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Pathology Tables for Peer Review
Pathology Tables for Peer Review
Home » Study Results & Research Projects » Pathology Tables for Peer Review » The National Toxicology Program
NTP Experiment-Test: 96021-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 06/05/03 Route: GAVAGE Time: 10:34:18 14 WEEK SSAC FINAL#1 Facility: Battelle Columbus Laboratory Chemical CAS #: 35065-27-1 Lock Date: 01/16/02 Cage Range: All Reasons For Removal: 25017 Scheduled Sacrifice Removal Date Range: 11/23/98 - 11/24/98 Treatment Groups: Include 001 0 UG/KG Include 002 10 UG/KG Include 003 100 UG/KG Include 004 300 UG/KG Include 005 1000 UG/KG Include 006 3000 UG/KG a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 96021-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 06/05/03 Route: GAVAGE Time: 10:34:18 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 UG/KG 10 UG/KG 100 300 1000 3000 UG/KG UG/KG UG/KG UG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 98 86 98 98 98 80 Scheduled Sacrifice 16 10 16 16 16 10 Early Deaths Survivors Animals Examined Microscopically 10 10 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (10) (10) (10) (10) (10) Inflammation 10 (100%) 10 (100%) 10 (100%) 9 (90%) 10 (100%) 10 (100%) Mixed Cell Focus 1 (10%) Hepatocyte, Hypertrophy 9 (90%) 10 (100%) Pancreas (10) (10) Inflammation, Chronic Active 1 (10%) Acinus, Atrophy 1 (10%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Thyroid Gland (10) (10) (10) (10) (10) (10) Follicular Cell, Hypertrophy 2 (20%) 3 (30%) 1 (10%) 1 (10%) 4 (40%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (10) (10) Atrophy 1 (10%) 1 (10%) Uterus (10) (10) Metaplasia, Squamous 1 (10%) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 96021-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 06/05/03 Route: GAVAGE Time: 10:34:18 ____________________________________________________________________________________________________________________________________ SPRAGUE-DAWLEY RATS FEMALE 0 UG/KG 10 UG/KG 100 300 1000 3000 UG/KG UG/KG UG/KG UG/KG ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - CONT Endometrium, Hyperplasia, Cystic 5 (50%) 2 (20%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Spleen (10) (10) Pigmentation 10 (100%) 10 (100%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) (10) (10) (10) (10) (10) Infiltration Cellular, Histiocyte 1 (10%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM None a Number of animals examined microscopically at site and number of animals with lesion Page 3 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------
Web page last updated on November 02, 2004
The National Institute of Environmental Health Sciences is one of the National Institutes of Health within the U.S. Department of Health and Human Services. The National Toxicology Program is headquartered on the NIEHS campus in Research Triangle Park, NC.