Testing Status of Agents at NTP
Coumaphos
CASRN: 56-72-4
Formula: C14 H16 CL O5 P S
Synonyms/Common Names:
- PHOSPHOROTHIOIC ACID, O-(3-CHLORO-4-METHYL-2-OXO-2H-1-BENZOPYRAN-7-YL)0,0-DIETHYL ESTER (9CI)
Known Uses:
LIVESTOCK INSECTICIDE WHICH FUNCTIONS SYSTEMICALLY BY ABSORPTION
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C08662) Completed
- NTIS No. PB290305
(Peer Review 10/25/1978)
Citation: Bioassay of Coumaphos for Possible Carcinogenicity (CAS No. 56-72-4) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB290305
(Peer Review 10/25/1978)
- 13-Week (Dosed-Feed)
(C08662) Completed
- NTIS No. PB290305
(Peer Review 10/25/1978)
Citation: Bioassay of Coumaphos for Possible Carcinogenicity (CAS No. 56-72-4) - Rats: F344/N; Mice: B6C3F1
- Dose: 0,320,640 PPM/10 PER GROUP
- NTIS No. PB290305
(Peer Review 10/25/1978)
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C08662) Report Complete
- TR-096 (NTIS No. PB290305)
(Peer Review 10/25/1978)
Bioassay of Coumaphos for Possible Carcinogenicity (CAS No. 56-72-4) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Negative
- Female Rats Negative
- Male Mice Negative
- Female Mice Negative
- Dose: 0,10,20 PPM/50 PER GROUP
- TR-096 (NTIS No. PB290305)
(Peer Review 10/25/1978)
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(051728) Completed
- Citation: Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94
- Chromosome Aberation Negative
- Sister Chromatid Exchange Negative
- Mouse Lymphoma
(110131) Completed
- Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
- Negative
- Salmonella (NCI)
(N-9276) Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
- Salmonella-NCI Negative
- Salmonella
(342560) Completed
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Negative
Web page last updated on April 27, 2009