National Toxicology Program

CASRN: 72-43-5

Related: KID PEST PROJECT (METHOXYCHLOR)

Formula: C16-H15-CL3-O2

Synonyms/Common Names:

• 1,1'-(2,2,2-TRICHLOROETHYLIDENE)BIS(4-METHOXYBENZENE) (9CI)

Known Uses:

insecticide

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C00497) Completed 
  • NTIS No. PB278271  (Peer Review 11/18/1977)
    Citation: Bioassay of Methoxychlor for Possible Carcinogenicity (CAS No. 72-43-5)
  • Rats: Osborne Mendel; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C00497) Completed 
  • NTIS No. PB278271  (Peer Review 11/18/1977)
    Citation: Bioassay of Methoxychlor for Possible Carcinogenicity (CAS No. 72-43-5)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Dose: R: 0,316,3160, M: 0,1000,10000 PPM/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C00497) Report Complete 
  • TR-035 (NTIS No. PB278271)  (Peer Review 11/18/1977)
    Bioassay of Methoxychlor for Possible Carcinogenicity (CAS No. 72-43-5)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: MR: 0,448,845 (AVG), FR: 0,750,1385 (AVG), MM: 0,1746,3491 (AVG), FM: 0,997,1994 (AVG) PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (344617) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Positive 
• In Vitro Cytogenetics (CA/SCE)  (639870) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Not Tested 
• Mouse Lymphoma (NCI)  (G16413) Completed 
  • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
  • Mouse Lymphoma-NCI  Positive 
• Mouse Lymphoma (NCI)  (G84704) Completed 
  • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
  • Mouse Lymphoma-NCI  Positive 
• Salmonella (NCI)  (N-9092) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escerichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1985) 1-251
  • Salmonella-NCI  Negative 
• Salmonella  (391422) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
  •  Negative 
• Salmonella  (684566) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
  •  Negative