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Pathology Tables for Peer Review
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NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08 LAB: Southern Research Inst FURAN DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 TIME: 03:04:04 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1 CONT: NO1CP9565101 ROUTE: GAVAGE NTP C#: 56202 PATHOLOGIST: D. FARNELL S. EUSTIS CAS: 110-00-9 ------------------------------------------------------------------------------------------------------------------------------------ REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE ALL NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08 LAB: Southern Research Inst FURAN DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 TIME: 03:04:04 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE CONT: NO1CP9565101 ROUTE: GAVAGE NTP C#: 56202 PATHOLOGIST: D. FARNELL S. EUSTIS CAS: 110-00-9 MICE(B6C3F1) ---------------------------- FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED. IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED. ---------------- Adrenal Gland Bone Marrow Brain Clitoral Gland Epididymis Gallbladder Heart Islets, Pancreatic Kidney Liver Lung Nose Ovary Pancreas Parathyroid Gland Pituitary Gland Preputial Gland Prostate Salivary Glands Spleen Testes Thymus Thyroid Gland Urinary Bladder NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08 LAB: Southern Research Inst FURAN DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 TIME: 03:04:04 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE CONT: NO1CP9565101 ROUTE: GAVAGE NTP C#: 56202 PATHOLOGIST: D. FARNELL S. EUSTIS CAS: 110-00-9 SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS IN THE ANALYSIS OF THE STUDY OF FURAN ==================================================================================================== MALE MICE ------------- ORGAN MORPHOLOGY ------- ------------ Adrenal Cortex Adenoma Adrenal Medulla Pheochromocytoma Benign Liver Hepatocellular Adenoma Hepatocellular Carcinoma Hepatocellular Carcinoma or Hepatoblastoma Hepatocellular Carcinoma or Hepatocellular Adenoma Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma Lung Alveolar/Bronchiolar Adenoma Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma Skin: Subcutaneous Tissue Fibroma Neurofibrosarcoma, Fibrosarcoma, or Sarcoma Spleen Hemangiosarcoma Stomach, Forestomach Squamous Cell Papilloma All Organs Malignant Lymphoma And Histiocytic Sarcoma Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated Cell Type Benign Tumors Malignant Tumors Malignant and Benign Tumors ==================================================================================================== NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08 LAB: Southern Research Inst FURAN DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 TIME: 03:04:04 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE CONT: NO1CP9565101 ROUTE: GAVAGE NTP C#: 56202 PATHOLOGIST: D. FARNELL S. EUSTIS CAS: 110-00-9 SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS IN THE ANALYSIS OF THE STUDY OF FURAN ==================================================================================================== FEMALE MICE ------------- ORGAN MORPHOLOGY ------- ------------ Adrenal Medulla Pheochromocytoma Benign Liver Hepatocellular Adenoma Hepatocellular Carcinoma Hepatocellular Carcinoma or Hepatoblastoma Hepatocellular Carcinoma or Hepatocellular Adenoma Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma Mammary Gland Carcinoma Pituitary Gland: Pars Distalis or Unspecified Site Adenoma Carcinoma or Adenoma Stomach, Forestomach Squamous Cell Papilloma All Organs Malignant Lymphoma And Histiocytic Sarcoma Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated Cell Type Benign Tumors Malignant Tumors Malignant and Benign Tumors ==================================================================================================== DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 1 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. | | | CONTROL MG/KG | CONTROL MG/KG | |=================================================================================================================================| | | |Adrenal Cortex | | Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 6/50 (12%) 3/50 (6%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) | |ADJUSTED (b) | 17.0% 13.2% 0.0% | 0.0% 0.0% 4.8% | |TERMINAL (d) | 5/33 (15%) 1/17 (6%) 0/16 (0%) | 0/29 (0%) 0/25 (0%) 0/2 (0%) | |FIRST INCIDENCE (DAYS) | 550 719 --- | --- --- 701 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.068N P=0.540N P=0.072N | P=0.221 (e) P=0.398 | |INCIDENTAL TUMOR | P=0.022N* P=0.338N P=0.033N* | P=0.413 (e) P=0.662 | |LOGISTIC REGRESSION | P=0.015N* P=0.308N P=0.018N* | P=0.254 (e) P=0.440 | |COCHRAN-ARMITAGE | P=0.011N* | P=0.293 | |FISHER EXACT | P=0.243N P=0.013N* | (e) P=0.500 | |=================================================================================================================================| | | |Adrenal Medulla | | Pheochromocytoma Benign | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/49 (2%) 6/50 (12%) 10/50 (20%) | 2/50 (4%) 1/50 (2%) 6/50 (12%) | |ADJUSTED (b) | 2.6% 24.6% 32.9% | 5.9% 4.0% 47.1% | |TERMINAL (d) | 0/33 (0%) 2/17 (12%) 2/16 (13%) | 1/29 (3%) 1/25 (4%) 0/2 (0%) | |FIRST INCIDENCE (DAYS) | 723 701 423 | 680 736 (T) 642 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P<0.001 ** P=0.016 * P=0.001 ** | P=0.003 ** P=0.537N P=0.003 ** | |INCIDENTAL TUMOR | P=0.012 * P=0.091 P=0.026 * | P=0.146 P=0.501N P=0.324 | |LOGISTIC REGRESSION | P=0.004 ** P=0.032 * P=0.009 ** | P=0.028 * P=0.499N P=0.040 * | |COCHRAN-ARMITAGE | P=0.004 ** | P=0.081 | |FISHER EXACT | P=0.059 P=0.004 ** | P=0.500N P=0.134 | |=================================================================================================================================| DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 2 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. | | | CONTROL MG/KG | CONTROL MG/KG | |=================================================================================================================================| | | |Bone Marrow | | Hemangiosarcoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/50 (4%) 0/50 (0%) 1/50 (2%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) | |ADJUSTED (b) | 4.7% 0.0% 2.3% | 3.4% 0.0% 0.0% | |TERMINAL (d) | 0/33 (0%) 0/17 (0%) 0/16 (0%) | 1/29 (3%) 0/25 (0%) 0/2 (0%) | |FIRST INCIDENCE (DAYS) | 660 --- 610 | 736 (T) --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.397N P=0.290N P=0.550N | P=0.490N P=0.530N P=0.962N | |INCIDENTAL TUMOR | P=0.145N P=0.133N P=0.205N | P=0.490N P=0.530N P=0.962N | |LOGISTIC REGRESSION | P=0.340N P=0.238N P=0.442N | P=0.490N P=0.530N P=0.962N | |COCHRAN-ARMITAGE | P=0.352N | P=0.274N | |FISHER EXACT | P=0.247N P=0.500N | P=0.500N P=0.500N | |=================================================================================================================================| | | |Harderian Gland | | Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 3/50 (6%) 4/50 (8%) 0/50 (0%) | 2/50 (4%) 4/50 (8%) 2/50 (4%) | |ADJUSTED (b) | 7.9% 15.2% 0.0% | 6.9% 14.2% 13.9% | |TERMINAL (d) | 1/33 (3%) 1/17 (6%) 0/16 (0%) | 2/29 (7%) 3/25 (12%) 0/2 (0%) | |FIRST INCIDENCE (DAYS) | 715 663 --- | 736 (T) 673 685 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.273N P=0.308 P=0.193N | P=0.083 P=0.281 P=0.150 | |INCIDENTAL TUMOR | P=0.085N P=0.600 P=0.084N | P=0.273 P=0.302 P=0.507 | |LOGISTIC REGRESSION | P=0.159N P=0.429 P=0.146N | P=0.357 P=0.332 P=0.482 | |COCHRAN-ARMITAGE | P=0.132N | P=0.578 | |FISHER EXACT | P=0.500 P=0.121N | P=0.339 P=0.691N | |=================================================================================================================================| DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 3 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. | | | CONTROL MG/KG | CONTROL MG/KG | |=================================================================================================================================| | | |Harderian Gland | | Carcinoma or Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 3/50 (6%) 5/50 (10%) 0/50 (0%) | 2/50 (4%) 4/50 (8%) 2/50 (4%) | |ADJUSTED (b) | 7.9% 17.2% 0.0% | 6.9% 14.2% 13.9% | |TERMINAL (d) | 1/33 (3%) 1/17 (6%) 0/16 (0%) | 2/29 (7%) 3/25 (12%) 0/2 (0%) | |FIRST INCIDENCE (DAYS) | 715 556 --- | 736 (T) 673 685 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.291N P=0.200 P=0.193N | P=0.083 P=0.281 P=0.150 | |INCIDENTAL TUMOR | P=0.069N P=0.526 P=0.084N | P=0.273 P=0.302 P=0.507 | |LOGISTIC REGRESSION | P=0.159N P=0.329 P=0.146N | P=0.357 P=0.332 P=0.482 | |COCHRAN-ARMITAGE | P=0.152N | P=0.578 | |FISHER EXACT | P=0.357 P=0.121N | P=0.339 P=0.691N | |=================================================================================================================================| | | |Liver | | Hemangiosarcoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 2/50 (4%) 4/50 (8%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) 1/50 (2%) | |ADJUSTED (b) | 5.5% 15.2% 8.4% | 0.0% 0.0% 7.1% | |TERMINAL (d) | 1/33 (3%) 0/17 (0%) 1/16 (6%) | 0/29 (0%) 0/25 (0%) 0/2 (0%) | |FIRST INCIDENCE (DAYS) | 715 704 610 | --- --- 717 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.372 P=0.188 P=0.539 | P=0.180 (e) P=0.329 | |INCIDENTAL TUMOR | P=0.460N P=0.487 P=0.659N | P=0.413 (e) P=0.662 | |LOGISTIC REGRESSION | P=0.536 P=0.251 P=0.698 | P=0.220 (e) P=0.390 | |COCHRAN-ARMITAGE | P=0.578 | P=0.293 | |FISHER EXACT | P=0.339 P=0.691N | (e) P=0.500 | |=================================================================================================================================| DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 4 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. | | | CONTROL MG/KG | CONTROL MG/KG | |=================================================================================================================================| | | |Liver | | Hepatocellular Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 20/50 (40%) 33/50 (66%) 42/50 (84%) | 5/50 (10%) 31/50 (62%) 48/50 (96%) | |ADJUSTED (b) | 51.7% 86.4% 100.0% | 17.2% 78.5% 100.0% | |TERMINAL (d) | 15/33 (45%) 12/17 (71%) 16/16 (100%) | 5/29 (17%) 17/25 (68%) 2/2 (100%) | |FIRST INCIDENCE (DAYS) | 550 444 498 | 736 (T) 446 360 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** | |INCIDENTAL TUMOR | P<0.001 ** P=0.002 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** | |LOGISTIC REGRESSION | P<0.001 ** P=0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** | |COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** | |FISHER EXACT | P=0.008 ** P<0.001 ** | P<0.001 ** P<0.001 ** | |=================================================================================================================================| | | |Liver | | Hepatocellular Carcinoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 7/50 (14%) 33/50 (66%) 34/50 (68%) | 2/50 (4%) 7/50 (14%) 27/50 (54%) | |ADJUSTED (b) | 17.1% 77.4% 77.9% | 5.8% 21.8% 94.7% | |TERMINAL (d) | 0/33 (0%) 8/17 (47%) 7/16 (44%) | 1/29 (3%) 3/25 (12%) 1/2 (50%) | |FIRST INCIDENCE (DAYS) | 514 444 423 | 646 499 475 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P=0.070 P<0.001 ** | |INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P=0.082 P<0.001 ** | |LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P=0.081 P<0.001 ** | |COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** | |FISHER EXACT | P<0.001 ** P<0.001 ** | P=0.080 P<0.001 ** | |=================================================================================================================================| DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 5 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. | | | CONTROL MG/KG | CONTROL MG/KG | |=================================================================================================================================| | | |Liver | | Hepatocellular Carcinoma or Hepatoblastoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 7/50 (14%) 33/50 (66%) 34/50 (68%) | 2/50 (4%) 7/50 (14%) 27/50 (54%) | |ADJUSTED (b) | 17.1% 77.4% 77.9% | 5.8% 21.8% 94.7% | |TERMINAL (d) | 0/33 (0%) 8/17 (47%) 7/16 (44%) | 1/29 (3%) 3/25 (12%) 1/2 (50%) | |FIRST INCIDENCE (DAYS) | 514 444 423 | 646 499 475 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P=0.070 P<0.001 ** | |INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P=0.082 P<0.001 ** | |LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P=0.081 P<0.001 ** | |COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** | |FISHER EXACT | P<0.001 ** P<0.001 ** | P=0.080 P<0.001 ** | |=================================================================================================================================| | | |Liver | | Hepatocellular Carcinoma or Hepatocellular Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 26/50 (52%) 44/50 (88%) 50/50 (100%) | 7/50 (14%) 35/50 (70%) 50/50 (100%) | |ADJUSTED (b) | 58.9% 97.8% 100.0% | 22.6% 82.7% 100.0% | |TERMINAL (d) | 15/33 (45%) 16/17 (94%) 16/16 (100%) | 6/29 (21%) 18/25 (72%) 2/2 (100%) | |FIRST INCIDENCE (DAYS) | 514 444 423 | 646 446 360 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** | |INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** | |LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** | |COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** | |FISHER EXACT | P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** | |=================================================================================================================================| DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 6 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. | | | CONTROL MG/KG | CONTROL MG/KG | |=================================================================================================================================| | | |Liver | | Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 26/50 (52%) 44/50 (88%) 50/50 (100%) | 7/50 (14%) 35/50 (70%) 50/50 (100%) | |ADJUSTED (b) | 58.9% 97.8% 100.0% | 22.6% 82.7% 100.0% | |TERMINAL (d) | 15/33 (45%) 16/17 (94%) 16/16 (100%) | 6/29 (21%) 18/25 (72%) 2/2 (100%) | |FIRST INCIDENCE (DAYS) | 514 444 423 | 646 446 360 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** | |INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** | |LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** P<0.001 ** | |COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** | |FISHER EXACT | P<0.001 ** P<0.001 ** | P<0.001 ** P<0.001 ** | |=================================================================================================================================| | | |Liver | | Hepatocholangiocarcinoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | |ADJUSTED (b) | 0.0% 5.6% 0.0% | 0.0% 0.0% 0.0% | |TERMINAL (d) | 0/33 (0%) 0/17 (0%) 0/16 (0%) | 0/29 (0%) 0/25 (0%) 0/2 (0%) | |FIRST INCIDENCE (DAYS) | --- 557 --- | --- --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.613 P=0.204 (e) | (e) (e) (e) | |INCIDENTAL TUMOR | P=0.505N P=0.439 (e) | (e) (e) (e) | |LOGISTIC REGRESSION | P=0.669 P=0.261 (e) | (e) (e) (e) | |COCHRAN-ARMITAGE | P=0.650 | (e) | |FISHER EXACT | P=0.247 (e) | (e) (e) | |=================================================================================================================================| DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 7 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. | | | CONTROL MG/KG | CONTROL MG/KG | |=================================================================================================================================| | | |Lung | | Alveolar/Bronchiolar Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 9/50 (18%) 7/50 (14%) 16/50 (32%) | 3/50 (6%) 4/50 (8%) 3/50 (6%) | |ADJUSTED (b) | 23.8% 30.3% 58.4% | 8.7% 13.6% 37.0% | |TERMINAL (d) | 6/33 (18%) 4/17 (24%) 6/16 (38%) | 1/29 (3%) 2/25 (8%) 0/2 (0%) | |FIRST INCIDENCE (DAYS) | 638 556 577 | 690 673 668 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.003 ** P=0.410 P=0.004 ** | P=0.104 P=0.454 P=0.159 | |INCIDENTAL TUMOR | P=0.056 P=0.475N P=0.097 | P=0.520N P=0.555 P=0.490N | |LOGISTIC REGRESSION | P=0.041 * P=0.478N P=0.044 * | P=0.391 P=0.502 P=0.474 | |COCHRAN-ARMITAGE | P=0.065 | P=0.578 | |FISHER EXACT | P=0.393N P=0.083 | P=0.500 P=0.661N | |=================================================================================================================================| | | |Lung | | Alveolar/Bronchiolar Carcinoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 4/50 (8%) 3/50 (6%) 0/50 (0%) | 2/50 (4%) 2/50 (4%) 1/50 (2%) | |ADJUSTED (b) | 11.0% 11.6% 0.0% | 6.0% 4.9% 2.7% | |TERMINAL (d) | 3/33 (9%) 1/17 (6%) 0/16 (0%) | 1/29 (3%) 0/25 (0%) 0/2 (0%) | |FIRST INCIDENCE (DAYS) | 542 584 --- | 690 627 586 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.151N P=0.571 P=0.148N | P=0.612N P=0.685 P=0.704 | |INCIDENTAL TUMOR | P=0.083N P=0.577N P=0.173N | P=0.223N P=0.635N P=0.496N | |LOGISTIC REGRESSION | P=0.052N P=0.507N P=0.053N | P=0.388N P=0.695 P=0.511N | |COCHRAN-ARMITAGE | P=0.053N | P=0.402N | |FISHER EXACT | P=0.500N P=0.059N | P=0.691N P=0.500N | |=================================================================================================================================| DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 8 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. | | | CONTROL MG/KG | CONTROL MG/KG | |=================================================================================================================================| | | |Lung | | Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 13/50 (26%) 10/50 (20%) 16/50 (32%) | 4/50 (8%) 6/50 (12%) 4/50 (8%) | |ADJUSTED (b) | 33.7% 39.5% 58.4% | 11.9% 17.9% 38.7% | |TERMINAL (d) | 9/33 (27%) 5/17 (29%) 6/16 (38%) | 2/29 (7%) 2/25 (8%) 0/2 (0%) | |FIRST INCIDENCE (DAYS) | 542 556 577 | 690 627 586 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.028 * P=0.373 P=0.029 * | P=0.089 P=0.336 P=0.099 | |INCIDENTAL TUMOR | P=0.250 P=0.425N P=0.282 | P=0.441N P=0.437 P=0.557N | |LOGISTIC REGRESSION | P=0.241 P=0.387N P=0.248 | P=0.445 P=0.372 P=0.507 | |COCHRAN-ARMITAGE | P=0.303 | P=0.561 | |FISHER EXACT | P=0.318N P=0.330 | P=0.370 P=0.643N | |=================================================================================================================================| | | |Mammary Gland | | Carcinoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | 3/50 (6%) 1/50 (2%) 3/50 (6%) | |ADJUSTED (b) | 0.0% 0.0% 0.0% | 10.3% 2.9% 28.3% | |TERMINAL (d) | 0/33 (0%) 0/17 (0%) 0/16 (0%) | 3/29 (10%) 0/25 (0%) 0/2 (0%) | |FIRST INCIDENCE (DAYS) | --- --- --- | 736 (T) 702 685 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | (e) (e) (e) | P=0.168 P=0.346N P=0.046 * | |INCIDENTAL TUMOR | (e) (e) (e) | P=0.560 P=0.319N P=0.397 | |LOGISTIC REGRESSION | (e) (e) (e) | P=0.415 P=0.310N P=0.342 | |COCHRAN-ARMITAGE | (e) | P=0.583N | |FISHER EXACT | (e) (e) | P=0.309N P=0.661N | |=================================================================================================================================| DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 9 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. | | | CONTROL MG/KG | CONTROL MG/KG | |=================================================================================================================================| | | |Pituitary Gland: Pars Distalis or Unspecified Site | | Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/50 (0%) 0/44 (0%) 1/48 (2%) | 25/49 (51%) 19/47 (40%) 9/46 (20%) | |ADJUSTED (b) | 0.0% 0.0% 2.5% | 68.7% 58.2% 35.9% | |TERMINAL (d) | 0/33 (0%) 0/17 (0%) 0/16 (0%) | 18/29 (62%) 11/24 (46%) 0/2 (0%) | |FIRST INCIDENCE (DAYS) | --- --- 641 | 557 646 549 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.280 (e) P=0.477 | P=0.284 P=0.357N P=0.215 | |INCIDENTAL TUMOR | P=0.514 (e) P=0.814 | P=0.017N* P=0.225N P=0.044N* | |LOGISTIC REGRESSION | P=0.292 (e) P=0.541 | P=0.009N** P=0.204N P=0.008N** | |COCHRAN-ARMITAGE | P=0.290 | P=0.001N** | |FISHER EXACT | (e) P=0.490 | P=0.201N P=0.001N** | |=================================================================================================================================| | | |Pituitary Gland: Pars Distalis or Unspecified Site | | Carcinoma or Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 0/50 (0%) 0/44 (0%) 1/48 (2%) | 26/49 (53%) 19/47 (40%) 9/46 (20%) | |ADJUSTED (b) | 0.0% 0.0% 2.5% | 71.5% 58.2% 35.9% | |TERMINAL (d) | 0/33 (0%) 0/17 (0%) 0/16 (0%) | 19/29 (66%) 11/24 (46%) 0/2 (0%) | |FIRST INCIDENCE (DAYS) | --- --- 641 | 557 646 549 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.280 (e) P=0.477 | P=0.328 P=0.295N P=0.225 | |INCIDENTAL TUMOR | P=0.514 (e) P=0.814 | P=0.012N* P=0.170N P=0.040N* | |LOGISTIC REGRESSION | P=0.292 (e) P=0.541 | P=0.005N** P=0.149N P=0.005N** | |COCHRAN-ARMITAGE | P=0.290 | P<0.001N** | |FISHER EXACT | (e) P=0.490 | P=0.150N P<0.001N** | |=================================================================================================================================| DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 10 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. | | | CONTROL MG/KG | CONTROL MG/KG | |=================================================================================================================================| | | |Skin: Subcutaneous Tissue | | Fibroma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 3/50 (6%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | |ADJUSTED (b) | 9.1% 0.0% 0.0% | 0.0% 0.0% 0.0% | |TERMINAL (d) | 3/33 (9%) 0/17 (0%) 0/16 (0%) | 0/29 (0%) 0/25 (0%) 0/2 (0%) | |FIRST INCIDENCE (DAYS) | 736 (T) --- --- | --- --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.108N P=0.259N P=0.273N | (e) (e) (e) | |INCIDENTAL TUMOR | P=0.108N P=0.259N P=0.273N | (e) (e) (e) | |LOGISTIC REGRESSION | P=0.108N P=0.259N P=0.273N | (e) (e) (e) | |COCHRAN-ARMITAGE | P=0.035N* | (e) | |FISHER EXACT | P=0.121N P=0.121N | (e) (e) | |=================================================================================================================================| | | |Skin: Subcutaneous Tissue | | Fibrosarcoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 0/50 (0%) 3/50 (6%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | |ADJUSTED (b) | 0.0% 11.4% 3.6% | 0.0% 0.0% 0.0% | |TERMINAL (d) | 0/33 (0%) 0/17 (0%) 0/16 (0%) | 0/29 (0%) 0/25 (0%) 0/2 (0%) | |FIRST INCIDENCE (DAYS) | --- 698 722 | --- --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.245 P=0.071 P=0.439 | (e) (e) (e) | |INCIDENTAL TUMOR | P=0.546 P=0.220 P=0.621 | (e) (e) (e) | |LOGISTIC REGRESSION | P=0.315 P=0.092 P=0.468 | (e) (e) (e) | |COCHRAN-ARMITAGE | P=0.360 | (e) | |FISHER EXACT | P=0.121 P=0.500 | (e) (e) | |=================================================================================================================================| DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 11 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. | | | CONTROL MG/KG | CONTROL MG/KG | |=================================================================================================================================| | | |Skin: Subcutaneous Tissue | | Neurofibroma or Fibroma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 3/50 (6%) 1/50 (2%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) | |ADJUSTED (b) | 9.1% 5.9% 0.0% | 0.0% 0.0% 0.0% | |TERMINAL (d) | 3/33 (9%) 1/17 (6%) 0/16 (0%) | 0/29 (0%) 0/25 (0%) 0/2 (0%) | |FIRST INCIDENCE (DAYS) | 736 (T) 736 (T) --- | --- --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.187N P=0.561N P=0.273N | (e) (e) (e) | |INCIDENTAL TUMOR | P=0.187N P=0.561N P=0.273N | (e) (e) (e) | |LOGISTIC REGRESSION | P=0.187N P=0.561N P=0.273N | (e) (e) (e) | |COCHRAN-ARMITAGE | P=0.061N | (e) | |FISHER EXACT | P=0.309N P=0.121N | (e) (e) | |=================================================================================================================================| | | |Skin: Subcutaneous Tissue | | Neurofibrosarcoma, Fibrosarcoma, Sarcoma, | | Neurofibroma, or Fibroma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 4/50 (8%) 6/50 (12%) 3/50 (6%) | 0/50 (0%) 2/50 (4%) 0/50 (0%) | |ADJUSTED (b) | 11.2% 23.8% 8.4% | 0.0% 5.4% 0.0% | |TERMINAL (d) | 3/33 (9%) 2/17 (12%) 0/16 (0%) | 0/29 (0%) 0/25 (0%) 0/2 (0%) | |FIRST INCIDENCE (DAYS) | 697 600 556 | --- 638 --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.419 P=0.138 P=0.597 | P=0.538 P=0.238 (e) | |INCIDENTAL TUMOR | P=0.353N P=0.358 P=0.415N | P=0.493N P=0.297 (e) | |LOGISTIC REGRESSION | P=0.481N P=0.287 P=0.502N | P=0.650 P=0.237 (e) | |COCHRAN-ARMITAGE | P=0.450N | P=0.650 | |FISHER EXACT | P=0.370 P=0.500N | P=0.247 (e) | |=================================================================================================================================| DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 12 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. | | | CONTROL MG/KG | CONTROL MG/KG | |=================================================================================================================================| | | |Skin: Subcutaneous Tissue | | Neurofibrosarcoma, Fibrosarcoma, or Sarcoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 1/50 (2%) 5/50 (10%) 3/50 (6%) | 0/50 (0%) 2/50 (4%) 0/50 (0%) | |ADJUSTED (b) | 2.3% 18.7% 8.4% | 0.0% 5.4% 0.0% | |TERMINAL (d) | 0/33 (0%) 1/17 (6%) 0/16 (0%) | 0/29 (0%) 0/25 (0%) 0/2 (0%) | |FIRST INCIDENCE (DAYS) | 697 600 556 | --- 638 --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.150 P=0.048 * P=0.251 | P=0.538 P=0.238 (e) | |INCIDENTAL TUMOR | P=0.520 P=0.214 P=0.622 | P=0.493N P=0.297 (e) | |LOGISTIC REGRESSION | P=0.247 P=0.085 P=0.346 | P=0.650 P=0.237 (e) | |COCHRAN-ARMITAGE | P=0.250 | P=0.650 | |FISHER EXACT | P=0.102 P=0.309 | P=0.247 (e) | |=================================================================================================================================| | | |Skin: Subcutaneous Tissue | | Sarcoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 1/50 (2%) 2/50 (4%) 2/50 (4%) | 0/50 (0%) 2/50 (4%) 0/50 (0%) | |ADJUSTED (b) | 2.3% 8.2% 5.1% | 0.0% 5.4% 0.0% | |TERMINAL (d) | 0/33 (0%) 1/17 (6%) 0/16 (0%) | 0/29 (0%) 0/25 (0%) 0/2 (0%) | |FIRST INCIDENCE (DAYS) | 697 600 556 | --- 638 --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.314 P=0.386 P=0.458 | P=0.538 P=0.238 (e) | |INCIDENTAL TUMOR | P=0.614 P=0.620 P=0.687N | P=0.493N P=0.297 (e) | |LOGISTIC REGRESSION | P=0.404 P=0.505 P=0.565 | P=0.650 P=0.237 (e) | |COCHRAN-ARMITAGE | P=0.393 | P=0.650 | |FISHER EXACT | P=0.500 P=0.500 | P=0.247 (e) | |=================================================================================================================================| DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 13 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. | | | CONTROL MG/KG | CONTROL MG/KG | |=================================================================================================================================| | | |Spleen | | Hemangiosarcoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 3/50 (6%) 0/50 (0%) 2/49 (4%) | 1/50 (2%) 0/50 (0%) 2/50 (4%) | |ADJUSTED (b) | 7.4% 0.0% 8.5% | 3.4% 0.0% 15.6% | |TERMINAL (d) | 0/33 (0%) 0/17 (0%) 1/16 (6%) | 1/29 (3%) 0/25 (0%) 0/2 (0%) | |FIRST INCIDENCE (DAYS) | 660 --- 621 | 736 (T) --- 716 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.508N P=0.183N P=0.649N | P=0.125 P=0.530N P=0.100 | |INCIDENTAL TUMOR | P=0.224N P=0.045N* P=0.280N | P=0.395 P=0.530N P=0.471 | |LOGISTIC REGRESSION | P=0.386N P=0.130N P=0.491N | P=0.228 P=0.530N P=0.253 | |COCHRAN-ARMITAGE | P=0.380N | P=0.388 | |FISHER EXACT | P=0.121N P=0.510N | P=0.500N P=0.500 | |=================================================================================================================================| | | |Stomach, Forestomach | | Squamous Cell Papilloma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 0/50 (0%) 1/50 (2%) 3/50 (6%) | 2/50 (4%) 6/50 (12%) 3/50 (6%) | |ADJUSTED (b) | 0.0% 3.3% 15.2% | 6.9% 19.7% 26.9% | |TERMINAL (d) | 0/33 (0%) 0/17 (0%) 2/16 (13%) | 2/29 (7%) 3/25 (12%) 0/2 (0%) | |FIRST INCIDENCE (DAYS) | --- 719 716 | 736 (T) 638 709 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.029 * P=0.453 P=0.047 * | P=0.018 * P=0.108 P=0.025 * | |INCIDENTAL TUMOR | P=0.051 P=0.602 P=0.070 | P=0.287 P=0.138 P=0.365 | |LOGISTIC REGRESSION | P=0.045 * P=0.467 P=0.077 | P=0.172 P=0.133 P=0.178 | |COCHRAN-ARMITAGE | P=0.065 | P=0.406 | |FISHER EXACT | P=0.500 P=0.121 | P=0.134 P=0.500 | |=================================================================================================================================| DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 14 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. | | | CONTROL MG/KG | CONTROL MG/KG | |=================================================================================================================================| | | |Thyroid Gland: Follicular Cell | | Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) | 2/50 (4%) 3/50 (6%) 2/50 (4%) | |ADJUSTED (b) | 3.0% 0.0% 0.0% | 6.9% 12.0% 6.5% | |TERMINAL (d) | 1/33 (3%) 0/17 (0%) 0/16 (0%) | 2/29 (7%) 3/25 (12%) 0/2 (0%) | |FIRST INCIDENCE (DAYS) | 736 (T) --- --- | 736 (T) 736 (T) 601 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.392N P=0.632N P=0.644N | P=0.112 P=0.431 P=0.252 | |INCIDENTAL TUMOR | P=0.392N P=0.632N P=0.644N | P=0.232 P=0.431 P=0.540 | |LOGISTIC REGRESSION | P=0.392N P=0.632N P=0.644N | P=0.481 P=0.431 P=0.659 | |COCHRAN-ARMITAGE | P=0.274N | P=0.592 | |FISHER EXACT | P=0.500N P=0.500N | P=0.500 P=0.691N | |=================================================================================================================================| | | |Thyroid Gland: Follicular Cell | | Carcinoma or Adenoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | | |----------- | | | |OVERALL (a) | 1/50 (2%) 0/50 (0%) 1/50 (2%) | 2/50 (4%) 3/50 (6%) 2/50 (4%) | |ADJUSTED (b) | 3.0% 0.0% 6.3% | 6.9% 12.0% 6.5% | |TERMINAL (d) | 1/33 (3%) 0/17 (0%) 1/16 (6%) | 2/29 (7%) 3/25 (12%) 0/2 (0%) | |FIRST INCIDENCE (DAYS) | 736 (T) --- 736 (T) | 736 (T) 736 (T) 601 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.518 P=0.632N P=0.592 | P=0.112 P=0.431 P=0.252 | |INCIDENTAL TUMOR | P=0.518 P=0.632N P=0.592 | P=0.232 P=0.431 P=0.540 | |LOGISTIC REGRESSION | P=0.518 P=0.632N P=0.592 | P=0.481 P=0.431 P=0.659 | |COCHRAN-ARMITAGE | P=0.665N | P=0.592 | |FISHER EXACT | P=0.500N P=0.753N | P=0.500 P=0.691N | |=================================================================================================================================| DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 15 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. | | | CONTROL MG/KG | CONTROL MG/KG | |=================================================================================================================================| | | |Uterus | | Polyp Stromal | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | # # # | |----------- | | | |OVERALL (a) | | 2/50 (4%) 0/50 (0%) 4/50 (8%) | |ADJUSTED (b) | | 6.4% 0.0% 14.0% | |TERMINAL (d) | | 1/29 (3%) 0/25 (0%) 0/2 (0%) | |FIRST INCIDENCE (DAYS) | | 718 --- 549 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | | P=0.085 P=0.267N P=0.082 | |INCIDENTAL TUMOR | | P=0.468 P=0.223N P=0.580 | |LOGISTIC REGRESSION | | P=0.270 P=0.240N P=0.345 | |COCHRAN-ARMITAGE | | P=0.249 | |FISHER EXACT | | P=0.247N P=0.339 | |=================================================================================================================================| | | |Uterus | | Sarcoma Stromal | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | # # # | |----------- | | | |OVERALL (a) | | 2/50 (4%) 0/50 (0%) 0/50 (0%) | |ADJUSTED (b) | | 5.5% 0.0% 0.0% | |TERMINAL (d) | | 1/29 (3%) 0/25 (0%) 0/2 (0%) | |FIRST INCIDENCE (DAYS) | | 494 --- --- | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | | P=0.152N P=0.256N P=0.454N | |INCIDENTAL TUMOR | | P=0.126N P=0.313N P=0.371N | |LOGISTIC REGRESSION | | P=0.072N P=0.234N P=0.184N | |COCHRAN-ARMITAGE | | P=0.094N | |FISHER EXACT | | P=0.247N P=0.247N | |=================================================================================================================================| DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 16 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. | | | CONTROL MG/KG | CONTROL MG/KG | |=================================================================================================================================| | | |Uterus | | Sarcoma Stromal or Polyp Stromal | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | | # # # | |----------- | | | |OVERALL (a) | | 4/50 (8%) 0/50 (0%) 4/50 (8%) | |ADJUSTED (b) | | 11.6% 0.0% 14.0% | |TERMINAL (d) | | 2/29 (7%) 0/25 (0%) 0/2 (0%) | |FIRST INCIDENCE (DAYS) | | 494 --- 549 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | | P=0.327 P=0.079N P=0.217 | |INCIDENTAL TUMOR | | P=0.398N P=0.081N P=0.543N | |LOGISTIC REGRESSION | | P=0.503N P=0.063N P=0.597N | |COCHRAN-ARMITAGE | | P=0.563N | |FISHER EXACT | | P=0.059N P=0.643N | |=================================================================================================================================| | | |All Organs | | Hemangiosarcoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 5/50 (10%) 5/50 (10%) 5/50 (10%) | 2/50 (4%) 2/50 (4%) 3/50 (6%) | |ADJUSTED (b) | 12.2% 19.0% 19.1% | 5.4% 8.0% 21.7% | |TERMINAL (d) | 1/33 (3%) 0/17 (0%) 2/16 (13%) | 1/29 (3%) 2/25 (8%) 0/2 (0%) | |FIRST INCIDENCE (DAYS) | 660 704 610 | 430 736 (T) 716 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.315 P=0.405 P=0.403 | P=0.076 P=0.654 P=0.132 | |INCIDENTAL TUMOR | P=0.307N P=0.364N P=0.391N | P=0.321 P=0.607 P=0.607 | |LOGISTIC REGRESSION | P=0.533 P=0.546 P=0.614N | P=0.386 P=0.694 P=0.506 | |COCHRAN-ARMITAGE | P=0.571 | P=0.417 | |FISHER EXACT | P=0.630N P=0.630N | P=0.691N P=0.500 | |=================================================================================================================================| DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 17 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. | | | CONTROL MG/KG | CONTROL MG/KG | |=================================================================================================================================| | | |All Organs | | Hemangiosarcoma or Hemangioma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 5/50 (10%) 5/50 (10%) 5/50 (10%) | 3/50 (6%) 2/50 (4%) 3/50 (6%) | |ADJUSTED (b) | 12.2% 19.0% 19.1% | 8.8% 8.0% 21.7% | |TERMINAL (d) | 1/33 (3%) 0/17 (0%) 2/16 (13%) | 2/29 (7%) 2/25 (8%) 0/2 (0%) | |FIRST INCIDENCE (DAYS) | 660 704 610 | 430 736 (T) 716 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.315 P=0.405 P=0.403 | P=0.139 P=0.554N P=0.154 | |INCIDENTAL TUMOR | P=0.307N P=0.364N P=0.391N | P=0.433 P=0.600N P=0.629 | |LOGISTIC REGRESSION | P=0.533 P=0.546 P=0.614N | P=0.552 P=0.501N P=0.639 | |COCHRAN-ARMITAGE | P=0.571 | P=0.586N | |FISHER EXACT | P=0.630N P=0.630N | P=0.500N P=0.661N | |=================================================================================================================================| | | |All Organs | | Malignant Lymphoma And Histiocytic Sarcoma | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 5/50 (10%) 12/50 (24%) 1/50 (2%) | 20/50 (40%) 14/50 (28%) 7/50 (14%) | |ADJUSTED (b) | 13.5% 44.2% 2.3% | 55.9% 41.8% 50.1% | |TERMINAL (d) | 3/33 (9%) 5/17 (29%) 0/16 (0%) | 14/29 (48%) 7/25 (28%) 0/2 (0%) | |FIRST INCIDENCE (DAYS) | 676 600 612 | 414 446 652 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.493N P=0.006 ** P=0.242N | P=0.438 P=0.266N P=0.217 | |INCIDENTAL TUMOR | P=0.145N P=0.046 * P=0.072N | P=0.019N* P=0.170N P=0.071N | |LOGISTIC REGRESSION | P=0.218N P=0.025 * P=0.105N | P=0.011N* P=0.141N P=0.023N* | |COCHRAN-ARMITAGE | P=0.173N | P=0.003N** | |FISHER EXACT | P=0.054 P=0.102N | P=0.146N P=0.003N** | |=================================================================================================================================| DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 18 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. | | | CONTROL MG/KG | CONTROL MG/KG | |=================================================================================================================================| | | |All Organs | | Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, | | NOS, or Undifferentiated Cell Type | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 5/50 (10%) 12/50 (24%) 1/50 (2%) | 20/50 (40%) 14/50 (28%) 7/50 (14%) | |ADJUSTED (b) | 13.5% 44.2% 2.3% | 55.9% 41.8% 50.1% | |TERMINAL (d) | 3/33 (9%) 5/17 (29%) 0/16 (0%) | 14/29 (48%) 7/25 (28%) 0/2 (0%) | |FIRST INCIDENCE (DAYS) | 676 600 612 | 414 446 652 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P=0.493N P=0.006 ** P=0.242N | P=0.438 P=0.266N P=0.217 | |INCIDENTAL TUMOR | P=0.145N P=0.046 * P=0.072N | P=0.019N* P=0.170N P=0.071N | |LOGISTIC REGRESSION | P=0.218N P=0.025 * P=0.105N | P=0.011N* P=0.141N P=0.023N* | |COCHRAN-ARMITAGE | P=0.173N | P=0.003N** | |FISHER EXACT | P=0.054 P=0.102N | P=0.146N P=0.003N** | |=================================================================================================================================| | | |All Organs | | Benign Tumors | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 32/50 (64%) 38/50 (76%) 46/50 (92%) | 34/50 (68%) 38/50 (76%) 48/50 (96%) | |ADJUSTED (b) | 77.6% 94.9% 100.0% | 86.9% 88.1% 100.0% | |TERMINAL (d) | 24/33 (73%) 15/17 (88%) 16/16 (100%) | 24/29 (83%) 20/25 (80%) 2/2 (100%) | |FIRST INCIDENCE (DAYS) | 550 444 423 | 557 446 360 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P=0.136 P<0.001 ** | |INCIDENTAL TUMOR | P<0.001 ** P=0.017 * P<0.001 ** | P<0.001 ** P=0.244 P<0.001 ** | |LOGISTIC REGRESSION | P<0.001 ** P=0.017 * P<0.001 ** | P<0.001 ** P=0.264 P<0.001 ** | |COCHRAN-ARMITAGE | P<0.001 ** | P<0.001 ** | |FISHER EXACT | P=0.138 P<0.001 ** | P=0.252 P<0.001 ** | |=================================================================================================================================| DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 19 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN TERMINAL SACRIFICE AT 106 WEEKS |=================================================================================================================================| | | | | | | MALES | FEMALES | | | | | |DOSE | VEHICLE 8. MG/KG 15. | VEHICLE 8. MG/KG 15. | | | CONTROL MG/KG | CONTROL MG/KG | |=================================================================================================================================| | | |All Organs | | Malignant Tumors | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 19/50 (38%) 41/50 (82%) 39/50 (78%) | 30/50 (60%) 24/50 (48%) 32/50 (64%) | |ADJUSTED (b) | 41.7% 89.1% 86.1% | 73.9% 59.7% 95.9% | |TERMINAL (d) | 7/33 (21%) 12/17 (71%) 10/16 (63%) | 19/29 (66%) 10/25 (40%) 1/2 (50%) | |FIRST INCIDENCE (DAYS) | 514 444 423 | 414 446 475 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** | P<0.001 ** P=0.336N P<0.001 ** | |INCIDENTAL TUMOR | P<0.001 ** P<0.001 ** P=0.002 ** | P=0.503 P=0.193N P=0.281 | |LOGISTIC REGRESSION | P<0.001 ** P<0.001 ** P<0.001 ** | P=0.289 P=0.158N P=0.224 | |COCHRAN-ARMITAGE | P<0.001 ** | P=0.408 | |FISHER EXACT | P<0.001 ** P<0.001 ** | P=0.158N P=0.418 | |=================================================================================================================================| | | |All Organs | | Malignant and Benign Tumors | | | |---------------------------------------------------------------------------------------------------------------------------------| |TUMOR RATES | # # # | # # # | |----------- | | | |OVERALL (a) | 43/50 (86%) 45/50 (90%) 50/50 (100%) | 43/50 (86%) 43/50 (86%) 50/50 (100%) | |ADJUSTED (b) | 87.8% 97.8% 100.0% | 97.7% 93.4% 100.0% | |TERMINAL (d) | 27/33 (82%) 16/17 (94%) 16/16 (100%) | 28/29 (97%) 22/25 (88%) 2/2 (100%) | |FIRST INCIDENCE (DAYS) | 514 444 423 | 414 446 360 | |-----------------------| | | |STATISTICAL TESTS (f) | | | |-----------------------| | | |LIFE TABLE | P<0.001 ** P=0.002 ** P<0.001 ** | P<0.001 ** P=0.315 P<0.001 ** | |INCIDENTAL TUMOR | P=0.028 * P=0.255 P=0.059 | P=0.003 ** P=0.530 P<0.001 ** | |LOGISTIC REGRESSION | P=0.002 ** P=0.050 * P=0.009 ** | P=0.006 ** P=0.606N P=0.005 ** | |COCHRAN-ARMITAGE | P=0.009 ** | P=0.015 * | |FISHER EXACT | P=0.380 P=0.006 ** | P=0.613N P=0.006 ** | |=================================================================================================================================| DATE: 09/03/94 EXPERIMENT: 05004 TEST: 04 PAGE 20 STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- FURAN TERMINAL SACRIFICE AT 106 WEEKS (a) Number of tumor-bearing animals / number of animals examined at site. (b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for intercurrent mortality. (d) Observed incidence at terminal kill. (f) Beneath the control incidence are the P-values associated with the trend test. Beneath the dosed group incidence are the P-values corresponding to pairwise comparisons between the controls and that dosed group. The life table analysis regards tumors in animals dying prior to terminal kill as being (directly or indirectly) the cause of death. The incidental tumor test regards these lesions as non-fatal. Logistic regression is an alternative method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage and Fisher's exact tests compare directly the overall incidence rates. For all tests, a negative trend is indicated by "N". (e) Value of Statistic cannot be computed. (I) Interim sacrifice (T) Terminal sacrifice # Tumor rates based on number of animals necropsied. * To the right of any statistical result, indicates significance at (P<=0.05). ** To the right of any statistical result, indicates significance at (P<=0.01). --multipart-boundary Content-type: text/plain Range: bytes 138311-138311/138311 --multipart-boundary--
Web page last updated on October 03, 2004
The National Institute of Environmental Health Sciences is one of the National Institutes of Health within the U.S. Department of Health and Human Services. The National Toxicology Program is headquartered on the NIEHS campus in Research Triangle Park, NC.