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Pathology Tables for Peer Review
Pathology Tables for Peer Review
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NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 Facility: Southern Research Institute Chemical CAS #: 110-00-9 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 _____________________________________________________________________________________________________________________ | 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 2| 5| 2| 2| 2| 8| 2| 2| 2| 2| 0| 8| 2| 3| 3| 7| 8| 1| 3| 3| 9| 3| 3| 3| 3| | 8| 6| 9| 9| 9| 4| 9| 9| 9| 9| 5| 8| 9| 0| 0| 0| 8| 4| 0| 0| 5| 0| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + M + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Sarcoma, Metastatic, Tissue NOS | X | __________________________________________________________________________| Mesentery | + + + + + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Pharynx | | Squamous Cell Carcinoma | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pheochromocytoma Complex | X | Pheochromocytoma Benign | X | Pheochromocytoma Benign, Multiple | | __________________________________________________________________________| Islets, Pancreatic | + + + + + M + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X X X X X X| Pars Distalis, Adenoma, Multiple | X | Pars Distalis, Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 _____________________________________________________________________________________________________________________ | 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 2| 5| 2| 2| 2| 8| 2| 2| 2| 2| 0| 8| 2| 3| 3| 7| 8| 1| 3| 3| 9| 3| 3| 3| 3| | 8| 6| 9| 9| 9| 4| 9| 9| 9| 9| 5| 8| 9| 0| 0| 0| 8| 4| 0| 0| 5| 0| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pars Intermedia, Leukemia Mononuclear| | Pars Nervosa, Leukemia Mononuclear | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X | C-Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | Abdominal, Sarcoma | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + M + + + + M + + + + + + + + + + + + + + + + +| Adenoma | X| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | X | Polyp Stromal | X X X X X X | Polyp Stromal, Multiple | | Sarcoma Stromal | X | __________________________________________________________________________| Vagina | | Polyp | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + + | Leukemia Mononuclear | X X | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Pancreatic, Leukemia Mononuclear | | Renal, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Bronchial | + M M + M M + M M + + M + M + + + + + M + M + M M| Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + M + M + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Thymus | + + + + + M M + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 _____________________________________________________________________________________________________________________ | 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 2| 5| 2| 2| 2| 8| 2| 2| 2| 2| 0| 8| 2| 3| 3| 7| 8| 1| 3| 3| 9| 3| 3| 3| 3| | 8| 6| 9| 9| 9| 4| 9| 9| 9| 9| 5| 8| 9| 0| 0| 0| 8| 4| 0| 0| 5| 0| 0| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | | Fibroadenoma | X X X X X X X | Fibroadenoma, Multiple | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Spinal Cord | | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma | X | Leukemia Mononuclear | X X X X | Sarcoma, Metastatic, Tissue NOS | X | Sarcoma Stromal, Metastatic, Uterus | X | Mediastinum, Leukemia Mononuclear | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | + + | __________________________________________________________________________| Lacrimal Gland | | Squamous Cell Carcinoma, Metastatic, | | Pharynx | | __________________________________________________________________________| Zymbal's Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 5| 8| 3| 3| 3| 0| 3| 2| 3| 3| 5| 6| 6| 3| 3| 3| 3| 3| 3| 3| | | 0| 0| 0| 0| 0| 9| 7| 0| 0| 1| 5| 7| 9| 1| 1| 5| 5| 6| 1| 1| 1| 1| 1| 1| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 8 | Sarcoma, Metastatic, Tissue NOS | | 1 | __________________________________________________________________________|____________| Mesentery | + + + | 8 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Pharynx | + | 1 | Squamous Cell Carcinoma | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 1 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 4 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 3 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 4 | Pheochromocytoma Complex | | 1 | Pheochromocytoma Benign | | 1 | Pheochromocytoma Benign, Multiple | X | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 5 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 5| 8| 3| 3| 3| 0| 3| 2| 3| 3| 5| 6| 6| 3| 3| 3| 3| 3| 3| 3| | | 0| 0| 0| 0| 0| 9| 7| 0| 0| 1| 5| 7| 9| 1| 1| 5| 5| 6| 1| 1| 1| 1| 1| 1| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + M M + +| 48 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Adenoma | X X X X X X X X X X X X | 26 | Pars Distalis, Adenoma, Multiple | X | 2 | Pars Distalis, Leukemia Mononuclear | X X | 2 | Pars Intermedia, Leukemia Mononuclear| X | 1 | Pars Nervosa, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Adenoma | X X X X X | 8 | C-Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | Abdominal, Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + M + M + + + + + + + M + + + M + + + + M + + + +| 43 | Adenoma | X X | 3 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenocarcinoma | | 1 | Polyp Stromal | X X X | 9 | Polyp Stromal, Multiple | X | 1 | Sarcoma Stromal | | 1 | __________________________________________________________________________|____________| Vagina | + + | 2 | Polyp | X X | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | | 2 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 3 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pancreatic, Leukemia Mononuclear | X | 1 | Renal, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + M + + M + + M + + + + + + M M + M M M M + M M| 27 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + M + + + + +| 47 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 6 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 5| 8| 3| 3| 3| 0| 3| 2| 3| 3| 5| 6| 6| 3| 3| 3| 3| 3| 3| 3| | | 0| 0| 0| 0| 0| 9| 7| 0| 0| 1| 5| 7| 9| 1| 1| 5| 5| 6| 1| 1| 1| 1| 1| 1| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Leukemia Mononuclear | X X | 4 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + M + + + + M + + + + + + + + + +| 48 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X X | 3 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 8 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + M + + + + + + + + + + + + + + +| 47 | Leukemia Mononuclear | X | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenocarcinoma | X | 1 | Fibroadenoma | X X X X X X X | 14 | Fibroadenoma, Multiple | X | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 3 | __________________________________________________________________________|____________| Spinal Cord | + | 1 | Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Carcinoma | | 1 | Leukemia Mononuclear | X X X | 7 | Sarcoma, Metastatic, Tissue NOS | | 1 | Sarcoma Stromal, Metastatic, Uterus | | 1 | Mediastinum, Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 2 | __________________________________________________________________________|____________| Harderian Gland | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 7 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 5| 8| 3| 3| 3| 0| 3| 2| 3| 3| 5| 6| 6| 3| 3| 3| 3| 3| 3| 3| | | 0| 0| 0| 0| 0| 9| 7| 0| 0| 1| 5| 7| 9| 1| 1| 5| 5| 6| 1| 1| 1| 1| 1| 1| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lacrimal Gland | + | 1 | Squamous Cell Carcinoma, Metastatic, | | | Pharynx | X | 1 | __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 8 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 _____________________________________________________________________________________________________________________ | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 1| 5| 6| 7| 7| 5| 6| 6| 6| 7| 4| 4| 6| 7| 7| DAY ON TEST | 9| 4| 3| 3| 3| 9| 1| 6| 3| 3| 4| 3| 8| 3| 3| 2| 9| 9| 9| 3| 2| 5| 6| 1| 3| | 6| 4| 0| 0| 0| 8| 3| 5| 1| 1| 3| 2| 9| 1| 1| 1| 6| 7| 8| 1| 4| 7| 4| 6| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + M + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Serosa, Fibrous Histiocytoma | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma | X | Cholangiocarcinoma, Multiple | X X X X X X X X X X X X X X X X X X X X X X X| Fibrous Histiocytoma | | Hepatocellular Carcinoma | X | Hepatocellular Adenoma | X X X | Hepatocellular Adenoma, Multiple | X | Leukemia Mononuclear | X X X X X X X X X X | __________________________________________________________________________| Mesentery | + + + + + + + | Fibrous Histiocytoma, Multiple | | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Leukemia Mononuclear | X X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma, Metastatic, Liver| X | Fibrous Histiocytoma | | Leukemia Mononuclear | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Tongue | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | Abdominal, Cholangiocarcinoma, | | Metastatic, Liver | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| Page 9 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 _____________________________________________________________________________________________________________________ | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 1| 5| 6| 7| 7| 5| 6| 6| 6| 7| 4| 4| 6| 7| 7| DAY ON TEST | 9| 4| 3| 3| 3| 9| 1| 6| 3| 3| 4| 3| 8| 3| 3| 2| 9| 9| 9| 3| 2| 5| 6| 1| 3| | 6| 4| 0| 0| 0| 8| 3| 5| 1| 1| 3| 2| 9| 1| 1| 1| 6| 7| 8| 1| 4| 7| 4| 6| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma, Metastatic,| | Liver | X | Leukemia Mononuclear | X X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Pheochromocytoma Malignant | X X | Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | + + + M + + + + + + + + + + + + + + M + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X| Pars Distalis, Adenoma, Multiple | | Pars Distalis, Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | C-Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | M M + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | | Leukemia Mononuclear | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Leukemia Mononuclear | X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | | Adenoma | X X | Leukemia Mononuclear | | Polyp Stromal | X X X X X X | Polyp Stromal, Multiple | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 10 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 _____________________________________________________________________________________________________________________ | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 1| 5| 6| 7| 7| 5| 6| 6| 6| 7| 4| 4| 6| 7| 7| DAY ON TEST | 9| 4| 3| 3| 3| 9| 1| 6| 3| 3| 4| 3| 8| 3| 3| 2| 9| 9| 9| 3| 2| 5| 6| 1| 3| | 6| 4| 0| 0| 0| 8| 3| 5| 1| 1| 3| 2| 9| 1| 1| 1| 6| 7| 8| 1| 4| 7| 4| 6| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Fibrous Histiocytoma | | Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Pancreatic, Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Lymph Node, Bronchial | M + M M + + + + + + + + M + M + M M + + + + + M M| Fibrous Histiocytoma | | Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + M + M + + + + + M + + + M + + + + + + +| Fibrous Histiocytoma | | Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Leukemia Mononuclear | X X X X | Pancreatic, Cholangiocarcinoma, | | Metastatic, Liver | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma | | Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma | | Leukemia Mononuclear | X X X X X X X X X X X | __________________________________________________________________________| Thymus | + + + M + + + + + + + + M + + + + + + + + + + + +| Fibrous Histiocytoma | | Leukemia Mononuclear | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | X | Adenoma | | Fibroadenoma | X X X X X X | Fibroadenoma, Multiple | X | Leukemia Mononuclear | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | Diaphragm, Hepatocellular Carcinoma, | | Metastatic, Liver | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 _____________________________________________________________________________________________________________________ | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 1| 5| 6| 7| 7| 5| 6| 6| 6| 7| 4| 4| 6| 7| 7| DAY ON TEST | 9| 4| 3| 3| 3| 9| 1| 6| 3| 3| 4| 3| 8| 3| 3| 2| 9| 9| 9| 3| 2| 5| 6| 1| 3| | 6| 4| 0| 0| 0| 8| 3| 5| 1| 1| 3| 2| 9| 1| 1| 1| 6| 7| 8| 1| 4| 7| 4| 6| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Astrocytoma Malignant | X | Fibrous Histiocytoma | | Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma | | Leukemia Mononuclear | X X X X X X X X | Mediastinum, Fibrous Histiocytoma | | Venule, Mediastinum, | | Cholangiocarcinoma, Metastatic, | | Liver | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | | Leukemia Mononuclear | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Histiocytoma | | Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Transitional Epithelium, Papilloma | X X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X | _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 3| 4| 5| 5| 6| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| 6| 6| | DAY ON TEST | 3| 7| 1| 4| 6| 9| 3| 1| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 3| 7| 8| 2| 2| 6| | | 9| 1| 1| 9| 3| 2| 3| 8| 1| 1| 8| 1| 1| 1| 1| 9| 1| 1| 1| 1| 5| 3| 3| 7| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Serosa, Fibrous Histiocytoma | X | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cholangiocarcinoma | X | 2 | Cholangiocarcinoma, Multiple | X X X X X X X X X X X X X X X X X X X X X X X| 46 | Fibrous Histiocytoma | X | 1 | Hepatocellular Carcinoma | | 1 | Hepatocellular Adenoma | X X X | 6 | Hepatocellular Adenoma, Multiple | | 1 | Leukemia Mononuclear | X X X X X X X X X| 19 | __________________________________________________________________________|____________| Mesentery | + + + + + + | 13 | Fibrous Histiocytoma, Multiple | X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cholangiocarcinoma, Metastatic, Liver| | 1 | Fibrous Histiocytoma | X | 1 | Leukemia Mononuclear | X X | 2 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Tongue | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 13 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 3| 4| 5| 5| 6| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| 6| 6| | DAY ON TEST | 3| 7| 1| 4| 6| 9| 3| 1| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 3| 7| 8| 2| 2| 6| | | 9| 1| 1| 9| 3| 2| 3| 8| 1| 1| 8| 1| 1| 1| 1| 9| 1| 1| 1| 1| 5| 3| 3| 7| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 1 | Abdominal, Cholangiocarcinoma, | | | Metastatic, Liver | X | 1 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X | 11 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | Leukemia Mononuclear | X X X X X | 7 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 | Leukemia Mononuclear | X X X X X | 9 | Pheochromocytoma Malignant | | 2 | Pheochromocytoma Benign | X X | 3 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + M + + +| 46 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 | Pars Distalis, Adenoma | X X X X X X X X X X | 19 | Pars Distalis, Adenoma, Multiple | X | 1 | Pars Distalis, Leukemia Mononuclear | X X X X X | 10 | __________________________________________________________________________|____________| Thyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 1 | C-Cell, Adenoma | X X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 47 | Adenoma | X | 2 | Carcinoma | X | 1 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Histiocytoma | X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 14 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 3| 4| 5| 5| 6| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| 6| 6| | DAY ON TEST | 3| 7| 1| 4| 6| 9| 3| 1| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 3| 7| 8| 2| 2| 6| | | 9| 1| 1| 9| 3| 2| 3| 8| 1| 1| 8| 1| 1| 1| 1| 9| 1| 1| 1| 1| 5| 3| 3| 7| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Leukemia Mononuclear | X X X X | 6 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenocarcinoma | X | 1 | Adenoma | | 2 | Leukemia Mononuclear | X | 1 | Polyp Stromal | X | 7 | Polyp Stromal, Multiple | X X | 2 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Histiocytoma | X | 1 | Leukemia Mononuclear | X X X X X | 7 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pancreatic, Leukemia Mononuclear | X X X X X X X| 14 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + + M + + + M M M + M M M + + M + + + M M M +| 30 | Fibrous Histiocytoma | X | 1 | Leukemia Mononuclear | X X X | 4 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | Fibrous Histiocytoma | X | 1 | Leukemia Mononuclear | X X X X X X X| 13 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 | Fibrous Histiocytoma | X | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | Leukemia Mononuclear | X X X X X| 9 | Pancreatic, Cholangiocarcinoma, | | | Metastatic, Liver | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + + +| 48 | Fibrous Histiocytoma | X | 1 | Leukemia Mononuclear | X X X X X X X| 12 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Histiocytoma | X | 1 | Leukemia Mononuclear | X X X X X X X X X X| 21 | __________________________________________________________________________|____________| Thymus | + + + + M + + + + M + + M + + + + M M + + + + + +| 43 | Fibrous Histiocytoma | X | 1 | Leukemia Mononuclear | X X | 4 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 15 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 3| 4| 5| 5| 6| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| 6| 6| | DAY ON TEST | 3| 7| 1| 4| 6| 9| 3| 1| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 3| 7| 8| 2| 2| 6| | | 9| 1| 1| 9| 3| 2| 3| 8| 1| 1| 8| 1| 1| 1| 1| 9| 1| 1| 1| 1| 5| 3| 3| 7| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | Adenocarcinoma | | 1 | Adenoma | X | 1 | Fibroadenoma | X X X X X X| 12 | Fibroadenoma, Multiple | X | 2 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Diaphragm, Hepatocellular Carcinoma, | | | Metastatic, Liver | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Astrocytoma Malignant | | 1 | Fibrous Histiocytoma | X | 1 | Leukemia Mononuclear | X X X X X X | 9 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Histiocytoma | X | 1 | Leukemia Mononuclear | X X X X X X X X| 16 | Mediastinum, Fibrous Histiocytoma | X | 1 | Venule, Mediastinum, | | | Cholangiocarcinoma, Metastatic, | | | Liver | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + | 1 | Leukemia Mononuclear | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Histiocytoma | X | 1 | Leukemia Mononuclear | X X X X X X | 11 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 16 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 3| 4| 5| 5| 6| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| 6| 6| | DAY ON TEST | 3| 7| 1| 4| 6| 9| 3| 1| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 3| 7| 8| 2| 2| 6| | | 9| 1| 1| 9| 3| 2| 3| 8| 1| 1| 8| 1| 1| 1| 1| 9| 1| 1| 1| 1| 5| 3| 3| 7| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | 8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | Transitional Epithelium, Papilloma | X | 3 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X| 21 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 17 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 5| 5| 5| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 6| 7| 7| DAY ON TEST | 2| 5| 3| 3| 3| 4| 5| 6| 3| 3| 2| 5| 0| 0| 2| 2| 3| 3| 3| 3| 8| 4| 8| 0| 3| | 7| 4| 2| 2| 2| 1| 7| 1| 2| 2| 1| 5| 2| 3| 9| 9| 2| 2| 2| 2| 8| 9| 8| 8| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma | X X | Cholangiocarcinoma, Multiple | X X X X X X X X X X X X X X X X X X X X X X X| Hepatocellular Adenoma | X | Leukemia Mononuclear | X X X X X X X X X| __________________________________________________________________________| Mesentery | + + + + + | Leukemia Mononuclear | X X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Leukemia Mononuclear | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Tongue | + | Squamous Cell Papilloma | X | __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X X X| Pars Distalis, Leukemia Mononuclear | X X X X X | _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 5| 5| 5| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 6| 7| 7| DAY ON TEST | 2| 5| 3| 3| 3| 4| 5| 6| 3| 3| 2| 5| 0| 0| 2| 2| 3| 3| 3| 3| 8| 4| 8| 0| 3| | 7| 4| 2| 2| 2| 1| 7| 1| 2| 2| 1| 5| 2| 3| 9| 9| 2| 2| 2| 2| 8| 9| 8| 8| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X | Follicular Cell, Adenocarcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X X | Carcinoma | X | Leukemia Mononuclear | X | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Polyp Stromal | X X X X X | Polyp Stromal, Multiple | X | Cervix, Sarcoma | X | __________________________________________________________________________| Vagina | + + | Sarcoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + | Leukemia Mononuclear | X | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Pancreatic, Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + M + M + + M + + + + + + + + + + M + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X| __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + M + + + + + + M + + +| Leukemia Mononuclear | X | Mediastinum, Carcinoma, Metastatic, | | Zymbal's Gland | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 _____________________________________________________________________________________________________________________ | 6| 6| 7| 7| 7| 5| 5| 5| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 6| 7| 7| DAY ON TEST | 2| 5| 3| 3| 3| 4| 5| 6| 3| 3| 2| 5| 0| 0| 2| 2| 3| 3| 3| 3| 8| 4| 8| 0| 3| | 7| 4| 2| 2| 2| 1| 7| 1| 2| 2| 1| 5| 2| 3| 9| 9| 2| 2| 2| 2| 8| 9| 8| 8| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 4 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| Adenocarcinoma | X | Adenoma | X | Fibroadenoma | X X X X X X X X| Fibroadenoma, Multiple | | Leukemia Mononuclear | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Keratoacanthoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Granular Cell Tumor Malignant | | Leukemia Mononuclear | X X X X X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Zymbal's Gland| X | Leukemia Mononuclear | X X X X X X | Mediastinum, Leukemia Mononuclear | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | X | Squamous Cell Papilloma | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | __________________________________________________________________________| Harderian Gland | | __________________________________________________________________________| Lacrimal Gland | + | __________________________________________________________________________| Zymbal's Gland | + | Carcinoma | X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | Sarcoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + M + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X| _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 8| 2| 3| 3| 3| 6| 9| 3| 3| 3| 0| 9| 1| 3| 3| 2| 6| 3| 3| 3| | | 5| 2| 2| 2| 2| 8| 9| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 4| 2| 2| 7| 6| 2| 2| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A | 4 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cholangiocarcinoma | | 2 | Cholangiocarcinoma, Multiple | X X X X X X X X X X X X X X X X X X X X X X X X X| 48 | Hepatocellular Adenoma | X X X | 4 | Leukemia Mononuclear | X X X X X X X X| 17 | __________________________________________________________________________|____________| Mesentery | + + + + | 9 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Tongue | | 1 | Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Tooth | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 7 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X | 11 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 7 | Pheochromocytoma Benign | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 21 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 8| 2| 3| 3| 3| 6| 9| 3| 3| 3| 0| 9| 1| 3| 3| 2| 6| 3| 3| 3| | | 5| 2| 2| 2| 2| 8| 9| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 4| 2| 2| 7| 6| 2| 2| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A | 4 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Islets, Pancreatic | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X| 25 | Pars Distalis, Leukemia Mononuclear | X X | 7 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Adenoma | X X X X | 5 | Follicular Cell, Adenocarcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 5 | Carcinoma | X| 2 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 7 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | Polyp Stromal | X X X X X X X X | 13 | Polyp Stromal, Multiple | | 1 | Cervix, Sarcoma | | 1 | __________________________________________________________________________|____________| Vagina | | 2 | Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + | 2 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 8 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pancreatic, Leukemia Mononuclear | X X | 6 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + M + + + + + M + + M + + + + M + + + + + + + + +| 42 | Leukemia Mononuclear | X X | 6 | __________________________________________________________________________|____________| Lymph Node, Mandibular | M + + + M + + + + + + + + + + + + + + + + + + + +| 47 | Leukemia Mononuclear | X X | 8 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 22 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 8| 2| 3| 3| 3| 6| 9| 3| 3| 3| 0| 9| 1| 3| 3| 2| 6| 3| 3| 3| | | 5| 2| 2| 2| 2| 8| 9| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 4| 2| 2| 7| 6| 2| 2| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A | 4 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Leukemia Mononuclear | X X | 6 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 6 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X| 17 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +| 47 | Leukemia Mononuclear | X | 2 | Mediastinum, Carcinoma, Metastatic, | | | Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenocarcinoma | X X | 3 | Adenoma | X | 2 | Fibroadenoma | X X X X X X X X| 16 | Fibroadenoma, Multiple | X X | 2 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Keratoacanthoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granular Cell Tumor Malignant | X | 1 | Leukemia Mononuclear | X | 7 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Zymbal's Gland| | 1 | Leukemia Mononuclear | X X X X | 10 | Mediastinum, Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Carcinoma | | 1 | Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 23 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 3| 3| 8| 2| 3| 3| 3| 6| 9| 3| 3| 3| 0| 9| 1| 3| 3| 2| 6| 3| 3| 3| | | 5| 2| 2| 2| 2| 8| 9| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 4| 2| 2| 7| 6| 2| 2| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A | 4 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Eye | | 2 | __________________________________________________________________________|____________| Harderian Gland | + | 1 | __________________________________________________________________________|____________| Lacrimal Gland | | 1 | __________________________________________________________________________|____________| Zymbal's Gland | | 1 | Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 9 | Sarcoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X| 17 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 24 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 3| 6| 7| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 7| 3| 3| 3| 3| 4| 3| 8| 9| 3| 6| 3| 3| 3| 3| 6| 6| 2| 3| 3| 1| 3| 3| 3| 3| | 5| 5| 5| 5| 5| 1| 9| 8| 7| 5| 1| 5| 5| 5| 5| 4| 7| 9| 5| 5| 7| 5| 5| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma, Multiple | X X X X X X X X X X X X X X X X X X X X X X X X| Hepatocellular Adenoma | | Hepatocellular Adenoma, Multiple | X | Leukemia Mononuclear | X X X X| __________________________________________________________________________| Mesentery | + + + + + + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Pheochromocytoma Malignant | X | Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X X X | Pars Distalis, Leukemia Mononuclear | X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X | C-Cell, Carcinoma | | Follicular Cell, Adenocarcinoma | | _____________________________________________________________________________________________________________________| Page 25 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 3| 6| 7| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 7| 3| 3| 3| 3| 4| 3| 8| 9| 3| 6| 3| 3| 3| 3| 6| 6| 2| 3| 3| 1| 3| 3| 3| 3| | 5| 5| 5| 5| 5| 1| 9| 8| 7| 5| 1| 5| 5| 5| 5| 4| 7| 9| 5| 5| 7| 5| 5| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + M + + + + + + + + + + + + + + + + M + + + +| Adenoma | X X X X X | Squamous Cell Papilloma | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Malignant | | Leukemia Mononuclear | X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Polyp Stromal | X X X X X | Sarcoma Stromal | X | __________________________________________________________________________| Vagina | + | Sarcoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Axillary, Adenocarcinoma, Metastatic,| | Mammary Gland | | Pancreatic, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + M + + + + + + + + + M + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node, Mandibular | + + M + + + + + + + + + + M + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + M + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| __________________________________________________________________________| Thymus | + + + + + + M + + + + + + M + + + + + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | X X | Adenocarcinoma, Multiple | | Fibroadenoma | X X X X X X X X X | Fibroadenoma, Multiple | X X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | X | Squamous Cell Papilloma | X | _____________________________________________________________________________________________________________________| Page 26 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 3| 6| 7| 7| 7| 6| 7| 7| 7| 7| DAY ON TEST | 7| 3| 3| 3| 3| 4| 3| 8| 9| 3| 6| 3| 3| 3| 3| 6| 6| 2| 3| 3| 1| 3| 3| 3| 3| | 5| 5| 5| 5| 5| 1| 9| 8| 7| 5| 1| 5| 5| 5| 5| 4| 7| 9| 5| 5| 7| 5| 5| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | Rhabdomyosarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Glioma Malignant | X | Leukemia Mononuclear | X X | Oligodendroglioma Malignant | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| Mediastinum, Leukemia Mononuclear | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | Fibrosarcoma | | Pinna, Sarcoma | | __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X| _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 4| 5| 6| 7| 7| 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 7| 7| 5| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 4| 6| 0| 3| 3| 3| 3| 3| 3| 3| | | 8| 5| 9| 5| 5| 6| 2| 9| 5| 5| 3| 5| 5| 5| 5| 2| 5| 3| 5| 5| 5| 5| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A | 2 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cholangiocarcinoma, Multiple | X X X X X X X X X X X X X X X X X X X X X X X X X| 49 | Hepatocellular Adenoma | X | 1 | Hepatocellular Adenoma, Multiple | | 1 | Leukemia Mononuclear | X X X X X | 9 | __________________________________________________________________________|____________| Mesentery | + + + + + + | 12 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 | Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 3 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 6 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X | 6 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Benign | X X X | 3 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + M + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Adenoma | X X X X X X X X X X X X X X X | 26 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 28 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 4| 5| 6| 7| 7| 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 7| 7| 5| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 4| 6| 0| 3| 3| 3| 3| 3| 3| 3| | | 8| 5| 9| 5| 5| 6| 2| 9| 5| 5| 3| 5| 5| 5| 5| 2| 5| 3| 5| 5| 5| 5| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A | 2 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Pars Distalis, Leukemia Mononuclear | X X X | 6 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Adenoma | X X X | 4 | C-Cell, Carcinoma | X | 1 | Follicular Cell, Adenocarcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Adenoma | X X | 7 | Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granulosa Cell Tumor Malignant | X X| 2 | Leukemia Mononuclear | X X X | 5 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | Polyp Stromal | X X X X X X X| 12 | Sarcoma Stromal | | 1 | __________________________________________________________________________|____________| Vagina | | 1 | Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 6 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Axillary, Adenocarcinoma, Metastatic,| | | Mammary Gland | X | 1 | Pancreatic, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | + + + M + M M + + + M + + + + + + + + + + + + + M| 43 | Leukemia Mononuclear | X | 3 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X X | 3 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 4 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 29 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 4| 5| 6| 7| 7| 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 7| 7| 5| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 4| 6| 0| 3| 3| 3| 3| 3| 3| 3| | | 8| 5| 9| 5| 5| 6| 2| 9| 5| 5| 3| 5| 5| 5| 5| 2| 5| 3| 5| 5| 5| 5| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A | 2 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Leukemia Mononuclear | X X X X X | 9 | __________________________________________________________________________|____________| Thymus | + + + + + + M + + + M + + + + + + + + + + + + + +| 46 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenocarcinoma | | 2 | Adenocarcinoma, Multiple | X | 1 | Fibroadenoma | X X X X | 13 | Fibroadenoma, Multiple | X | 4 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibroma | | 1 | Squamous Cell Papilloma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | Rhabdomyosarcoma | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Glioma Malignant | | 1 | Leukemia Mononuclear | X X | 4 | Oligodendroglioma Malignant | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 8 | Mediastinum, Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + + | 2 | Fibrosarcoma | X | 1 | Pinna, Sarcoma | X | 1 | __________________________________________________________________________|____________| Eye | + + | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 30 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 4| 5| 6| 7| 7| 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 7| 7| 5| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 4| 6| 0| 3| 3| 3| 3| 3| 3| 3| | | 8| 5| 9| 5| 5| 6| 2| 9| 5| 5| 3| 5| 5| 5| 5| 2| 5| 3| 5| 5| 5| 5| 5| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| A | 2 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Leukemia Mononuclear | X X X | 5 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X | 9 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 31 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 _____________________________________________________________________________________________________________________ | 1| 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 4| 7| 7| 7| 6| 6| 7| 7| 7| DAY ON TEST | 1| 1| 2| 4| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 8| 0| 3| 3| 3| 1| 1| 1| 3| 3| | 5| 9| 9| 5| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 8| 7| 1| 1| 1| 1| 3| 6| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + M M + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + M + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + A + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + M + + + + + + + + + + + + + A + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + A M + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Adenoma | | Leukemia Mononuclear | X X X X | __________________________________________________________________________| Mesentery | + + | Leukemia Mononuclear | X | Mesothelioma Malignant | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X| Adenoma, Multiple | X X | Leukemia Mononuclear | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + M + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Tongue | | Squamous Cell Papilloma | | __________________________________________________________________________| Tooth | + | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X X | Pheochromocytoma Benign, Multiple | X| _____________________________________________________________________________________________________________________| Page 32 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 _____________________________________________________________________________________________________________________ | 1| 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 4| 7| 7| 7| 6| 6| 7| 7| 7| DAY ON TEST | 1| 1| 2| 4| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 8| 0| 3| 3| 3| 1| 1| 1| 3| 3| | 5| 9| 9| 5| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 8| 7| 1| 1| 1| 1| 3| 6| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Adenoma, Multiple | X | Carcinoma | X | __________________________________________________________________________| Parathyroid Gland | M + + + + + + + + + + + + + + M M + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X | Pars Distalis, Leukemia Mononuclear | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + M M + + + + + + + +| C-Cell, Adenoma | X X | C-Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Squamous Cell Carcinoma | X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | | Leukemia Mononuclear | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Adenoma | X X | Interstitial Cell, Adenoma, Multiple | X X X X X X X X X X X X X X X X X X X| Interstitial Tissue, Adenoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Axillary, Leukemia Mononuclear | | Inguinal, Leukemia Mononuclear | | Pancreatic, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + + + + + + + + M + M + + + + M M M M M +| Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + M + + M + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + A M + M + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 33 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 _____________________________________________________________________________________________________________________ | 1| 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 4| 7| 7| 7| 6| 6| 7| 7| 7| DAY ON TEST | 1| 1| 2| 4| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 8| 0| 3| 3| 3| 1| 1| 1| 3| 3| | 5| 9| 9| 5| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 8| 7| 1| 1| 1| 1| 3| 6| 1| 1| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Leukemia Mononuclear | X X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + M + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M + + + + + M + + + + + + + + + + + + + + + + +| Fibroadenoma | X X | Leukemia Mononuclear | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Adenoma | X | Squamous Cell Papilloma | | Subcutaneous Tissue, Fibrosarcoma | | Subcutaneous Tissue, Lipoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Granular Cell Tumor Benign | X | Leukemia Mononuclear | X | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | Squamous Cell Carcinoma, Metastatic, | | Preputial Gland | X | Mediastinum, Leukemia Mononuclear | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + M M + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 0| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| | DAY ON TEST | 6| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 4| 3| 3| 3| 6| 8| 3| 3| 3| 6| 8| 3| 3| 3| | | 4| 1| 1| 1| 1| 9| 1| 1| 1| 1| 3| 9| 1| 1| 1| 0| 0| 1| 1| 1| 6| 9| 1| 2| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + M + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + M + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Adenoma | X | 1 | Leukemia Mononuclear | X X X X | 8 | __________________________________________________________________________|____________| Mesentery | + + + | 5 | Leukemia Mononuclear | | 1 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X X | 4 | Adenoma, Multiple | | 2 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Tongue | + | 1 | Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Tooth | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 4 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 35 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 0| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| | DAY ON TEST | 6| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 4| 3| 3| 3| 6| 8| 3| 3| 3| 6| 8| 3| 3| 3| | | 4| 1| 1| 1| 1| 9| 1| 1| 1| 1| 3| 9| 1| 1| 1| 0| 0| 1| 1| 1| 6| 9| 1| 2| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | Pheochromocytoma Malignant | | 1 | Pheochromocytoma Benign | X X X X X | 7 | Pheochromocytoma Benign, Multiple | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 3 | Adenoma, Multiple | X X | 3 | Carcinoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 46 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Adenoma | X X X X X | 11 | Pars Distalis, Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | C-Cell, Adenoma | X X X X| 6 | C-Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Preputial Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X | 1 | Squamous Cell Carcinoma | | 1 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Seminal Vesicle | + | 1 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Interstitial Cell, Adenoma | X | 3 | Interstitial Cell, Adenoma, Multiple | X X X X X X X X X X X X X X X X X X X X X X| 41 | Interstitial Tissue, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 4 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Axillary, Leukemia Mononuclear | X | 1 | Inguinal, Leukemia Mononuclear | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 36 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 0| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| | DAY ON TEST | 6| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 4| 3| 3| 3| 6| 8| 3| 3| 3| 6| 8| 3| 3| 3| | | 4| 1| 1| 1| 1| 9| 1| 1| 1| 1| 3| 9| 1| 1| 1| 0| 0| 1| 1| 1| 6| 9| 1| 2| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Pancreatic, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | M + + M M M + + + + + M + + M + + + M + + M + + M| 34 | Leukemia Mononuclear | X X | 4 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X X X | 4 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + + + + + + + + + M + + + + M + + + + + + + + + +| 48 | Leukemia Mononuclear | X X X | 4 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + M +| 46 | Leukemia Mononuclear | X X | 5 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 8 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 | Leukemia Mononuclear | X X X | 4 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Fibroadenoma | X X | 4 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basal Cell Adenoma | | 1 | Squamous Cell Papilloma | X | 1 | Subcutaneous Tissue, Fibrosarcoma | X | 1 | Subcutaneous Tissue, Lipoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granular Cell Tumor Benign | | 1 | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Spinal Cord | + | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 6 | Squamous Cell Carcinoma, Metastatic, | | | Preputial Gland | | 1 | Mediastinum, Leukemia Mononuclear | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 37 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 0| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| | DAY ON TEST | 6| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 4| 3| 3| 3| 6| 8| 3| 3| 3| 6| 8| 3| 3| 3| | | 4| 1| 1| 1| 1| 9| 1| 1| 1| 1| 3| 9| 1| 1| 1| 0| 0| 1| 1| 1| 6| 9| 1| 2| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 4 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 8 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 38 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4| 6| 6| 7| 6| 5| 6| 6| 7| 6| 6| 6| 7| 7| DAY ON TEST | 2| 2| 3| 3| 3| 4| 8| 8| 3| 3| 2| 4| 5| 9| 3| 6| 8| 6| 9| 3| 8| 9| 9| 3| 3| | 9| 9| 0| 0| 0| 5| 6| 8| 0| 0| 1| 8| 6| 5| 0| 5| 3| 7| 5| 0| 8| 5| 6| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 8 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma, Multiple | X X X X X X X X X X X X X X X X X X X X X X X X X| Hepatocellular Carcinoma | X X X X X | Hepatocellular Carcinoma, Multiple | | Hepatocellular Adenoma | X X X X X X X X X X | Hepatocellular Adenoma, Multiple | X X X X | Leukemia Mononuclear | X X X X X X X X X X X X| __________________________________________________________________________| Mesentery | + + + + + | Cholangiocarcinoma, Metastatic, Liver| X | Leukemia Mononuclear | | Mesothelioma Malignant | X | __________________________________________________________________________| Pancreas | + + M + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X | Adenoma, Multiple | | Leukemia Mononuclear | X | Mesothelioma Malignant | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + M + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | Pheochromocytoma Benign | X X X X X| Pheochromocytoma Benign, Multiple | | _____________________________________________________________________________________________________________________| Page 39 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4| 6| 6| 7| 6| 5| 6| 6| 7| 6| 6| 6| 7| 7| DAY ON TEST | 2| 2| 3| 3| 3| 4| 8| 8| 3| 3| 2| 4| 5| 9| 3| 6| 8| 6| 9| 3| 8| 9| 9| 3| 3| | 9| 9| 0| 0| 0| 5| 6| 8| 0| 0| 1| 8| 6| 5| 0| 5| 3| 7| 5| 0| 8| 5| 6| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 8 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Islets, Pancreatic | + + M + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | + M + + + + + + + M + + + M + + + + + + M + + + +| Adenoma | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X| Pars Distalis, Carcinoma | X | Pars Distalis, Leukemia Mononuclear | X X X X X X X X X X | Pars Intermedia, Leukemia Mononuclear| X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Bilateral, Adenoma | | __________________________________________________________________________| Prostate | + + + + + + + M + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant | X | Interstitial Cell, Adenoma | X | Interstitial Cell, Adenoma, Multiple | X X X X X X X X X X X X X X X X X X X X X X X| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Pancreatic, Leukemia Mononuclear | X X X X X | Renal, Leukemia Mononuclear | X | __________________________________________________________________________| Lymph Node, Bronchial | + + + + + M M + M M M M M + + + + M M M M + M + +| Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + M + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + M M + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 40 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4| 6| 6| 7| 6| 5| 6| 6| 7| 6| 6| 6| 7| 7| DAY ON TEST | 2| 2| 3| 3| 3| 4| 8| 8| 3| 3| 2| 4| 5| 9| 3| 6| 8| 6| 9| 3| 8| 9| 9| 3| 3| | 9| 9| 0| 0| 0| 5| 6| 8| 0| 0| 1| 8| 6| 5| 0| 5| 3| 7| 5| 0| 8| 5| 6| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 8 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Leukemia Mononuclear | X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X| Mesothelioma Malignant | X | Sarcoma | X | __________________________________________________________________________| Thymus | + M + + + + M + + + + + + + + + + + M + + + M + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Carcinoma | X | Keratoacanthoma | X | Squamous Cell Papilloma | X | Subcutaneous Tissue, Fibroma | X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Pituitary | | Gland | X | Leukemia Mononuclear | X X X X X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | Mediastinum, Leukemia Mononuclear | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | __________________________________________________________________________| Harderian Gland | | __________________________________________________________________________| Zymbal's Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4| 6| 6| 7| 6| 5| 6| 6| 7| 6| 6| 6| 7| 7| DAY ON TEST | 2| 2| 3| 3| 3| 4| 8| 8| 3| 3| 2| 4| 5| 9| 3| 6| 8| 6| 9| 3| 8| 9| 9| 3| 3| | 9| 9| 0| 0| 0| 5| 6| 8| 0| 0| 1| 8| 6| 5| 0| 5| 3| 7| 5| 0| 8| 5| 6| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 8 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X X X X X| Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| Page 42 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 4| 4| 6| 6| 7| 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 5| 5| 6| 6| 7| 0| 4| 6| 6| 6| | DAY ON TEST | 5| 9| 9| 9| 3| 4| 8| 9| 2| 2| 2| 9| 3| 3| 3| 7| 9| 0| 9| 0| 5| 2| 1| 5| 6| | | 6| 0| 4| 4| 0| 3| 0| 8| 3| 9| 4| 4| 0| 0| 0| 5| 1| 9| 5| 7| 2| 1| 7| 5| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cholangiocarcinoma, Multiple | X X X X X X X X X X X X X X X X X X X X X X X X| 49 | Hepatocellular Carcinoma | X X X X X X X X X X X X| 17 | Hepatocellular Carcinoma, Multiple | X | 1 | Hepatocellular Adenoma | X X X X X X X | 17 | Hepatocellular Adenoma, Multiple | X X X X X X| 10 | Leukemia Mononuclear | X X X X X X X X X| 21 | __________________________________________________________________________|____________| Mesentery | + + + + + + + + + | 14 | Cholangiocarcinoma, Metastatic, Liver| X | 2 | Leukemia Mononuclear | X X X X | 4 | Mesothelioma Malignant | X X | 3 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X | 4 | Adenoma, Multiple | X X | 2 | Leukemia Mononuclear | X | 2 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________|____________| Salivary Glands | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X| 9 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 43 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 4| 4| 6| 6| 7| 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 5| 5| 6| 6| 7| 0| 4| 6| 6| 6| | DAY ON TEST | 5| 9| 9| 9| 3| 4| 8| 9| 2| 2| 2| 9| 3| 3| 3| 7| 9| 0| 9| 0| 5| 2| 1| 5| 6| | | 6| 0| 4| 4| 0| 3| 0| 8| 3| 9| 4| 4| 0| 0| 0| 5| 1| 9| 5| 7| 2| 1| 7| 5| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X | 9 | Pheochromocytoma Benign | X X X | 8 | Pheochromocytoma Benign, Multiple | X X | 2 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Adenoma | X | 1 | __________________________________________________________________________|____________| Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + M + M| 43 | Adenoma | X | 1 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Adenoma | X X X X X| 11 | Pars Distalis, Carcinoma | | 1 | Pars Distalis, Leukemia Mononuclear | X X X X X X| 16 | Pars Intermedia, Leukemia Mononuclear| | 1 | __________________________________________________________________________|____________| Thyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 48 | C-Cell, Adenoma | X | 4 | Follicular Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | X X | 3 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Adenoma | X | 3 | Bilateral, Adenoma | X | 1 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Seminal Vesicle | + | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | Mesothelioma Malignant | X X | 3 | Interstitial Cell, Adenoma | X | 2 | Interstitial Cell, Adenoma, Multiple | X X X X X X X X X X X X X X X X X X X X | 43 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + | 1 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X| 14 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 44 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 4| 4| 6| 6| 7| 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 5| 5| 6| 6| 7| 0| 4| 6| 6| 6| | DAY ON TEST | 5| 9| 9| 9| 3| 4| 8| 9| 2| 2| 2| 9| 3| 3| 3| 7| 9| 0| 9| 0| 5| 2| 1| 5| 6| | | 6| 0| 4| 4| 0| 3| 0| 8| 3| 9| 4| 4| 0| 0| 0| 5| 1| 9| 5| 7| 2| 1| 7| 5| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pancreatic, Leukemia Mononuclear | X X X X X X X| 12 | Renal, Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Lymph Node, Bronchial | M M + + M + + M M + + + + M + + M + + M M M M + +| 27 | Leukemia Mononuclear | X X X | 3 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + M + +| 48 | Leukemia Mononuclear | X X X X X X X X X| 14 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | + M + + + + + + + + + + + + + + + + + + M + + + M| 45 | Leukemia Mononuclear | X X X X X X | 11 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X X X X X| 11 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X| 25 | Mesothelioma Malignant | X | 2 | Sarcoma | X | 2 | __________________________________________________________________________|____________| Thymus | M + + + + M + + + + + + + + + + + + M + + + + + M| 42 | Leukemia Mononuclear | X X X | 6 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibroadenoma | | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basal Cell Carcinoma | | 1 | Keratoacanthoma | X | 2 | Squamous Cell Papilloma | | 1 | Subcutaneous Tissue, Fibroma | X | 3 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | Mesothelioma Malignant | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Pituitary | | | Gland | | 1 | Leukemia Mononuclear | X X X| 9 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 45 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 4| 4| 6| 6| 7| 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 5| 5| 6| 6| 7| 0| 4| 6| 6| 6| | DAY ON TEST | 5| 9| 9| 9| 3| 4| 8| 9| 2| 2| 2| 9| 3| 3| 3| 7| 9| 0| 9| 0| 5| 2| 1| 5| 6| | | 6| 0| 4| 4| 0| 3| 0| 8| 3| 9| 4| 4| 0| 0| 0| 5| 1| 9| 5| 7| 2| 1| 7| 5| 6| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | 8 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X| 17 | Mediastinum, Leukemia Mononuclear | X | 2 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | __________________________________________________________________________|____________| Harderian Gland | + | 1 | __________________________________________________________________________|____________| Zymbal's Gland | +| 1 | Carcinoma | X| 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X | 5 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X X X X X| 25 | Mesothelioma Malignant | X X | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 46 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 6| 7| 7| 7| 0| 6| 6| 6| 7| 0| 3| 6| 7| 7| DAY ON TEST | 3| 0| 3| 3| 3| 5| 2| 2| 2| 3| 5| 8| 0| 3| 3| 7| 3| 3| 8| 3| 4| 9| 1| 3| 3| | 9| 3| 0| 0| 0| 6| 7| 5| 9| 0| 4| 8| 7| 0| 0| 0| 3| 4| 8| 0| 6| 4| 8| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + M + + + + + + + + M + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma, Multiple | X X X X X X X X X X X X X X X X X X X X X X X| Hepatocellular Carcinoma | X X X| Hepatocellular Adenoma | X X X X X X X X | Hepatocellular Adenoma, Multiple | X| Leukemia Mononuclear | X X X X X X X X X | __________________________________________________________________________| Mesentery | + + + + + | Mesothelioma Malignant | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | | Adenoma | X X X X X | Adenoma, Multiple | | Leukemia Mononuclear | X X | Mesothelioma Malignant | X | __________________________________________________________________________| Pharynx | + | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | | __________________________________________________________________________| Tongue | | __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Adrenal Gland, Medulla | + M + M + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | _____________________________________________________________________________________________________________________| Page 47 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 6| 7| 7| 7| 0| 6| 6| 6| 7| 0| 3| 6| 7| 7| DAY ON TEST | 3| 0| 3| 3| 3| 5| 2| 2| 2| 3| 5| 8| 0| 3| 3| 7| 3| 3| 8| 3| 4| 9| 1| 3| 3| | 9| 3| 0| 0| 0| 6| 7| 5| 9| 0| 4| 8| 7| 0| 0| 0| 3| 4| 8| 0| 6| 4| 8| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Pheochromocytoma Malignant | X | Pheochromocytoma Benign | X X X X | Pheochromocytoma Benign, Multiple | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| Pars Distalis, Adenoma | X X X X X X X X X | Pars Distalis, Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | | C-Cell, Carcinoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + M M + +| Adenoma | X X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Seminal Vesicle | + + | Mesothelioma Malignant | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant | X X | Interstitial Cell, Adenoma | | Interstitial Cell, Adenoma, Multiple | X X X X X X X X X X X X X X X X X X| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + | Leukemia Mononuclear | X | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Iliac, Leukemia Mononuclear | | Pancreatic, Leukemia Mononuclear | X X X X X | Renal, Leukemia Mononuclear | | __________________________________________________________________________| Lymph Node, Bronchial | + + M + M M + M + M M + + + + + + + + M M + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | _____________________________________________________________________________________________________________________| Page 48 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 6| 7| 7| 7| 0| 6| 6| 6| 7| 0| 3| 6| 7| 7| DAY ON TEST | 3| 0| 3| 3| 3| 5| 2| 2| 2| 3| 5| 8| 0| 3| 3| 7| 3| 3| 8| 3| 4| 9| 1| 3| 3| | 9| 3| 0| 0| 0| 6| 7| 5| 9| 0| 4| 8| 7| 0| 0| 0| 3| 4| 8| 0| 6| 4| 8| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | Mesothelioma Malignant, Metastatic, | | Mesentery | | __________________________________________________________________________| Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | Mesothelioma Malignant | X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroadenoma | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibroma | X | Keratoacanthoma | X | Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Fibrosarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Glioma Malignant | X | Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Carcinoma | X | Leukemia Mononuclear | X X X X X X X | Pheochromocytoma Malignant, | | Metastatic, Adrenal Gland | | Mediastinum, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | X | Mediastinum, Leukemia Mononuclear | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | | Nasolacrimal Duct, Squamous Cell | | Carcinoma | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | _____________________________________________________________________________________________________________________| Page 49 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 6| 7| 7| 7| 0| 6| 6| 6| 7| 0| 3| 6| 7| 7| DAY ON TEST | 3| 0| 3| 3| 3| 5| 2| 2| 2| 3| 5| 8| 0| 3| 3| 7| 3| 3| 8| 3| 4| 9| 1| 3| 3| | 9| 3| 0| 0| 0| 6| 7| 5| 9| 0| 4| 8| 7| 0| 0| 0| 3| 4| 8| 0| 6| 4| 8| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Zymbal's Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X X | Mesothelioma Malignant | X X | _____________________________________________________________________________________________________________________| Page 50 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 5| 6| 7| 7| | DAY ON TEST | 2| 3| 3| 3| 3| 4| 7| 1| 3| 3| 6| 2| 3| 3| 3| 8| 3| 3| 3| 3| 1| 2| 1| 3| 3| | | 7| 0| 0| 0| 0| 1| 8| 3| 2| 2| 5| 9| 2| 2| 2| 9| 2| 2| 2| 2| 0| 0| 8| 2| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 4 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cholangiocarcinoma, Multiple | X X X X X X X X X X X X X X X X X X X X X X X X X| 48 | Hepatocellular Carcinoma | X X X | 6 | Hepatocellular Adenoma | X X X X X X X X| 16 | Hepatocellular Adenoma, Multiple | X | 2 | Leukemia Mononuclear | X X X X X X X | 16 | __________________________________________________________________________|____________| Mesentery | + + + + + + + | 12 | Mesothelioma Malignant | X | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenocarcinoma | X | 1 | Adenoma | X X X X | 9 | Adenoma, Multiple | X | 1 | Leukemia Mononuclear | | 2 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Pharynx | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 3 | Mesothelioma Malignant | X | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________|____________| Tongue | + + | 2 | __________________________________________________________________________|____________| Tooth | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X | 11 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 51 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 5| 6| 7| 7| | DAY ON TEST | 2| 3| 3| 3| 3| 4| 7| 1| 3| 3| 6| 2| 3| 3| 3| 8| 3| 3| 3| 3| 1| 2| 1| 3| 3| | | 7| 0| 0| 0| 0| 1| 8| 3| 2| 2| 5| 9| 2| 2| 2| 9| 2| 2| 2| 2| 0| 0| 8| 2| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 4 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X | 12 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Leukemia Mononuclear | X X X | 10 | Pheochromocytoma Malignant | X X | 3 | Pheochromocytoma Benign | X X X X | 8 | Pheochromocytoma Benign, Multiple | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Pars Distalis, Adenoma | X X X X X X X X | 17 | Pars Distalis, Leukemia Mononuclear | X X X X X X X | 12 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Adenoma | X | 1 | C-Cell, Carcinoma | | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | X | 2 | __________________________________________________________________________|____________| Preputial Gland | + + M + + + + + + + + + + + + + + + M + + + + + +| 46 | Adenoma | X X | 4 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + | 4 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 2 | Mesothelioma Malignant | X | 3 | Interstitial Cell, Adenoma | X | 1 | Interstitial Cell, Adenoma, Multiple | X X X X X X X X X X X X X X X X X X X X X| 39 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | | 1 | Leukemia Mononuclear | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 52 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 5| 6| 7| 7| | DAY ON TEST | 2| 3| 3| 3| 3| 4| 7| 1| 3| 3| 6| 2| 3| 3| 3| 8| 3| 3| 3| 3| 1| 2| 1| 3| 3| | | 7| 0| 0| 0| 0| 1| 8| 3| 2| 2| 5| 9| 2| 2| 2| 9| 2| 2| 2| 2| 0| 0| 8| 2| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 4 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X | 13 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Iliac, Leukemia Mononuclear | X | 1 | Pancreatic, Leukemia Mononuclear | X X | 7 | Renal, Leukemia Mononuclear | X | 1 | __________________________________________________________________________|____________| Lymph Node, Bronchial | M + M M + M + + + + + + + + + + + M + + M M + + +| 35 | Leukemia Mononuclear | X X X X | 9 | __________________________________________________________________________|____________| Lymph Node, Mandibular | M + + + + + + + + + + + + + + + + + + + + + M + +| 48 | Leukemia Mononuclear | X X X X | 12 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | M + + + + + + + + + + + + + + + + + + + M + + + +| 48 | Leukemia Mononuclear | X X X | 11 | Mesothelioma Malignant, Metastatic, | | | Mesentery | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | X X X | 11 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X | 17 | Mesothelioma Malignant | X | 2 | __________________________________________________________________________|____________| Thymus | M + + + + M + + + + + + + + + + M + + + + + + + +| 46 | Leukemia Mononuclear | X | 4 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibroadenoma | X | 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibroma | | 1 | Keratoacanthoma | X X X X | 5 | Subcutaneous Tissue, Fibroma | X X X | 4 | Subcutaneous Tissue, Fibrosarcoma | X | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Glioma Malignant | | 1 | Leukemia Mononuclear | X X X X X | 9 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 53 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 5| 6| 7| 7| | DAY ON TEST | 2| 3| 3| 3| 3| 4| 7| 1| 3| 3| 6| 2| 3| 3| 3| 8| 3| 3| 3| 3| 1| 2| 1| 3| 3| | | 7| 0| 0| 0| 0| 1| 8| 3| 2| 2| 5| 9| 2| 2| 2| 9| 2| 2| 2| 2| 0| 0| 8| 2| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | 4 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Carcinoma | X | 2 | Leukemia Mononuclear | X X X X X X | 13 | Pheochromocytoma Malignant, | | | Metastatic, Adrenal Gland | X | 1 | Mediastinum, Alveolar/Bronchiolar | | | Carcinoma, Metastatic, Lung | | 1 | Mediastinum, Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X | 1 | Nasolacrimal Duct, Squamous Cell | | | Carcinoma | X | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | __________________________________________________________________________|____________| Zymbal's Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X | 12 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X X X X X X | 17 | Mesothelioma Malignant | X | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 54 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 _____________________________________________________________________________________________________________________ | 5| 6| 6| 7| 7| 0| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 7| 7| DAY ON TEST | 2| 6| 6| 2| 2| 2| 3| 2| 2| 2| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 6| 8| 3| 3| | 5| 0| 8| 9| 9| 5| 9| 9| 9| 9| 0| 2| 2| 2| 2| 4| 2| 2| 5| 5| 4| 0| 7| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Cholangiocarcinoma, Multiple | X X X X X X X X X X X X X X X X X X X X X X X| Hepatocellular Carcinoma | X | Hepatocellular Adenoma | X X | Hepatocellular Adenoma, Multiple | X | Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Mesentery | + + + + + + + | Leukemia Mononuclear | X X X | Mesothelioma Malignant | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X X X | Adenoma, Multiple | X | Leukemia Mononuclear | X | Mixed Tumor Benign | | __________________________________________________________________________| Pharynx | | Squamous Cell Papilloma | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Tooth | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | Leukemia Mononuclear | X X X X | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + M + + + + + + + + + + + + + + M + + + +| _____________________________________________________________________________________________________________________| Page 55 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 _____________________________________________________________________________________________________________________ | 5| 6| 6| 7| 7| 0| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 7| 7| DAY ON TEST | 2| 6| 6| 2| 2| 2| 3| 2| 2| 2| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 6| 8| 3| 3| | 5| 0| 8| 9| 9| 5| 9| 9| 9| 9| 0| 2| 2| 2| 2| 4| 2| 2| 5| 5| 4| 0| 7| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Leukemia Mononuclear | X X X | Pheochromocytoma Benign | X X X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X X X X| Pars Distalis, Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Adenoma | X X X X | C-Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Carcinoma | X X X| Leukemia Mononuclear | X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | Mesothelioma Malignant | X | Interstitial Cell, Adenoma | | Interstitial Cell, Adenoma, Multiple | X X X X X X X X X X X X X X X X X X X| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Inguinal, Leukemia Mononuclear | X | Pancreatic, Leukemia Mononuclear | X X | __________________________________________________________________________| Lymph Node, Bronchial | M + + + + + + + + + + + + + + + + + + + + M + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + M + + + + + + M + + + + + M M + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Lymph Node, Mediastinal | + + + + + M M + + + + + + + + + + + + + + M + + +| Leukemia Mononuclear | X X X X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 56 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 _____________________________________________________________________________________________________________________ | 5| 6| 6| 7| 7| 0| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 7| 7| DAY ON TEST | 2| 6| 6| 2| 2| 2| 3| 2| 2| 2| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 6| 8| 3| 3| | 5| 0| 8| 9| 9| 5| 9| 9| 9| 9| 0| 2| 2| 2| 2| 4| 2| 2| 5| 5| 4| 0| 7| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Leukemia Mononuclear | X X X X X X X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X | Mediastinum, Schwannoma Malignant | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenocarcinoma | X | Fibroadenoma | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Basal Cell Carcinoma | X | Keratoacanthoma | X X | Squamous Cell Carcinoma | X | Squamous Cell Papilloma | X | Subcutaneous Tissue, Fibroma | X X | Subcutaneous Tissue, Fibrous | | Histiocytoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X X X | Mediastinum, Leukemia Mononuclear | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Leukemia Mononuclear | X X X X X X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 57 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 _____________________________________________________________________________________________________________________ | 5| 6| 6| 7| 7| 0| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 7| 7| DAY ON TEST | 2| 6| 6| 2| 2| 2| 3| 2| 2| 2| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 6| 8| 3| 3| | 5| 0| 8| 9| 9| 5| 9| 9| 9| 9| 0| 2| 2| 2| 2| 4| 2| 2| 5| 5| 4| 0| 7| 5| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2 MG/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS - cont | | | | Leukemia Mononuclear | X X X X X X X X | Mesothelioma Malignant | X | _____________________________________________________________________________________________________________________| Page 58 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 5| 6| 6| 0| 0| 6| 7| 7| | DAY ON TEST | 6| 0| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 3| 3| 2| 6| 8| 2| 8| 2| 8| 0| 3| 3| | | 0| 2| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 5| 5| 1| 0| 7| 9| 0| 9| 5| 2| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 2 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A M + +| 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + + +| 49 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cholangiocarcinoma, Multiple | X X X X X X X X X X X X X X X X X X X X| 43 | Hepatocellular Carcinoma | | 1 | Hepatocellular Adenoma | X | 3 | Hepatocellular Adenoma, Multiple | | 1 | Leukemia Mononuclear | X X X | 11 | __________________________________________________________________________|____________| Mesentery | + + + + +| 12 | Leukemia Mononuclear | | 3 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X | 6 | Adenoma, Multiple | X X | 3 | Leukemia Mononuclear | | 1 | Mixed Tumor Benign | X | 1 | __________________________________________________________________________|____________| Pharynx | + | 1 | Squamous Cell Papilloma | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Tooth | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + | 1 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 4 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 59 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 5| 6| 6| 0| 0| 6| 7| 7| | DAY ON TEST | 6| 0| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 3| 3| 2| 6| 8| 2| 8| 2| 8| 0| 3| 3| | | 0| 2| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 5| 5| 1| 0| 7| 9| 0| 9| 5| 2| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 2 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 1 | Leukemia Mononuclear | X | 5 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +| 47 | Leukemia Mononuclear | X | 4 | Pheochromocytoma Benign | X | 4 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X X | 2 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + M| 47 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Adenoma | X X X X X | 11 | Pars Distalis, Leukemia Mononuclear | X | 6 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Adenoma | X X | 6 | C-Cell, Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenoma | X | 2 | Carcinoma | X | 4 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | Mesothelioma Malignant | | 1 | Interstitial Cell, Adenoma | X X | 2 | Interstitial Cell, Adenoma, Multiple | X X X X X X X X X X X X X X X X X| 36 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 5 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inguinal, Leukemia Mononuclear | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 60 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 5| 6| 6| 0| 0| 6| 7| 7| | DAY ON TEST | 6| 0| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 3| 3| 2| 6| 8| 2| 8| 2| 8| 0| 3| 3| | | 0| 2| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 5| 5| 1| 0| 7| 9| 0| 9| 5| 2| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 2 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Pancreatic, Leukemia Mononuclear | | 2 | __________________________________________________________________________|____________| Lymph Node, Bronchial | M + + + M M + + + + M M + + + + + + + + + M M M +| 40 | Leukemia Mononuclear | | 3 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + + +| 45 | Leukemia Mononuclear | | 3 | __________________________________________________________________________|____________| Lymph Node, Mediastinal | M + + + + M + + + + + + + + + + + + + + + + + + +| 45 | Leukemia Mononuclear | | 5 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 3 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 11 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 | Leukemia Mononuclear | | 2 | Mediastinum, Schwannoma Malignant | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Adenocarcinoma | | 1 | Fibroadenoma | X X | 3 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basal Cell Carcinoma | | 1 | Keratoacanthoma | X | 3 | Squamous Cell Carcinoma | | 1 | Squamous Cell Papilloma | X | 2 | Subcutaneous Tissue, Fibroma | X | 3 | Subcutaneous Tissue, Fibrous | | | Histiocytoma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 3 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X | 10 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 61 NTP Experiment-Test: 05004-03 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC FURAN Date: 04/10/97 Route: GAVAGE Time: 07:23:47 __________________________________________________________________________________________________________________________________ | 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 5| 6| 6| 0| 0| 6| 7| 7| | DAY ON TEST | 6| 0| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 3| 3| 2| 6| 8| 2| 8| 2| 8| 0| 3| 3| | | 0| 2| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 5| 5| 1| 0| 7| 9| 0| 9| 5| 2| 5| 5| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | 2 MG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Mediastinum, Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 1 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + + | 3 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | | 6 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mesothelioma Malignant | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Leukemia Mononuclear | X X X | 11 | Mesothelioma Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 62 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------ --multipart-boundary Content-type: text/plain Range: bytes 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Web page last updated on October 03, 2004
The National Institute of Environmental Health Sciences is one of the National Institutes of Health within the U.S. Department of Health and Human Services. The National Toxicology Program is headquartered on the NIEHS campus in Research Triangle Park, NC.