Testing Information

Testing Status of Agents at NTP

Methyleugenol

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http://ntp.niehs.nih.gov/go/TS-10265-L

CASRN: 93-15-2

Formula: C11 H14 O2

Synonyms/Common Names:

  • 1,2-DIMETHOXY-4-(2-PROPENYL)BENZENE

Known Uses:

FLAVORING AGENT IN FOODS AND BEVERAGES; AS A FRAGRANCE IN COSMETICS; AS AN INSECT ATTRACTANT IN ERADICATION PROGRAMS AND AS AN ANESETHETIC IN RODENTS.

Short-Term Toxicity

  • 2-WEEK (Gavage)  (C60991) Completed 
    • NTIS No. PB2000-107865
      Citation: Toxicology and Carcinogenesis Studies of Methyleugenol (CAS No. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 10000, 20000 AND 40000 PPM/ RATS: 10 MALE, 5 FEMALE/GROUP; MICE: 5/SEX/GROUP
  • 13-WEEK (Gavage)  (C60991) Completed 
    • NTIS No. PB2000-107865
      Citation: Toxicology and Carcinogenesis Studies of Methyleugenol (CAS No. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0,10,30,100,300,1000 MG/KG PLUS SHAM GAVAGE GROUP

Long-Term Carcinogenicity

  • 2-YEAR (Gavage)  (C60991B) Report Complete 
    • TR-491 (NTIS No. PB2000-107865)  (Peer Review 10/30/1998)
      Toxicology and Carcinogenesis Studies of Methyleugenol (CAS No. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R&M: 0, 37, 75, OR 150 MG/KG; 50/SEX/SPECIES/GROUP

Special Studies

  • Absorption Disposition Metabolism Elimination (in-vitro)  (K10265) On Test 
    • Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Gavage)  (S0844) Completed 
      • Citation: FINAL REPORT: CHEMICAL DISPOSITION IN MAMMALS, 03/15/98 - 06/30/99. I.G. SIPES. J.L. BURKEY, M.J. KATTNIG. DEPARTMENT OF PHARMACOLOGY AND TOXICOLOGY, CENTER FOR TOXICOLOGY, COLLEGE OF PHARMACY, THE UNIVERSITY OF ARIZONA, TUCSON, ARIZONA 85721. IN VIVO AND IN IN VITRO METABOLISM, DISPOSITION, AND COVALENT BINDING OF METHYLEUGENOL.
      • M Rats: F344/N; M Rats: F344/N; F Mice: B6C3F1
      • Dose: 118 mg/kg, 50 uCi/kg gavage; 11.8 mg/kg, 120 uCi/kg intravenously; 118 mg/kg, 50 uCi/kg gavage
    • Metabolism (in-vitro)  (S0658) Completed 
      • Citation: CYTOTOXICITY & GENOTOXICITY OF METHYLEUGENOL & RELATED CONGENERS - A MECHANISM OF ACTIVATION FOR METHYLEUGENOL.
      • M/F Rats; M/F Mice; M/F Human
    • Metabolism  (S0898) Completed 
      • Citation: FINAL REPORT: CHEMICAL DISPOSITION IN MAMMALS, 03/15/98 - 06/30/99. I.G. SIPES. J.L. BURKEY, M.J. KATTNIG. DEPARTMENT OF PHARMACOLOGY AND TOXICOLOGY, CENTER FOR TOXICOLOGY, COLLEGE OF PHARMACY, THE UNIVERSITY OF ARIZONA, TUCSON, ARIZONA 85721. IN VITRO STUDIES WITH METHYLEUGENOL AND COMPARISONS WITH RELATED COMPOUNDS.
      • F Mice: B6C3F1; M Rats: F344/N; Human
    • Other  (S0826) Completed 
      • Citation: CYTOTOXICITY AND GENOTOXICITY OF METHYLEUGENOL AND RELATED CONGENERS-A MECHANISM OF ACTIVATION FOR METHYLEUGENOL. J.L. BURKEY, J-M SAUER, C.A. MCQUEEN, I.G. SIPES. MUTATION RESEARCH 453 (2000) 25-33. FUN-DAMENTALS & MOLECULAR MECHANISMS OF MUTAGENESIS. KEYWORDS: CYTOTOXICITY; GENOTOXICITY; METHYLEUGENOL.
    • Toxicokinetic Study (Gavage)  (S0577) Completed 
      • Citation: SEE TECHNICAL REPORT 491
      • M/F Rats: F344/N; M/F Mice: B6C3F1

    Genetic Toxicology

    • In Vitro Cytogenetics (CA/SCE)  (614248) Completed 
      • Chromosome Aberation Negative 
      • Sister Chromatid Exchange Positive 
    • Micronucleus  (A29699) Completed 
      • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
      • Mice: B6C3F1
      • Male Negative 
      • Female Negative 
    • Salmonella  (690169) Completed 
      • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
      •  Negative 

    Organ Systems Toxicity

    • GD 6 TO 19 Conventional Teratology (Gavage)  (TER97007) Completed 
      • NTIS No. PB2004-104348
        Citation: DEVELOPMENTAL TOXICITY EVALUATION FOR METHYLEUGENOL (CAS NO. 93-15-2) ADMINISTERED BY GAVAGE TO SPRAGUE-DAWLEY (CD(r)) RATS ON GESTATIONAL DAYS 6 THROUGH 19
      • NTIS No. PB2004-104349
        Citation: DEVELOPMENTAL TOXICITY EVALUATION FOR METHYLEUGENOL (CAS NO. 93-15-2) ADMINISTERED BY GAVAGE TO SPRAGUE-DAWLEY (CD(r)) RATS ON GESTATIONAL DAYS 6 THROUGH 19 (Laboratory Supplement)
      • F Rats: Sprague Dawley
      • Dose: 0, 80, 200, OR 500 MG/KG/DAY
    • GD 6 THROUGH 15 Teratology Pilot Studies (Gavage)  (TRP92045) Completed 
      • F Rats: Sprague Dawley
      • Dose: 0, 300, 600, 800, 1000, OR 1200 MG/KG
    • GD 6 THROUGH 19 Teratology Pilot Studies (Gavage)  (TRP92046) Completed 
      • F Rabbit: New Zealand White
      • Dose: 0, 100, 400, 600, 800, OR 1000 MG/KG
    • GD 6-19 Teratology Pilot Studies (Gavage)  (TRP97007) Completed 
      • F Rats: Sprague Dawley
      • Dose: 0, 31.25, 62.5, 125, 250, OR 500 MG/KG/DAY

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    Web page last updated on April 27, 2009