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Pathology Tables for Peer Review
Pathology Tables for Peer Review
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NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 Facility: BIORELIANCE Chemical CAS #: 60-13-9 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 6| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| DAY ON TEST | 3| 9| 5| 4| 7| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 1| 6| 9| 3| 3| 2| 1| 8| | 1| 4| 5| 1| 8| 1| 1| 1| 1| 9| 1| 1| 1| 1| 7| 1| 1| 9| 6| 3| 1| 1| 6| 0| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | 2 | |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer, Chronic | 3 | |__________________________________________________________________________| Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + + + + A| |__________________________________________________________________________| Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | | Fatty Change | 4 2 3 3 2 2 3 1| Focal Cellular Change | X X X X X X X X X X X X X X X X X X X | Granuloma | 2 | Hematopoietic Cell Proliferation, | | Multifocal | | Hepatodiaphragmatic Nodule | X X X | Hyperplasia, Multifocal | 4 | Infiltration Cellular, Multifocal, | | Lymphocyte | | Inflammation, Chronic, Multifocal | 2 1 2 1 2 2 1 2 4 2 1 1 1 2 | Bile Duct, Hyperplasia, Multifocal | 2 1 2 1 2 2 2 2 3 | |__________________________________________________________________________| Mesentery | + + + | Fat, Necrosis | 4 3 3 | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 2 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 6| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| DAY ON TEST | 3| 9| 5| 4| 7| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 1| 6| 9| 3| 3| 2| 1| 8| | 1| 4| 5| 1| 8| 1| 1| 1| 1| 9| 1| 1| 1| 1| 7| 1| 1| 9| 6| 3| 1| 1| 6| 0| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Metaplasia, Focal | 1 | Acinus, Atrophy, Diffuse | 3 2 | Acinus, Atrophy, Focal | 1 1 | Acinus, Atrophy, Multifocal | 2 2 2 | Acinus, Focal Cellular Change | 2 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Diffuse, Squamous | 2 2 | Hyperplasia, Focal, Squamous | | Inflammation, Acute | 2 | Ulcer, Multiple | 3 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion, Focal | 2 | |__________________________________________________________________________| Tongue | + | Abscess | 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Multifocal | 1 2 1 1 1 1 1 2 1 2 2 1 2 2 1 | Mineralization, Multifocal | 4 2| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Focal | 2 1 1 1 | Degeneration, Multifocal | 2 | Fibrosis, Focal | 2 | Hematocyst | | __________________________________________|__________________________________________________________________________| Page 3 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 6| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| DAY ON TEST | 3| 9| 5| 4| 7| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 1| 6| 9| 3| 3| 2| 1| 8| | 1| 4| 5| 1| 8| 1| 1| 1| 1| 9| 1| 1| 1| 1| 7| 1| 1| 9| 6| 3| 1| 1| 6| 0| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Hematopoietic Cell Proliferation, | | Multifocal | | Hyperplasia, Focal | 1 1 1 2 | Hyperplasia, Multifocal | 3 | Necrosis, Multifocal | 2| |__________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 3 | Hyperplasia, Multifocal | 4 4 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis, Focal | 1 | Pars Distalis, Cyst | 2 3 2 2 2 2| Pars Distalis, Hyperplasia, Focal | 1 4 2 | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia, Diffuse | 1 | C-Cell, Hyperplasia, Focal | 2 2 3 | C-Cell, Hyperplasia, Multifocal | 1 2 1 2 1 1 | Follicle, Cyst | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + + + M + + + + + + M + M M + M + + + + + +| Ectasia | 2 | Hyperplasia, Focal | 3 1 | Hyperplasia | 2 | Inflammation, Acute, Focal | | Inflammation, Chronic, Focal | 1 | Inflammation, Chronic, Multifocal | 2 2 | __________________________________________|__________________________________________________________________________| Page 4 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 6| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| DAY ON TEST | 3| 9| 5| 4| 7| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 1| 6| 9| 3| 3| 2| 1| 8| | 1| 4| 5| 1| 8| 1| 1| 1| 1| 9| 1| 1| 1| 1| 7| 1| 1| 9| 6| 3| 1| 1| 6| 0| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X X 2 X | Inflammation, Chronic, Multifocal | | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 3 | Cervix, Cyst | 2 4 | Cervix, Inflammation, Chronic | | Cervix, Inflammation, Chronic Active | 4 | Cervix, Metaplasia, Squamous | 3 | Endometrium, Cyst, Multiple | 1 | Endometrium, Hyperplasia | | Lumen, Hemorrhage | | |__________________________________________________________________________| Vagina | + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | Hyperplasia | 2 2 2 2 3 2 2 | Myelofibrosis, Multifocal | | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 2 | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 2 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + M + + + + + M + + + + + + + + + + +| Hemorrhage | 2 | Hyperplasia, Lymphoid | 2 | Infiltration Cellular, Histiocyte | 2 2 2 2 2 2 2 | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 2 | Infarct | 1 2 | __________________________________________|__________________________________________________________________________| Page 5 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 6| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| DAY ON TEST | 3| 9| 5| 4| 7| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 1| 6| 9| 3| 3| 2| 1| 8| | 1| 4| 5| 1| 8| 1| 1| 1| 1| 9| 1| 1| 1| 1| 7| 1| 1| 9| 6| 3| 1| 1| 6| 0| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Pigmentation | 2 | Lymphoid Follicle, Atrophy | 3 | Lymphoid Follicle, Hyperplasia, Focal| 3 4 | |__________________________________________________________________________| Thymus | + + + + M + + + + + + + + + + + + + + + + + + M +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| Acinus, Hyperplasia, Focal | 2 | Duct, Ectasia | 2 2 2 2 2 2 2 2 2 3 2 2 3 1 1 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 3 | Subcutaneous Tissue, Hemorrhage | | Subcutaneous Tissue, Inflammation, | | Chronic Active, Focal | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 3 2 | Osteomalacia | 2| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Cerebrum, Hydrocephalus | 2 | Cerebrum, Infiltration Cellular, | | Focal, Lymphocyte | | Hypothalamus, Compression | 2 4 3 | |__________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 6 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 6| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| DAY ON TEST | 3| 9| 5| 4| 7| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 1| 6| 9| 3| 3| 2| 1| 8| | 1| 4| 5| 1| 8| 1| 1| 1| 1| 9| 1| 1| 1| 1| 7| 1| 1| 9| 6| 3| 1| 1| 6| 0| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2| Infiltration Cellular, Multifocal, | | Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 | Alveolar Epithelium, Hyperplasia, | | Focal | 2 | Interstitium, Inflammation, Chronic, | | Focal | | Peribronchial, Hyperplasia, Lymphoid | | Pleura, Inflammation, Chronic, Focal | 1 | Pleura, Inflammation, Multifocal, | | Proliferative | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | | Fungus | X | Mucosa, Cytoplasmic Alteration, | | Multifocal | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Mucosa, Inflammation, Acute, | | Multifocal | | Mucosa, Inflammation, Chronic, | | Multifocal | 1 | Mucosa, Inflammation, Chronic Active,| | Multifocal | | Mucosa, Inflammation, Multifocal, | | Subacute | 1 2 | Mucosa, Metaplasia, Focal, Squamous | | Nasolacrimal Duct, Inflammation, | | Chronic | | Nasolacrimal Duct, Inflammation, | | Chronic Active | 2 2 | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Ear | | __________________________________________|__________________________________________________________________________| Page 7 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 6| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4| DAY ON TEST | 3| 9| 5| 4| 7| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 1| 6| 9| 3| 3| 2| 1| 8| | 1| 4| 5| 1| 8| 1| 1| 1| 1| 9| 1| 1| 1| 1| 7| 1| 1| 9| 6| 3| 1| 1| 6| 0| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Lens, Cataract | 4 2 3 | Retina, Atrophy | 1 1 1 4 2 1 2 | Sclera, Metaplasia, Focal, Osseous | 2 1 1 1 1 1 1 | Sclera, Metaplasia, Multifocal, | | Osseous | 1 1 1 | |__________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy, Chronic, Multifocal | 3 1 1 2 2 1 2 1 1 2 1 2 1 | Papilla, Necrosis | 4| Pelvis, Mineralization, Multifocal | 1 | Renal Tubule, Pigmentation | 2 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Subacute | 2| Transitional Epithelium, Hyperplasia | 3| __________________________________________|__________________________________________________________________________ Page 8 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| | | 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | | 1 2.0| |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer, Chronic | | 1 3.0| |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + M + + + + + + + + + + +| 47 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | 1| 1 1.0| Fatty Change | 2 3 4 2| 12 2.6| Focal Cellular Change | X X X X X X X X X X X X X X X X X X X X X X X | 42 | Granuloma | | 1 2.0| Hematopoietic Cell Proliferation, | | | Multifocal | 1 | 1 1.0| Hepatodiaphragmatic Nodule | X X | 5 | Hyperplasia, Multifocal | | 1 4.0| Infiltration Cellular, Multifocal, | | | Lymphocyte | 2 | 1 2.0| Inflammation, Chronic, Multifocal | 1 1 2 2 2 2 2 1 1 1 1 1 1 1| 28 1.5| Bile Duct, Hyperplasia, Multifocal | 1 2 1 2 3 2 1 2 2 1 2 2 2 2 1 2 2 1| 27 1.8| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| | | 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | |__________________________________________________________________________|____________| Mesentery | + + + | 6 | Fat, Necrosis | 4 3 2 | 6 3.2| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Metaplasia, Focal | 1 | 2 1.0| Acinus, Atrophy, Diffuse | | 2 2.5| Acinus, Atrophy, Focal | 2 1 2 1 2 2 2 2| 10 1.6| Acinus, Atrophy, Multifocal | 2 2 1 | 6 1.8| Acinus, Focal Cellular Change | | 1 2.0| |__________________________________________________________________________|____________| Salivary Glands | + + + + + + M + + + + + + + + + + + + + + M + + +| 48 | |__________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 | Hyperplasia, Diffuse, Squamous | | 2 2.0| Hyperplasia, Focal, Squamous | 4 | 1 4.0| Inflammation, Acute | | 1 2.0| Ulcer, Multiple | | 1 3.0| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 | Erosion, Focal | 2 | 2 2.0| |__________________________________________________________________________|____________| Tongue | | 1 | Abscess | | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cardiomyopathy, Multifocal | 2 1 2 1 2 2 1 1 2 2 3 2 1 2 1| 30 1.5| Mineralization, Multifocal | | 2 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 10 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| | | 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | |__________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Focal | 1 2 1 4 1| 9 1.6| Degeneration, Multifocal | | 1 2.0| Fibrosis, Focal | | 1 2.0| Hematocyst | 3 | 1 3.0| Hematopoietic Cell Proliferation, | | | Multifocal | 2 | 1 2.0| Hyperplasia, Focal | 1 1 | 6 1.2| Hyperplasia, Multifocal | 2 1 2 2 | 5 2.0| Necrosis, Multifocal | | 1 2.0| |__________________________________________________________________________|____________| Adrenal Gland, Medulla | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia, Focal | 1 | 2 2.0| Hyperplasia, Multifocal | 2 1 | 4 2.8| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 4 | 1 4.0| |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + M M + M + + + + + + + + + M + + + +| 45 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Angiectasis, Focal | 2 | 2 1.5| Pars Distalis, Cyst | 2 2 3 2 2 | 11 2.2| Pars Distalis, Hyperplasia, Focal | 2 2 | 5 2.2| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia, Diffuse | | 1 1.0| C-Cell, Hyperplasia, Focal | 2 | 4 2.3| C-Cell, Hyperplasia, Multifocal | 3 | 7 1.6| Follicle, Cyst | | 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 11 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| | | 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + M + M + M + M + + + + + M + + + M +| 39 | Ectasia | | 1 2.0| Hyperplasia, Focal | 3 | 3 2.3| Hyperplasia | | 1 2.0| Inflammation, Acute, Focal | 1 | 1 1.0| Inflammation, Chronic, Focal | 1 | 2 1.0| Inflammation, Chronic, Multifocal | | 2 2.0| |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 4 2.0| Inflammation, Chronic, Multifocal | 4 | 1 4.0| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 2 2 | 3 2.3| Cervix, Cyst | 2 | 3 2.7| Cervix, Inflammation, Chronic | 3 | 1 3.0| Cervix, Inflammation, Chronic Active | 4 3 | 3 3.7| Cervix, Metaplasia, Squamous | 3 3 | 3 3.0| Endometrium, Cyst, Multiple | 2 | 2 1.5| Endometrium, Hyperplasia | 2 | 1 2.0| Lumen, Hemorrhage | 3 | 1 3.0| |__________________________________________________________________________|____________| Vagina | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 2.0| Hyperplasia | 2 | 8 2.1| Myelofibrosis, Multifocal | 2 | 1 2.0| |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 12 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| | | 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + M + + + + + + + + M + + + + + M + + +| 47 | Hyperplasia, Lymphoid | 2 | 2 2.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + + + +| 46 | Hemorrhage | | 1 2.0| Hyperplasia, Lymphoid | 2 | 2 2.0| Infiltration Cellular, Histiocyte | 2 2 1 | 10 1.9| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hematopoietic Cell Proliferation | 2 | 3 2.0| Infarct | 2 | 3 1.7| Pigmentation | | 1 2.0| Lymphoid Follicle, Atrophy | 1 | 2 2.0| Lymphoid Follicle, Hyperplasia, Focal| 4 | 3 3.7| |__________________________________________________________________________|____________| Thymus | + + + + + + M + + + + + + + M + + + + M + + + + +| 45 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 | Acinus, Hyperplasia, Focal | 2 | 2 2.0| Duct, Ectasia | 2 3 2 1 2 2 2 2 2 3 2 1 | 27 2.0| |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | | 1 3.0| Subcutaneous Tissue, Hemorrhage | 3 | 1 3.0| Subcutaneous Tissue, Inflammation, | | | Chronic Active, Focal | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperostosis | 2 3 | 4 2.5| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 13 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| | | 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM - cont | | | Osteomalacia | | 1 2.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cerebrum, Hydrocephalus | | 1 2.0| Cerebrum, Infiltration Cellular, | | | Focal, Lymphocyte | 2 | 1 2.0| Hypothalamus, Compression | 2 4 3 | 6 3.0| |__________________________________________________________________________|____________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | | 1 2.0| Infiltration Cellular, Multifocal, | | | Histiocyte | 2 1 1 1 1 1 1 1 | 19 1.1| Alveolar Epithelium, Hyperplasia, | | | Focal | 4 | 2 3.0| Interstitium, Inflammation, Chronic, | | | Focal | 1 | 1 1.0| Peribronchial, Hyperplasia, Lymphoid | 2 | 1 2.0| Pleura, Inflammation, Chronic, Focal | | 1 1.0| Pleura, Inflammation, Multifocal, | | | Proliferative | 1 | 1 1.0| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | 2 | 1 2.0| Fungus | 4 | 2 4.0| Mucosa, Cytoplasmic Alteration, | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| | | 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | Multifocal | 2 1 2 1 2 1 2 1 1 1 1 1 1 1 1 2 1 1 2 1 1 1| 37 1.2| Mucosa, Inflammation, Acute, | | | Multifocal | 2 2 | 2 2.0| Mucosa, Inflammation, Chronic, | | | Multifocal | | 1 1.0| Mucosa, Inflammation, Chronic Active,| | | Multifocal | 3 | 1 3.0| Mucosa, Inflammation, Multifocal, | | | Subacute | | 2 1.5| Mucosa, Metaplasia, Focal, Squamous | 2 | 1 2.0| Nasolacrimal Duct, Inflammation, | | | Chronic | 2 1 | 2 1.5| Nasolacrimal Duct, Inflammation, | | | Chronic Active | 2 2 | 4 2.0| |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Ear | M | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lens, Cataract | 4 1 2 1 2 4 2 4 1 | 12 2.5| Retina, Atrophy | 4 2 2 2 2 2 2 2 1 2 1 2 1 2 4 2 2 1| 25 1.9| Sclera, Metaplasia, Focal, Osseous | 1 1 1 1 | 11 1.1| Sclera, Metaplasia, Multifocal, | | | Osseous | 1 1 1 1 1 | 8 1.0| |__________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Nephropathy, Chronic, Multifocal | 1 2 1 1 3 2 1 2 2 2 2 2 1 1 2 1 1 2 2| 32 1.6| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| | | 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | Papilla, Necrosis | | 1 4.0| Pelvis, Mineralization, Multifocal | | 1 1.0| Renal Tubule, Pigmentation | 1 | 2 1.5| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Subacute | | 1 2.0| Transitional Epithelium, Hyperplasia | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 16 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Acute | 3 | Submucosa, Hemorrhage | 4 | |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + M + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Fatty Change | 2 | Focal Cellular Change | X X X X X X X X X X X X X X X X X X X X X X| Hematopoietic Cell Proliferation, | | Multifocal | 2 | Hepatodiaphragmatic Nodule | X X X 1 | Hyperplasia, Focal | 4 | Hyperplasia, Multifocal | 3 | Inflammation, Chronic, Multifocal | 2 2 1 3 1 2 1 2 2 2 2 3 2 2| Bile Duct, Hyperplasia, Multifocal | 2 2 1 1 1 2 1 2 2 1 2 2 3 2 2 2 2 1 2 2| Centrilobular, Necrosis, Acute | 3 | |__________________________________________________________________________| Mesentery | | Fat, Necrosis | | |__________________________________________________________________________| Pancreas | + + + + M + + + + + + + + + + + + + + + + + + + +| Necrosis, Acute, Multifocal | 4 | __________________________________________|__________________________________________________________________________| Page 17 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Acinus, Atrophy, Diffuse | 2 | Acinus, Atrophy, Focal | 1 1 1 | Acinus, Atrophy, Multifocal | | |__________________________________________________________________________| Pharynx | + | Palate, Ulcer | 2 | |__________________________________________________________________________| Salivary Glands | + + + + + + + M + + + + + + + + + + + + + + + + +| Atrophy, Diffuse | | |__________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | | |__________________________________________________________________________| Tooth | | Abscess | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | + + | Aorta, Inflammation, Chronic, Focal | 4 | Artery, Thrombosis | 4 | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Multifocal | 2 2 2 1 1 1 2 2 1 1 2 1 1| Inflammation, Acute, Multifocal | 3 | Atrium, Thrombosis | 3 | Valve, Inflammation, Chronic Active | 4 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Focal | 1 2 | __________________________________________|__________________________________________________________________________| Page 18 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Degeneration, Multifocal | 2 | Hematocyst, Focal | 2 | Hematocyst | 2 2 | Hyperplasia, Focal | 1 4 2 | Hyperplasia, Multifocal | 3 3 | |__________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + M + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 2 2 2| Hyperplasia, Multifocal | | |__________________________________________________________________________| Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis, Focal | 2 2 | Pars Distalis, Cyst | 2 2 | Pars Distalis, Hemorrhage | | Pars Distalis, Hyperplasia, Focal | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia, Focal | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + + + M M M + + + + + + + + + M M + + M M + + +| Hyperplasia, Focal | 2 | Inflammation, Chronic, Multifocal | 1 | Inflammation, Chronic Active, | | Multifocal | 2 | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 2 X | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 19 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | 3 | Amyloid Deposition | 1 | Cervix, Cyst | 2 | Cervix, Dilatation | 3 | Cervix, Inflammation, Acute | 2 | Endometrium, Cyst, Multiple | 2 2 2 | |__________________________________________________________________________| Vagina | + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 | Myelofibrosis, Multifocal | 1 1 | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +| Degeneration, Cystic, Focal | | Pigmentation | | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 4 | Hyperplasia, Lymphoid | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 | Hematopoietic Cell Proliferation | 2 | Lymphoid Follicle, Atrophy | 4 | Lymphoid Follicle, Hyperplasia, Focal| 3 | |__________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + M +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| Acinus, Hyperplasia, Focal | | __________________________________________|__________________________________________________________________________| Page 20 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | Duct, Ectasia | 2 2 2 2 2 3 3 2 2| |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 3 3 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Cerebrum, Necrosis, Focal | 2 | Hypothalamus, Compression | 2 3 | |__________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Multifocal, | | Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 | Pigmentation, Multifocal | 3 | Alveolar Epithelium, Hyperplasia, | | Focal | 4 2 | Interstitium, Inflammation, Chronic, | | Diffuse | | Pleura, Fibrosis, Focal | 3 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | | Fungus | 2 2 2 | Mucosa, Cytoplasmic Alteration, | | Multifocal | 2 1 1 1 2 1 1 1 2 1 2 1 2 2 2 1 1 1 1 2 2 1 1| Mucosa, Inflammation, Chronic, Focal | 1 | __________________________________________|__________________________________________________________________________| Page 21 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | Mucosa, Inflammation, Chronic Active,| | Multifocal | 3 2 2 | Mucosa, Inflammation, Multifocal, | | Subacute | | Mucosa, Metaplasia, Focal, Squamous | 2 2 | Nasolacrimal Duct, Inflammation, | | Chronic | 1 1 | Nasolacrimal Duct, Inflammation, | | Chronic Active | 2 | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Ear | M M| |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Lens, Cataract | 4 | Retina, Atrophy | 3 1 2 | Sclera, Metaplasia, Focal, Osseous | 1 1 1 1| Sclera, Metaplasia, Multifocal, | | Osseous | 1 1 2 1 1 2 2 1 2 | |__________________________________________________________________________| Harderian Gland | | Inflammation, Acute | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Bacterium | X | Cyst | 2 | Inflammation, Acute, Multifocal | 4 | Nephropathy, Chronic, Multifocal | 2 1 2 3 1 1 1 1| Pelvis, Mineralization, Multifocal | 1 | Renal Tubule, Pigmentation | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________ Page 22 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 4| 3| 3| 3| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| | | 3| 3| 3| 3| 8| 2| 2| 0| 2| 2| 2| 2| 2| 9| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 | Inflammation, Acute | | 1 3.0| Submucosa, Hemorrhage | | 1 4.0| |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fatty Change | 4 4 3| 4 3.3| Focal Cellular Change | X X X X X X X X X X X X X X X X X X X X | 42 | Hematopoietic Cell Proliferation, | | | Multifocal | | 1 2.0| Hepatodiaphragmatic Nodule | X X X X X | 9 1.0| Hyperplasia, Focal | 3 | 2 3.5| Hyperplasia, Multifocal | 2 | 2 2.5| Inflammation, Chronic, Multifocal | 2 2 1 2 3 2 2 2 1 1 1 | 25 1.8| Bile Duct, Hyperplasia, Multifocal | 2 2 1 2 2 2 2 2 2 3 1 2 1 2 1 3| 36 1.8| Centrilobular, Necrosis, Acute | | 1 3.0| |__________________________________________________________________________|____________| Mesentery | + | 1 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 23 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 4| 3| 3| 3| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| | | 3| 3| 3| 3| 8| 2| 2| 0| 2| 2| 2| 2| 2| 9| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Fat, Necrosis | 3 | 1 3.0| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Necrosis, Acute, Multifocal | | 1 4.0| Acinus, Atrophy, Diffuse | | 1 2.0| Acinus, Atrophy, Focal | 1 2 | 5 1.2| Acinus, Atrophy, Multifocal | 2 | 1 2.0| |__________________________________________________________________________|____________| Pharynx | | 1 | Palate, Ulcer | | 1 2.0| |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy, Diffuse | 3 | 1 3.0| |__________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | 2 | 1 2.0| |__________________________________________________________________________|____________| Tooth | + | 1 | Abscess | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | | 2 | Aorta, Inflammation, Chronic, Focal | | 1 4.0| Artery, Thrombosis | | 1 4.0| |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy, Multifocal | 3 2 2 1 1 2 2 1 1 1 2 1 2 1 | 27 1.5| Inflammation, Acute, Multifocal | | 1 3.0| Atrium, Thrombosis | | 1 3.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 24 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 4| 3| 3| 3| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| | | 3| 3| 3| 3| 8| 2| 2| 0| 2| 2| 2| 2| 2| 9| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| CARDIOVASCULAR SYSTEM - cont | | | Valve, Inflammation, Chronic Active | | 1 4.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + M + + + + + + + + + + + +| 48 | Degeneration, Focal | 2 2 2 3 | 6 2.0| Degeneration, Multifocal | 2 2 | 3 2.0| Hematocyst, Focal | | 1 2.0| Hematocyst | 2 2 | 4 2.0| Hyperplasia, Focal | 2 2 2 1 | 7 2.0| Hyperplasia, Multifocal | 2 | 3 2.7| |__________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 | Hyperplasia, Focal | 1 2 1 4 | 8 2.0| Hyperplasia, Multifocal | 2 | 1 2.0| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + M +| 48 | Hyperplasia, Focal | 2 | 1 2.0| |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + M M M + + + + M + M + + + + + + M| 44 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 | Pars Distalis, Angiectasis, Focal | 2 | 3 2.0| Pars Distalis, Cyst | 2 2| 4 2.0| Pars Distalis, Hemorrhage | 2 | 1 2.0| Pars Distalis, Hyperplasia, Focal | 2 | 1 2.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia, Focal | 2 3 2 | 4 2.3| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 25 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 4| 3| 3| 3| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| | | 3| 3| 3| 3| 8| 2| 2| 0| 2| 2| 2| 2| 2| 9| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + + + + + M + M M + + + + + + + M + M + M + +| 37 | Hyperplasia, Focal | 3 | 2 2.5| Inflammation, Chronic, Multifocal | 1 | 2 1.0| Inflammation, Chronic Active, | | | Multifocal | 1 3 | 3 2.0| |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | X | 4 2.0| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Abscess | | 1 3.0| Amyloid Deposition | | 1 1.0| Cervix, Cyst | | 1 2.0| Cervix, Dilatation | 3 | 2 3.0| Cervix, Inflammation, Acute | | 1 2.0| Endometrium, Cyst, Multiple | 1 | 4 1.8| |__________________________________________________________________________|____________| Vagina | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 2 2.0| Myelofibrosis, Multifocal | | 2 1.0| |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Degeneration, Cystic, Focal | 1 | 1 1.0| Pigmentation | 2 | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 | Congestion | | 1 4.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 26 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 4| 3| 3| 3| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| | | 3| 3| 3| 3| 8| 2| 2| 0| 2| 2| 2| 2| 2| 9| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Hyperplasia, Lymphoid | 2 | 1 2.0| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | | 1 3.0| Hematopoietic Cell Proliferation | 2 | 2 2.0| Lymphoid Follicle, Atrophy | | 1 4.0| Lymphoid Follicle, Hyperplasia, Focal| | 1 3.0| |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + M + + + + M + + + + + + + + +| 47 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acinus, Hyperplasia, Focal | 4 | 1 4.0| Duct, Ectasia | 2 2 2 2 2 3 3 4 3 4 2| 20 2.5| |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperostosis | 3 3 | 4 3.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cerebrum, Necrosis, Focal | | 1 2.0| Hypothalamus, Compression | 4 2 4 2 3 | 7 2.9| |__________________________________________________________________________|____________| Spinal Cord | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 27 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 4| 3| 3| 3| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| | | 3| 3| 3| 3| 8| 2| 2| 0| 2| 2| 2| 2| 2| 9| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Multifocal, | | | Histiocyte | 1 1 1 1 1 1 1 1 1| 22 1.0| Pigmentation, Multifocal | | 1 3.0| Alveolar Epithelium, Hyperplasia, | | | Focal | 4 | 3 3.3| Interstitium, Inflammation, Chronic, | | | Diffuse | 2 | 1 2.0| Pleura, Fibrosis, Focal | | 1 3.0| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | 2 | 1 2.0| Fungus | | 3 2.0| Mucosa, Cytoplasmic Alteration, | | | Multifocal | 1 1 2 1 1 1 2 2 2 2 1 2 1 1 1 1 | 39 1.4| Mucosa, Inflammation, Chronic, Focal | | 1 1.0| Mucosa, Inflammation, Chronic Active,| | | Multifocal | 2 | 4 2.3| Mucosa, Inflammation, Multifocal, | | | Subacute | 2 2 1 | 3 1.7| Mucosa, Metaplasia, Focal, Squamous | | 2 2.0| Nasolacrimal Duct, Inflammation, | | | Chronic | 2 1 | 4 1.3| Nasolacrimal Duct, Inflammation, | | | Chronic Active | | 1 2.0| |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Ear | M | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 28 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 4| 3| 3| 3| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| | | 3| 3| 3| 3| 8| 2| 2| 0| 2| 2| 2| 2| 2| 9| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | 20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lens, Cataract | 2 2 2 4 2 1 | 7 2.4| Retina, Atrophy | 3 3 3 1 2 2 3 2 3 2 3 3 2 2 | 17 2.4| Sclera, Metaplasia, Focal, Osseous | 1 1 1 1 1 1 | 10 1.0| Sclera, Metaplasia, Multifocal, | | | Osseous | 1 2 2 1 1 2 | 15 1.5| |__________________________________________________________________________|____________| Harderian Gland | + + | 2 | Inflammation, Acute | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Bacterium | | 1 | Cyst | | 1 2.0| Inflammation, Acute, Multifocal | | 1 4.0| Nephropathy, Chronic, Multifocal | 2 2 3 2 2 3 2 1 1 1 | 18 1.7| Pelvis, Mineralization, Multifocal | 2 | 2 1.5| Renal Tubule, Pigmentation | 3 | 1 3.0| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + M + + + + + M + + + + +| 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 29 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 2| 7| 7| 7| 7| 7| 7| 5| DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 3| | 1| 1| 1| 1| 1| 3| 1| 1| 1| 1| 2| 2| 2| 9| 4| 2| 2| 0| 4| 0| 2| 2| 2| 2| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Fatty Change | 2 | Focal Cellular Change | X X X X X X X X X X X X X X X X X X | Hematopoietic Cell Proliferation, | | Multifocal | | Hepatodiaphragmatic Nodule | X X X X | Hyperplasia, Focal | 2 | Hyperplasia, Multifocal | 3 | Inflammation, Chronic, Multifocal | 2 2 1 1 2 | Inflammation, Focal, Granulomatous | 4 | Necrosis, Multifocal | 3 | Bile Duct, Hyperplasia, Focal | 1 | Bile Duct, Hyperplasia, Multifocal | 2 1 2 2 2 2 3 2 1 2 2 2 2 2 2 1 2 2| Vein, Thrombosis | 4 | |__________________________________________________________________________| Mesentery | + | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + A + + + + + +| Acinus, Atrophy, Focal | 1 2 1 | __________________________________________|__________________________________________________________________________| Page 30 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 2| 7| 7| 7| 7| 7| 7| 5| DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 3| | 1| 1| 1| 1| 1| 3| 1| 1| 1| 1| 2| 2| 2| 9| 4| 2| 2| 0| 4| 0| 2| 2| 2| 2| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Acinus, Atrophy, Multifocal | 1 2 2 2 1 2| |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion, Focal | | Hyperplasia, Diffuse, Squamous | 2| Inflammation, Chronic Active | 4| |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | 3| |__________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Multifocal | 1 2 1 2 2 2 2 3 1 2 1 | Atrium, Thrombosis | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Focal | 2 1 2 | Hematocyst | 2 | Hyperplasia, Focal | 3 | Hyperplasia, Multifocal | 2 | |__________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 1 | Hyperplasia, Multifocal | 3 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 31 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 2| 7| 7| 7| 7| 7| 7| 5| DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 3| | 1| 1| 1| 1| 1| 3| 1| 1| 1| 1| 2| 2| 2| 9| 4| 2| 2| 0| 4| 0| 2| 2| 2| 2| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis, Focal | | Pars Distalis, Cyst | X X | Pars Distalis, Fibrosis | 4| Pars Distalis, Hyperplasia, Focal | 2 | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia, Focal | | C-Cell, Hyperplasia, Multifocal | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Clitoral Gland | + + M + M + + M + M + M + + + + + M M + + + + + +| Inflammation, Chronic, Focal | | |__________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X | |__________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | | Endometrium, Cyst | 2 X X| Endometrium, Cyst, Multiple | X X X 1 1 | Endometrium, Inflammation, Focal, | | Subacute | 1 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Blood | + | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + A + + + + + +| Atrophy | 3 | Hyperplasia | | Myelofibrosis, Focal | 2 | __________________________________________|__________________________________________________________________________| Page 32 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 2| 7| 7| 7| 7| 7| 7| 5| DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 3| | 1| 1| 1| 1| 1| 3| 1| 1| 1| 1| 2| 2| 2| 9| 4| 2| 2| 0| 4| 0| 2| 2| 2| 2| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Myelofibrosis, Multifocal | 2 1 2 1 | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mediastinal, Pigmentation | | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 | Infiltration Cellular, Histiocyte | 2 2 | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + A + + + + + +| Infarct | 4 | |__________________________________________________________________________| Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Hyperplasia, Focal | 2 | Duct, Ectasia | 3 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 2 2 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Cerebrum, Hydrocephalus | | Hypothalamus, Compression | | |__________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 33 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 2| 7| 7| 7| 7| 7| 7| 5| DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 3| | 1| 1| 1| 1| 1| 3| 1| 1| 1| 1| 2| 2| 2| 9| 4| 2| 2| 0| 4| 0| 2| 2| 2| 2| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic, Focal | | |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Infiltration Cellular, Multifocal, | | Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 | Pigmentation, Multifocal | 3 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Fungus | | Mucosa, Cytoplasmic Alteration, | | Multifocal | 2 1 2 2 1 2 2 1 2 2 1 2 1 1 2 2 2 1 2 2| Mucosa, Inflammation, Acute, | | Multifocal | | Mucosa, Inflammation, Chronic Active,| | Focal | 1 | Mucosa, Metaplasia, Focal, Squamous | | Nasolacrimal Duct, Inflammation, | | Chronic | 2 | Nasolacrimal Duct, Inflammation, | | Chronic Active | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Ear | + | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Lens, Cataract | 2 2 2 2 2 2 2 2 1 2 2 2 2 | Retina, Atrophy | 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1| Sclera, Metaplasia, Focal, Osseous | 1 1 1 1 1 1 1 | Sclera, Metaplasia, Multifocal, | | Osseous | 1 2 | |__________________________________________________________________________| Harderian Gland | + + | Infiltration Cellular, Multifocal, | | __________________________________________|__________________________________________________________________________| Page 34 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 2| 7| 7| 7| 7| 7| 7| 5| DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 3| | 1| 1| 1| 1| 1| 3| 1| 1| 1| 1| 2| 2| 2| 9| 4| 2| 2| 0| 4| 0| 2| 2| 2| 2| 5| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | Lymphocyte | 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Bacterium | X | Cyst | | Inflammation, Acute, Multifocal | 3 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Calculus Gross Observation | X | Inflammation, Chronic | 2 | Transitional Epithelium, Hyperplasia | 3 | __________________________________________|__________________________________________________________________________ Page 35 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 6| 6| | DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 3| 9| 3| 3| 3| 9| 7| | | 2| 2| 2| 2| 4| 2| 1| 2| 2| 2| 2| 2| 2| 2| 6| 3| 2| 2| 2| 4| 2| 2| 2| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fatty Change | 1 | 2 1.5| Focal Cellular Change | X X X X X X X X X X X X X X X X X X X X X X X| 41 | Hematopoietic Cell Proliferation, | | | Multifocal | 2 | 1 2.0| Hepatodiaphragmatic Nodule | X X X X X| 9 | Hyperplasia, Focal | | 1 2.0| Hyperplasia, Multifocal | | 1 3.0| Inflammation, Chronic, Multifocal | 2 2 1 1 1 1 2 1 1 2 1 2 1 2 | 19 1.5| Inflammation, Focal, Granulomatous | | 1 4.0| Necrosis, Multifocal | | 1 3.0| Bile Duct, Hyperplasia, Focal | | 1 1.0| Bile Duct, Hyperplasia, Multifocal | 1 1 2 1 2 2 1 1 1 2 2 3| 30 1.8| Vein, Thrombosis | | 1 4.0| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 36 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 6| 6| | DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 3| 9| 3| 3| 3| 9| 7| | | 2| 2| 2| 2| 4| 2| 1| 2| 2| 2| 2| 2| 2| 2| 6| 3| 2| 2| 2| 4| 2| 2| 2| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Mesentery | | 1 | |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acinus, Atrophy, Focal | 1 1 1 1 1 2 | 9 1.2| Acinus, Atrophy, Multifocal | 2 2 1 | 9 1.7| |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erosion, Focal | 2 | 1 2.0| Hyperplasia, Diffuse, Squamous | | 1 2.0| Inflammation, Chronic Active | | 1 4.0| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | | 1 3.0| |__________________________________________________________________________|____________| Tooth | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy, Multifocal | 2 1 2 2 1 2 1 1 1 2 1 1 1 1 2 2 1 | 28 1.5| Atrium, Thrombosis | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Focal | | 3 1.7| Hematocyst | 2 2 2 | 4 2.0| Hyperplasia, Focal | 1 2 2 2 2 | 6 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 37 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 6| 6| | DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 3| 9| 3| 3| 3| 9| 7| | | 2| 2| 2| 2| 4| 2| 1| 2| 2| 2| 2| 2| 2| 2| 6| 3| 2| 2| 2| 4| 2| 2| 2| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Hyperplasia, Multifocal | | 1 2.0| |__________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia, Focal | 2 | 3 1.7| Hyperplasia, Multifocal | | 1 3.0| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Parathyroid Gland | + + + + M + + + + + + M + + + + + + + + + + + + M| 47 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Angiectasis, Focal | 2 | 1 2.0| Pars Distalis, Cyst | X X 2 X X 2 | 8 2.0| Pars Distalis, Fibrosis | | 1 4.0| Pars Distalis, Hyperplasia, Focal | 3 1 1 | 4 1.8| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia, Focal | 4 2 3 | 3 3.0| C-Cell, Hyperplasia, Multifocal | | 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Clitoral Gland | + + + M M + + + + + + M M + + + + + + + + + + + +| 39 | Inflammation, Chronic, Focal | 2 | 1 2.0| |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | 2 2 3 2 | 4 2.3| Endometrium, Cyst | 2 | 4 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 38 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 6| 6| | DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 3| 9| 3| 3| 3| 9| 7| | | 2| 2| 2| 2| 4| 2| 1| 2| 2| 2| 2| 2| 2| 2| 6| 3| 2| 2| 2| 4| 2| 2| 2| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | Endometrium, Cyst, Multiple | 2 X 1 X X X| 11 1.3| Endometrium, Inflammation, Focal, | | | Subacute | | 1 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Blood | | 1 | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy | | 1 3.0| Hyperplasia | 2 | 1 2.0| Myelofibrosis, Focal | | 1 2.0| Myelofibrosis, Multifocal | 4 1 1 1 1 2 | 10 1.6| |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mediastinal, Pigmentation | 2 | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 | Congestion | | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 | Congestion | 1 1 1 | 4 1.3| Infiltration Cellular, Histiocyte | 1 | 3 1.7| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Infarct | 2 | 2 3.0| |__________________________________________________________________________|____________| Thymus | + + + + + + + + M + + + + + + + M + + + + + + + +| 47 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + M + + + M + + + M + + + + + + + + + + + +| 47 | Acinus, Hyperplasia, Focal | | 1 2.0| Duct, Ectasia | 2 2 2 2 | 5 2.2| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 39 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 6| 6| | DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 3| 9| 3| 3| 3| 9| 7| | | 2| 2| 2| 2| 4| 2| 1| 2| 2| 2| 2| 2| 2| 2| 6| 3| 2| 2| 2| 4| 2| 2| 2| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | 3 3 | 2 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperostosis | 4 2 4 2 | 6 2.7| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cerebrum, Hydrocephalus | 2 | 1 2.0| Hypothalamus, Compression | 2 2 | 2 2.0| |__________________________________________________________________________|____________| Spinal Cord | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic, Focal | 1 | 1 1.0| |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infiltration Cellular, Multifocal, | | | Histiocyte | 1 1 1 1 1 1 1 1 1| 20 1.0| Pigmentation, Multifocal | | 1 3.0| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fungus | 3 | 1 3.0| Mucosa, Cytoplasmic Alteration, | | | Multifocal | 1 1 2 1 2 1 2 1 2 1 2 2 2 1| 34 1.6| Mucosa, Inflammation, Acute, | | | Multifocal | 3 2 | 2 2.5| Mucosa, Inflammation, Chronic Active,| | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 40 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 6| 6| | DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 3| 9| 3| 3| 3| 9| 7| | | 2| 2| 2| 2| 4| 2| 1| 2| 2| 2| 2| 2| 2| 2| 6| 3| 2| 2| 2| 4| 2| 2| 2| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | Focal | | 1 1.0| Mucosa, Metaplasia, Focal, Squamous | 2 | 1 2.0| Nasolacrimal Duct, Inflammation, | | | Chronic | 2 | 2 2.0| Nasolacrimal Duct, Inflammation, | | | Chronic Active | 2 2 2 | 3 2.0| |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Ear | | 1 | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lens, Cataract | 2 2 2 1 3 4 2 2 2 2 2 2 3 2 1 1 1 2 2 1 3 3 1| 37 2.0| Retina, Atrophy | 2 2 3 2 2 3 3 3 3 2 2 2 2 2 3 2 2 2 3 2 2 2 2| 42 2.2| Sclera, Metaplasia, Focal, Osseous | 1 1 1 1 2 | 12 1.1| Sclera, Metaplasia, Multifocal, | | | Osseous | 1 1 1 | 5 1.2| |__________________________________________________________________________|____________| Harderian Gland | | 2 | Infiltration Cellular, Multifocal, | | | Lymphocyte | | 1 2.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Bacterium | | 1 | Cyst | 2 | 1 2.0| Inflammation, Acute, Multifocal | | 1 3.0| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Calculus Gross Observation | | 1 | Inflammation, Chronic | | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 41 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 6| 6| | DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 3| 9| 3| 3| 3| 9| 7| | | 2| 2| 2| 2| 4| 2| 1| 2| 2| 2| 2| 2| 2| 2| 6| 3| 2| 2| 2| 4| 2| 2| 2| 6| 6| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | Transitional Epithelium, Hyperplasia | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 42 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 3| 7| 6| 7| 6| 7| 6| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| DAY ON TEST | 2| 2| 2| 0| 7| 1| 2| 9| 2| 8| 2| 3| 2| 5| 3| 2| 2| 2| 9| 3| 2| 2| 2| 5| 3| | 9| 9| 9| 8| 6| 6| 9| 1| 2| 4| 9| 7| 9| 8| 3| 9| 9| 9| 5| 8| 9| 9| 9| 9| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Subacute | 3 | |__________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + M + + + + + M + + + + + + +| |__________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +| Inflammation, Chronic, Multifocal | | |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + + + +| Inflammation, Chronic, Focal | | |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic, Focal | 1 | Degeneration, Cystic, Multifocal | 3 | Fatty Change | 2 1 3 | Focal Cellular Change | X X X X X X X X X X | Hematopoietic Cell Proliferation, | | Multifocal | 2 2 | Hepatodiaphragmatic Nodule | X X X X X | Hyperplasia, Focal | 2 2 | Inflammation, Chronic, Multifocal | 1 2 | Bile Duct, Hyperplasia, Multifocal | 3 2 2 2 3 2 3 3 3 3 2 1 2 2 2 1 3 1 2 2 3 3 2| Centrilobular, Necrosis, Acute | 3 | |__________________________________________________________________________| Mesentery | + + + + | Inflammation, Chronic, Multifocal | 2 | Fat, Necrosis | 4 4 4 | __________________________________________|__________________________________________________________________________| Page 43 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 3| 7| 6| 7| 6| 7| 6| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| DAY ON TEST | 2| 2| 2| 0| 7| 1| 2| 9| 2| 8| 2| 3| 2| 5| 3| 2| 2| 2| 9| 3| 2| 2| 2| 5| 3| | 9| 9| 9| 8| 6| 6| 9| 1| 2| 4| 9| 7| 9| 8| 3| 9| 9| 9| 5| 8| 9| 9| 9| 9| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + A + + + + + + + + + + + + +| Acinus, Atrophy, Diffuse | 3 | Acinus, Atrophy, Focal | 1 2 2 1 2 2 2 1 1 2 | Acinus, Atrophy, Multifocal | 3 3 2 | Acinus, Focal Cellular Change | X | Acinus, Hyperplasia, Focal | 4 | Artery, Inflammation, Chronic | 2 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage, Focal | | Inflammation, Chronic | | |__________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + M + + + + + + + + + + + + + +| Hyperplasia, Multifocal, Squamous | 2 | Hyperplasia, Squamous | 2 | Inflammation, Acute | 1 | Ulcer | 2 | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Multifocal | 2 2 2 3 2 1 2 2 2 2 2 1 3 2 2 2 2 2 1 2 | Atrium, Thrombosis | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| |__________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + M + + + +| Degeneration, Focal | 1 1 2 | Hematopoietic Cell Proliferation, | | Multifocal | | __________________________________________|__________________________________________________________________________| Page 44 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 3| 7| 6| 7| 6| 7| 6| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| DAY ON TEST | 2| 2| 2| 0| 7| 1| 2| 9| 2| 8| 2| 3| 2| 5| 3| 2| 2| 2| 9| 3| 2| 2| 2| 5| 3| | 9| 9| 9| 8| 6| 6| 9| 1| 2| 4| 9| 7| 9| 8| 3| 9| 9| 9| 5| 8| 9| 9| 9| 9| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Hemorrhage | 4 | Hyperplasia, Focal | 1 | Hyperplasia, Multifocal | 2 | |__________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + M + + + +| Hemorrhage | 4 | Hyperplasia, Focal | 1 1 4 1 | Hyperplasia, Multifocal | 4 3 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + M + + M M| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Abscess | | Pars Distalis, Cyst | | Pars Distalis, Hemorrhage | 2 | Pars Distalis, Hyperplasia, Focal | 1 2 1 4| Pars Intermedia, Cyst | | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia, Focal | 2 | C-Cell, Hyperplasia, Multifocal | 3 3 2 | Follicle, Cyst | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Preputial Gland | + + + M + M + + + + + + + + + + + + + + + + + + +| Abscess | 3 | Inflammation, Acute, Focal | 2| Inflammation, Acute, Multifocal | 2 | Inflammation, Chronic, Focal | | __________________________________________|__________________________________________________________________________| Page 45 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 3| 7| 6| 7| 6| 7| 6| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| DAY ON TEST | 2| 2| 2| 0| 7| 1| 2| 9| 2| 8| 2| 3| 2| 5| 3| 2| 2| 2| 9| 3| 2| 2| 2| 5| 3| | 9| 9| 9| 8| 6| 6| 9| 1| 2| 4| 9| 7| 9| 8| 3| 9| 9| 9| 5| 8| 9| 9| 9| 9| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | Inflammation, Chronic, Multifocal | 2 1 2 1 2 2 2 1 | Inflammation, Chronic Active, Focal | | Inflammation, Chronic Active, | | Multifocal | | Inflammation, Multifocal, Subacute | | |__________________________________________________________________________| Prostate | + + + + + + + + M + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 1 2 | Inflammation, Acute, Focal | | Inflammation, Chronic, Focal | 2 | Inflammation, Chronic, Multifocal | | Inflammation, Chronic Active, | | Multifocal | 3 | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + M + + + + + + + + + + + + + + + +| Atrophy, Diffuse | 3 1 3 4 2 4 4 3 3 4 2 4 3 3 | Dilatation | 2 | Inflammation, Chronic, Multifocal | 2 | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy, Diffuse | 3 2 | Atrophy, Focal | | Atrophy | 2 | Granuloma Sperm | | Interstitial Cell, Hyperplasia, | | Multifocal | 2 2| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Blood | + | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 | Infiltration Cellular, Focal, | | Histiocyte | 2 | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 46 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 3| 7| 6| 7| 6| 7| 6| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| DAY ON TEST | 2| 2| 2| 0| 7| 1| 2| 9| 2| 8| 2| 3| 2| 5| 3| 2| 2| 2| 9| 3| 2| 2| 2| 5| 3| | 9| 9| 9| 8| 6| 6| 9| 1| 2| 4| 9| 7| 9| 8| 3| 9| 9| 9| 5| 8| 9| 9| 9| 9| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic | 2 | Hyperplasia, Plasma Cell | 1 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + + + + +| Congestion | 2 | Degeneration, Cystic | 3 | Hyperplasia, Lymphoid | | Infiltration Cellular, Histiocyte | 2 | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy, Focal | 2 | Fibrosis, Diffuse | 2 | Fibrosis, Focal | 4 | Hematopoietic Cell Proliferation | 2 2 | Lymphoid Follicle, Atrophy | | |__________________________________________________________________________| Thymus | M + M M + + + + + + + + M + + M + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | M + M + + M + + M + + M + + + + + + + + + + + + +| Inflammation, Chronic | | Acinus, Hyperplasia, Focal | 3 | Duct, Ectasia | 2 2 3 2 2 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | | Inflammation, Acute, Focal | 1 | Inflammation, Chronic, Focal | | Subcutaneous Tissue, Fibrosis, Focal | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 2 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | __________________________________________|__________________________________________________________________________| Page 47 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 3| 7| 6| 7| 6| 7| 6| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| DAY ON TEST | 2| 2| 2| 0| 7| 1| 2| 9| 2| 8| 2| 3| 2| 5| 3| 2| 2| 2| 9| 3| 2| 2| 2| 5| 3| | 9| 9| 9| 8| 6| 6| 9| 1| 2| 4| 9| 7| 9| 8| 3| 9| 9| 9| 5| 8| 9| 9| 9| 9| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| NERVOUS SYSTEM - cont | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hydrocephalus | 2 | Cerebellum, Necrosis, Focal | | Hypothalamus, Compression | 3 2 2 | |__________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + M + + + + + + + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrosis, Focal | | Foreign Body | 2 | Infiltration Cellular, Multifocal, | | Histiocyte | 1 1 | Inflammation, Acute, Multifocal | 3 | Inflammation, Granulomatous, | | Multifocal | | Alveolar Epithelium, Hyperplasia, | | Focal | 4 3 | Interstitium, Inflammation, Chronic, | | Multifocal | 2 2 | Peribronchiolar, Hyperplasia, | | Lymphoid | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | | Fungus | 2 2 2| Mucosa, Cytoplasmic Alteration, | | Multifocal | | Mucosa, Foreign Body, Focal | | Mucosa, Inflammation, Acute, Focal | 3| Mucosa, Inflammation, Acute, | | Multifocal | 2 1 | Mucosa, Inflammation, Chronic, | | __________________________________________|__________________________________________________________________________| Page 48 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 3| 7| 6| 7| 6| 7| 6| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| DAY ON TEST | 2| 2| 2| 0| 7| 1| 2| 9| 2| 8| 2| 3| 2| 5| 3| 2| 2| 2| 9| 3| 2| 2| 2| 5| 3| | 9| 9| 9| 8| 6| 6| 9| 1| 2| 4| 9| 7| 9| 8| 3| 9| 9| 9| 5| 8| 9| 9| 9| 9| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | Multifocal | | Mucosa, Inflammation, Chronic Active,| | Multifocal | 2 | Mucosa, Inflammation, Focal, Subacute| | Mucosa, Inflammation, Multifocal, | | Subacute | 2 | Mucosa, Metaplasia, Multifocal, | | Squamous | 2 | Nasolacrimal Duct, Inflammation, | | Chronic | 2 1 1 | Nasolacrimal Duct, Inflammation, | | Chronic Active | 2 2 | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Lens, Cataract | 3 2| Retina, Atrophy | 2 2| Sclera, Metaplasia, Focal, Osseous | 1 1 1 1 2 2 1 1 1| Sclera, Metaplasia, Multifocal, | | Osseous | 2 2 3 1 1 2 2 2 2 3 2 2 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Nephropathy, Chronic, Multifocal | 3 3 3 2 1 2 2 3 2 3 2 3 2 1 2 3 2 2 3 3 3 2 2 2| Renal Tubule, Pigmentation | 2 | Transitional Epithelium, Hyperplasia | | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Dilatation | 4 | __________________________________________|__________________________________________________________________________ Page 49 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 2| 2| 6| 2| 1| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| | | 9| 9| 4| 9| 7| 9| 9| 4| 5| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Subacute | | 1 3.0| |__________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic, Multifocal | 2 | 1 2.0| |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic, Focal | 2 | 1 2.0| |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Cystic, Focal | 2 2 1 | 4 1.5| Degeneration, Cystic, Multifocal | | 1 3.0| Fatty Change | 2 2 | 5 2.0| Focal Cellular Change | X X X X X X X X X X X X X X X X X X X | 29 | Hematopoietic Cell Proliferation, | | | Multifocal | | 2 2.0| Hepatodiaphragmatic Nodule | X | 6 | Hyperplasia, Focal | 2 | 3 2.0| Inflammation, Chronic, Multifocal | 2 1 1 2 1 | 7 1.4| Bile Duct, Hyperplasia, Multifocal | 1 2 2 2 2 2 2 3 1 2 2 2 2 2 2 2 2 2 2 2 1 2 2| 46 2.1| Centrilobular, Necrosis, Acute | | 1 3.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 50 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 2| 2| 6| 2| 1| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| | | 9| 9| 4| 9| 7| 9| 9| 4| 5| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | |__________________________________________________________________________|____________| Mesentery | + + | 6 | Inflammation, Chronic, Multifocal | | 1 2.0| Fat, Necrosis | 2 | 4 3.5| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acinus, Atrophy, Diffuse | | 1 3.0| Acinus, Atrophy, Focal | 3 2 2 2 | 14 1.8| Acinus, Atrophy, Multifocal | 2 2 2 2 2 1 2 2 | 11 2.1| Acinus, Focal Cellular Change | | 1 | Acinus, Hyperplasia, Focal | | 1 4.0| Artery, Inflammation, Chronic | | 1 2.0| |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage, Focal | 2 | 1 2.0| Inflammation, Chronic | 4 | 1 4.0| |__________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 | Hyperplasia, Multifocal, Squamous | | 1 2.0| Hyperplasia, Squamous | | 1 2.0| Inflammation, Acute | | 1 1.0| Ulcer | | 1 2.0| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy, Multifocal | 2 1 2 2 2 2 2 2 3 2 3 2 3 3 1 2 1 2 2 2 | 40 2.0| Atrium, Thrombosis | | 1 | _____________________________________________________________________________________________________________________| | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 51 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 2| 2| 6| 2| 1| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| | | 9| 9| 4| 9| 7| 9| 9| 4| 5| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Degeneration, Focal | 2 1 2 | 6 1.5| Hematopoietic Cell Proliferation, | | | Multifocal | 2 2 | 2 2.0| Hemorrhage | | 1 4.0| Hyperplasia, Focal | 2 2 2 | 4 1.8| Hyperplasia, Multifocal | 2 | 2 2.0| |__________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemorrhage | | 1 4.0| Hyperplasia, Focal | 1 | 5 1.6| Hyperplasia, Multifocal | 3 | 3 3.3| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 2 | 1 2.0| |__________________________________________________________________________|____________| Parathyroid Gland | + M + + M + + + + + + + + + + M + + + M + M + + +| 41 | |__________________________________________________________________________|____________| Pituitary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Abscess | 4 | 1 4.0| Pars Distalis, Cyst | 2 | 1 2.0| Pars Distalis, Hemorrhage | | 1 2.0| Pars Distalis, Hyperplasia, Focal | 2 2 2 | 7 2.0| Pars Intermedia, Cyst | X | 1 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia, Focal | 2 2 | 3 2.0| C-Cell, Hyperplasia, Multifocal | | 3 2.7| Follicle, Cyst | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 52 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 2| 2| 6| 2| 1| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| | | 9| 9| 4| 9| 7| 9| 9| 4| 5| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Abscess | | 1 3.0| Inflammation, Acute, Focal | | 1 2.0| Inflammation, Acute, Multifocal | | 1 2.0| Inflammation, Chronic, Focal | 2 2 1 | 3 1.7| Inflammation, Chronic, Multifocal | 2 2 2 2 2 2 2 | 15 1.8| Inflammation, Chronic Active, Focal | 2 2 | 2 2.0| Inflammation, Chronic Active, | | | Multifocal | 2 | 1 2.0| Inflammation, Multifocal, Subacute | 2 | 1 2.0| |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia, Focal | 1 1 1 2 | 7 1.4| Inflammation, Acute, Focal | 3 | 1 3.0| Inflammation, Chronic, Focal | 2 2 2| 4 2.0| Inflammation, Chronic, Multifocal | 2 | 1 2.0| Inflammation, Chronic Active, | | | Multifocal | | 1 3.0| |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy, Diffuse | 3 3 4 3 2 3 3 2 3 4 3 3 3| 27 3.0| Dilatation | | 1 2.0| Inflammation, Chronic, Multifocal | | 1 2.0| |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy, Diffuse | 3 3| 4 2.8| Atrophy, Focal | 1 | 1 1.0| Atrophy | | 1 2.0| Granuloma Sperm | 2 | 1 2.0| Interstitial Cell, Hyperplasia, | | | Multifocal | 2 2 2| 5 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 53 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 2| 2| 6| 2| 1| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| | | 9| 9| 4| 9| 7| 9| 9| 4| 5| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Blood | | 1 | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 | 3 2.0| Infiltration Cellular, Focal, | | | Histiocyte | | 1 2.0| |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + M + + +| 48 | Degeneration, Cystic | 2 3 | 3 2.3| Hyperplasia, Plasma Cell | | 1 1.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 | Congestion | | 1 2.0| Degeneration, Cystic | | 1 3.0| Hyperplasia, Lymphoid | 2 | 1 2.0| Infiltration Cellular, Histiocyte | 3 2 | 3 2.3| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy, Focal | | 1 2.0| Fibrosis, Diffuse | | 1 2.0| Fibrosis, Focal | 2 2 | 3 2.7| Hematopoietic Cell Proliferation | | 2 2.0| Lymphoid Follicle, Atrophy | 2 | 1 2.0| |__________________________________________________________________________|____________| Thymus | + + + + + + + M M + + + M + + + + M M M + + + + +| 39 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + M M M + + M + M + M + + M + + + + + M| 37 | Inflammation, Chronic | 3 | 1 3.0| Acinus, Hyperplasia, Focal | | 1 3.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 54 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 2| 2| 6| 2| 1| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| | | 9| 9| 4| 9| 7| 9| 9| 4| 5| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | Duct, Ectasia | 2 2 3 | 8 2.3| |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst Epithelial Inclusion | X | 1 | Inflammation, Acute, Focal | | 1 1.0| Inflammation, Chronic, Focal | 2 | 1 2.0| Subcutaneous Tissue, Fibrosis, Focal | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperostosis | 3 | 2 2.5| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hydrocephalus | | 1 2.0| Cerebellum, Necrosis, Focal | 2| 1 2.0| Hypothalamus, Compression | | 3 2.3| |__________________________________________________________________________|____________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis, Focal | 1 | 1 1.0| Foreign Body | 2 | 2 2.0| Infiltration Cellular, Multifocal, | | | Histiocyte | 1 1 | 4 1.0| Inflammation, Acute, Multifocal | | 1 3.0| Inflammation, Granulomatous, | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 55 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 2| 2| 6| 2| 1| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| | | 9| 9| 4| 9| 7| 9| 9| 4| 5| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | Multifocal | 2 | 1 2.0| Alveolar Epithelium, Hyperplasia, | | | Focal | 4 | 3 3.7| Interstitium, Inflammation, Chronic, | | | Multifocal | | 2 2.0| Peribronchiolar, Hyperplasia, | | | Lymphoid | 2 | 1 2.0| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | 2 2 | 2 2.0| Fungus | 2 2 2 2 | 7 2.0| Mucosa, Cytoplasmic Alteration, | | | Multifocal | 1 1 | 2 1.0| Mucosa, Foreign Body, Focal | 2 | 1 2.0| Mucosa, Inflammation, Acute, Focal | | 1 3.0| Mucosa, Inflammation, Acute, | | | Multifocal | | 2 1.5| Mucosa, Inflammation, Chronic, | | | Multifocal | 2 2 | 2 2.0| Mucosa, Inflammation, Chronic Active,| | | Multifocal | 2 2 2 2 | 5 2.0| Mucosa, Inflammation, Focal, Subacute| 1 | 1 1.0| Mucosa, Inflammation, Multifocal, | | | Subacute | 2 | 2 2.0| Mucosa, Metaplasia, Multifocal, | | | Squamous | | 1 2.0| Nasolacrimal Duct, Inflammation, | | | Chronic | 1 2 2 1 | 7 1.4| Nasolacrimal Duct, Inflammation, | | | Chronic Active | | 2 2.0| |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 56 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| | DAY ON TEST | 2| 2| 6| 2| 1| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| | | 9| 9| 4| 9| 7| 9| 9| 4| 5| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| SPECIAL SENSES SYSTEM - cont | | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lens, Cataract | 4 4 3 2 | 6 3.0| Retina, Atrophy | 4 3 1 1 1 2 2 2 2 1 2 3 | 14 2.0| Sclera, Metaplasia, Focal, Osseous | 1 1 1 1 1 2 1 1 1 1 2 1 | 21 1.2| Sclera, Metaplasia, Multifocal, | | | Osseous | 3 2 2 2 1 1 2 2 2 | 22 2.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 2.0| Nephropathy, Chronic, Multifocal | 3 2 2 4 3 3 1 2 2 3 3 3 1 3 3 3 2 3 3 3 2 3 2| 47 2.4| Renal Tubule, Pigmentation | 3 | 2 2.5| Transitional Epithelium, Hyperplasia | 2 | 1 2.0| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Dilatation | | 1 4.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 57 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 2| 7| 7| 7| 5| 7| 7| 6| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| DAY ON TEST | 3| 3| 3| 3| 7| 2| 2| 7| 8| 1| 2| 2| 2| 6| 5| 3| 3| 3| 8| 8| 3| 3| 3| 2| 8| | 6| 1| 1| 1| 6| 9| 9| 4| 5| 5| 9| 9| 9| 6| 5| 0| 0| 0| 8| 2| 0| 0| 0| 3| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + M + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | M + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + M + + + + + + + + + + + + + + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic, Focal | 2 2 2 | Degeneration, Cystic, Multifocal | 2 2 | Fatty Change | 1 2 3 1 3 | Focal Cellular Change | X X X X X X X X X X X | Hepatodiaphragmatic Nodule | X | Hyperplasia, Focal | | Hyperplasia, Multifocal | | Inflammation, Chronic, Multifocal | 1 | Necrosis, Acute, Multifocal | 4 | Bile Duct, Hyperplasia, Multifocal | 2 2 2 3 3 2 2 3 2 2 3 3 1 2 2 1 2 2 1 2 1 3 1| Centrilobular, Necrosis, Acute | 3 4 | Vein, Thrombosis | | |__________________________________________________________________________| Mesentery | + + + | Fat, Necrosis | 2 | |__________________________________________________________________________| Pancreas | M + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy, Focal | 2 2 1 1 | __________________________________________|__________________________________________________________________________| Page 58 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 2| 7| 7| 7| 5| 7| 7| 6| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| DAY ON TEST | 3| 3| 3| 3| 7| 2| 2| 7| 8| 1| 2| 2| 2| 6| 5| 3| 3| 3| 8| 8| 3| 3| 3| 2| 8| | 6| 1| 1| 1| 6| 9| 9| 4| 5| 5| 9| 9| 9| 6| 5| 0| 0| 0| 8| 2| 0| 0| 0| 3| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Acinus, Atrophy, Multifocal | 2 2 3 2 2 | Acinus, Focal Cellular Change | | Acinus, Hyperplasia, Focal | 2 | Artery, Inflammation, Chronic | | |__________________________________________________________________________| Salivary Glands | + + + + + M + + + + + + + + + + + + + + + + + M +| |__________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Ulcer | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion, Focal | | Erosion, Multifocal | 3 | |__________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Blood Vessel | +| Aorta, Arteriosclerosis | 4| |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Multifocal | 2 2 1 2 2 2 2 2 2 1 1 2 2 2 2 2 2 1 2 2 | Mineralization, Multifocal | | Atrium, Thrombosis | X X | Valve, Inflammation, Chronic | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + M +| Accessory Adrenal Cortical Nodule | | Degeneration, Focal | 2 | Hyperplasia, Focal | 2 | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 59 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 2| 7| 7| 7| 5| 7| 7| 6| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| DAY ON TEST | 3| 3| 3| 3| 7| 2| 2| 7| 8| 1| 2| 2| 2| 6| 5| 3| 3| 3| 8| 8| 3| 3| 3| 2| 8| | 6| 1| 1| 1| 6| 9| 9| 4| 5| 5| 9| 9| 9| 6| 5| 0| 0| 0| 8| 2| 0| 0| 0| 3| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Adrenal Gland, Medulla | + + + + + + + + + + + M + + + + + + + M + + M +| Hyperplasia, Focal | | Hyperplasia, Multifocal | 2 | |__________________________________________________________________________| Islets, Pancreatic | M + + + + + + + + + + + + + + + + + + + + + + M +| |__________________________________________________________________________| Parathyroid Gland | + + M M + + + + + + + + M M + M + + M + M + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| Pars Distalis, Angiectasis | 2 2 | Pars Distalis, Cyst | | Pars Distalis, Hyperplasia, Focal | 2 2 2 2 | Pars Distalis, Hyperplasia, | | Multifocal | 2 | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia, Focal | 2 2 1 2 | C-Cell, Hyperplasia, Multifocal | 2 2 2 | Follicle, Cyst | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + M + + + + + + + + + + M +| Hyperplasia, Focal | 1 | Inflammation, Acute, Multifocal | | Inflammation, Chronic, Diffuse | 2 2 4 | Inflammation, Chronic, Focal | | Inflammation, Chronic, Multifocal | 2 2 1 2 2 1 2 2 | Inflammation, Chronic Active, Focal | 2 | Inflammation, Chronic Active, | | Multifocal | 2 2 | |__________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + M + + + +| __________________________________________|__________________________________________________________________________| Page 60 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 2| 7| 7| 7| 5| 7| 7| 6| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| DAY ON TEST | 3| 3| 3| 3| 7| 2| 2| 7| 8| 1| 2| 2| 2| 6| 5| 3| 3| 3| 8| 8| 3| 3| 3| 2| 8| | 6| 1| 1| 1| 6| 9| 9| 4| 5| 5| 9| 9| 9| 6| 5| 0| 0| 0| 8| 2| 0| 0| 0| 3| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | Hyperplasia, Focal | | Inflammation, Chronic, Focal | 2 | Inflammation, Chronic Active, Diffuse| | Inflammation, Focal, Subacute | | Epithelium, Hyperplasia, Multifocal | 2 | |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + M + + + +| Atrophy, Diffuse | 2 2 2 3 4 2 2 4 3 2 4 3 3 2 | Inflammation, Acute | | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy, Diffuse | 3 4 4 4 | Interstitial Cell, Hyperplasia, | | Multifocal | 2 1 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 4 2 | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mediastinal, Hemorrhage | 4 | |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + M +| Congestion | 2 | Degeneration, Cystic | | Hyperplasia, Lymphoid | 2 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic | | Hemorrhage | 2 | Hyperplasia, Lymphoid | 2 | Infiltration Cellular, Histiocyte | | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 4 | Fibrosis, Focal | 3 | Hematopoietic Cell Proliferation | 2 2 2 | __________________________________________|__________________________________________________________________________| Page 61 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 2| 7| 7| 7| 5| 7| 7| 6| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| DAY ON TEST | 3| 3| 3| 3| 7| 2| 2| 7| 8| 1| 2| 2| 2| 6| 5| 3| 3| 3| 8| 8| 3| 3| 3| 2| 8| | 6| 1| 1| 1| 6| 9| 9| 4| 5| 5| 9| 9| 9| 6| 5| 0| 0| 0| 8| 2| 0| 0| 0| 3| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Artery, Thrombosis | X | |__________________________________________________________________________| Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + M + + + + + + + + + + + + + + + + + M + M| Acinus, Hyperplasia, Diffuse | 2 | Acinus, Hyperplasia, Focal | | Duct, Ectasia | 2 3 2 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active, Focal | | Subcutaneous Tissue, Inflammation, | | Chronic, Focal | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 3 | |__________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hypothalamus, Compression | 2 | |__________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage, Multifocal | 2 | Hyperplasia, Lymphoid | 2 | Infiltration Cellular, Focal, | | __________________________________________|__________________________________________________________________________| Page 62 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 2| 7| 7| 7| 5| 7| 7| 6| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| DAY ON TEST | 3| 3| 3| 3| 7| 2| 2| 7| 8| 1| 2| 2| 2| 6| 5| 3| 3| 3| 8| 8| 3| 3| 3| 2| 8| | 6| 1| 1| 1| 6| 9| 9| 4| 5| 5| 9| 9| 9| 6| 5| 0| 0| 0| 8| 2| 0| 0| 0| 3| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | Histiocyte | 1 | Infiltration Cellular, Multifocal, | | Histiocyte | 1 1 | Inflammation, Acute, Multifocal | | Leukocytosis | 3| Alveolar Epithelium, Hyperplasia, | | Multifocal | | Interstitium, Inflammation, Chronic, | | Multifocal | 2 1 | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Fungus | 2 2 3 3 | Inflammation, Chronic Active, | | Multifocal | | Mucosa, Inflammation, Acute, Focal | 2 | Mucosa, Inflammation, Acute, | | Multifocal | 4 | Mucosa, Inflammation, Chronic, Focal | 2 | Mucosa, Inflammation, Chronic, | | Multifocal | 1 | Mucosa, Inflammation, Chronic Active,| | Multifocal | 1 2 2 2 3 | Mucosa, Metaplasia, Focal, Squamous | 2 | Nasolacrimal Duct, Inflammation, | | Chronic | 2 2 2 | Nasolacrimal Duct, Inflammation, | | Chronic Active | 2 | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Ear | M M | |__________________________________________________________________________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| Anterior Chamber, Hemorrhage | | Cornea, Inflammation, Chronic Active | 2 | Lens, Cataract | 2 3 2 1 2 2 | __________________________________________|__________________________________________________________________________| Page 63 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 2| 7| 7| 7| 5| 7| 7| 6| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| DAY ON TEST | 3| 3| 3| 3| 7| 2| 2| 7| 8| 1| 2| 2| 2| 6| 5| 3| 3| 3| 8| 8| 3| 3| 3| 2| 8| | 6| 1| 1| 1| 6| 9| 9| 4| 5| 5| 9| 9| 9| 6| 5| 0| 0| 0| 8| 2| 0| 0| 0| 3| 4| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | Retina, Atrophy | 4 2 4 2 | Sclera, Metaplasia, Focal, Osseous | 1 1 1 2 2 1| Sclera, Metaplasia, Multifocal, | | Osseous | 2 2 1 2 2 2 2 2 1 2 2 1 2 2 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Nephropathy, Chronic, Multifocal | 2 3 3 1 2 2 2 2 2 2 2 2 1 2 2 2 2 2 3 2 3 3 | Papilla, Necrosis | | Pelvis, Dilatation | 2| Renal Tubule, Mineralization, | | Multifocal | 3| Renal Tubule, Pigmentation | 3 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + M + + + +| Calculus Micro Observation Only | | Inflammation, Hemorrhagic | 3| Inflammation, Subacute | | __________________________________________|__________________________________________________________________________ Page 64 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 9| 6| 2| 3| 3| 3| 3| 3| 6| 3| 3| 3| 9| 6| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 4| 0| 4| 7| 0| 0| 0| 0| 7| 0| 0| 0| 5| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 | |__________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Cystic, Focal | 1 1 1 | 6 1.5| Degeneration, Cystic, Multifocal | | 2 2.0| Fatty Change | 2 1 1 2| 9 1.8| Focal Cellular Change | X X X X X X X X X X X X | 23 | Hepatodiaphragmatic Nodule | X X X | 4 | Hyperplasia, Focal | 3 | 1 3.0| Hyperplasia, Multifocal | 3 | 1 3.0| Inflammation, Chronic, Multifocal | 2 | 2 1.5| Necrosis, Acute, Multifocal | | 1 4.0| Bile Duct, Hyperplasia, Multifocal | 2 2 2 2 2 2 1 1 2 2 3 1 2 1 2 2 2 2 2 2 1 2 3 2| 47 2.0| Centrilobular, Necrosis, Acute | | 2 3.5| Vein, Thrombosis | 2 | 1 2.0| |__________________________________________________________________________|____________| Mesentery | + + | 5 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 65 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 9| 6| 2| 3| 3| 3| 3| 3| 6| 3| 3| 3| 9| 6| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 4| 0| 4| 7| 0| 0| 0| 0| 7| 0| 0| 0| 5| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | Fat, Necrosis | 3 | 2 2.5| |__________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acinus, Atrophy, Focal | 2 2 1 1 2 2 2| 11 1.6| Acinus, Atrophy, Multifocal | 1 2 2 | 8 2.0| Acinus, Focal Cellular Change | X | 1 | Acinus, Hyperplasia, Focal | 2 | 2 2.0| Artery, Inflammation, Chronic | 3 | 1 3.0| |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | |__________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ulcer | 3 3 | 2 3.0| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erosion, Focal | 2 | 1 2.0| Erosion, Multifocal | | 1 3.0| |__________________________________________________________________________|____________| Tooth | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + | 2 | Aorta, Arteriosclerosis | 4 | 2 4.0| |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cardiomyopathy, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 1 2| 40 1.9| Mineralization, Multifocal | 3 | 1 3.0| Atrium, Thrombosis | X | 3 | Valve, Inflammation, Chronic | 3 3 | 2 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 66 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 9| 6| 2| 3| 3| 3| 3| 3| 6| 3| 3| 3| 9| 6| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 4| 0| 4| 7| 0| 0| 0| 0| 7| 0| 0| 0| 5| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | |__________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Accessory Adrenal Cortical Nodule | X | 1 | Degeneration, Focal | 2 2 2 2 2| 6 2.0| Hyperplasia, Focal | 2 2 1 1 2 2 2 | 8 1.8| |__________________________________________________________________________|____________| Adrenal Gland, Medulla | + M + + + + M + + + + + + + + + + + + + + + + + +| 44 | Hyperplasia, Focal | 2 2 | 2 2.0| Hyperplasia, Multifocal | 2 | 2 2.0| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + M + + + + +| 47 | |__________________________________________________________________________|____________| Parathyroid Gland | M + M + + M M + + + + + + + + + + + + + + + + + +| 39 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 | Pars Distalis, Angiectasis | | 2 2.0| Pars Distalis, Cyst | X | 1 | Pars Distalis, Hyperplasia, Focal | 2 2 | 6 2.0| Pars Distalis, Hyperplasia, | | | Multifocal | | 1 2.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia, Focal | 2 2 | 6 1.8| C-Cell, Hyperplasia, Multifocal | | 3 2.0| Follicle, Cyst | | 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 67 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 9| 6| 2| 3| 3| 3| 3| 3| 6| 3| 3| 3| 9| 6| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 4| 0| 4| 7| 0| 0| 0| 0| 7| 0| 0| 0| 5| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | |__________________________________________________________________________|____________| Preputial Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 47 | Hyperplasia, Focal | 2 | 2 1.5| Inflammation, Acute, Multifocal | 4 | 1 4.0| Inflammation, Chronic, Diffuse | | 3 2.7| Inflammation, Chronic, Focal | 2 | 1 2.0| Inflammation, Chronic, Multifocal | 1 2 2 2 3 2 1 1 1 2 1 1 1 | 21 1.6| Inflammation, Chronic Active, Focal | | 1 2.0| Inflammation, Chronic Active, | | | Multifocal | 1 2 2 2 | 6 1.8| |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia, Focal | 2 2 2 | 3 2.0| Inflammation, Chronic, Focal | 2 | 2 2.0| Inflammation, Chronic Active, Diffuse| 4 | 1 4.0| Inflammation, Focal, Subacute | 2 | 1 2.0| Epithelium, Hyperplasia, Multifocal | | 1 2.0| |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Atrophy, Diffuse | 1 3 2 3 2 2 3 3 3 3 2 2 2 2 3 2| 30 2.5| Inflammation, Acute | 2 | 1 2.0| |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy, Diffuse | 1 | 5 3.2| Interstitial Cell, Hyperplasia, | | | Multifocal | 1 2 2 2 2 | 8 1.8| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 | 6 2.3| |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mediastinal, Hemorrhage | | 1 4.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 68 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 9| 6| 2| 3| 3| 3| 3| 3| 6| 3| 3| 3| 9| 6| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 4| 0| 4| 7| 0| 0| 0| 0| 7| 0| 0| 0| 5| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + M + M + +| 45 | Congestion | | 1 2.0| Degeneration, Cystic | 2 | 1 2.0| Hyperplasia, Lymphoid | | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Degeneration, Cystic | 2 | 1 2.0| Hemorrhage | | 1 2.0| Hyperplasia, Lymphoid | | 1 2.0| Infiltration Cellular, Histiocyte | 2 2 2 | 3 2.0| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 | Congestion | | 1 4.0| Fibrosis, Focal | | 1 3.0| Hematopoietic Cell Proliferation | | 3 2.0| Artery, Thrombosis | | 1 | |__________________________________________________________________________|____________| Thymus | + + + + + M M + + + + + + + + M + M + + + + + + +| 45 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + M + + + + + + + + + + + + + M + + + + + M + + +| 44 | Acinus, Hyperplasia, Diffuse | | 1 2.0| Acinus, Hyperplasia, Focal | 1 | 1 1.0| Duct, Ectasia | 2 3 2 2 1 | 8 2.1| |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active, Focal | 2 | 1 2.0| Subcutaneous Tissue, Inflammation, | | | Chronic, Focal | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 69 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 9| 6| 2| 3| 3| 3| 3| 3| 6| 3| 3| 3| 9| 6| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 4| 0| 4| 7| 0| 0| 0| 0| 7| 0| 0| 0| 5| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM - cont | | | Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperostosis | 2 | 2 2.5| |__________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hypothalamus, Compression | 3 4 3 | 4 3.0| |__________________________________________________________________________|____________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage, Multifocal | | 1 2.0| Hyperplasia, Lymphoid | | 1 2.0| Infiltration Cellular, Focal, | | | Histiocyte | | 1 1.0| Infiltration Cellular, Multifocal, | | | Histiocyte | 1 1 1 1 1 1 1 | 9 1.0| Inflammation, Acute, Multifocal | 2 | 1 2.0| Leukocytosis | | 1 3.0| Alveolar Epithelium, Hyperplasia, | | | Multifocal | 2 2| 2 2.0| Interstitium, Inflammation, Chronic, | | | Multifocal | | 2 1.5| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fungus | 2 2 2 2 2| 9 2.2| Inflammation, Chronic Active, | | | Multifocal | 2 2 | 2 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 70 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 9| 6| 2| 3| 3| 3| 3| 3| 6| 3| 3| 3| 9| 6| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 4| 0| 4| 7| 0| 0| 0| 0| 7| 0| 0| 0| 5| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | Mucosa, Inflammation, Acute, Focal | | 1 2.0| Mucosa, Inflammation, Acute, | | | Multifocal | 2 | 2 3.0| Mucosa, Inflammation, Chronic, Focal | 1 | 2 1.5| Mucosa, Inflammation, Chronic, | | | Multifocal | 1 | 2 1.0| Mucosa, Inflammation, Chronic Active,| | | Multifocal | 3 2 2| 8 2.1| Mucosa, Metaplasia, Focal, Squamous | | 1 2.0| Nasolacrimal Duct, Inflammation, | | | Chronic | 2 2 2 2 1 2 2 | 10 1.9| Nasolacrimal Duct, Inflammation, | | | Chronic Active | 2 | 2 2.0| |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Ear | + | 1 | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Anterior Chamber, Hemorrhage | 4 | 1 4.0| Cornea, Inflammation, Chronic Active | | 1 2.0| Lens, Cataract | 1 3 3 2 | 10 2.1| Retina, Atrophy | 1 4 4 2 2 | 9 2.8| Sclera, Metaplasia, Focal, Osseous | 2 1 2 1 2 1 1 | 13 1.4| Sclera, Metaplasia, Multifocal, | | | Osseous | 2 2 2 1 1 2 2 2 2 2 2 2 2 2 2| 30 1.8| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 2.0| Nephropathy, Chronic, Multifocal | 2 3 2 2 2 2 2 3 3 4 3 2 2 2 2 2 3 2 2 2 2 2 2 2| 46 2.2| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 71 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 9| 6| 2| 3| 3| 3| 3| 3| 6| 3| 3| 3| 9| 6| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 4| 0| 4| 7| 0| 0| 0| 0| 7| 0| 0| 0| 5| 7| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | Papilla, Necrosis | 4 | 1 4.0| Pelvis, Dilatation | 2 | 2 2.0| Renal Tubule, Mineralization, | | | Multifocal | | 1 3.0| Renal Tubule, Pigmentation | 2 2| 3 2.3| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Calculus Micro Observation Only | 2 | 1 2.0| Inflammation, Hemorrhagic | | 1 3.0| Inflammation, Subacute | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 72 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 6| 2| 9| 3| 2| 3| 1| 8| 3| 3| 3| 7| 2| 3| 3| 0| 3| 6| | 0| 0| 0| 0| 6| 0| 0| 6| 7| 8| 0| 6| 0| 1| 2| 0| 0| 0| 5| 1| 0| 0| 7| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM | | |__________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + + + + A + +| |__________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +| Ectopic Tissue | X | |__________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + A + +| |__________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | 1 1 | Degeneration, Cystic, Focal | 4 | Fatty Change | 1 2 4| Focal Cellular Change | X X X X X X X X X X X X X | Hepatodiaphragmatic Nodule | X | Hyperplasia, Multifocal | 3 | Inflammation, Chronic, Multifocal | | Necrosis, Acute, Multifocal | | Bile Duct, Hyperplasia, Multifocal | 1 2 1 2 2 2 2 1 2 1 2 2 1 2 2 3 3 2 2 2 2 2| Centrilobular, Congestion, Chronic | 3 | |__________________________________________________________________________| Mesentery | | Fat, Necrosis | | |__________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy, Diffuse | | Acinus, Atrophy, Focal | 2 1 1 3 3 | __________________________________________|__________________________________________________________________________| Page 73 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 6| 2| 9| 3| 2| 3| 1| 8| 3| 3| 3| 7| 2| 3| 3| 0| 3| 6| | 0| 0| 0| 0| 6| 0| 0| 6| 7| 8| 0| 6| 0| 1| 2| 0| 0| 0| 5| 1| 0| 0| 7| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ALIMENTARY SYSTEM - cont | | Acinus, Atrophy, Multifocal | 2 | Artery, Inflammation, Chronic | 4 | |__________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | | Inflammation, Chronic Active, Diffuse| | Inflammation, Subacute | | Ulcer | | |__________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion, Focal | 2 2 | |__________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | |__________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy, Multifocal | 1 1 1 1 1 2 2 1 1 2 2 2 2 1 2 2 2 1 2 2 2 | Atrium, Thrombosis | 2 X X | Coronary Artery, Inflammation, | | Chronic | 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | |__________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Focal | 2 2 | Degeneration, Multifocal | | Hematopoietic Cell Proliferation, | | Multifocal | 2 1 | Hyperplasia, Focal | 1 | Hyperplasia, Multifocal | 1 | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 74 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 6| 2| 9| 3| 2| 3| 1| 8| 3| 3| 3| 7| 2| 3| 3| 0| 3| 6| | 0| 0| 0| 0| 6| 0| 0| 6| 7| 8| 0| 6| 0| 1| 2| 0| 0| 0| 5| 1| 0| 0| 7| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| ENDOCRINE SYSTEM - cont | | Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 1 1 | |__________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 | |__________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| |__________________________________________________________________________| Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| Hemorrhage | 2 | Pars Distalis, Angiectasis | | Pars Distalis, Cyst | | Pars Distalis, Hyperplasia, Focal | 2 2 4 1 | Pars Distalis, Hyperplasia, | | Multifocal | 2 | |__________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia, Focal | 1 2 | Follicle, Cyst | X 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | |__________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | | |__________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | 2 | Hyperplasia, Focal | | Inflammation, Chronic, Diffuse | | Inflammation, Chronic, Focal | 1 2 | Inflammation, Chronic, Multifocal | 1 2 1 2 2 2| Inflammation, Chronic Active, Focal | | Inflammation, Chronic Active, | | Multifocal | 2 2 2 | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 75 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 6| 2| 9| 3| 2| 3| 1| 8| 3| 3| 3| 7| 2| 3| 3| 0| 3| 6| | 0| 0| 0| 0| 6| 0| 0| 6| 7| 8| 0| 6| 0| 1| 2| 0| 0| 0| 5| 1| 0| 0| 7| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| GENITAL SYSTEM - cont | | Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 | Hyperplasia, Multifocal | 2 2 | Inflammation, Acute, Multifocal | | Inflammation, Chronic Active, | | Multifocal | 2| |__________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy, Diffuse | 2 3 2 2 3 3 2 4 2 3 4 3 2 3 3 3 2 4 4| Dilatation | | Inflammation, Chronic, Focal | | |__________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy, Diffuse | 3 | Atrophy, Focal | | Interstitial Cell, Hyperplasia, | | Multifocal | 2| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | |__________________________________________________________________________| Blood | | |__________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 2 | |__________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + M + +| Congestion | 2 | Degeneration, Cystic | | Hyperplasia, Lymphoid | 2 | Hyperplasia, Plasma Cell | 2 | |__________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Infiltration Cellular, Histiocyte | 1 2 2 | |__________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________| Page 76 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 6| 2| 9| 3| 2| 3| 1| 8| 3| 3| 3| 7| 2| 3| 3| 0| 3| 6| | 0| 0| 0| 0| 6| 0| 0| 6| 7| 8| 0| 6| 0| 1| 2| 0| 0| 0| 5| 1| 0| 0| 7| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | Fibrosis, Focal | | Hematopoietic Cell Proliferation | 2 | Lymphoid Follicle, Atrophy | 2 2 | |__________________________________________________________________________| Thymus | + + + + + M M + + + + M + + M + + + M + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | |__________________________________________________________________________| Mammary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| Duct, Ectasia | 2 2 | |__________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Hair Follicle, Atrophy | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | |__________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | |__________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Cerebrum, Necrosis, Focal | | Hypothalamus, Compression | 3 | |__________________________________________________________________________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | |__________________________________________________________________________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| |__________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess, Multifocal | 3 | Foreign Body | | Infiltration Cellular, Multifocal, | | Histiocyte | 1 1 1 | Inflammation, Acute, Multifocal | | Alveolar Epithelium, Hyperplasia, | | Focal | 4 3 | __________________________________________|__________________________________________________________________________| Page 77 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 6| 2| 9| 3| 2| 3| 1| 8| 3| 3| 3| 7| 2| 3| 3| 0| 3| 6| | 0| 0| 0| 0| 6| 0| 0| 6| 7| 8| 0| 6| 0| 1| 2| 0| 0| 0| 5| 1| 0| 0| 7| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| RESPIRATORY SYSTEM - cont | | |__________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Foreign Body | 2 | Fungus | 2 | Metaplasia, Focal, Squamous | | Mucosa, Inflammation, Chronic, | | Multifocal | 2 | Mucosa, Inflammation, Chronic Active,| | Multifocal | 4 | Mucosa, Inflammation, Multifocal, | | Subacute | | Mucosa, Metaplasia, Multifocal, | | Squamous | | Nasolacrimal Duct, Inflammation, | | Chronic | 2 | Nasolacrimal Duct, Inflammation, | | Chronic Active | | Nasolacrimal Duct, Inflammation, | | Subacute | | |__________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | |__________________________________________________________________________| Ear | M | |__________________________________________________________________________| Eye | + + + + + + + M + M + + + + + + + + + + + + + + +| Inflammation, Chronic | | Lens, Cataract | 1 2 1 2 | Retina, Atrophy | 1 3 | Sclera, Metaplasia, Focal, Osseous | 1 1 1 1 1 1 1 1 1 | Sclera, Metaplasia, Multifocal, | | Osseous | 1 2 2 2 2 1 2 2 2| |__________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | |__________________________________________________________________________| __________________________________________|__________________________________________________________________________| Page 78 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 6| 2| 9| 3| 2| 3| 1| 8| 3| 3| 3| 7| 2| 3| 3| 0| 3| 6| | 0| 0| 0| 0| 6| 0| 0| 6| 7| 8| 0| 6| 0| 1| 2| 0| 0| 0| 5| 1| 0| 0| 7| 0| 0| __________________________________________|__________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| __________________________________________|__________________________________________________________________________| URINARY SYSTEM - cont | | Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | Nephropathy, Chronic, Multifocal | 2 3 1 2 1 2 2 2 3 1 3 2 2 1 3 1 2 2 1 2 2| Renal Tubule, Pigmentation | 2 | |__________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________|__________________________________________________________________________ Page 79 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| | DAY ON TEST | 3| 3| 3| 0| 5| 3| 3| 3| 9| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| | | 0| 0| 0| 3| 9| 0| 0| 0| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 6| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Intestine Large | + + + + A + + + + + + + + + + + + + A + + + + +| 46 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + A + + + + +| 44 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + A + + + + + + + + + + + + + A + + + + +| 46 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + + + + A + + + + + + + M + + + + + A + + + + +| 45 | |__________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | Ectopic Tissue | | 1 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + A + + + + +| 48 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + A + + + + +| 46 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | | 2 1.0| Degeneration, Cystic, Focal | 1 1 | 3 2.0| Fatty Change | 2 3 2| 6 2.3| Focal Cellular Change | X X X X X X X X X X X X X X X X X X X| 32 | Hepatodiaphragmatic Nodule | X | 2 | Hyperplasia, Multifocal | 2 | 2 2.5| Inflammation, Chronic, Multifocal | 1 1 | 2 1.0| Necrosis, Acute, Multifocal | 2 | 1 2.0| Bile Duct, Hyperplasia, Multifocal | 2 3 2 2 2 3 2 2 3 2 3 2 2 1 2 3 2 2 2 1 2 2 3| 45 2.0| Centrilobular, Congestion, Chronic | | 1 3.0| |__________________________________________________________________________|____________| Mesentery | + + + + + | 5 | Fat, Necrosis | 3 3 3 3 | 4 3.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 80 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| | DAY ON TEST | 3| 3| 3| 0| 5| 3| 3| 3| 9| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| | | 0| 0| 0| 3| 9| 0| 0| 0| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 6| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM - cont | | | |__________________________________________________________________________|____________| Pancreas | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 | Acinus, Atrophy, Diffuse | 4 2| 2 3.0| Acinus, Atrophy, Focal | 1 2 | 7 1.9| Acinus, Atrophy, Multifocal | 2 2 3 2 1 2 2 | 8 2.0| Artery, Inflammation, Chronic | | 1 4.0| |__________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erosion | 2 | 1 2.0| Inflammation, Chronic Active, Diffuse| 3 | 1 3.0| Inflammation, Subacute | 2 | 1 2.0| Ulcer | 2 2 | 2 2.0| |__________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erosion, Focal | | 2 2.0| |__________________________________________________________________________|____________| Tooth | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy, Multifocal | 1 3 2 2 2 1 2 2 2 2 2 2 1 1 2 2 1 2 2| 40 1.7| Atrium, Thrombosis | 4 | 4 3.0| Coronary Artery, Inflammation, | | | Chronic | 2 | 2 2.5| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 81 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| | DAY ON TEST | 3| 3| 3| 0| 5| 3| 3| 3| 9| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| | | 0| 0| 0| 3| 9| 0| 0| 0| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 6| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Focal | 2 | 3 2.0| Degeneration, Multifocal | 1 | 1 1.0| Hematopoietic Cell Proliferation, | | | Multifocal | 2 1 1 | 5 1.4| Hyperplasia, Focal | 1 2 | 3 1.3| Hyperplasia, Multifocal | 3 | 2 2.0| |__________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | | 2 1.0| |__________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 3 | 2 2.5| |__________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemorrhage | | 1 2.0| Pars Distalis, Angiectasis | 2 | 1 2.0| Pars Distalis, Cyst | 2 2 2 | 3 2.0| Pars Distalis, Hyperplasia, Focal | 3 2 3 | 7 2.4| Pars Distalis, Hyperplasia, | | | Multifocal | 2 | 2 2.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia, Focal | 3 3 2 | 5 2.2| Follicle, Cyst | | 2 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 82 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| | DAY ON TEST | 3| 3| 3| 0| 5| 3| 3| 3| 9| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| | | 0| 0| 0| 3| 9| 0| 0| 0| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 6| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| GENITAL SYSTEM - cont | | | Granuloma Sperm | 2 | 1 2.0| |__________________________________________________________________________|____________| Preputial Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 | Abscess | 4 | 2 3.0| Hyperplasia, Focal | 3 | 1 3.0| Inflammation, Chronic, Diffuse | 2 | 1 2.0| Inflammation, Chronic, Focal | 2 1 2 | 5 1.6| Inflammation, Chronic, Multifocal | 1 1 2 3 2 2 2 1 3 1 1 | 17 1.7| Inflammation, Chronic Active, Focal | 2 | 1 2.0| Inflammation, Chronic Active, | | | Multifocal | 2 1| 5 1.8| |__________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Focal | 1 1 | 3 1.3| Hyperplasia, Multifocal | | 2 2.0| Inflammation, Acute, Multifocal | 2 | 1 2.0| Inflammation, Chronic Active, | | | Multifocal | | 1 2.0| |__________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | Atrophy, Diffuse | 3 3 3 3 3 4 3 3 4 4 2 3 4 4 3 3 2| 36 3.0| Dilatation | 3 | 1 3.0| Inflammation, Chronic, Focal | 3 | 1 3.0| |__________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy, Diffuse | | 1 3.0| Atrophy, Focal | 2| 1 2.0| Interstitial Cell, Hyperplasia, | | | Multifocal | 2| 2 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Blood | + | 1 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 83 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| | DAY ON TEST | 3| 3| 3| 0| 5| 3| 3| 3| 9| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| | | 0| 0| 0| 3| 9| 0| 0| 0| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 6| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 2 | 6 2.0| |__________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Congestion | | 1 2.0| Degeneration, Cystic | 2 | 1 2.0| Hyperplasia, Lymphoid | 2 2 | 3 2.0| Hyperplasia, Plasma Cell | | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 3 | 1 3.0| Infiltration Cellular, Histiocyte | 1 1 | 5 1.4| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrosis, Focal | 2 | 1 2.0| Hematopoietic Cell Proliferation | | 1 2.0| Lymphoid Follicle, Atrophy | 2 4 | 4 2.5| |__________________________________________________________________________|____________| Thymus | + + + M M + + + + + + + + + + + + + + + + + + + +| 43 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 | Duct, Ectasia | 3 2 | 4 2.3| |__________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hair Follicle, Atrophy | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 84 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| | DAY ON TEST | 3| 3| 3| 0| 5| 3| 3| 3| 9| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| | | 0| 0| 0| 3| 9| 0| 0| 0| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 6| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cerebrum, Necrosis, Focal | 4 | 1 4.0| Hypothalamus, Compression | | 1 3.0| |__________________________________________________________________________|____________| Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Larynx | + + + + + + + + + + + + + + + + + + + + + + + + | 49 | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Abscess, Multifocal | | 1 3.0| Foreign Body | 2 | 1 2.0| Infiltration Cellular, Multifocal, | | | Histiocyte | 1 1 1 | 6 1.0| Inflammation, Acute, Multifocal | 2 | 1 2.0| Alveolar Epithelium, Hyperplasia, | | | Focal | 3 3 | 4 3.3| |__________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Foreign Body | 2 1 | 3 1.7| Fungus | 2 2 2 | 4 2.0| Metaplasia, Focal, Squamous | 1 | 1 1.0| Mucosa, Inflammation, Chronic, | | | Multifocal | | 1 2.0| Mucosa, Inflammation, Chronic Active,| | | Multifocal | 2 2 2 3 | 5 2.6| Mucosa, Inflammation, Multifocal, | | | Subacute | 2 2 | 2 2.0| Mucosa, Metaplasia, Multifocal, | | | Squamous | 3 | 1 3.0| Nasolacrimal Duct, Inflammation, | | | Chronic | 2 2 1 1 1 | 6 1.5| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 85 NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01 Route: DOSED FEED Time: 10:01:32 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| | DAY ON TEST | 3| 3| 3| 0| 5| 3| 3| 3| 9| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| | | 0| 0| 0| 3| 9| 0| 0| 0| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 6| 0| | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | _____________________________________________________________________________________________________________________|____________| RESPIRATORY SYSTEM - cont | | | Nasolacrimal Duct, Inflammation, | | | Chronic Active | 2 | 1 2.0| Nasolacrimal Duct, Inflammation, | | | Subacute | 2 | 1 2.0| |__________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | |__________________________________________________________________________|____________| Ear | M | | |__________________________________________________________________________|____________| Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Inflammation, Chronic | 4 | 1 4.0| Lens, Cataract | 2 1 | 6 1.5| Retina, Atrophy | 1 | 3 1.7| Sclera, Metaplasia, Focal, Osseous | 1 1 1 1 1 | 14 1.0| Sclera, Metaplasia, Multifocal, | | | Osseous | 2 2 1 1 1 2 2 2 2 2 1 1 1 2 2 1 2| 26 1.7| |__________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 2.0| Nephropathy, Chronic, Multifocal | 2 2 1 2 1 2 2 2 2 2 2 1 2 2 2 1 1 2 2 2 2 1 1 2| 45 1.8| Renal Tubule, Pigmentation | 2 2 2 | 4 2.0| |__________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 86 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------ --multipart-boundary Content-type: text/plain Range: bytes 662133-662133/662133 --multipart-boundary--
Web page last updated on October 03, 2004
The National Institute of Environmental Health Sciences is one of the National Institutes of Health within the U.S. Department of Health and Human Services. The National Toxicology Program is headquartered on the NIEHS campus in Research Triangle Park, NC.