Testing Information

Testing Status of Agents at NTP

2-Nitro-p-phenylenediamine

Print this pageFriendly URL

http://ntp.niehs.nih.gov/go/TS-10730-V

CASRN: 5307-14-2

Formula: C6 H7 N3 O2

Synonyms/Common Names:

  • 2-NITRO-1,4-BENZENEDIAMINE

Known Uses:

IN DYEING FURS, SEMI-PERMANENT AND PERMANENT HAIR DYES (HSDB 1990).

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C02222) Completed 
    • NTIS No. PB290304  (Peer Review 08/31/1978)
      Citation: Bioassay of 2-Nitro-p-phenylenediamine for Possible Carcinogenicity (CAS No. 5307-14-2)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C02222) Completed 
    • NTIS No. PB290304  (Peer Review 08/31/1978)
      Citation: Bioassay of 2-Nitro-p-phenylenediamine for Possible Carcinogenicity (CAS No. 5307-14-2)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0,315,6800, M: 0,810,11830 PPM/5 PER GROUP

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C02222) Report Complete 
    • TR-169 (NTIS No. PB290304)  (Peer Review 08/31/1978)
      Bioassay of 2-Nitro-p-phenylenediamine for Possible Carcinogenicity (CAS No. 5307-14-2)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Positive 
    • Dose: MR: 0,550,1100, FR: 0,1100,2200, M: 0,2200,4400 PPM/50 PER GROUP

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (186397) Completed 
    • Chromosome Aberation Positive 
    • Sister Chromatid Exchange Positive 
  • Mouse Lymphoma (NCI)  (G10538) Completed 
    • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
    • Mouse Lymphoma-NCI  Positive 
  • Mouse Lymphoma (NCI)  (G41276) Completed 
    • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
    • Mouse Lymphoma-NCI  Positive 
  • Salmonella (NCI)  (N-9229) Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
    • Salmonella-NCI  Positive 
  • Salmonella  (987998) Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
    •  Positive 

Back to top

Web page last updated on April 27, 2009