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 7| 7| 1| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 2| 7| | DAY ON TEST | 3| 1| 8| 7| 0| 3| 2| 0| 4| 5| 3| 3| 3| 3| 0| 3| 3| 3| 2| 2| 6| 3| 0| 8| 2| | | 1| 1| 3| 9| 3| 1| 4| 9| 1| 3| 0| 0| 1| 1| 3| 1| 0| 1| 8| 4| 5| 0| 9| 8| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A | 300 | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| L | MG/KG | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 7| 9| 0| 1| 2| 3| 4| 5| 6| 9| 0| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Zymbal's Gland | + + | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Nephropathy | 3 1 3 2 2 2 2 2 1 3 3 3 2 2 2 3 4 1 4 2 3 1 2| 45 2.2| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| DAY ON TEST | 3| 3| 1| 6| 4| 3| 2| 2| 3| 3| 6| 2| 3| 3| 2| 3| 3| 0| 3| 3| 0| 3| 1| 4| 3| | 0| 0| 5| 1| 2| 0| 1| 1| 0| 0| 2| 6| 0| 0| 2| 0| 0| 7| 9| 0| 4| 0| 4| 4| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + M + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | | Peyer's Patch, Hyperplasia | 2 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X X X X X| Clear Cell Focus | X | Degeneration, Cystic, Focal | 2 1 1 | Degeneration, Fatty, Focal | | Eosinophilic Focus | X X X X X | Hepatodiaphragmatic Nodule | X X | Inflammation, Acute | 1 | Mixed Cell Focus | X | Necrosis, Focal | | Bile Duct, Hyperplasia | 1 2 3 1 1 4 2 1 1 2 2 2 2 3 2 2| Centrilobular, Degeneration, Fatty | 1 2 | Centrilobular, Degeneration | 2 2 2 | Centrilobular, Necrosis | 2 | Oval Cell, Hyperplasia | 3 1 1 | __________________________________________________________________________| Mesentery | + + +| Fat, Necrosis | 2 2 2| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy, Acute | | Hyperplasia, Focal | 3 1 | Acinus, Atrophy | 1 3 2 2 1 1 2 1 1 1 1| Acinus, Hyperplasia, Focal | 1 | Artery, Inflammation, Chronic | 1 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Submandibular Gland, Cytoplasmic | | Alteration | 2 2 2 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis, Focal | 2 | Mineralization | 1 | Ulcer | 3 4 3 2 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| DAY ON TEST | 3| 3| 1| 6| 4| 3| 2| 2| 3| 3| 6| 2| 3| 3| 2| 3| 3| 0| 3| 3| 0| 3| 1| 4| 3| | 0| 0| 5| 1| 2| 0| 1| 1| 0| 0| 2| 6| 0| 0| 2| 0| 0| 7| 9| 0| 4| 0| 4| 4| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Inflammation, Focal, Suppurative | | Mineralization | 2 2 4 1 4 3 | Ulcer | 3 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 | Aorta, Mineralization | 2 4 2 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrium, Thrombosis | 2 | Myocardium, Degeneration | 1 2 2 1 1 1 2 1 2 2 3 2 2 2 2 2 1 2 1 3 1 2| Myocardium, Mineralization | 2 1 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 1 1 1 1 1 1 1 1 1| Necrosis | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 3 4 1 2 1 3 3 3 2 1| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 | Hyperplasia | 3 2 4 2 | Bilateral, Hyperplasia | 4 3 4 3 4 2 2 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Pars Distalis, Hyperplasia, Focal | 1 2 2 1 2 1 1 3 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 2 1 1 1 1 1 3 1 1 | Follicle, Cyst | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Hyperplasia, Focal | 1 2 | Inflammation, Chronic | 2 1 1 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 1 2 1 2 1 1 1 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| DAY ON TEST | 3| 3| 1| 6| 4| 3| 2| 2| 3| 3| 6| 2| 3| 3| 2| 3| 3| 0| 3| 3| 0| 3| 1| 4| 3| | 0| 0| 5| 1| 2| 0| 1| 1| 0| 0| 2| 6| 0| 0| 2| 0| 0| 7| 9| 0| 4| 0| 4| 4| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Germinal Epithelium, Atrophy | 4 3 2 | Interstitial Cell, Hyperplasia | 3 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 3 | Hyperplasia | 1 1 1 1 1 1 1 2 1 | __________________________________________________________________________| Lymph Node | + + + | Mediastinal, Hyperplasia, Lymphoid | 2 2 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 1 1 1 2 1 | Hematopoietic Cell Proliferation | | Metaplasia, Lipocyte | 1 | Lymphoid Follicle, Depletion Cellular| | __________________________________________________________________________| Thymus | + + + + M + + + + + + + + + + + + + + + + + + + +| Cyst | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 2 1 2 | Galactocele | 3 | Duct, Granuloma | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | | Ulcer | | Subcutaneous Tissue, Fibrosis | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 3 2 3 1 2 3 | Osteopetrosis | 2 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Focal | | Hydrocephalus | | Necrosis | 2 | __________________________________________________________________________| Peripheral Nerve | | __________________________________________________________________________| Spinal Cord | | Axon, Degeneration, Focal | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 5| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| DAY ON TEST | 3| 3| 1| 6| 4| 3| 2| 2| 3| 3| 6| 2| 3| 3| 2| 3| 3| 0| 3| 3| 0| 3| 1| 4| 3| | 0| 0| 5| 1| 2| 0| 1| 1| 0| 0| 2| 6| 0| 0| 2| 0| 0| 7| 9| 0| 4| 0| 4| 4| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Histiocyte | 3 | Inflammation, Granulomatous | | Inflammation, Suppurative | 3 | Interstitium, Inflammation, Chronic | | Interstitium, Mineralization | 3 2 | Vein, Thrombosis | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 2 2 1 1 2 1| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Cataract | | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy | 2 4 4 4 4 3 1 2 3 4 3 4 3 3 4 2 3 1 2 2 3 2 2 3| Renal Tubule, Hyperplasia, Focal | 4 1 2 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | | Transitional Epithelium, Hyperplasia | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 5| 7| 6| 7| 6| 6| 7| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 6| 5| 7| 7| 7| | DAY ON TEST | 0| 1| 3| 6| 3| 1| 3| 1| 0| 3| 3| 5| 3| 1| 5| 8| 0| 2| 2| 3| 6| 2| 1| 3| 1| | | 4| 0| 0| 4| 0| 7| 0| 0| 3| 0| 0| 3| 0| 4| 2| 8| 7| 2| 9| 0| 8| 9| 8| 0| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| L | | 7| 8| 9| 1| 2| 4| 6| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | 1 4 1 | 3 2.0| Peyer's Patch, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | 2 | 1 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X X X X| 23 | Clear Cell Focus | X X X | 4 | Degeneration, Cystic, Focal | 1 | 4 1.3| Degeneration, Fatty, Focal | 1 | 1 1.0| Eosinophilic Focus | X X X X X X | 11 | Hepatodiaphragmatic Nodule | X X | 4 | Inflammation, Acute | | 1 1.0| Mixed Cell Focus | | 1 | Necrosis, Focal | 1 1 | 2 1.0| Bile Duct, Hyperplasia | 1 2 1 1 4 3 3 1 1 2 4 2 3 1 1 2 2 2 3 2| 36 2.0| Centrilobular, Degeneration, Fatty | | 2 1.5| Centrilobular, Degeneration | 2 2 3 | 6 2.2| Centrilobular, Necrosis | | 1 2.0| Oval Cell, Hyperplasia | 1 4 2 3 1 3 3 1 1 2 2 | 14 2.0| __________________________________________________________________________|____________| Mesentery | + + | 5 | Fat, Necrosis | 4 2 | 5 2.4| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy, Acute | 2 | 1 2.0| Hyperplasia, Focal | 1 | 3 1.7| Acinus, Atrophy | 1 1 1 1 1 1 1 1 2 | 20 1.3| Acinus, Hyperplasia, Focal | | 1 1.0| Artery, Inflammation, Chronic | 4 2 | 4 2.3| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Submandibular Gland, Cytoplasmic | | | Alteration | 3 | 4 2.3| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 5| 7| 6| 7| 6| 6| 7| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 6| 5| 7| 7| 7| | DAY ON TEST | 0| 1| 3| 6| 3| 1| 3| 1| 0| 3| 3| 5| 3| 1| 5| 8| 0| 2| 2| 3| 6| 2| 1| 3| 1| | | 4| 0| 0| 4| 0| 7| 0| 0| 3| 0| 0| 3| 0| 4| 2| 8| 7| 2| 9| 0| 8| 9| 8| 0| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| L | | 7| 8| 9| 1| 2| 4| 6| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperkeratosis, Focal | | 1 2.0| Mineralization | 3 2 | 3 2.0| Ulcer | 2 3 | 7 2.9| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Focal, Suppurative | 2 2 | 2 2.0| Mineralization | 2 3 2 4 | 10 2.7| Ulcer | 2 1 | 4 1.8| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | | 1 2.0| Aorta, Mineralization | 3 4 | 5 3.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrium, Thrombosis | 2 4 4 4 3 | 6 3.2| Myocardium, Degeneration | 1 2 1 2 2 2 1 1 2 2 1 1 2 3 3 3 2 1 2 1 2 2 2| 45 1.8| Myocardium, Mineralization | 2 3 | 5 1.8| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 1 1 1 1 | 13 1.0| Necrosis | 1 | 1 1.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 3 4 1 1 1 3| 16 2.3| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + M + + + + + + + + + M + + + + + + + + + + + + +| 48 | Hyperplasia, Focal | 1 | 2 1.5| Hyperplasia | 4 2 2 | 7 2.7| Bilateral, Hyperplasia | 3 3 2| 10 3.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 1 | 2 1.5| Pars Distalis, Hyperplasia, Focal | 1 2 2 | 12 1.7| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 1 1 2 1 1 1 1 2 2 1 3 2 | 22 1.5| Follicle, Cyst | | 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | + | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 5| 7| 6| 7| 6| 6| 7| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 6| 5| 7| 7| 7| | DAY ON TEST | 0| 1| 3| 6| 3| 1| 3| 1| 0| 3| 3| 5| 3| 1| 5| 8| 0| 2| 2| 3| 6| 2| 1| 3| 1| | | 4| 0| 0| 4| 0| 7| 0| 0| 3| 0| 0| 3| 0| 4| 2| 8| 7| 2| 9| 0| 8| 9| 8| 0| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| L | | 7| 8| 9| 1| 2| 4| 6| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 3 3 2 3 | 5 2.8| Hyperplasia, Focal | 3 | 3 2.0| Inflammation, Chronic | 4 1 2 2 1 2 | 9 1.8| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 1 1 1 1 2 1 2 1 1 | 16 1.3| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Germinal Epithelium, Atrophy | | 3 3.0| Interstitial Cell, Hyperplasia | 2 | 3 2.7| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 2 2 | 3 2.3| Hyperplasia | 1 2 2 1 1 1 1 2 1 | 18 1.2| __________________________________________________________________________|____________| Lymph Node | + + + + + | 8 | Mediastinal, Hyperplasia, Lymphoid | | 2 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 3 | 1 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 2 2 | 8 1.5| Hematopoietic Cell Proliferation | 4 4 | 2 4.0| Metaplasia, Lipocyte | | 1 1.0| Lymphoid Follicle, Depletion Cellular| 4 | 1 4.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + M + + + + + + M + M + + + +| 46 | Cyst | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 2 1 1 1 2 4 1 1 1 2 | 13 1.6| Galactocele | | 1 3.0| Duct, Granuloma | 4 | 1 4.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst Epithelial Inclusion | 3 | 1 3.0| Ulcer | 3 3 | 2 3.0| Subcutaneous Tissue, Fibrosis | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 5| 7| 6| 7| 6| 6| 7| 7| 5| 7| 6| 6| 5| 7| 7| 7| 7| 6| 5| 7| 7| 7| | DAY ON TEST | 0| 1| 3| 6| 3| 1| 3| 1| 0| 3| 3| 5| 3| 1| 5| 8| 0| 2| 2| 3| 6| 2| 1| 3| 1| | | 4| 0| 0| 4| 0| 7| 0| 0| 3| 0| 0| 3| 0| 4| 2| 8| 7| 2| 9| 0| 8| 9| 8| 0| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | 0 MG/KG | 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 6| L | | 7| 8| 9| 1| 2| 4| 6| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 2 3 | 8 2.4| Osteopetrosis | | 1 2.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Focal | 2 | 1 2.0| Hydrocephalus | 2 2 | 2 2.0| Necrosis | | 1 2.0| __________________________________________________________________________|____________| Peripheral Nerve | + | 1 | __________________________________________________________________________|____________| Spinal Cord | + | 1 | Axon, Degeneration, Focal | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Histiocyte | | 1 3.0| Inflammation, Granulomatous | 1 1 | 2 1.0| Inflammation, Suppurative | | 1 3.0| Interstitium, Inflammation, Chronic | 1 1 | 2 1.0| Interstitium, Mineralization | 3 2 | 4 2.5| Vein, Thrombosis | 4 | 1 4.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 1 1 2 2 | 11 1.5| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | Cataract | 4 | 1 4.0| __________________________________________________________________________|____________| Zymbal's Gland | +| 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Nephropathy | 2 1 3 2 4 3 3 3 3 3 3 3 2 3 1 3 4 3 4 3 2 2 4 2 3| 49 2.8| Renal Tubule, Hyperplasia, Focal | 2 | 5 2.2| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 | Ulcer | 3 | 1 3.0| Transitional Epithelium, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 5| 7| 6| 7| 5| 7| 5| 7| 7| 6| 5| 6| 6| 7| 7| 5| 6| 4| 6| 6| DAY ON TEST | 0| 7| 3| 3| 0| 7| 3| 0| 3| 8| 1| 9| 3| 3| 2| 7| 0| 5| 3| 3| 7| 8| 3| 3| 7| | 4| 3| 0| 0| 4| 9| 0| 2| 0| 9| 8| 1| 0| 0| 5| 9| 6| 0| 0| 0| 2| 0| 1| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 37 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | 1 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic, Focal | 2 | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X| Clear Cell Focus | X X X | Degeneration, Cystic, Focal | 1 | Eosinophilic Focus | X X X X X X X X X X X X X X X X| Hepatodiaphragmatic Nodule | X | Mixed Cell Focus | X X X X X | Necrosis, Focal | 1 | Bile Duct, Hyperplasia | 2 1 1 1 1 1 1 1 1 3 | Centrilobular, Degeneration | | Centrilobular, Necrosis | 3 2 2 | Hepatocyte, Hypertrophy | 2 2 2 3 1 1 3 1| Oval Cell, Hyperplasia | 4 1 1 1 1 1 2 1 1 2| __________________________________________________________________________| Mesentery | + + | Fat, Necrosis | 2 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | Acinus, Atrophy | 1 1 1 1 1 2 2 1 | Acinus, Hyperplasia, Focal | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Submandibular Gland, Cytoplasmic | | Alteration | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 3 1 1 1 1 3 | Inflammation, Focal, Suppurative | 2 1 | Mineralization | 1 1 | Ulcer | 3 | __________________________________________________________________________| Tongue | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 5| 7| 6| 7| 5| 7| 5| 7| 7| 6| 5| 6| 6| 7| 7| 5| 6| 4| 6| 6| DAY ON TEST | 0| 7| 3| 3| 0| 7| 3| 0| 3| 8| 1| 9| 3| 3| 2| 7| 0| 5| 3| 3| 7| 8| 3| 3| 7| | 4| 3| 0| 0| 4| 9| 0| 2| 0| 9| 8| 1| 0| 0| 5| 9| 6| 0| 0| 0| 2| 0| 1| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 37 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Mineralization | 2 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Focal, Suppurative | 2 | Atrium, Thrombosis | 3 2 | Endocardium, Fibrosis | 2 | Myocardium, Degeneration | 2 1 1 1 1 2 1 1 1 1 3 2 2 2 1 2 1 2| Myocardium, Mineralization | | Valve, Thrombosis | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 1 1 1 1 3 1| Necrosis | 3 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 3 1 2 2 2 2 4 2 2 1 2 1 | Hyperplasia | 4 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 | __________________________________________________________________________| Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 | Bilateral, Hyperplasia | 1 1| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Hyperplasia, Focal | 2 2 1 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 2 1 1 2 1 2 3 1 1 1 1 3 | Follicle, Cyst | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Hyperplasia, Focal | 3 1 2 4 | Inflammation, Chronic | 2 1 1 1 2 2 1| Inflammation, Chronic Active | 3 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | Inflammation, Chronic | 1 1 2 1 1 1 1 1 2 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Germinal Epithelium, Atrophy | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 5| 7| 6| 7| 5| 7| 5| 7| 7| 6| 5| 6| 6| 7| 7| 5| 6| 4| 6| 6| DAY ON TEST | 0| 7| 3| 3| 0| 7| 3| 0| 3| 8| 1| 9| 3| 3| 2| 7| 0| 5| 3| 3| 7| 8| 3| 3| 7| | 4| 3| 0| 0| 4| 9| 0| 2| 0| 9| 8| 1| 0| 0| 5| 9| 6| 0| 0| 0| 2| 0| 1| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 37 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 1 2 1 1 1| Necrosis | 1 | __________________________________________________________________________| Lymph Node | + | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Fibrosis | 2 2 2 | Hematopoietic Cell Proliferation | 2 3 1 4 | __________________________________________________________________________| Thymus | + M + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 2 1 2 1 1 1 1 | Hyperplasia, Focal | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Dermis, Inflammation, Focal, | | Suppurative | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | | Osteopetrosis | 3 3 | __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrocephalus | 3 3 | Necrosis, Focal | 1 2 | Hypothalamus, Degeneration | | __________________________________________________________________________| Peripheral Nerve | | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Erythrophagocytosis | 3 | Inflammation, Suppurative | 3 | Alveolar Epithelium, Hyperplasia, | | Focal | | Interstitium, Inflammation, Chronic | | Interstitium, Mineralization | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 5| 7| 6| 7| 5| 7| 5| 7| 7| 6| 5| 6| 6| 7| 7| 5| 6| 4| 6| 6| DAY ON TEST | 0| 7| 3| 3| 0| 7| 3| 0| 3| 8| 1| 9| 3| 3| 2| 7| 0| 5| 3| 3| 7| 8| 3| 3| 7| | 4| 3| 0| 0| 4| 9| 0| 2| 0| 9| 8| 1| 0| 0| 5| 9| 6| 0| 0| 0| 2| 0| 1| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 37 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Perivascular, Edema | 3 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 2 1 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Cornea, Inflammation, Chronic | 1 | __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Focal, Suppurative | 2 | Nephropathy | 3 3 3 3 4 2 2 2 3 3 3 2 2 3 2 1 1 2 3 2 3 1 2 3| Renal Tubule, Cyst | 3 | Renal Tubule, Hyperplasia, Focal | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 7| 5| 5| 7| 4| 5| 7| 7| 6| 6| 7| 7| 7| 5| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| | DAY ON TEST | 0| 4| 9| 2| 0| 3| 3| 3| 6| 3| 3| 0| 3| 7| 6| 6| 3| 9| 1| 0| 1| 3| 1| 3| 3| | | 4| 2| 6| 5| 6| 5| 0| 0| 1| 9| 0| 3| 0| 5| 4| 0| 0| 5| 8| 3| 2| 0| 8| 0| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 37 MG/KG | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | | 2 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | X X X | 3 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | | 1 1.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic, Focal | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X X X X X X| 21 | Clear Cell Focus | | 3 | Degeneration, Cystic, Focal | 1| 2 1.0| Eosinophilic Focus | X X X X X X X X X X X X| 28 | Hepatodiaphragmatic Nodule | | 1 | Mixed Cell Focus | X X | 7 | Necrosis, Focal | 4 | 2 2.5| Bile Duct, Hyperplasia | 1 1 1 2 1 1 1 | 17 1.2| Centrilobular, Degeneration | 3 | 1 3.0| Centrilobular, Necrosis | 3 | 4 2.5| Hepatocyte, Hypertrophy | 1 1 1 2 2| 13 1.7| Oval Cell, Hyperplasia | 2 1 2 1 3 1 1| 17 1.5| __________________________________________________________________________|____________| Mesentery | + + + + | 6 | Fat, Necrosis | 2 3 2 2 | 6 2.2| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 1 1 | 2 1.0| Acinus, Atrophy | 1 1 2 1 1 1 1 | 15 1.2| Acinus, Hyperplasia, Focal | 1 | 1 1.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Submandibular Gland, Cytoplasmic | | | Alteration | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 50 2.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | 3 | 1 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 2 2 2 1 1 1 1 | 14 1.6| Inflammation, Focal, Suppurative | 2 | 3 1.7| Mineralization | 3 3 | 4 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 7| 5| 5| 7| 4| 5| 7| 7| 6| 6| 7| 7| 7| 5| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| | DAY ON TEST | 0| 4| 9| 2| 0| 3| 3| 3| 6| 3| 3| 0| 3| 7| 6| 6| 3| 9| 1| 0| 1| 3| 1| 3| 3| | | 4| 2| 6| 5| 6| 5| 0| 0| 1| 9| 0| 3| 0| 5| 4| 0| 0| 5| 8| 3| 2| 0| 8| 0| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 37 MG/KG | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Ulcer | 2 | 2 2.5| __________________________________________________________________________|____________| Tongue | + + | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 3 | 2 2.5| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Focal, Suppurative | | 1 2.0| Atrium, Thrombosis | 3 3 2 | 5 2.6| Endocardium, Fibrosis | | 1 2.0| Myocardium, Degeneration | 2 2 1 1 3 1 1 1 2 1 2 1 1 1 2 2 1 1 2 1 2 1 2| 41 1.5| Myocardium, Mineralization | 2 3 | 2 2.5| Valve, Thrombosis | | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 2 1 1 1 1 2| 12 1.3| Necrosis | | 1 3.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 4 1 4 3 1 1 1 2 | 20 2.1| Hyperplasia | | 1 4.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 1 | 4 1.5| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | | 2 1.0| Bilateral, Hyperplasia | 1 3 3 1 | 6 1.7| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Hyperplasia, Focal | 2 1 1 1 1| 9 1.3| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 2 1 2 2 2 1 2 1 1 2 2| 25 1.6| Follicle, Cyst | 1| 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | + | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 3 | 2 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 7| 5| 5| 7| 4| 5| 7| 7| 6| 6| 7| 7| 7| 5| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| | DAY ON TEST | 0| 4| 9| 2| 0| 3| 3| 3| 6| 3| 3| 0| 3| 7| 6| 6| 3| 9| 1| 0| 1| 3| 1| 3| 3| | | 4| 2| 6| 5| 6| 5| 0| 0| 1| 9| 0| 3| 0| 5| 4| 0| 0| 5| 8| 3| 2| 0| 8| 0| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 37 MG/KG | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Hyperplasia, Focal | | 4 2.5| Inflammation, Chronic | 4 1 1 1 2 2 1 | 14 1.6| Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 1 | 1 1.0| Inflammation, Chronic | 1 1 1 2 2 3 1 1 1 | 18 1.3| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | | 1 2.0| __________________________________________________________________________|____________| Testes | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 | Germinal Epithelium, Atrophy | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 2 1 1 1 2 1| 14 1.4| Necrosis | 2 | 2 1.5| __________________________________________________________________________|____________| Lymph Node | + + + | 4 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 2 | 1 2.0| Fibrosis | 3 1 2 2 1 1 1 2 | 11 1.7| Hematopoietic Cell Proliferation | 2 4 2 3 3| 9 2.7| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + M M + M + + + + M| 45 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 | Dilatation | 2 2 1 1 1 1| 13 1.3| Hyperplasia, Focal | 4 | 1 4.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dermis, Inflammation, Focal, | | | Suppurative | | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 1 1 | 2 1.0| Osteopetrosis | | 2 3.0| __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 7| 5| 5| 7| 4| 5| 7| 7| 6| 6| 7| 7| 7| 5| 6| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| | DAY ON TEST | 0| 4| 9| 2| 0| 3| 3| 3| 6| 3| 3| 0| 3| 7| 6| 6| 3| 9| 1| 0| 1| 3| 1| 3| 3| | | 4| 2| 6| 5| 6| 5| 0| 0| 1| 9| 0| 3| 0| 5| 4| 0| 0| 5| 8| 3| 2| 0| 8| 0| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 37 MG/KG | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydrocephalus | 3 | 3 3.0| Necrosis, Focal | | 2 1.5| Hypothalamus, Degeneration | 3 | 1 3.0| __________________________________________________________________________|____________| Peripheral Nerve | + | 1 | __________________________________________________________________________|____________| Spinal Cord | + | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erythrophagocytosis | | 1 3.0| Inflammation, Suppurative | 3 1 | 3 2.3| Alveolar Epithelium, Hyperplasia, | | | Focal | 2 | 1 2.0| Interstitium, Inflammation, Chronic | 1 | 1 1.0| Interstitium, Mineralization | 2 | 1 2.0| Perivascular, Edema | | 1 3.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 1 1 2 1 1 1 1 4 2 1 | 14 1.4| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | Cornea, Inflammation, Chronic | | 1 1.0| __________________________________________________________________________|____________| Zymbal's Gland | + | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Focal, Suppurative | | 1 2.0| Nephropathy | 4 1 4 4 1 3 3 1 3 2 2 2 2 2 2 1 2 3 2 1 3 3| 46 2.4| Renal Tubule, Cyst | 3 | 2 3.0| Renal Tubule, Hyperplasia, Focal | 4 | 1 4.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 4| 6| 7| 6| 6| 6| 6| 6| 7| 7| 6| 6| 7| 4| 6| 5| 5| 7| 6| 7| 6| 7| 5| 5| 5| DAY ON TEST | 6| 5| 3| 6| 6| 3| 1| 5| 3| 3| 5| 3| 3| 3| 9| 9| 6| 3| 4| 3| 4| 3| 9| 2| 7| | 7| 9| 0| 4| 1| 8| 9| 8| 0| 0| 1| 9| 0| 8| 6| 5| 8| 0| 2| 0| 2| 0| 6| 1| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 75 MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Perforation | X | Periesophageal Tissue, Inflammation | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X X| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + M + + + + + + + + +| Parasite Metazoan | X X X X X| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X X X X X | Clear Cell Focus | X X X X | Degeneration, Cystic, Focal | 1 2 1 1 2 1 1 1 1 1 1 | Eosinophilic Focus | X X X X X X X X X X X X X X X X X X X X| Mixed Cell Focus | X X X X X X X| Necrosis, Focal | 1 1 2 | Bile Duct, Hyperplasia, Atypical, | | Focal | 3 | Bile Duct, Hyperplasia | 1 1 3 1 2 2 1 1 1 2| Centrilobular, Degeneration, Fatty | 3 | Hepatocyte, Hypertrophy | 2 2 1 3 2 3 2 4 3 3 2 3 4 3 4| Oval Cell, Hyperplasia | 2 2 1 1 1 1 2 2 2 1 2 1 1 2 1 2| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | Acinus, Atrophy | 1 1 1 2 1 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Parotid Gland, Atrophy | 2 | Submandibular Gland, Cytoplasmic | | Alteration | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| Submandibular Gland, Fibrosis | 1 | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperkeratosis | 2 | Mineralization | 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 1 2 2 2 1 2 2 2 1 2 1 1 3 3 2 2 1 1| Mineralization | 3 3 2 2 2 1 3 | Ulcer | 1 2 2 | Neuroendocrine Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 3 3 4 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 4| 6| 7| 6| 6| 6| 6| 6| 7| 7| 6| 6| 7| 4| 6| 5| 5| 7| 6| 7| 6| 7| 5| 5| 5| DAY ON TEST | 6| 5| 3| 6| 6| 3| 1| 5| 3| 3| 5| 3| 3| 3| 9| 9| 6| 3| 4| 3| 4| 3| 9| 2| 7| | 7| 9| 0| 4| 1| 8| 9| 8| 0| 0| 1| 9| 0| 8| 6| 5| 8| 0| 2| 0| 2| 0| 6| 1| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 75 MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | Aorta, Mineralization | 1 4 4 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrium, Thrombosis | 4 3 | Myocardium, Degeneration | 1 2 3 2 2 2 2 2 3 2 2 2 1 2 1 1 2 1 1| Myocardium, Mineralization | 2 2 2 2 1 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 1 1 2 1 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematocyst | 4 | Hyperplasia, Focal | 1 3 1 1 2 3 3 3 2 2 1 2 1 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + M + + + M + + + + + + + + + + + + +| Hyperplasia | 4 | Bilateral, Hyperplasia | 1 2 2 4 4 4 3 4 2 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | Pars Distalis, Hyperplasia, Focal | 1 2 1 1 | Rathke's Cleft, Cyst | 3 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 1 1 1 1 1 1 2 2 1 1 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + M + + + + + + + + +| Fibrosis | 3 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| Hyperplasia, Focal | 1 3 | Inflammation, Chronic | 1 1 2 2 1 1| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + M + + + + + + + + +| Hyperplasia | | Inflammation, Chronic | 2 1 3 2 2 2 1 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 | Mineralization | 3 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + M + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 4| 6| 7| 6| 6| 6| 6| 6| 7| 7| 6| 6| 7| 4| 6| 5| 5| 7| 6| 7| 6| 7| 5| 5| 5| DAY ON TEST | 6| 5| 3| 6| 6| 3| 1| 5| 3| 3| 5| 3| 3| 3| 9| 9| 6| 3| 4| 3| 4| 3| 9| 2| 7| | 7| 9| 0| 4| 1| 8| 9| 8| 0| 0| 1| 9| 0| 8| 6| 5| 8| 0| 2| 0| 2| 0| 6| 1| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 75 MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hyperplasia | 2 1 1 2 1 1 1 1 2 1 1 1 1| Necrosis | 2 | __________________________________________________________________________| Lymph Node | + + | Mediastinal, Inflammation, | | Suppurative | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 | Fibrosis | 1 4 2 1 2 2 | Hematopoietic Cell Proliferation | 2 1 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + M + M + + + + + + + M + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| Dilatation | 2 1 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Necrosis | 4 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 4 3 3 4 1 2 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrocephalus | 2 3 | Necrosis, Focal | 2 | Hypothalamus, Degeneration | | __________________________________________________________________________| Peripheral Nerve | + | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage, Focal | | Infiltration Cellular, Histiocyte | 2 | Inflammation, Granulomatous | 1 | Inflammation, Suppurative | 2 2 | Alveolar Epithelium, Hyperplasia, | | Focal | | Alveolar Epithelium, Interstitium, | | Mineralization | 3 | Bronchiole, Inflammation, Suppurative| 1 | Interstitium, Inflammation, Chronic | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 4| 6| 7| 6| 6| 6| 6| 6| 7| 7| 6| 6| 7| 4| 6| 5| 5| 7| 6| 7| 6| 7| 5| 5| 5| DAY ON TEST | 6| 5| 3| 6| 6| 3| 1| 5| 3| 3| 5| 3| 3| 3| 9| 9| 6| 3| 4| 3| 4| 3| 9| 2| 7| | 7| 9| 0| 4| 1| 8| 9| 8| 0| 0| 1| 9| 0| 8| 6| 5| 8| 0| 2| 0| 2| 0| 6| 1| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 75 MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Interstitium, Mineralization | 2 3 2 3 | Perivascular, Edema | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 1 2 1 1 2 2 2 1 1 1 1 1 2 1 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | Cataract | 3 | Degeneration | 4 | Retina, Atrophy | 3 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydronephrosis | 3 | Inflammation, Focal, Suppurative | | Nephropathy | 1 3 3 4 2 3 2 2 3 3 2 4 1 4 4 4 3 2 4 1 4 3 1 1| Renal Tubule, Hyperplasia, Focal | 3 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + M + + + + + + + + +| Ulcer | 4 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| 6| 7| 7| 5| 0| 6| 6| 5| 7| 6| 6| 6| 6| 6| | DAY ON TEST | 3| 3| 0| 3| 1| 8| 3| 0| 3| 9| 3| 3| 3| 3| 0| 1| 9| 7| 2| 0| 7| 9| 9| 9| 1| | | 0| 0| 9| 0| 2| 2| 0| 1| 0| 5| 0| 0| 0| 0| 2| 5| 5| 4| 2| 6| 3| 2| 5| 6| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 75 MG/KG | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Perforation | | 1 | Periesophageal Tissue, Inflammation | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X X | 5 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Parasite Metazoan | | 5 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X X X | 22 | Clear Cell Focus | X X X | 7 | Degeneration, Cystic, Focal | 1 2 1 1 1 1 1 1 1 3 2 2 2 1| 25 1.3| Eosinophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X| 43 | Mixed Cell Focus | X X X X X X X | 14 | Necrosis, Focal | 2 1| 5 1.4| Bile Duct, Hyperplasia, Atypical, | | | Focal | | 1 3.0| Bile Duct, Hyperplasia | 1 1 4 1 1 2| 16 1.6| Centrilobular, Degeneration, Fatty | | 1 3.0| Hepatocyte, Hypertrophy | 1 2 2 3 4 1 3 3 4 4 | 25 2.7| Oval Cell, Hyperplasia | 1 1 1 1 2 2 2 2| 24 1.5| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 2 | 1 2.0| Acinus, Atrophy | 1 1 1 1 2 1 1 1| 13 1.2| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parotid Gland, Atrophy | | 1 2.0| Submandibular Gland, Cytoplasmic | | | Alteration | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 49 2.0| Submandibular Gland, Fibrosis | | 1 1.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperkeratosis | | 1 2.0| Mineralization | | 1 1.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | 2 2 1 1 1 3 1 2 2 2 1 2 2| 32 1.7| Mineralization | 1 2 3 1 1 4 2 4 | 15 2.3| Ulcer | | 3 1.7| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| 6| 7| 7| 5| 0| 6| 6| 5| 7| 6| 6| 6| 6| 6| | DAY ON TEST | 3| 3| 0| 3| 1| 8| 3| 0| 3| 9| 3| 3| 3| 3| 0| 1| 9| 7| 2| 0| 7| 9| 9| 9| 1| | | 0| 0| 9| 0| 2| 2| 0| 1| 0| 5| 0| 0| 0| 0| 2| 5| 5| 4| 2| 6| 3| 2| 5| 6| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 75 MG/KG | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Neuroendocrine Cell, Hyperplasia | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | | 3 3.3| Aorta, Mineralization | 2 2 3 4 3 4 | 9 3.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrium, Thrombosis | 4 4 | 4 3.8| Myocardium, Degeneration | 1 2 2 1 2 1 1 2 2 1 1 1 2 2 1| 34 1.6| Myocardium, Mineralization | 3 2 3 1 3 | 11 2.2| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 1 | 6 1.2| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematocyst | | 1 4.0| Hyperplasia, Focal | 3 2 1 4 2 4 1 | 21 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hyperplasia | 1 1 2 4 3 | 6 2.5| Bilateral, Hyperplasia | 1 3 1 2 3 3 3 | 16 2.6| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 1 | 1 1.0| Pars Distalis, Hyperplasia, Focal | 1 1 2 1 | 8 1.3| Rathke's Cleft, Cyst | | 1 3.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 1 2 1 1 2 1 4 1 1 2 2 1 2| 25 1.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | | 2 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Fibrosis | | 1 3.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia, Focal | 1 1 1 1 | 6 1.3| Inflammation, Chronic | 1 1 | 8 1.3| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| 6| 7| 7| 5| 0| 6| 6| 5| 7| 6| 6| 6| 6| 6| | DAY ON TEST | 3| 3| 0| 3| 1| 8| 3| 0| 3| 9| 3| 3| 3| 3| 0| 1| 9| 7| 2| 0| 7| 9| 9| 9| 1| | | 0| 0| 9| 0| 2| 2| 0| 1| 0| 5| 0| 0| 0| 0| 2| 5| 5| 4| 2| 6| 3| 2| 5| 6| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 75 MG/KG | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Hyperplasia | 4 | 1 4.0| Inflammation, Chronic | 1 2 1 1 2 2 | 13 1.7| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 2 | 2 1.5| Mineralization | | 1 3.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 2| 2 2.0| Hyperplasia | 1 1 1 1 2 1 1 1 1 | 22 1.2| Necrosis | 2 | 2 2.0| __________________________________________________________________________|____________| Lymph Node | + + | 4 | Mediastinal, Inflammation, | | | Suppurative | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Suppurative | 4 | 1 4.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | | 1 3.0| Fibrosis | 1 2 1 2 1 1 | 12 1.7| Hematopoietic Cell Proliferation | | 2 1.5| __________________________________________________________________________|____________| Thymus | + + M + + + M M + M + + + + + + + + + + + + + + +| 43 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Dilatation | 1 1| 4 1.3| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Subcutaneous Tissue, Necrosis | | 1 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 2 2 2 4 3 4 | 12 2.8| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydrocephalus | 4 | 3 3.0| Necrosis, Focal | | 1 2.0| Hypothalamus, Degeneration | 4 | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7| 6| 7| 7| 5| 0| 6| 6| 5| 7| 6| 6| 6| 6| 6| | DAY ON TEST | 3| 3| 0| 3| 1| 8| 3| 0| 3| 9| 3| 3| 3| 3| 0| 1| 9| 7| 2| 0| 7| 9| 9| 9| 1| | | 0| 0| 9| 0| 2| 2| 0| 1| 0| 5| 0| 0| 0| 0| 2| 5| 5| 4| 2| 6| 3| 2| 5| 6| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 75 MG/KG | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| L | | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Peripheral Nerve | | 1 | __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage, Focal | 1 | 1 1.0| Infiltration Cellular, Histiocyte | | 1 2.0| Inflammation, Granulomatous | 1| 2 1.0| Inflammation, Suppurative | | 2 2.0| Alveolar Epithelium, Hyperplasia, | | | Focal | 1 | 1 1.0| Alveolar Epithelium, Interstitium, | | | Mineralization | | 1 3.0| Bronchiole, Inflammation, Suppurative| | 1 1.0| Interstitium, Inflammation, Chronic | 1 1 | 2 1.0| Interstitium, Mineralization | 2 3 2 2 | 8 2.4| Perivascular, Edema | 2 | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 1 2 2 1 | 20 1.4| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | Cataract | | 1 3.0| Degeneration | | 1 4.0| Retina, Atrophy | | 1 3.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydronephrosis | 2 | 2 2.5| Inflammation, Focal, Suppurative | 1 | 1 1.0| Nephropathy | 3 3 4 3 3 1 3 2 3 3 3 2 3 4 1 4 4 2 3 4 4 4 4 2| 48 2.8| Renal Tubule, Hyperplasia, Focal | 4 2 1 4 4 | 7 2.9| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Ulcer | 4 | 2 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 6| 4| 6| 6| 6| 6| 6| 6| 5| 6| 6| 5| 7| 6| 5| 6| 7| 6| 4| 5| 6| 3| 5| 6| 5| DAY ON TEST | 3| 6| 3| 8| 5| 6| 7| 4| 7| 0| 2| 9| 1| 5| 4| 8| 0| 5| 9| 9| 9| 3| 8| 8| 8| | 8| 7| 3| 0| 8| 9| 0| 2| 5| 0| 1| 8| 2| 9| 7| 3| 0| 0| 5| 8| 9| 7| 4| 0| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 150 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Perforation | X | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic, Focal | 3| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X | Clear Cell Focus | X X| Degeneration, Cystic, Focal | 3 3 3 3 3 3 2 2 3 3 1 1 1 2 2 1 3 2| Eosinophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X X X| Inflammation, Acute | | Mixed Cell Focus | X X X X X X| Necrosis, Focal | 2 1 | Bile Duct, Hyperplasia, Atypical, | | Focal | | Bile Duct, Hyperplasia | 2 2 2 1| Centrilobular, Necrosis | 3 | Hepatocyte, Hypertrophy | 3 3 3 3 3 3 2 3 3 2 3 4 3| Oval Cell, Hyperplasia | 3 2 1 1 1 1 1 2 2 1 1 1 1 2| __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Oral Mucosa | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 3 | Acinus, Atrophy | 2 2 1 1 1| __________________________________________________________________________| Salivary Glands | + + + + + M + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 2 | Submandibular Gland, Cytoplasmic | | Alteration | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 2 | Mineralization | 3 3 4 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 3 3 2 3 2 2 2 2 2 2 2 2 3 2| Mineralization | 1 3 3 2 1 2 4 4 | Ulcer | 2 | Neuroendocrine Cell, Hyperplasia | 1 2 1 | __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 6| 4| 6| 6| 6| 6| 6| 6| 5| 6| 6| 5| 7| 6| 5| 6| 7| 6| 4| 5| 6| 3| 5| 6| 5| DAY ON TEST | 3| 6| 3| 8| 5| 6| 7| 4| 7| 0| 2| 9| 1| 5| 4| 8| 0| 5| 9| 9| 9| 3| 8| 8| 8| | 8| 7| 3| 0| 8| 9| 0| 2| 5| 0| 1| 8| 2| 9| 7| 3| 0| 0| 5| 8| 9| 7| 4| 0| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 150 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 3 4 | Aorta, Mineralization | 3 3 1 1 4 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrium, Thrombosis | | Myocardium, Degeneration | 2 2 2 1 2 1 2 2 1 2 1 2 1 1 2 1 2| Myocardium, Mineralization | 3 3 1 1 2 | Valve, Inflammation, Chronic | 4 | Ventricle, Thrombosis | 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 1 | Necrosis, Focal | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 1 3 1 2 3 3 4 4 3 1 3 1 2| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + M + + + + + + + + M + + + + + + + + M +| Hyperplasia | 2 2 | Bilateral, Hyperplasia | 3 3 3 4 4 4 3 | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 1 | Pars Distalis, Hyperplasia, Focal | 1 | Pars Nervosa, Inflammation, Focal, | | Suppurative | 1 | __________________________________________________________________________| Thyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 2 2| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 2 3 3 3 | Hyperplasia, Focal | 1 1 4 1| Inflammation, Chronic | 1 1 2 1 1| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 | Hyperplasia | | Inflammation, Chronic | 1 1 2 2 1 3 1 1 1| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 6| 4| 6| 6| 6| 6| 6| 6| 5| 6| 6| 5| 7| 6| 5| 6| 7| 6| 4| 5| 6| 3| 5| 6| 5| DAY ON TEST | 3| 6| 3| 8| 5| 6| 7| 4| 7| 0| 2| 9| 1| 5| 4| 8| 0| 5| 9| 9| 9| 3| 8| 8| 8| | 8| 7| 3| 0| 8| 9| 0| 2| 5| 0| 1| 8| 2| 9| 7| 3| 0| 0| 5| 8| 9| 7| 4| 0| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 150 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 2 2 | Epithelium, Atrophy | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Germinal Epithelium, Atrophy | 4 4 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 1 1 1 1 1 1 2 1 2 1 1| Necrosis | 2 | __________________________________________________________________________| Lymph Node | + | Lumbar, Hyperplasia, Lymphoid | | Mediastinal, Erythrophagocytosis | 1 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Erythrophagocytosis | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 | Fibrosis | 3 2 2 2 1 | Hematopoietic Cell Proliferation | 2 3 3 2 1| Hemorrhage | 4 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + M + M + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + M + + + + + + + + M| Dilatation | 1 2 1 | Hyperplasia, Focal | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 4 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 1 3 3 4 2 3 3 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrocephalus | | Necrosis, Focal | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Granulomatous | | Inflammation, Suppurative | 1 | Alveolar Epithelium, Hyperplasia, | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 6| 4| 6| 6| 6| 6| 6| 6| 5| 6| 6| 5| 7| 6| 5| 6| 7| 6| 4| 5| 6| 3| 5| 6| 5| DAY ON TEST | 3| 6| 3| 8| 5| 6| 7| 4| 7| 0| 2| 9| 1| 5| 4| 8| 0| 5| 9| 9| 9| 3| 8| 8| 8| | 8| 7| 3| 0| 8| 9| 0| 2| 5| 0| 1| 8| 2| 9| 7| 3| 0| 0| 5| 8| 9| 7| 4| 0| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 150 | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Focal | 2 | Alveolar Epithelium, Interstitium, | | Mineralization | 2 | Bronchus, Inflammation, Suppurative | 3| Interstitium, Inflammation, Chronic | 1 | Interstitium, Mineralization | 2 2 2 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 1 1 2 2 1 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | Cataract | | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Focal, Suppurative | 3 2 | Nephropathy | 4 2 3 4 4 4 4 2 3 4 3 4 3 3 3 4 3 4 1 4 3 1 2 3 2| Renal Tubule, Hyperplasia, Focal | | Renal Tubule, Hyperplasia, Oncocytic | | __________________________________________________________________________| Urethra | + | __________________________________________________________________________| Urinary Bladder | + + + + + + + M + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 6| 6| 5| 4| 5| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 7| 6| 6| 5| 6| 6| 6| 5| 6| | DAY ON TEST | 1| 6| 4| 5| 6| 1| 2| 4| 8| 0| 4| 4| 0| 8| 5| 0| 0| 6| 6| 0| 6| 8| 4| 2| 6| | | 4| 1| 6| 7| 8| 0| 5| 2| 8| 9| 2| 8| 2| 8| 4| 7| 4| 0| 0| 2| 0| 4| 6| 3| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 150 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Perforation | | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | X X X X | 4 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic, Focal | | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | | 1 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X | 7 | Clear Cell Focus | X | 3 | Degeneration, Cystic, Focal | 1 3 1 2 3 2 2 2 2 2 2 2 3 3 1 1 2 3 1 3| 38 2.2| Eosinophilic Focus | X X X X X X X X X X X X X X X X X X X X X X| 47 | Inflammation, Acute | 2 | 1 2.0| Mixed Cell Focus | X X | 8 | Necrosis, Focal | 2 | 3 1.7| Bile Duct, Hyperplasia, Atypical, | | | Focal | 2 1 | 2 1.5| Bile Duct, Hyperplasia | 1 2 2 1 2 1 1 2 2 1 4 2 3| 17 1.8| Centrilobular, Necrosis | | 1 3.0| Hepatocyte, Hypertrophy | 3 4 2 2 3 3 2 2 2 4 3 2 2 4 2 3 3| 30 2.8| Oval Cell, Hyperplasia | 2 2 2 3 2 2 1 2 1 1 3 2 3 1 2 2 1 2 2 3| 34 1.7| __________________________________________________________________________|____________| Mesentery | | 1 | __________________________________________________________________________|____________| Oral Mucosa | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 4 | 2 3.5| Acinus, Atrophy | 1 1 1 1 | 9 1.2| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 | Inflammation, Chronic | | 1 2.0| Submandibular Gland, Cytoplasmic | | | Alteration | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 48 2.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | | 1 2.0| Mineralization | 2 3 3| 6 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 6| 6| 5| 4| 5| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 7| 6| 6| 5| 6| 6| 6| 5| 6| | DAY ON TEST | 1| 6| 4| 5| 6| 1| 2| 4| 8| 0| 4| 4| 0| 8| 5| 0| 0| 6| 6| 0| 6| 8| 4| 2| 6| | | 4| 1| 6| 7| 8| 0| 5| 2| 8| 9| 2| 8| 2| 8| 4| 7| 4| 0| 0| 2| 0| 4| 6| 3| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 150 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Atrophy | 2 2 2 2 2 3 3 2 2 3 1 1 3 2 3 2 4 3 3 1 1 1 3| 37 2.2| Mineralization | 1 2 2 4 2 2| 14 2.4| Ulcer | 1 | 2 1.5| Neuroendocrine Cell, Hyperplasia | 1 2 2 1 2 | 8 1.5| __________________________________________________________________________|____________| Tongue | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 2 4 3 4 3| 7 3.3| Aorta, Mineralization | 1 | 6 2.2| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrium, Thrombosis | 1 4 | 2 2.5| Myocardium, Degeneration | 1 2 1 1 2 2 2 1 2 1 2 1 2 2 2 2 3 2 1 1| 37 1.6| Myocardium, Mineralization | 1 3 3 2| 9 2.1| Valve, Inflammation, Chronic | | 1 4.0| Ventricle, Thrombosis | | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 1 1 1 | 4 1.0| Necrosis, Focal | 1 | 1 1.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 3 1 1 1 3 3 4 3| 21 2.4| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + M + + + + + M + + + + + + + + + + + + +| 45 | Hyperplasia | 4 | 3 2.7| Bilateral, Hyperplasia | 3 1 3 2 1 3 2 3 4 4 4| 18 3.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 2 1.5| Pars Distalis, Hyperplasia, Focal | 1 | 2 1.0| Pars Nervosa, Inflammation, Focal, | | | Suppurative | | 1 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 | C-Cell, Hyperplasia | 2 2 1 1 1 2 1 | 10 1.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | + + + + | 6 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 6| 6| 5| 4| 5| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 7| 6| 6| 5| 6| 6| 6| 5| 6| | DAY ON TEST | 1| 6| 4| 5| 6| 1| 2| 4| 8| 0| 4| 4| 0| 8| 5| 0| 0| 6| 6| 0| 6| 8| 4| 2| 6| | | 4| 1| 6| 7| 8| 0| 5| 2| 8| 9| 2| 8| 2| 8| 4| 7| 4| 0| 0| 2| 0| 4| 6| 3| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 150 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granuloma Sperm | 2 | 1 2.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 1| 6 2.3| Hyperplasia, Focal | | 4 1.8| Inflammation, Chronic | 1 2 1 2 1 1 2 | 12 1.3| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 | Hyperplasia, Focal | | 1 2.0| Hyperplasia | 4 | 1 4.0| Inflammation, Chronic | 1 1 4 2 1 2 | 15 1.6| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 3 2 2| 6 2.0| Epithelium, Atrophy | 2 | 1 2.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Germinal Epithelium, Atrophy | 2 | 3 3.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 1 2 1 1 2 1 1 1 2 1 | 23 1.3| Necrosis | | 1 2.0| __________________________________________________________________________|____________| Lymph Node | + + + | 4 | Lumbar, Hyperplasia, Lymphoid | 2 | 1 2.0| Mediastinal, Erythrophagocytosis | | 1 1.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erythrophagocytosis | | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | | 1 3.0| Fibrosis | 2 1 2 2 2 2 2| 12 1.9| Hematopoietic Cell Proliferation | 4 2 2 2 2 2 2 2 | 13 2.2| Hemorrhage | | 1 4.0| __________________________________________________________________________|____________| Thymus | M M + + + + M + + + + + + + + + + M M + + + M + +| 42 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + + + + M + + M + + + + + + + + + + + + + + + +| 45 | Dilatation | 2 2 1 1 | 7 1.4| Hyperplasia, Focal | 4| 1 4.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 6| 6| 5| 4| 5| 6| 6| 6| 6| 4| 6| 6| 6| 6| 6| 6| 7| 6| 6| 5| 6| 6| 6| 5| 6| | DAY ON TEST | 1| 6| 4| 5| 6| 1| 2| 4| 8| 0| 4| 4| 0| 8| 5| 0| 0| 6| 6| 0| 6| 8| 4| 2| 6| | | 4| 1| 6| 7| 8| 0| 5| 2| 8| 9| 2| 8| 2| 8| 4| 7| 4| 0| 0| 2| 0| 4| 6| 3| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 150 | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| L | MG/KG | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 2 4 4 4 4 4 4| 14 3.2| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydrocephalus | 2 | 1 2.0| Necrosis, Focal | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Granulomatous | 1 1 1 | 3 1.0| Inflammation, Suppurative | | 1 1.0| Alveolar Epithelium, Hyperplasia, | | | Focal | 1 | 2 1.5| Alveolar Epithelium, Interstitium, | | | Mineralization | | 1 2.0| Bronchus, Inflammation, Suppurative | | 1 3.0| Interstitium, Inflammation, Chronic | | 1 1.0| Interstitium, Mineralization | 3 1 3 1 3 3| 10 2.2| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 1 2 2 1 3 | 11 1.5| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | Cataract | 3 | 1 3.0| __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Focal, Suppurative | | 2 2.5| Nephropathy | 2 4 3 1 4 2 2 2 4 1 2 3 2 3 4 2 4 4 3 2 4 4 4 4 4| 50 3.0| Renal Tubule, Hyperplasia, Focal | 4 4 2 4 | 4 3.5| Renal Tubule, Hyperplasia, Oncocytic | 1 2 | 2 1.5| __________________________________________________________________________|____________| Urethra | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 5| 2| 5| 6| 5| 6| 6| 6| 6| 5| 2| 1| 5| 5| 4| 6| 0| 5| 6| 6| 5| 5| 5| 5| 5| DAY ON TEST | 4| 9| 0| 0| 5| 3| 3| 7| 0| 1| 1| 7| 1| 5| 9| 0| 1| 8| 1| 8| 5| 7| 8| 5| 2| | 0| 9| 2| 8| 6| 1| 8| 4| 4| 3| 9| 7| 7| 7| 8| 4| 8| 9| 9| 0| 6| 0| 9| 3| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 300 | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| MG/KG | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + M + + + + + + + + + + + + + + + + + + +| Periesophageal Tissue, Inflammation | 2 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | | Mineralization | 3 | Necrosis | | Parasite Metazoan | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Parasite Metazoan | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X | Clear Cell Focus | X X | Degeneration, Cystic, Focal | 2 3 3 3 3 3 3 3 3 2 3 2 2 2 2 2 2 3 2 2| Eosinophilic Focus | X X X X X X X X X X X X X X X X X X X X| Mixed Cell Focus | X X | Necrosis, Focal | 2 | Bile Duct, Cyst | 3 | Bile Duct, Hyperplasia, Atypical, | | Focal | | Bile Duct, Hyperplasia | 2 4 1 1 2 1 1 3 1 2 2 2 | Centrilobular, Necrosis | 3 | Hepatocyte, Hypertrophy | 4 2 4 4 3 2 1 2 1 4 3 3 3 4 3 3 2 1| Oval Cell, Hyperplasia | 1 3 1 1 2 2 2 2 1 1 2 1 1 2 1 1| __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 1 3 | Acinus, Atrophy | 1 1 1 1 1 2 1 | __________________________________________________________________________| Salivary Glands | + + + + + M + + + + + + + + + + + + + + + + + + +| Submandibular Gland, Cytoplasmic | | Alteration | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 2 3 3 | Ulcer | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 1 2 2 1 2 3 3 3 2 2 1 2 3 3| Inflammation, Focal, Suppurative | | Mineralization | 3 3 3 3 3 4 4 4 3 1| Ulcer | 2 2 3 2 | Neuroendocrine Cell, Hyperplasia | 3 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 5| 2| 5| 6| 5| 6| 6| 6| 6| 5| 2| 1| 5| 5| 4| 6| 0| 5| 6| 6| 5| 5| 5| 5| 5| DAY ON TEST | 4| 9| 0| 0| 5| 3| 3| 7| 0| 1| 1| 7| 1| 5| 9| 0| 1| 8| 1| 8| 5| 7| 8| 5| 2| | 0| 9| 2| 8| 6| 1| 8| 4| 4| 3| 9| 7| 7| 7| 8| 4| 8| 9| 9| 0| 6| 0| 9| 3| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 300 | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| MG/KG | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 4 4 4 4 4 | Aorta, Hyperplasia | | Aorta, Mineralization | 3 1 4 4 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Focal, Suppurative | | Myocardium, Degeneration | 2 2 2 1 1 1 2 2 1 2 1 1 | Myocardium, Mineralization | 2 3 3 2 3 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 1 1 | Necrosis, Focal | 1 | Vacuolization Cytoplasmic, Focal | 1 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 3 4 1 1 1 1 4 4 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + M + + + + + + + + M + I + + + + + + + +| Hyperplasia, Focal | 2 | Hyperplasia | 3 2 4 1 | Bilateral, Hyperplasia | 3 4 3 3 2 4 3 3| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Pars Distalis, Hyperplasia, Focal | 4 | Pars Intermedia, Hyperplasia, Focal | 1 | __________________________________________________________________________| Thyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 2 2 1 1 1 1| Follicle, Cyst | 3 | Follicular Cell, Hyperplasia, Focal | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | | Serosa, Hyperplasia, Mesothelium | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 1 2 3 | Fibrosis | 3 | Hyperplasia, Focal | 4 2 2 1| Inflammation, Chronic | 1 2 1 3 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 5| 2| 5| 6| 5| 6| 6| 6| 6| 5| 2| 1| 5| 5| 4| 6| 0| 5| 6| 6| 5| 5| 5| 5| 5| DAY ON TEST | 4| 9| 0| 0| 5| 3| 3| 7| 0| 1| 1| 7| 1| 5| 9| 0| 1| 8| 1| 8| 5| 7| 8| 5| 2| | 0| 9| 2| 8| 6| 1| 8| 4| 4| 3| 9| 7| 7| 7| 8| 4| 8| 9| 9| 0| 6| 0| 9| 3| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 300 | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| MG/KG | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Inflammation, Chronic | 2 2 2 2 1 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 | Mineralization | 2 | Serosa, Hyperplasia, Mesothelium | 1 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 4 | Germinal Epithelium, Atrophy | 4 | Interstitial Cell, Hyperplasia | 3 | Tunic, Hyperplasia, Mesothelium | 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 1 1 1 1 1 1 2 1 | Necrosis | 2 | __________________________________________________________________________| Lymph Node | + | Mediastinal, Erythrophagocytosis | 1 | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis | 2 2| Hematopoietic Cell Proliferation | 3 | Lymphoid Follicle, Atrophy | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + M + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 2 | Galactocele | 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | 2 | Pinna, Ulcer | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 1 2 2 4 4 4 3 2 4 3| Cranium, Hyperostosis | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrocephalus | 1 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 _____________________________________________________________________________________________________________________ | 5| 2| 5| 6| 5| 6| 6| 6| 6| 5| 2| 1| 5| 5| 4| 6| 0| 5| 6| 6| 5| 5| 5| 5| 5| DAY ON TEST | 4| 9| 0| 0| 5| 3| 3| 7| 0| 1| 1| 7| 1| 5| 9| 0| 1| 8| 1| 8| 5| 7| 8| 5| 2| | 0| 9| 2| 8| 6| 1| 8| 4| 4| 3| 9| 7| 7| 7| 8| 4| 8| 9| 9| 0| 6| 0| 9| 3| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 300 | 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| MG/KG | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Congestion | 2 | Inflammation, Granulomatous | 1| Alveolar Epithelium, Hyperplasia, | | Focal | 1 | Interstitium, Inflammation, Chronic | 1 | Interstitium, Mineralization | 3 2 3 2 2 3 2 3 3 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 1 1 2 1 | __________________________________________________________________________| Trachea | + + + + + M + + + + + + + + + + + + + + + + + + +| Inflammation | 2 | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydronephrosis | | Inflammation, Focal, Suppurative | | Nephropathy | 4 4 3 2 4 4 4 4 3 1 3 4 2 4 3 3 3 2 4 4 4 4| Renal Tubule, Cyst | 3| Renal Tubule, Hyperplasia, Focal | 2 1 | Renal Tubule, Hyperplasia, Oncocytic | 4 | __________________________________________________________________________| Ureter | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 1 | Transitional Epithelium, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 5| 5| 3| 5| 4| 6| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 5| 6| 5| 5| 5| 5| 5| 4| 6| | DAY ON TEST | 2| 2| 8| 3| 3| 2| 9| 9| 4| 8| 9| 3| 2| 5| 3| 3| 8| 8| 7| 7| 0| 3| 9| 9| 0| | | 8| 6| 0| 3| 7| 7| 2| 2| 8| 2| 7| 3| 1| 3| 7| 4| 9| 4| 2| 2| 6| 3| 1| 5| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 300 | 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| L | MG/KG | 9| 1| 2| 4| 5| 6| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 | Periesophageal Tissue, Inflammation | | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis | 3 | 1 3.0| Mineralization | 2 3 2 | 4 2.5| Necrosis | 3 | 1 3.0| Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Parasite Metazoan | | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X | 6 | Clear Cell Focus | X | 3 | Degeneration, Cystic, Focal | 2 2 2 1 2 2 2 3 2 2 2 2 1 2 1 2 2 2 3 2 2| 41 2.2| Eosinophilic Focus | X X X X X X X X X X X X X X X X X X X| 39 | Mixed Cell Focus | | 2 | Necrosis, Focal | 3 | 2 2.5| Bile Duct, Cyst | | 1 3.0| Bile Duct, Hyperplasia, Atypical, | | | Focal | 2 | 1 2.0| Bile Duct, Hyperplasia | 2 2 1 1 1 1 1 1 2 1 1 3 2 3 2 1| 28 1.7| Centrilobular, Necrosis | | 1 3.0| Hepatocyte, Hypertrophy | 3 2 2 3 2 2 2 1 | 26 2.5| Oval Cell, Hyperplasia | 1 2 1 2 2 2 2 2 1 3 1| 27 1.6| __________________________________________________________________________|____________| Mesentery | | 1 | __________________________________________________________________________|____________| Pancreas | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia, Focal | | 2 2.0| Acinus, Atrophy | 1 1 2 | 10 1.2| __________________________________________________________________________|____________| Salivary Glands | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 | Submandibular Gland, Cytoplasmic | | | Alteration | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 48 2.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 | Mineralization | 3 2 | 5 2.6| Ulcer | 4 | 1 4.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | 2 2 3 3 2 3 2 3 3 2 2 3 2 1 2 | 29 2.2| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 5| 5| 3| 5| 4| 6| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 5| 6| 5| 5| 5| 5| 5| 4| 6| | DAY ON TEST | 2| 2| 8| 3| 3| 2| 9| 9| 4| 8| 9| 3| 2| 5| 3| 3| 8| 8| 7| 7| 0| 3| 9| 9| 0| | | 8| 6| 0| 3| 7| 7| 2| 2| 8| 2| 7| 3| 1| 3| 7| 4| 9| 4| 2| 2| 6| 3| 1| 5| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 300 | 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| L | MG/KG | 9| 1| 2| 4| 5| 6| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Inflammation, Focal, Suppurative | 1 | 1 1.0| Mineralization | 4 2 3 2 2 3 2 1 2 3 | 20 2.8| Ulcer | 2 2 2 2 | 8 2.1| Neuroendocrine Cell, Hyperplasia | 2 2 2 2 1 1| 8 1.8| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 3 4 3 1 | 9 3.4| Aorta, Hyperplasia | 4 | 1 4.0| Aorta, Mineralization | 2 3 4 4 2 4 | 10 3.1| __________________________________________________________________________|____________| Heart | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Focal, Suppurative | 2 | 1 2.0| Myocardium, Degeneration | 1 1 2 2 1 2 1 2 2 2 1 1 1 | 25 1.5| Myocardium, Mineralization | 2 1 3 1 2 1 1 1 3 | 15 2.1| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 1 1 1 | 5 1.0| Necrosis, Focal | | 1 1.0| Vacuolization Cytoplasmic, Focal | | 1 1.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 1 3 1 3 4 | 14 2.3| __________________________________________________________________________|____________| Islets, Pancreatic | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 46 | Hyperplasia, Focal | | 1 2.0| Hyperplasia | 1 1 3 | 7 2.1| Bilateral, Hyperplasia | 4 3 3 3 3 3 3 3 3 4 | 18 3.2| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 | 1 3.0| Pars Distalis, Hyperplasia, Focal | | 1 4.0| Pars Intermedia, Hyperplasia, Focal | | 1 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 | C-Cell, Hyperplasia | 1 1 1 2 1 1 2 1 2 2| 17 1.4| Follicle, Cyst | | 1 3.0| Follicular Cell, Hyperplasia, Focal | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | + | 2 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 5| 5| 3| 5| 4| 6| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 5| 6| 5| 5| 5| 5| 5| 4| 6| | DAY ON TEST | 2| 2| 8| 3| 3| 2| 9| 9| 4| 8| 9| 3| 2| 5| 3| 3| 8| 8| 7| 7| 0| 3| 9| 9| 0| | | 8| 6| 0| 3| 7| 7| 2| 2| 8| 2| 7| 3| 1| 3| 7| 4| 9| 4| 2| 2| 6| 3| 1| 5| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 300 | 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| L | MG/KG | 9| 1| 2| 4| 5| 6| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granuloma Sperm | 2 | 1 2.0| Serosa, Hyperplasia, Mesothelium | 1 4 | 2 2.5| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 4 2.3| Fibrosis | | 1 3.0| Hyperplasia, Focal | 1 | 5 2.0| Inflammation, Chronic | | 4 1.8| __________________________________________________________________________|____________| Prostate | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic | 1 1 1 1| 9 1.4| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 2 2| 3 2.0| Mineralization | 2 3 | 3 2.3| Serosa, Hyperplasia, Mesothelium | | 1 1.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 4.0| Germinal Epithelium, Atrophy | | 1 4.0| Interstitial Cell, Hyperplasia | | 1 3.0| Tunic, Hyperplasia, Mesothelium | 1 4 | 3 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 1 2 1 1 1 1 1 | 18 1.2| Necrosis | | 1 2.0| __________________________________________________________________________|____________| Lymph Node | + + | 3 | Mediastinal, Erythrophagocytosis | | 1 1.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + M| 47 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + M M + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Spleen | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 | Fibrosis | 2 2 | 4 2.0| Hematopoietic Cell Proliferation | 3 2 2 | 4 2.5| Lymphoid Follicle, Atrophy | 3 | 1 3.0| __________________________________________________________________________|____________| Thymus | + + M M + + + + + + M + + + + + + + + + M M + + M| 43 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + M + + + + + + + + M + + + + + + + M + + M + + +| 46 | Dilatation | | 1 2.0| Galactocele | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 5| 5| 3| 5| 4| 6| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 5| 6| 5| 5| 5| 5| 5| 4| 6| | DAY ON TEST | 2| 2| 8| 3| 3| 2| 9| 9| 4| 8| 9| 3| 2| 5| 3| 3| 8| 8| 7| 7| 0| 3| 9| 9| 0| | | 8| 6| 0| 3| 7| 7| 2| 2| 8| 2| 7| 3| 1| 3| 7| 4| 9| 4| 2| 2| 6| 3| 1| 5| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 300 | 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| L | MG/KG | 9| 1| 2| 4| 5| 6| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | | 1 2.0| Pinna, Ulcer | | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 1 3 3 4 4 2 3 2 1 3 1 | 21 2.7| Cranium, Hyperostosis | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydrocephalus | | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 | Congestion | | 1 2.0| Inflammation, Granulomatous | 2 | 2 1.5| Alveolar Epithelium, Hyperplasia, | | | Focal | | 1 1.0| Interstitium, Inflammation, Chronic | | 1 1.0| Interstitium, Mineralization | 3 1 1 1 3 3 1 2 3 | 18 2.3| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 2 2 2 1| 9 1.6| __________________________________________________________________________|____________| Trachea | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 | Inflammation | | 1 2.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydronephrosis | 3 | 1 3.0| Inflammation, Focal, Suppurative | 3 | 1 3.0| Nephropathy | 3 4 1 4 3 4 4 4 3 4 2 4 3 4 2 4 4 3 4 3 2 2 4 2 3| 47 3.3| Renal Tubule, Cyst | 3 | 2 3.0| Renal Tubule, Hyperplasia, Focal | 3 | 3 2.0| Renal Tubule, Hyperplasia, Oncocytic | | 1 4.0| __________________________________________________________________________|____________| Ureter | + | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 09:02:53 __________________________________________________________________________________________________________________________________ | 5| 5| 3| 5| 4| 6| 5| 5| 5| 5| 5| 6| 5| 6| 5| 6| 5| 6| 5| 5| 5| 5| 5| 4| 6| | DAY ON TEST | 2| 2| 8| 3| 3| 2| 9| 9| 4| 8| 9| 3| 2| 5| 3| 3| 8| 8| 7| 7| 0| 3| 9| 9| 0| | | 8| 6| 0| 3| 7| 7| 2| 2| 8| 2| 7| 3| 1| 3| 7| 4| 9| 4| 2| 2| 6| 3| 1| 5| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | 300 | 3| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| L | MG/KG | 9| 1| 2| 4| 5| 6| 8| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Inflammation, Suppurative | | 1 1.0| Transitional Epithelium, Hyperplasia | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------
Web page last updated on November 15, 2004
The National Institute of Environmental Health Sciences is one of the National Institutes of Health within the U.S. Department of Health and Human Services. The National Toxicology Program is headquartered on the NIEHS campus in Research Triangle Park, NC.