Pathology Tables for Peer Review
The National Toxicology Program
NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:12:38
27 WEEK SSAC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 434-07-01
Lock Date: 01/02/96
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 10/21/93 - 10/22/93
Treatment Groups: Include 002 0 MG/KG
Include 004 3 MG/KG
Include 006 30 MG/KG
Include 008 100 MG/KG
Include 001 0 MG/KG
Include 003 3 MG/KG
Include 005 30 MG/KG
Include 007 150 MG/KG
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:12:38
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 30 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 90 90 90 90
Scheduled Sacrifice 10 10 10 10
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Rectum (10) (10) (10) (10)
Parasite Metazoan 1 (10%)
Liver (10) (10) (10) (10)
Basophilic Focus 1 (10%)
Hepatodiaphragmatic Nodule 1 (10%) 5 (50%) 1 (10%) 2 (20%)
Inflammation, Chronic Active 2 (20%) 5 (50%) 4 (40%) 2 (20%)
Centrilobular, Vacuolization Cytoplasmic 1 (10%)
Mesentery (1) (1)
Fat, Inflammation, Chronic Active 1 (100%) 1 (100%)
Pancreas (10) (10) (10) (10)
Inflammation, Chronic Active 1 (10%)
Acinus, Atrophy 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10) (10) (10)
Myocardium, Degeneration, Chronic 5 (50%) 5 (50%) 7 (70%) 10 (100%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Accessory Adrenal Cortical Nodule 3 (30%) 2 (20%) 1 (10%)
Thyroid Gland (10) (10) (10) (10)
Ultimobranchial Cyst 1 (10%) 1 (10%) 2 (20%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:12:38
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 30 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (10) (10) (10) (10)
Inflammation, Chronic Active 6 (60%) 7 (70%) 10 (100%) 8 (80%)
Ovary (10) (10) (10) (10)
DYSGENESIS 10 (100%) 10 (100%)
Follicle, Cyst 1 (10%)
Periovarian Tissue, Cyst 1 (10%)
Uterus (10) (10) (10) (10)
Hydrometra 2 (20%) 3 (30%) 4 (40%) 1 (10%)
Endometrium, Cyst 1 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (10) (10) (10) (10)
Dilatation 1 (10%)
Lobular, Hyperplasia 10 (100%) 10 (100%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Hemorrhage 1 (10%)
Inflammation, Chronic Active 2 (20%) 4 (40%) 7 (70%) 2 (20%)
Mineralization 2 (20%) 4 (40%) 1 (10%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:12:38
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 3 MG/KG 30 MG/KG 100
MG/KG
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Lens, Mineralization 1 (100%)
Retina, Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Inflammation, Chronic Active 1 (10%)
Mineralization 10 (100%) 10 (100%) 10 (100%) 9 (90%)
Nephropathy 1 (10%) 2 (20%) 7 (70%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:12:38
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 30 MG/KG 150
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 90 90 90 90
Scheduled Sacrifice 10 10 10 10
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Duodenum (10) (10) (10) (10)
Inflammation, Chronic Active 1 (10%)
Intestine Small, Jejunum (10) (10) (10) (10)
Inflammation, Granulomatous 1 (10%)
Peyer's Patch, Mineralization 1 (10%)
Liver (10) (10) (10) (10)
Hepatodiaphragmatic Nodule 1 (10%) 1 (10%) 1 (10%) 1 (10%)
Inflammation, Chronic Active 3 (30%) 1 (10%) 3 (30%) 1 (10%)
Bile Duct, Hyperplasia 3 (30%)
Centrilobular, Vacuolization Cytoplasmic 1 (10%)
Mesentery (1)
Fat, Inflammation, Chronic Active 1 (100%)
Pancreas (10) (10) (10) (10)
Acinus, Atrophy 2 (20%)
Vein, Inflammation, Granulomatous 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10) (10) (10)
Myocardium, Degeneration, Chronic 10 (100%) 10 (100%) 9 (90%) 10 (100%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Accessory Adrenal Cortical Nodule 1 (10%) 1 (10%) 1 (10%)
Vacuolization Cytoplasmic 10 (100%) 8 (80%) 8 (80%)
Thyroid Gland (10) (10) (10) (10)
Ultimobranchial Cyst 1 (10%)
Follicle, Cyst 2 (20%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:12:38
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 30 MG/KG 150
MG/KG
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (10) (10) (10) (10)
Inflammation, Chronic Active 1 (10%)
Preputial Gland (10) (10) (10) (10)
Cyst 1 (10%)
Inflammation, Chronic Active 7 (70%) 10 (100%) 9 (90%) 8 (80%)
Testes (10) (10) (10) (10)
Mineralization 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (10) (10) (10) (10)
Capsule, Hyperplasia 1 (10%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (10) (10) (10) (10)
Dilatation 9 (90%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Inflammation, Chronic Active 2 (20%) 3 (30%) 8 (80%) 3 (30%)
Inflammation, Granulomatous 1 (10%) 2 (20%)
Mineralization 4 (40%) 4 (40%) 1 (10%)
Vacuolization Cytoplasmic 1 (10%) 1 (10%) 1 (10%)
Nose (10) (10) (10) (10)
Inflammation, Chronic Active 1 (10%) 2 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 88032-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC OXYMETHOLONE Date: 11/25/97
Route: GAVAGE Time: 07:12:38
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 3 MG/KG 30 MG/KG 150
MG/KG
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Mineralization 2 (20%) 1 (10%) 9 (90%)
Nephropathy 8 (80%) 7 (70%) 9 (90%) 10 (100%)
Urinary Bladder (10) (10) (10) (10)
Inflammation, Chronic Active 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
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Web page last updated on November 11, 2004
