![Study Results & Research Projects Study Results & Research Projects](https://webarchive.library.unt.edu/eot2008/20090511061100im_/http://ntp-server.niehs.nih.gov/images/template/subMastHead_studyResults.gif)
Pathology Tables for Peer Review
Pathology Tables for Peer Review
Home » Study Results & Research Projects » Pathology Tables for Peer Review » The National Toxicology Program
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: Southern Research Inst DATE: 09/03/94 EXP: 05004 FURAN TIME: 03:04:09 TEST: 04 CAGES FROM 0000 TO LAST CAGE PAGE: 1 TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 56202 CONT: NO1CP9565101 CAS: 110-00-9 PATHOLOGIST: D. FARNELL S. EUSTIS -------------------------------------------------------------------------------- REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE ALL NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: Southern Research Inst DATE: 09/03/94 EXP: 05004 FURAN TIME: 03:04:09 TEST: 04 CAGES FROM 0000 TO LAST CAGE TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 56202 CONT: NO1CP9565101 CAS: 110-00-9 PATHOLOGIST: D. FARNELL S. EUSTIS FURAN STATISTICAL ANALYSIS OF SURVIVAL DATA MALE MICE FIRST TERMINAL SACRIFICE AT 736 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = VEHICLE CONTROL | | ---------------------------- | | | | TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 | | | | UNCENSORED DEATHS | | 499 514 542 550 638 660 676 697 697 704 | | 715 715 723 723 723 726 726 | | CENSORED DEATHS | | NONE | | | |--------------------------------------------------------------------------------| | DOSE = 8. MG/KG | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 30 CENSORED DEATHS 3 TERMINAL 17 | | | | UNCENSORED DEATHS | | 444 444 508 549 556 557 584 600 612 642 | | 663 690 697 698 701 704 718 719 719 719 | | 723 723 724 725 725 731 733 733 733 733 | | CENSORED DEATHS | | 16 21 250 | | | |--------------------------------------------------------------------------------| | DOSE = 15. MG/KG | | ---------------------------- | | | | TOTAL 49 UNCENSORED DEATHS 33 CENSORED DEATHS 0 TERMINAL 16 | | | | UNCENSORED DEATHS | | 423 498 556 556 577 595 610 612 621 621 | | 641 642 649 663 689 691 716 718 718 718 | | 718 722 723 724 724 724 725 725 726 731 | | 731 731 733 | | CENSORED DEATHS | | NONE | | | ================================================================================== FURAN STATISTICAL ANALYSIS OF SURVIVAL DATA MALE MICE FIRST TERMINAL SACRIFICE AT 736 DAYS ================================================================================== | KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) | | | |--------------------------------------------------------------------------------| | DOSE TIME (DAYS) | | 90 180 270 365 425 485 545 605 665 736 (A) | | | |--------------------------------------------------------------------------------| | | | |VEHICLE | 100.0 100.0 100.0 100.0 100.0 100.0 94.0 92.0 88.0 66.0 | |CONTROL | | | | | |8. MG/KG | 100.0 100.0 100.0 100.0 100.0 95.7 93.6 83.0 76.6 36.2 | | | | | | | |15. | 100.0 100.0 100.0 100.0 98.0 98.0 95.9 87.8 71.4 32.7 | |MG/KG | | | | | ================================================================================== ================================================================================== | SURVIVAL SUMMARY STATISTICS | | | | | |--------------------------------------------------------------------------------| | DOSE | | | | VEHICLE 8. MG/KG 15. | | CONTROL MG/KG | |--------------------------------------------------------------------------------| |SURVIVAL AT END OF STUDY| 66.0% 36.2% 32.7% | |(KAPLAN-MEIER) | | | | | |SIGNIFICANCE (B) | P=0.002 P=0.009 P=0.003 | |(LIFE TABLE) | | | | | |MEAN DAY OF | 660.5 660.2 665.2 | |NATURAL DEATHS (C) | (19.7) (16.3) (13.6) | |(STANDARD ERROR) | | | | | |MEAN LIFE SPAN (D) | 710.3 652.1 688.3 | |(STANDARD ERROR) | ( 8.3) (23.2) (10.3) | | | | ================================================================================== (A) FIRST TERMINAL SACRIFICE (B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT. SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS (COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N". (C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE (D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE) FURAN STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE MICE FIRST TERMINAL SACRIFICE AT 736 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = VEHICLE CONTROL | | ---------------------------- | | | | TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 | | | | UNCENSORED DEATHS | | 414 430 485 494 534 557 557 623 642 646 | | 680 680 690 695 698 709 713 718 724 724 | | 725 | | CENSORED DEATHS | | NONE | | | |--------------------------------------------------------------------------------| | DOSE = 8. MG/KG | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 25 CENSORED DEATHS 0 TERMINAL 25 | | | | UNCENSORED DEATHS | | 330 446 479 499 592 627 638 642 642 646 | | 673 686 688 695 701 702 703 715 716 717 | | 721 724 725 728 733 | | CENSORED DEATHS | | NONE | | | |--------------------------------------------------------------------------------| | DOSE = 15. MG/KG | | ---------------------------- | | | | TOTAL 49 UNCENSORED DEATHS 46 CENSORED DEATHS 1 TERMINAL 2 | | | | UNCENSORED DEATHS | | 360 456 475 513 514 517 540 541 542 549 | | 562 570 577 586 586 601 621 621 632 642 | | 652 652 659 659 676 685 695 701 701 709 | | 712 715 716 716 717 717 717 717 719 719 | | 723 724 724 725 731 733 | | CENSORED DEATHS | | 625 | | | ================================================================================== FURAN STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE MICE FIRST TERMINAL SACRIFICE AT 736 DAYS ================================================================================== | KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) | | | |--------------------------------------------------------------------------------| | DOSE TIME (DAYS) | | 90 180 270 365 425 485 545 605 665 736 (A) | | | |--------------------------------------------------------------------------------| | | | |VEHICLE | 100.0 100.0 100.0 100.0 98.0 94.0 90.0 86.0 80.0 58.0 | |CONTROL | | | | | |8. MG/KG | 100.0 100.0 100.0 98.0 98.0 94.0 92.0 90.0 80.0 50.0 | | | | | | | |15. | 100.0 100.0 100.0 98.0 98.0 93.9 81.6 67.3 50.6 4.2 | |MG/KG | | | | | ================================================================================== ================================================================================== | SURVIVAL SUMMARY STATISTICS | | | | | |--------------------------------------------------------------------------------| | DOSE | | | | VEHICLE 8. MG/KG 15. | | CONTROL MG/KG | |--------------------------------------------------------------------------------| |SURVIVAL AT END OF STUDY| 58.0% 50.0% 4.2% | |(KAPLAN-MEIER) | | | | | |SIGNIFICANCE (B) | P<0.001 P=0.622 P<0.001 | |(LIFE TABLE) | | | | | |MEAN DAY OF | 625.6 646.7 637.4 | |NATURAL DEATHS (C) | (22.4) (20.6) (13.4) | |(STANDARD ERROR) | | | | | |MEAN LIFE SPAN (D) | 689.6 691.4 641.1 | |(STANDARD ERROR) | (12.1) (12.0) (12.9) | | | | ================================================================================== (A) FIRST TERMINAL SACRIFICE (B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT. SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS (COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N". (C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE (D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE) FURAN KAPLAN-MEIER SURVIVAL CURVES VEHICLE CONTROL = 1 8. MG/KG = 2 15. MG/KG = 3 ------------------------------------------------------ SPECIES=MICE SEX=MALE ------------------------------------------------------- Plot of SURVIVAL*WEEK. Symbol is value of DOSE. | | 100 + 1 3 2 1 | 3 1 1 | 2 321 113 | 2 12 3 1 90 + 3 3 1 1 | 2 2 3 3 1 1 P | 2 2 1 1 E | 2 23 11 R 80 + 23 2 1 1 C | 2 2 2 E | 33 22 11 N | 3 3 3 T 70 + 22 | 3 3 S | 2 21 1 U | R 60 + V | 22 I | V | A 50 + L | 2 2 | | 40 + 3 3 | | 22 | 33 30 + | --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-- 0 10 20 30 40 50 60 70 80 90 100 110 WEEK NOTE: 13 obs hidden. FURAN KAPLAN-MEIER SURVIVAL CURVES VEHICLE CONTROL = 1 8. MG/KG = 2 15. MG/KG = 3 ----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------ Plot of SURVIVAL*WEEK. Symbol is value of DOSE. | | 100 + 1 2 3 1 | 2 3 1 1 2 3 | 1 2 3 32112 3 | 12 1 2 90 + 1 1 2 2 | 3 3 2 2 | 1 1 1 | 33 11 80 + 3 3 1 21 | 33 22 | 33 111 | 33 22 P 70 + 3 3 1 1 E | 3 3 R | 2111 C | 3 3 E 60 + 33 3 N | 21 1 T | 3 3 | 2 2 S 50 + 3 3 22 U | 33 3 R | 33 V | I 40 + 33 V | A | 33 L | 30 + | | | 20 + | 33 | | 10 + | 3 3 | 33 | 0 + | --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-- 0 10 20 30 40 50 60 70 80 90 100 110 WEEK NOTE: 19 obs hidden. --multipart-boundary Content-type: text/plain Range: bytes 26129-26129/26129 --multipart-boundary--
Web page last updated on October 03, 2004
The National Institute of Environmental Health Sciences is one of the National Institutes of Health within the U.S. Department of Health and Human Services. The National Toxicology Program is headquartered on the NIEHS campus in Research Triangle Park, NC.