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Pathology Tables for Peer Review
Pathology Tables for Peer Review
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NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 08:53:18 52 WEEK SSAC Facility: Battelle Columbus Laboratory Chemical CAS #: 93-15-2 Lock Date: 09/17/96 Cage Range: All Reasons For Removal: 25017 Scheduled Sacrifice Removal Date Range: 02/02/95 - 02/03/95 Treatment Groups: Include 002 0 MG/KG Include 010 300 MG/KG Include 001 0 MG/KG Include 009 300 MG/KG Page 1 NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 08:53:18 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| | | | 1| 1| 1| 1| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 3| 3| | A | 0 MG/KG | 7| 8| 9| 0| 2| | L | | 7| 7| 3| 4| 9| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + | 5 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + | 5 | __________________________________________________________________________|____________| Liver | + + + + + | 5 | Basophilic Focus | X X X X X | 5 | Clear Cell Focus | X | 1 | Hepatodiaphragmatic Nodule | X X | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + | 5 | __________________________________________________________________________|____________| Salivary Glands | + + + + + | 5 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + | 5 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + | 5 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + | 5 | __________________________________________________________________________|____________| Heart | + + + + + | 5 | Myocardium, Degeneration | 1 1 | 2 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + | 5 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + | 5 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + | 5 | __________________________________________________________________________|____________| Parathyroid Gland | + M M + + | 3 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + | 5 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + | 5 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + | 5 | __________________________________________________________________________|____________| Ovary | + + + + + | 5 | __________________________________________________________________________|____________| Uterus | + + + + + | 5 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 08:53:18 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| | | | 1| 1| 1| 1| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 3| 3| | A | 0 MG/KG | 7| 8| 9| 0| 2| | L | | 7| 7| 3| 4| 9| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + | 5 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + | 5 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + | 5 | __________________________________________________________________________|____________| Spleen | + + + + + | 5 | __________________________________________________________________________|____________| Thymus | + + + + + | 5 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + | 5 | Dilatation | 1 1 2 | 3 1.3| __________________________________________________________________________|____________| Skin | + + + + + | 5 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + | 5 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + | 5 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + | 5 | __________________________________________________________________________|____________| Nose | + + + + + | 5 | __________________________________________________________________________|____________| Trachea | + + + + + | 5 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + | 5 | Nephropathy | 1 1 1 1 | 4 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + | 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 08:53:18 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| | | | 1| 1| 1| 1| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| | A | 300 | 0| 0| 2| 2| 3| | L | MG/KG | 0| 7| 6| 8| 7| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + | 5 | __________________________________________________________________________|____________| Liver | + + + + + | 5 | Basophilic Focus | X X X | 3 | Clear Cell Focus | X X | 2 | Eosinophilic Focus | X X X | 3 | Mixed Cell Focus | X X X X X | 5 | Bile Duct, Cyst | 3 | 1 3.0| Hepatocyte, Hypertrophy | 3 3 3 3 3 | 5 3.0| Oval Cell, Hyperplasia | 2 2 2 2 1 | 5 1.8| __________________________________________________________________________|____________| Pancreas | + + + + + | 5 | __________________________________________________________________________|____________| Salivary Glands | + + + + + | 5 | Submandibular Gland, Cytoplasmic | | | Alteration | 2 2 2 2 2 | 5 2.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + | 5 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + | 5 | Atrophy | 3 3 3 3 3 | 5 3.0| Neuroendocrine Cell, Hyperplasia | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + | 5 | __________________________________________________________________________|____________| Heart | + + + + + | 5 | Myocardium, Degeneration | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + | 5 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + | 5 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + | 5 | __________________________________________________________________________|____________| Parathyroid Gland | M + + M M | 2 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + | 5 | Cyst | 3 | 1 3.0| Pars Distalis, Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + | 5 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 4 NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 08:53:18 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| | | | 1| 1| 1| 1| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| | O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| | A | 300 | 0| 0| 2| 2| 3| | L | MG/KG | 0| 7| 6| 8| 7| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + M + + | 4 | __________________________________________________________________________|____________| Ovary | + + + + + | 5 | Cyst | 3 | 1 3.0| __________________________________________________________________________|____________| Uterus | + + + + + | 5 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + | 5 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + | 5 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + | 5 | __________________________________________________________________________|____________| Spleen | + + + + + | 5 | __________________________________________________________________________|____________| Thymus | + + + + + | 5 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + | 5 | __________________________________________________________________________|____________| Skin | + + + + + | 5 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + | 5 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + | 5 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + | 5 | __________________________________________________________________________|____________| Nose | + + + + + | 5 | __________________________________________________________________________|____________| Trachea | + + + + + | 5 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + | 5 | Nephropathy | 1 1 | 2 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + | 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 08:53:18 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| | | | 1| 1| 1| 1| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| | A | 0 MG/KG | 2| 3| 4| 5| 5| | L | | 3| 0| 5| 2| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + | 5 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + | 5 | __________________________________________________________________________|____________| Liver | + + + + + | 5 | Basophilic Focus | X | 1 | Clear Cell Focus | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + | 5 | __________________________________________________________________________|____________| Salivary Glands | + + + + + | 5 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + | 5 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + | 5 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + | 5 | __________________________________________________________________________|____________| Heart | + + + + + | 5 | Myocardium, Degeneration | 1 2 2 2 | 4 1.8| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + | 5 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + | 5 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + | 5 | Hyperplasia | 1 1 | 2 1.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + M | 4 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + | 5 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + | 5 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + | 5 | __________________________________________________________________________|____________| Preputial Gland | + + + + + | 5 | __________________________________________________________________________|____________| Prostate | + + + + + | 5 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + | 5 | __________________________________________________________________________|____________| Testes | + + + + + | 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 08:53:18 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| | | | 1| 1| 1| 1| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| | A | 0 MG/KG | 2| 3| 4| 5| 5| | L | | 3| 0| 5| 2| 6| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Interstitial Cell, Hyperplasia | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + | 5 | Hyperplasia | 1 | 1 1.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + | 5 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + | 5 | __________________________________________________________________________|____________| Spleen | + + + + + | 5 | __________________________________________________________________________|____________| Thymus | + + + + + | 5 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + | 5 | __________________________________________________________________________|____________| Skin | + + + + + | 5 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + | 5 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + | 5 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + | 5 | Alveolar Epithelium, Hypertrophy, | | | Focal | 1 | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + | 5 | __________________________________________________________________________|____________| Trachea | + + + + + | 5 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | Cataract | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + | 5 | Nephropathy | 1 1 1 1 1 | 5 1.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + | 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 08:53:18 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| | | | 1| 1| 1| 1| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| | A | 300 | 2| 4| 4| 5| 5| | L | MG/KG | 7| 0| 7| 1| 4| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + | 5 | Parasite Metazoan | X | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + | 5 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + | 5 | __________________________________________________________________________|____________| Liver | + + + + + | 5 | Basophilic Focus | X X X | 3 | Clear Cell Focus | X | 1 | Degeneration, Cystic, Focal | 1 1 1 1 1 | 5 1.0| Eosinophilic Focus | X X X X X | 5 | Hepatodiaphragmatic Nodule | X | 1 | Mixed Cell Focus | X X X X X | 5 | Bile Duct, Hyperplasia, Atypical, | | | Focal | 4 | 1 4.0| Bile Duct, Hyperplasia | 1 | 1 1.0| Hepatocyte, Hypertrophy | 3 3 3 3 3 | 5 3.0| Oval Cell, Hyperplasia | 1 2 1 1 2 | 5 1.4| __________________________________________________________________________|____________| Pancreas | + + + + + | 5 | __________________________________________________________________________|____________| Salivary Glands | + + + + + | 5 | Submandibular Gland, Cytoplasmic | | | Alteration | 2 2 2 2 2 | 5 2.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + | 5 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + | 5 | Atrophy | 1 2 2 2 3 | 5 2.0| Neuroendocrine Cell, Hyperplasia | 1 1 | 2 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + | 5 | __________________________________________________________________________|____________| Heart | + + + + + | 5 | Myocardium, Degeneration | 2 2 1 | 3 1.7| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + | 5 | __________________________________________________________________________|____________| Adrenal Medulla | + + + + + | 5 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + | 5 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + | 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 08:53:18 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| | | | 1| 1| 1| 1| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| | A | 300 | 2| 4| 4| 5| 5| | L | MG/KG | 7| 0| 7| 1| 4| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Pituitary Gland | + + + + + | 5 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + | 5 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + | 5 | __________________________________________________________________________|____________| Preputial Gland | + + + + + | 5 | __________________________________________________________________________|____________| Prostate | + + + + + | 5 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + | 5 | __________________________________________________________________________|____________| Testes | + + + + + | 5 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + | 5 | Hyperplasia | 1 1 1 1 1 | 5 1.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + | 5 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + | 5 | __________________________________________________________________________|____________| Spleen | + + + + + | 5 | __________________________________________________________________________|____________| Thymus | + + + + M | 4 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + | 5 | __________________________________________________________________________|____________| Skin | + + + + + | 5 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + | 5 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + | 5 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + | 5 | Inflammation, Granulomatous | 1 | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + | 5 | Inflammation, Suppurative | 2 | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + | 5 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 05187-09 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC METHYLEUGENOL Date: 07/20/98 Route: GAVAGE Time: 08:53:18 __________________________________________________________________________________________________________________________________ | 3| 3| 3| 3| 3| | | DAY ON TEST | 6| 6| 6| 6| 6| | | | 1| 1| 1| 1| 1| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| | O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| | A | 300 | 2| 4| 4| 5| 5| | L | MG/KG | 7| 0| 7| 1| 4| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + | 5 | Nephropathy | 2 2 2 2 2 | 5 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + | 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------
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The National Institute of Environmental Health Sciences is one of the National Institutes of Health within the U.S. Department of Health and Human Services. The National Toxicology Program is headquartered on the NIEHS campus in Research Triangle Park, NC.