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Pathology Tables for Peer Review
Pathology Tables for Peer Review
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NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 Facility: TSI Mason Research Chemical CAS #: 57-66-9 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6| DAY ON TEST | 3| 3| 2| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 9| 9| 3| 3| 2| 5| 3| | 5| 5| 2| 2| 0| 5| 6| 5| 4| 5| 5| 5| 5| 5| 5| 5| 6| 2| 3| 5| 5| 6| 9| 1| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + M M + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + M + + + + + + + + + + + + + + + +| Parasite | 1 | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + M + + + + + +| Parasite | 1 | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + M + + + + + +| Lymphoid Nodule, Hyperplasia | 1 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + M + + + + + +| Lymphoid Nodule, Hyperplasia | 2 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 3 | Basophilic Focus | X X X X X 1 X X X X X 2 X X X X X| Cyst | X | Fatty Change, Diffuse | 2 2 2 | Fatty Change, Focal | 1 1 1 2 1 1 | Focal Cellular Change | | Hepatodiaphragmatic Nodule | X X | Mixed Cell Focus | X X X X | Necrosis | 1 | Pigmentation | 2 2 | Regeneration, Focal | | Bile Duct, Hyperplasia | 2 2 2 2 2 | __________________________________________________________________________| Mesentery | + + + + | Artery, Pigmentation | 2 | Artery, Thrombosis | 2 | Fat, Inflammation, Chronic Active | 2 | Fat, Mineralization | | Fat, Necrosis | 1 4 | Fat, Pigmentation | 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | | Acinus, Hyperplasia | 3 2 | Artery, Pigmentation | 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Hypertrophy | | Acinus, Inflammation, Chronic Active | | Acinus, Necrosis | 1 1 | Duct, Inflammation, Chronic Active | 1 2 1 2 | Duct, Metaplasia, Squamous | 1 1 2 2 2 1 2 2 1| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6| DAY ON TEST | 3| 3| 2| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 9| 9| 3| 3| 2| 5| 3| | 5| 5| 2| 2| 0| 5| 6| 5| 4| 5| 5| 5| 5| 5| 5| 5| 6| 2| 3| 5| 5| 6| 9| 1| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + M + + + + + + + + + + + + + + + + + +| Acanthosis | 1 | Hyperkeratosis | 2 | Necrosis | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Vacuolization Cytoplasmic | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 1 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | __________________________________________________________________________| Parathyroid Gland | + + + + M M + M + M + + + + M + + + + + M + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 2 2 3 2 2 2 2 2 2 3 2 2| Pars Distalis, Cyst | X X X | Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 | Pars Intermedia, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 1 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | Abscess | 2 | Mineralization | 2 | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + M + + M M + M + + + M + + M + + + + + M| __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + + + + + + + + + + + + + | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hypoplasia | 3 | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6| DAY ON TEST | 3| 3| 2| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 9| 9| 3| 3| 2| 5| 3| | 5| 5| 2| 2| 0| 5| 6| 5| 4| 5| 5| 5| 5| 5| 5| 5| 6| 2| 3| 5| 5| 6| 9| 1| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + M + + + + +| Mediastinal, Angiectasis | | Mediastinal, Infiltration Cellular, | | Plasma Cell | | Mediastinal, Infiltration Cellular, | | Histiocyte | 2 2 | Pancreatic, Depletion Lymphoid | 2 | Pancreatic, Hematopoietic Cell | | Proliferation | 2 | Pancreatic, Infiltration Cellular, | | Histiocyte | 2 | Renal, Angiectasis | 2 2 | Renal, Infiltration Cellular, | | Histiocyte | 2 2 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + + +| Angiectasis | 2 2 | Depletion Lymphoid | 2 | Infiltration Cellular, Histiocyte | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | 2 2 | Fibrosis | 2 | Hematopoietic Cell Proliferation | 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2 3 2 2 2 2| Hemorrhage | 2 2 | Infiltration Cellular, Histiocyte | 2 2 3 | Necrosis | 3 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | 2 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + M +| Galactocele | X X X X X X X X X X X X X X X X X X X| Acinus, Hyperplasia | 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | Artery, Pigmentation | 2 | Artery, Thrombosis | 3 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Brain Stem, Hemorrhage | 2 | Cerebrum, Necrosis | 2 | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6| DAY ON TEST | 3| 3| 2| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 9| 9| 3| 3| 2| 5| 3| | 5| 5| 2| 2| 0| 5| 6| 5| 4| 5| 5| 5| 5| 5| 5| 5| 6| 2| 3| 5| 5| 6| 9| 1| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | Medulla, Hemorrhage | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Embolus Tumor | X | Hemorrhage | 1 | Infiltration Cellular, Histiocyte | 1 | Alveolar Epithelium, Hyperplasia | | Mediastinum, Atypia Cellular | 3 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + M + + + + + + + + + + +| Inflammation, Chronic Active | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + + | __________________________________________________________________________| Eye | + + + | Hemorrhage | | Lens, Cataract | 2 | __________________________________________________________________________| Harderian Gland | + + | Hyperplasia | 2 | Inflammation, Chronic Active | 1 | Pigmentation | 2 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | 2 | Hydronephrosis | 2 | Nephropathy | 1 2 2 1 3 1 2 1 2 1 1 1 1 1 1 2 1 2 2 1 1 1| Cortex, Mineralization | 1 | Papilla, Mineralization | 1 2 1 2 1 1 1 1 1 1 1 | Pelvis, Mineralization | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1| Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Inflammation, Acute | | _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 3| | DAY ON TEST | 3| 3| 7| 5| 3| 3| 3| 0| 6| 4| 3| 6| 7| 5| 7| 3| 3| 2| 2| 2| 3| 3| 4| 2| 5| | | 5| 6| 5| 2| 6| 5| 5| 4| 3| 4| 5| 3| 7| 2| 9| 5| 6| 0| 0| 9| 5| 5| 9| 2| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Parasite | 1 | 2 1.0| __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 | Parasite | | 1 1.0| __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoid Nodule, Hyperplasia | 3 | 2 2.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 | Lymphoid Nodule, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 2 2.5| Basophilic Focus | X X X X X X X X X X X X X X X X X X| 36 1.5| Cyst | | 1 | Fatty Change, Diffuse | 2 2 3 2 2 | 8 2.1| Fatty Change, Focal | 1 1 1 | 10 1.2| Focal Cellular Change | X | 1 | Hepatodiaphragmatic Nodule | X X | 4 | Mixed Cell Focus | 2 | 5 2.0| Necrosis | | 1 1.0| Pigmentation | | 2 2.0| Regeneration, Focal | 2 | 1 2.0| Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 | 12 2.0| __________________________________________________________________________|____________| Mesentery | + + | 6 | Artery, Pigmentation | | 1 2.0| Artery, Thrombosis | | 1 2.0| Fat, Inflammation, Chronic Active | | 1 2.0| Fat, Mineralization | 1 | 1 1.0| Fat, Necrosis | 2 3 | 4 2.5| Fat, Pigmentation | | 1 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | 2 | 1 2.0| Acinus, Hyperplasia | | 2 2.5| Artery, Pigmentation | | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Hypertrophy | 1 1 | 2 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 3| | DAY ON TEST | 3| 3| 7| 5| 3| 3| 3| 0| 6| 4| 3| 6| 7| 5| 7| 3| 3| 2| 2| 2| 3| 3| 4| 2| 5| | | 5| 6| 5| 2| 6| 5| 5| 4| 3| 4| 5| 3| 7| 2| 9| 5| 6| 0| 0| 9| 5| 5| 9| 2| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Acinus, Inflammation, Chronic Active | 1 | 1 1.0| Acinus, Necrosis | | 2 1.0| Duct, Inflammation, Chronic Active | 1 | 5 1.4| Duct, Metaplasia, Squamous | 1 1 1 1 1 1 1 1 2 | 18 1.3| __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acanthosis | 2 | 2 1.5| Hyperkeratosis | 2 | 2 2.0| Necrosis | 2 2 | 2 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 | 32 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Vacuolization Cytoplasmic | 2 | 1 2.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + M +| 48 | Hyperplasia | 1 2 | 5 1.6| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Parathyroid Gland | + M + + + + + + + + M + + + + + M M + M + + + + M| 38 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Angiectasis | 2 3 3 2 3 2 3 3 2 2 2 3| 24 2.3| Pars Distalis, Cyst | X X X X | 7 | Pars Distalis, Hyperplasia | 2 2 2 1 2 2 2 2 | 15 1.9| Pars Intermedia, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | C-Cell, Hyperplasia | 1 1 2 1 | 8 1.1| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | Abscess | | 1 2.0| Mineralization | | 1 2.0| _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 3| | DAY ON TEST | 3| 3| 7| 5| 3| 3| 3| 0| 6| 4| 3| 6| 7| 5| 7| 3| 3| 2| 2| 2| 3| 3| 4| 2| 5| | | 5| 6| 5| 2| 6| 5| 5| 4| 3| 4| 5| 3| 7| 2| 9| 5| 6| 0| 0| 9| 5| 5| 9| 2| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + M M + + + + + + + + + + + + M + M + M + M M| 36 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 2 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + + + + + + + + + + | 23 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hypoplasia | | 1 3.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Mediastinal, Angiectasis | 2 2 | 2 2.0| Mediastinal, Infiltration Cellular, | | | Plasma Cell | 3 | 1 3.0| Mediastinal, Infiltration Cellular, | | | Histiocyte | 2 | 3 2.0| Pancreatic, Depletion Lymphoid | | 1 2.0| Pancreatic, Hematopoietic Cell | | | Proliferation | | 1 2.0| Pancreatic, Infiltration Cellular, | | | Histiocyte | 1 | 2 1.5| Renal, Angiectasis | 2 | 3 2.0| Renal, Infiltration Cellular, | | | Histiocyte | 2 | 4 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | | 2 2.0| Depletion Lymphoid | | 1 2.0| Infiltration Cellular, Histiocyte | | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Depletion Lymphoid | 2 | 3 2.0| Fibrosis | | 1 2.0| Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 3 2 1 2 2 1 2 2 3| 38 2.1| Hemorrhage | | 2 2.0| Infiltration Cellular, Histiocyte | 2 2 2 2 2 3 | 9 2.2| Necrosis | 2 | 2 2.5| __________________________________________________________________________|____________| Thymus | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 | Depletion Lymphoid | | 2 2.5| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 3| | DAY ON TEST | 3| 3| 7| 5| 3| 3| 3| 0| 6| 4| 3| 6| 7| 5| 7| 3| 3| 2| 2| 2| 3| 3| 4| 2| 5| | | 5| 6| 5| 2| 6| 5| 5| 4| 3| 4| 5| 3| 7| 2| 9| 5| 6| 0| 0| 9| 5| 5| 9| 2| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 47 | Galactocele | X X X X X X X X X X X X X X X X X | 36 | Acinus, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Artery, Pigmentation | | 1 2.0| Artery, Thrombosis | | 1 3.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Brain Stem, Hemorrhage | | 1 2.0| Cerebrum, Necrosis | 3 | 2 2.5| Medulla, Hemorrhage | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 1 2 2 2 2 2 | 6 1.8| Embolus Tumor | | 1 | Hemorrhage | 2 | 2 1.5| Infiltration Cellular, Histiocyte | 2 2 | 3 1.7| Alveolar Epithelium, Hyperplasia | 2 2 | 2 2.0| Mediastinum, Atypia Cellular | | 1 3.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 1 | 1 1.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + + + +| 6 | __________________________________________________________________________|____________| Eye | + + + + + + + +| 11 | Hemorrhage | 2 | 1 2.0| Lens, Cataract | 2 2 | 3 2.0| __________________________________________________________________________|____________| Harderian Gland | + + + + | 6 | Hyperplasia | 2 | 2 2.0| Inflammation, Chronic Active | | 1 1.0| Pigmentation | 2 | 2 2.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 3| | DAY ON TEST | 3| 3| 7| 5| 3| 3| 3| 0| 6| 4| 3| 6| 7| 5| 7| 3| 3| 2| 2| 2| 3| 3| 4| 2| 5| | | 5| 6| 5| 2| 6| 5| 5| 4| 3| 4| 5| 3| 7| 2| 9| 5| 6| 0| 0| 9| 5| 5| 9| 2| 4| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 2.0| Hydronephrosis | | 1 2.0| Nephropathy | 1 1 2 1 1 2 1 1 1 1 1 2 1 2 2 1 2 1 1 | 41 1.4| Cortex, Mineralization | 1 1 1 | 4 1.0| Papilla, Mineralization | 1 1 2 1 1 1 2 | 18 1.2| Pelvis, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 43 1.0| Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1| 48 1.1| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 2 2 | 2 2.0| Inflammation, Acute | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 10 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 2| 2| 0| 3| 3| 3| 3| 3| 2| 3| 3| 0| 5| 3| 3| 3| 3| 3| | 4| 4| 4| 4| 3| 4| 4| 2| 2| 8| 4| 4| 4| 3| 7| 9| 4| 4| 3| 1| 4| 4| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| .1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + | __________________________________________________________________________| Intestine Large, Cecum | + + + + | __________________________________________________________________________| Intestine Large, Colon | + + + + | __________________________________________________________________________| Intestine Large, Rectum | + + + + | Parasite | 2 | __________________________________________________________________________| Intestine Small | + + + + + | __________________________________________________________________________| Intestine Small, Duodenum | + + + + | __________________________________________________________________________| Intestine Small, Ileum | + + + + | Lymphoid Tissue, Hyperplasia | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + | Lymphoid Nodule, Hyperplasia | 2 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + +| Angiectasis | 2 | Basophilic Focus | X X X X X X X X X X X X | Clear Cell Focus | | Fatty Change, Diffuse | 2 | Fatty Change, Focal | 1 1 1 2| Hepatodiaphragmatic Nodule | X X X | Mixed Cell Focus | X X | Pigmentation | 2 | Bile Duct, Hyperplasia | 2 2 2 | __________________________________________________________________________| Mesentery | + + | Fat, Necrosis | 3 2 | __________________________________________________________________________| Pancreas | + + + + + + | __________________________________________________________________________| Salivary Glands | + + + + + | Duct, Inflammation, Acute | 1 | Duct, Metaplasia, Squamous | 2 1 | __________________________________________________________________________| Stomach | + + + + | __________________________________________________________________________| Stomach, Forestomach | + + + + | Hyperkeratosis | | __________________________________________________________________________| Stomach, Glandular | + + + + | Hyperplasia | 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + | Cardiomyopathy | 2 2 | Mineralization | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + | Hyperplasia | 1 | _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 2| 2| 0| 3| 3| 3| 3| 3| 2| 3| 3| 0| 5| 3| 3| 3| 3| 3| | 4| 4| 4| 4| 3| 4| 4| 2| 2| 8| 4| 4| 4| 3| 7| 9| 4| 4| 3| 1| 4| 4| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| .1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Islets, Pancreatic | + + + + + | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 3 3 1 2 2 3 3 2 3 3 3 2| Pars Distalis, Cyst | X X | Pars Distalis, Hyperplasia | 2 1 2 2 2 2 | Pars Nervosa, Cyst | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 1 1 1 1 1 2 1 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + M + + M +| Hyperplasia | | Inflammation, Acute | | Necrosis | | __________________________________________________________________________| Ovary | + + + + + + | Cyst | | __________________________________________________________________________| Uterus | + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + | __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + | Lumbar, Infiltration Cellular, | | Plasma Cell | | Mandibular, Infiltration Cellular, | | Plasma Cell | 3 | Mediastinal, Infiltration Cellular, | | Plasma Cell | | Pancreatic, Infiltration Cellular, | | Histiocyte | | Renal, Infiltration Cellular, | | Histiocyte | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + | Angiectasis | 2 2 | Depletion Lymphoid | 2 | Infiltration Cellular, Histiocyte | 2 2 2 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + +| Angiectasis | | Depletion Lymphoid | | Hematopoietic Cell Proliferation | 1 2 2 | Hemorrhage | | _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 2| 2| 0| 3| 3| 3| 3| 3| 2| 3| 3| 0| 5| 3| 3| 3| 3| 3| | 4| 4| 4| 4| 3| 4| 4| 2| 2| 8| 4| 4| 4| 3| 7| 9| 4| 4| 3| 1| 4| 4| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| .1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Infiltration Cellular, Histiocyte | 2 | Necrosis | | Pigmentation | 2 3 3 | __________________________________________________________________________| Thymus | + + + + + | Depletion Lymphoid | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + +| Galactocele | X X X X X | Acinus, Hyperplasia | 2 | __________________________________________________________________________| Skin | + + + + + | Acanthosis | 2 | Hyperkeratosis | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + | Inflammation, Acute | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + | Congestion | 2 2 2 2 | Hemorrhage | 1 | Inflammation, Chronic Active | | Alveolar Epithelium, Hyperplasia | 2 2 | __________________________________________________________________________| Nose | + + + + | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + + | __________________________________________________________________________| Eye | + + + + + + +| Synechia | | Lens, Cataract | 2 2 | Retina, Atrophy | 2 2 | __________________________________________________________________________| Harderian Gland | + | Pigmentation | 2 | __________________________________________________________________________| Lacrimal Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 2 1 2| Pigmentation | X | _____________________________________________________________________________________________________________________| Page 13 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 2| 2| 0| 3| 3| 3| 3| 3| 2| 3| 3| 0| 5| 3| 3| 3| 3| 3| | 4| 4| 4| 4| 3| 4| 4| 2| 2| 8| 4| 4| 4| 3| 7| 9| 4| 4| 3| 1| 4| 4| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| .1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Cortex, Mineralization | 1 1 | Papilla, Mineralization | 1 1 1 1 | Pelvis, Mineralization | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Renal Tubule, Pigmentation | 1 1 2 2 2 2 2 1 1 1 2 2 2 1 2 1 1 1 1 1 1 2 1 1| __________________________________________________________________________| Urinary Bladder | + M + + | Mineralization | | _____________________________________________________________________________________________________________________| Page 14 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 6| 0| 7| 7| 6| 5| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | DAY ON TEST | 7| 3| 3| 9| 9| 3| 3| 9| 9| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| | | 2| 4| 4| 9| 7| 4| 4| 1| 2| 5| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | .1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large | + + + + +| 9 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + +| 9 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + +| 9 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + M +| 8 | Parasite | | 1 2.0| __________________________________________________________________________|____________| Intestine Small | + + + + + +| 11 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + +| 9 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + +| 10 | Lymphoid Tissue, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + +| 11 | Lymphoid Nodule, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + +| 30 | Angiectasis | | 1 2.0| Basophilic Focus | X X X X X X X X | 20 | Clear Cell Focus | X | 1 | Fatty Change, Diffuse | 2 | 2 2.0| Fatty Change, Focal | 1 2 2| 7 1.4| Hepatodiaphragmatic Nodule | X X X X | 7 | Mixed Cell Focus | | 2 | Pigmentation | | 1 2.0| Bile Duct, Hyperplasia | 2 2 2 2 | 7 2.0| __________________________________________________________________________|____________| Mesentery | | 2 | Fat, Necrosis | | 2 2.5| __________________________________________________________________________|____________| Pancreas | + + + + + + + +| 14 | __________________________________________________________________________|____________| Salivary Glands | + + + + +| 10 | Duct, Inflammation, Acute | | 1 1.0| Duct, Metaplasia, Squamous | | 2 1.5| __________________________________________________________________________|____________| Stomach | + + + + +| 9 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + +| 9 | Hyperkeratosis | 1 | 1 1.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + +| 9 | Hyperplasia | | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + +| 9 | Cardiomyopathy | 2 | 3 2.0| Mineralization | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 6| 0| 7| 7| 6| 5| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | DAY ON TEST | 7| 3| 3| 9| 9| 3| 3| 9| 9| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| | | 2| 4| 4| 9| 7| 4| 4| 1| 2| 5| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | .1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + +| 13 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + +| 13 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + +| 13 | Hyperplasia | | 1 1.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + +| 11 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + M + + + + M + + + + + + + + + + + + + +| 43 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Angiectasis | 2 3 2 2 2 2 3 2 2 2 2 2| 24 2.3| Pars Distalis, Cyst | X | 3 | Pars Distalis, Hyperplasia | 2 2 2 2 1 2 2 | 13 1.8| Pars Nervosa, Cyst | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | C-Cell, Hyperplasia | 1 1 1 1 1 | 13 1.2| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + M + M + + + + + + + +| 16 | Hyperplasia | 4 | 1 4.0| Inflammation, Acute | 3 3 4 | 3 3.3| Necrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + +| 16 | Cyst | X | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + +| 16 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | M + + + +| 8 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + +| 21 | Lumbar, Infiltration Cellular, | | | Plasma Cell | 2 | 1 2.0| Mandibular, Infiltration Cellular, | | | Plasma Cell | | 1 3.0| Mediastinal, Infiltration Cellular, | | | Plasma Cell | 2 | 1 2.0| Pancreatic, Infiltration Cellular, | | | Histiocyte | 2 | 1 2.0| Renal, Infiltration Cellular, | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 16 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 6| 0| 7| 7| 6| 5| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | DAY ON TEST | 7| 3| 3| 9| 9| 3| 3| 9| 9| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| | | 2| 4| 4| 9| 7| 4| 4| 1| 2| 5| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | .1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Histiocyte | 2 2 | 2 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + +| 20 | Angiectasis | | 2 2.0| Depletion Lymphoid | | 1 2.0| Infiltration Cellular, Histiocyte | 1 2 2 | 7 1.9| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + +| 23 | Angiectasis | 2 | 1 2.0| Depletion Lymphoid | 2 | 1 2.0| Hematopoietic Cell Proliferation | 2 2 2 | 6 1.8| Hemorrhage | 3 | 1 3.0| Infiltration Cellular, Histiocyte | 3 | 2 2.5| Necrosis | 3 | 1 3.0| Pigmentation | 2 | 4 2.5| __________________________________________________________________________|____________| Thymus | + + + + +| 10 | Depletion Lymphoid | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + +| 28 | Galactocele | X X X X X X X X| 13 | Acinus, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Skin | + + + + + + +| 12 | Acanthosis | | 1 2.0| Hyperkeratosis | | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | M + + + +| 8 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + +| 10 | Inflammation, Acute | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + +| 26 | Congestion | 2 2 2 2 2 2 | 10 2.0| Hemorrhage | 1 | 2 1.0| Inflammation, Chronic Active | 3 | 1 3.0| Alveolar Epithelium, Hyperplasia | | 2 2.0| __________________________________________________________________________|____________| Nose | + + + + +| 9 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 17 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 __________________________________________________________________________________________________________________________________ | 5| 7| 7| 6| 0| 7| 7| 6| 5| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| | DAY ON TEST | 7| 3| 3| 9| 9| 3| 3| 9| 9| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| | | 2| 4| 4| 9| 7| 4| 4| 1| 2| 5| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | .1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + + | 4 | __________________________________________________________________________|____________| Eye | + + + + + + | 13 | Synechia | 2 2 | 2 2.0| Lens, Cataract | 2 2 | 4 2.0| Retina, Atrophy | | 2 2.0| __________________________________________________________________________|____________| Harderian Gland | + + + + | 5 | Pigmentation | | 1 2.0| __________________________________________________________________________|____________| Lacrimal Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 33 1.1| Pigmentation | | 1 | Cortex, Mineralization | 1 | 3 1.0| Papilla, Mineralization | 1 1 1 1 1 1| 10 1.0| Pelvis, Mineralization | 1 1 1 1 2 1 1 1 1 1 1 1 1 | 30 1.1| Renal Tubule, Pigmentation | 2 2 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2| 47 1.3| __________________________________________________________________________|____________| Urinary Bladder | + + + + +| 8 | Mineralization | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 18 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 1| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 6| 4| 2| 7| 7| 6| 2| 2| DAY ON TEST | 3| 9| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 7| 5| 2| 3| 3| 2| 9| 1| 3| 3| 9| 8| 6| | 3| 5| 7| 3| 5| 4| 4| 3| 2| 9| 4| 4| 7| 7| 6| 4| 4| 4| 5| 6| 4| 4| 8| 8| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| .4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + M + + + + + + + + + + + + + + M| Inflammation, Chronic Active | 1 | __________________________________________________________________________| Intestine Large | + + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + A + + + + A| Parasite | 1 | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +| Parasite | 1 1 1 1 2 2 | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + A + + + + A| __________________________________________________________________________| Intestine Small | + + + + + + + + + A + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + M| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + A + + + + +| Lymphoid Nodule, Hyperplasia | 2 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + A + + + + A| Lymphoid Nodule, Hyperplasia | 2 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X X X X X | Clear Cell Focus | | Congestion | 2 | Fatty Change, Diffuse | 2 | Fatty Change, Focal | 1 1 | Hepatodiaphragmatic Nodule | X X | Mixed Cell Focus | X X X X | Necrosis | | Regeneration, Focal | 2 | Bile Duct, Hyperplasia | 2 2 2 | __________________________________________________________________________| Mesentery | + + | Fat, Hemorrhage | | Fat, Mineralization | | Fat, Necrosis | 3 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 2 | Acinus, Hyperplasia | 2| __________________________________________________________________________| Salivary Glands | + + + + + + + + + M + + + + + + + + + + + + + + M| Acinus, Inflammation, Chronic Active | 1 | Duct, Inflammation, Chronic Active | | Duct, Metaplasia, Squamous | 2 1 1 2 1 1 1 1 | Duct, Mineralization | | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | | Hemorrhage | 1| Inflammation, Chronic Active | 2| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + A| Necrosis | | _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 1| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 6| 4| 2| 7| 7| 6| 2| 2| DAY ON TEST | 3| 9| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 7| 5| 2| 3| 3| 2| 9| 1| 3| 3| 9| 8| 6| | 3| 5| 7| 3| 5| 4| 4| 3| 2| 9| 4| 4| 7| 7| 6| 4| 4| 4| 5| 6| 4| 4| 8| 8| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| .4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + | Artery, Inflammation, Chronic Active | 2 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 2 2 2 2 2 3 2 2 2 1 2 3 | Mineralization | 1 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2| Hemorrhage | | Vacuolization Cytoplasmic | | __________________________________________________________________________| Adrenal Gland, Medulla | M + + + + + M + + + + + + + + + + + + M + + + + +| Hyperplasia | 1 1 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | M + + + M + + M M M + + + + + + M + + + M + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 3 2 2 3 2 2 2 | Pars Distalis, Cyst | X X | Pars Distalis, Hyperplasia | 2 2 2 2 2 2 2 | Pars Intermedia, Angiectasis | | Pars Intermedia, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + + + M + + + + M + + + + + + + + + + + + + + +| Mineralization | 1 | C-Cell, Hyperplasia | 1 1 1 | Follicular Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| Inflammation, Chronic Active | 1 | Necrosis | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X X | Pigmentation | 3 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + M + + +| Decidual Reaction | X | Hemorrhage | 2 | Bilateral, Abscess | | _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 1| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 6| 4| 2| 7| 7| 6| 2| 2| DAY ON TEST | 3| 9| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 7| 5| 2| 3| 3| 2| 9| 1| 3| 3| 9| 8| 6| | 3| 5| 7| 3| 5| 4| 4| 3| 2| 9| 4| 4| 7| 7| 6| 4| 4| 4| 5| 6| 4| 4| 8| 8| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| .4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Endometrium, Hyperplasia, Adenomatous| 3 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + + + + + + + + + + | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mandibular, Hematopoietic Cell | | Proliferation | | Mediastinal, Infiltration Cellular, | | Histiocyte | 3 | Pancreatic, Infiltration Cellular, | | Histiocyte | 2 2 | Renal, Infiltration Cellular, | | Histiocyte | 3 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Depletion Lymphoid | 2 | Infiltration Cellular, Mast Cell | 2 | Infiltration Cellular, Histiocyte | 2 2 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | 2 2 2 | Hematopoietic Cell Proliferation | 2 2 1 2 1 2 2 2 2 2 | Hemorrhage | | Infiltration Cellular, Histiocyte | 3 3 3 2 2 3 3| Necrosis | | __________________________________________________________________________| Thymus | + + + + + + + + M + + + + + + + + + M + + + + + +| Cyst | | Depletion Lymphoid | 4 | Hemorrhage | 3 3 | Necrosis | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + M + + + + + + + + + M + + + + M + M + M M| Galactocele | X X X X | Acinus, Hyperplasia | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + M + + + + + + + + + +| Cyst Epithelial Inclusion | | Hyperkeratosis | | Necrosis | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 _____________________________________________________________________________________________________________________ | 7| 6| 6| 6| 1| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 6| 4| 2| 7| 7| 6| 2| 2| DAY ON TEST | 3| 9| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 7| 5| 2| 3| 3| 2| 9| 1| 3| 3| 9| 8| 6| | 3| 5| 7| 3| 5| 4| 4| 3| 2| 9| 4| 4| 7| 7| 6| 4| 4| 4| 5| 6| 4| 4| 8| 8| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| .4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | Cerebrum, Hemorrhage | | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Atelectasis | 3 | Congestion | 2 3 | Edema | 1 2 2 2| Fibrosis | 2 | Hemorrhage | 1 1 3 3| Infiltration Cellular, Histiocyte | 3 2 | Inflammation, Chronic Active | 2 2 | Mineralization | 1 | Alveolar Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | +| __________________________________________________________________________| Eye | + + + | Synechia | | Lens, Cataract | 3 | Retina, Atrophy | | __________________________________________________________________________| Harderian Gland | + + + | Pigmentation | 2 | __________________________________________________________________________| Lacrimal Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Nephropathy | 1 1 2 1 1 1 1 1 1 2 1 2 1 1 1 | Cortex, Inflammation, Acute | | Cortex, Mineralization | 2 1 1 1 1| Papilla, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 2 | Papilla, Necrosis | | Pelvis, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Renal Tubule, Pigmentation | 2 1 2 2 1 1 2 2 2 1 2 2 1 1 2 2 2 1 2 1 2 1 | __________________________________________________________________________| Urinary Bladder | + + + + M + + + + A + + + M + + + + + + + + + + +| Hemorrhage | | Necrosis | | Transitional Epithelium, Hyperplasia | | _____________________________________________________________________________________________________________________| Page 22 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 5| 0| 7| 6| 6| 5| 5| 7| 7| 5| 2| 2| 7| 7| 7| 6| 6| 7| 7| 7| 6| 2| | DAY ON TEST | 2| 0| 5| 9| 9| 3| 4| 0| 9| 1| 3| 3| 6| 7| 6| 3| 3| 3| 7| 0| 3| 3| 3| 5| 0| | | 1| 5| 2| 2| 4| 2| 9| 5| 2| 2| 4| 4| 1| 0| 6| 4| 4| 4| 0| 4| 4| 4| 4| 8| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | .4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Inflammation, Chronic Active | | 1 1.0| __________________________________________________________________________|____________| Intestine Large | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + A + + + + + + + + A + + + + + + + + + A +| 44 | Parasite | | 1 1.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 | Parasite | 1 1 1 | 9 1.2| __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + A + + + + + + + + M + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Small | + + + + A + + + + + + + + A + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + A + + + + + + + + A + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + A + + + + + + + + A M + + + + + + + + A +| 44 | Lymphoid Nodule, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + A + + + + + + + + A + + + + + + + + + A +| 44 | Lymphoid Nodule, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X X X X X X X X | 27 | Clear Cell Focus | X | 1 | Congestion | | 1 2.0| Fatty Change, Diffuse | | 1 2.0| Fatty Change, Focal | 1 | 3 1.0| Hepatodiaphragmatic Nodule | X X X | 5 | Mixed Cell Focus | X | 5 | Necrosis | 4 1| 2 2.5| Regeneration, Focal | 2 | 2 2.0| Bile Duct, Hyperplasia | 2 2 2 2 | 7 2.0| __________________________________________________________________________|____________| Mesentery | + + + +| 6 | Fat, Hemorrhage | 2| 1 2.0| Fat, Mineralization | 2 | 1 2.0| Fat, Necrosis | 4 3 | 4 3.3| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | | 1 2.0| Acinus, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Acinus, Inflammation, Chronic Active | | 1 1.0| Duct, Inflammation, Chronic Active | 1 | 1 1.0| Duct, Metaplasia, Squamous | 1 2 1 1 2 | 13 1.3| Duct, Mineralization | 1 | 1 1.0| __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 23 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 5| 0| 7| 6| 6| 5| 5| 7| 7| 5| 2| 2| 7| 7| 7| 6| 6| 7| 7| 7| 6| 2| | DAY ON TEST | 2| 0| 5| 9| 9| 3| 4| 0| 9| 1| 3| 3| 6| 7| 6| 3| 3| 3| 7| 0| 3| 3| 3| 5| 0| | | 1| 5| 2| 2| 4| 2| 9| 5| 2| 2| 4| 4| 1| 0| 6| 4| 4| 4| 0| 4| 4| 4| 4| 8| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | .4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Acanthosis | 2 | 1 2.0| Hemorrhage | | 1 1.0| Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + + + +| 47 | Necrosis | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | Artery, Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 31 2.0| Mineralization | | 1 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 | Congestion | | 1 2.0| Hemorrhage | 2 | 1 2.0| Vacuolization Cytoplasmic | 2 2 | 2 2.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + M + + + + + + + + + M + + + + + + + +| 45 | Hyperplasia | 1 1 2 | 6 1.2| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + M + + + M M + + M + M + + + + + + + M M M| 34 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Angiectasis | 2 3 2 3 2 2 2 2 | 15 2.3| Pars Distalis, Cyst | X X | 4 | Pars Distalis, Hyperplasia | 2 2 2 2 | 11 2.0| Pars Intermedia, Angiectasis | 1 | 1 1.0| Pars Intermedia, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 47 | Mineralization | | 1 1.0| C-Cell, Hyperplasia | 1 | 4 1.0| Follicular Cell, Hyperplasia | 3 1 | 2 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 24 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 5| 0| 7| 6| 6| 5| 5| 7| 7| 5| 2| 2| 7| 7| 7| 6| 6| 7| 7| 7| 6| 2| | DAY ON TEST | 2| 0| 5| 9| 9| 3| 4| 0| 9| 1| 3| 3| 6| 7| 6| 3| 3| 3| 7| 0| 3| 3| 3| 5| 0| | | 1| 5| 2| 2| 4| 2| 9| 5| 2| 2| 4| 4| 1| 0| 6| 4| 4| 4| 0| 4| 4| 4| 4| 8| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | .4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + M + M + M + + + + + + + + + + + + + + + + + M| 45 | Inflammation, Chronic Active | | 1 1.0| Necrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | X X | 4 | Pigmentation | | 1 3.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Decidual Reaction | | 1 | Hemorrhage | | 1 2.0| Bilateral, Abscess | 3 | 1 3.0| Endometrium, Hyperplasia, Adenomatous| | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + + + + + + + + | 18 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mandibular, Hematopoietic Cell | | | Proliferation | 2 | 1 2.0| Mediastinal, Infiltration Cellular, | | | Histiocyte | 2 2 | 3 2.3| Pancreatic, Infiltration Cellular, | | | Histiocyte | | 2 2.0| Renal, Infiltration Cellular, | | | Histiocyte | | 2 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 | 1 2.0| Depletion Lymphoid | | 1 2.0| Infiltration Cellular, Mast Cell | | 1 2.0| Infiltration Cellular, Histiocyte | 2 3 2 2 | 7 2.1| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Depletion Lymphoid | 2 2| 5 2.0| Hematopoietic Cell Proliferation | 2 2 3 2 2 2 2 2 2 2 2 2 2 | 23 2.0| Hemorrhage | 2 | 1 2.0| Infiltration Cellular, Histiocyte | 2 2 3 3 2 2 3 3| 15 2.6| Necrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Thymus | + + + M + + + + + M + + + + + + + + + + + + + + +| 46 | Cyst | X | 1 | Depletion Lymphoid | | 1 4.0| Hemorrhage | | 2 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 25 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 5| 0| 7| 6| 6| 5| 5| 7| 7| 5| 2| 2| 7| 7| 7| 6| 6| 7| 7| 7| 6| 2| | DAY ON TEST | 2| 0| 5| 9| 9| 3| 4| 0| 9| 1| 3| 3| 6| 7| 6| 3| 3| 3| 7| 0| 3| 3| 3| 5| 0| | | 1| 5| 2| 2| 4| 2| 9| 5| 2| 2| 4| 4| 1| 0| 6| 4| 4| 4| 0| 4| 4| 4| 4| 8| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | .4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Necrosis | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + M + M + M + + + M + + M M + + + + M M + + + +| 36 | Galactocele | X X | 6 | Acinus, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst Epithelial Inclusion | X | 1 | Hyperkeratosis | 3 | 1 3.0| Necrosis | | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 2.0| Cerebrum, Hemorrhage | 2| 1 2.0| __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atelectasis | | 1 3.0| Congestion | 3 3 3| 5 2.8| Edema | 1 2 2 2| 8 1.8| Fibrosis | | 1 2.0| Hemorrhage | 1 | 5 1.8| Infiltration Cellular, Histiocyte | 1 1 1 1 | 6 1.5| Inflammation, Chronic Active | 2| 3 2.0| Mineralization | | 1 1.0| Alveolar Epithelium, Hyperplasia | 2 3 | 3 2.3| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 2 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 2 | __________________________________________________________________________|____________| Eye | + + + | 6 | Synechia | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 26 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 5| 0| 7| 6| 6| 5| 5| 7| 7| 5| 2| 2| 7| 7| 7| 6| 6| 7| 7| 7| 6| 2| | DAY ON TEST | 2| 0| 5| 9| 9| 3| 4| 0| 9| 1| 3| 3| 6| 7| 6| 3| 3| 3| 7| 0| 3| 3| 3| 5| 0| | | 1| 5| 2| 2| 4| 2| 9| 5| 2| 2| 4| 4| 1| 0| 6| 4| 4| 4| 0| 4| 4| 4| 4| 8| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | .4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | Lens, Cataract | 2 3 | 3 2.7| Retina, Atrophy | 2 | 1 2.0| __________________________________________________________________________|____________| Harderian Gland | + + + + | 7 | Pigmentation | | 1 2.0| __________________________________________________________________________|____________| Lacrimal Gland | + | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | X | 1 | Nephropathy | 1 2 1 1 1 1 1 1 2 2 1 1 1 1 2 | 30 1.2| Cortex, Inflammation, Acute | 3| 1 3.0| Cortex, Mineralization | 2 1 1 1 2| 10 1.3| Papilla, Mineralization | 2 1 1 1 1 1 1 1 1 1 2| 24 1.1| Papilla, Necrosis | 3| 1 3.0| Pelvis, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1| 30 1.0| Renal Tubule, Pigmentation | 2 2 2 1 1 1 1 1 1 1 1 2 1 1 2 1 1 1 1 2 2 1 1 1| 46 1.4| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Hemorrhage | 2| 1 2.0| Necrosis | 3| 1 3.0| Transitional Epithelium, Hyperplasia | 1| 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 27 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5| DAY ON TEST | 3| 4| 0| 1| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 4| 0| 9| 3| 3| 3| 3| 9| | 7| 0| 7| 0| 7| 8| 7| 7| 7| 7| 8| 8| 7| 0| 6| 8| 8| 0| 8| 3| 8| 8| 8| 8| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + M + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + A + + + + + + + + + +| Parasite | 1 1 | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + M + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + M + + + + + + + + + + + M + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X X X X X X X X X | Clear Cell Focus | 1 | Congestion | 2 | Fatty Change, Diffuse | 2 2 3 3 1 | Fatty Change, Focal | 2 2 1 1 2 2 2 2 1 1 2| Hepatodiaphragmatic Nodule | X | Mixed Cell Focus | X | Necrosis | 2 | Regeneration, Focal | 2 | Artery, Inflammation, Chronic Active | 2 | Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | __________________________________________________________________________| Mesentery | + + + + + | Artery, Necrosis, Fibrinoid | 3 3 | Fat, Necrosis | 4 3 4 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 2 | Acinus, Hyperplasia | 2 3 | Artery, Necrosis, Fibrinoid | 1 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Inflammation, Chronic Active | 1 | Artery, Necrosis, Fibrinoid | 2 | Duct, Inflammation, Chronic Active | 2 1 1 | Duct, Metaplasia, Squamous | 1 1 1 2 2 1 1 1| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 2 | Hyperkeratosis | 2 2 | Inflammation, Chronic Active | 2 | Necrosis | 2 3 | Artery, Necrosis, Fibrinoid | 3 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Artery, Necrosis, Fibrinoid | 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5| DAY ON TEST | 3| 4| 0| 1| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 4| 0| 9| 3| 3| 3| 3| 9| | 7| 0| 7| 0| 7| 8| 7| 7| 7| 7| 8| 8| 7| 0| 6| 8| 8| 0| 8| 3| 8| 8| 8| 8| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________| Blood Vessel | + | Artery, Necrosis, Fibrinoid | 1 | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 3 1 2 1 2 2| Thrombosis | | Artery, Necrosis, Fibrinoid | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 1 3 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Parathyroid Gland | + + + M M M + + + + + + + + M + + + M M + + + + +| Hyperplasia | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 3 2 3 2 2 | Pars Distalis, Hemorrhage | 2 | Pars Distalis, Hyperplasia | 3 2 2 2 2 2| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| C-Cell, Hyperplasia | 2 2 1 1 | Capsule, Necrosis, Fibrinoid | 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | __________________________________________________________________________| Preputial Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| Cyst | | Inflammation, Chronic Active | 2 | Necrosis | 2 2 3 3| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + M + + + +| Inflammation, Chronic Active | 2 1 | Artery, Necrosis, Fibrinoid | 2 | Epithelium, Hyperplasia | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Hyperplasia | 2 1 2 2 2 2 2 2| Seminiferous Tubule, Atrophy | 2 2 2 2 2 2 3 2 2 2 2 4 4 1 3 2 | _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5| DAY ON TEST | 3| 4| 0| 1| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 4| 0| 9| 3| 3| 3| 3| 9| | 7| 0| 7| 0| 7| 8| 7| 7| 7| 7| 8| 8| 7| 0| 6| 8| 8| 0| 8| 3| 8| 8| 8| 8| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + + + + + + + + + + + + + + + | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Mediastinal, Angiectasis | 2 | Mediastinal, Infiltration Cellular, | | Histiocyte | 2 2 | Renal, Angiectasis | 2 2 | Renal, Depletion Lymphoid | 2 | Renal, Infiltration Cellular, | | Histiocyte | 2 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Hemorrhage | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | | Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 2 2 2 2| Infiltration Cellular, Histiocyte | 3 | Necrosis | 2 | Capsule, Fibrosis | 2 | Capsule, Inflammation, Chronic Active| 2 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy | | Epithelial Cell, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + M M M M + M M M + + + + M + + M + M M + +| Galactocele | X X X X X X | __________________________________________________________________________| Skin | + + + + + + M + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | X | Hyperkeratosis | 3 3 | Necrosis | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Artery, Necrosis, Fibrinoid | 2 | Brain Stem, Hemorrhage | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 30 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5| DAY ON TEST | 3| 4| 0| 1| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 4| 0| 9| 3| 3| 3| 3| 9| | 7| 0| 7| 0| 7| 8| 7| 7| 7| 7| 8| 8| 7| 0| 6| 8| 8| 0| 8| 3| 8| 8| 8| 8| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Bronchiectasis | 2 | Congestion | 2 2 | Edema | | Infiltration Cellular, Histiocyte | 2 | Inflammation, Chronic Active | 2 | Alveolar Epithelium, Hyperplasia | 1 | Artery, Necrosis, Fibrinoid | 3 | Bronchiole, Metaplasia, Squamous | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | + + + | Lens, Cataract | | Retina, Hemorrhage | | __________________________________________________________________________| Harderian Gland | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Nephropathy | 2 2 3 2 2 2 1 3 2 1 2 3 2 3 3 2 2 2 2 2 2 2 2| Artery, Inflammation | 2 | Cortex, Mineralization | 1 1 | Papilla, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| Pelvis, Mineralization | 1 1 1 | Pelvis, Transitional Epithelium, | | Hyperplasia | 1 | Renal Tubule, Hyperplasia | 1 1 | Renal Tubule, Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Calculus Gross Observation | | Calculus Micro Observation Only | X| _____________________________________________________________________________________________________________________| Page 31 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 4| 5| 3| 3| 3| 4| 5| 3| 3| 3| 3| 7| | | 8| 0| 7| 7| 7| 8| 8| 7| 7| 3| 8| 8| 8| 0| 1| 8| 8| 8| 0| 8| 8| 8| 0| 0| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + M + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large | + + + + A + + + + + + + + + + + + + + A + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + A + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + A + + + + +| 47 | Parasite | 1 | 3 1.0| __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + A + + + + + + + + + + + M + + A + + + + +| 46 | __________________________________________________________________________|____________| Intestine Small | + + + + A + + + + + + + + + + + + + + A + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + A + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + A + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + A + + + + +| 46 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X X X X X X X X X | 32 | Clear Cell Focus | | 1 1.0| Congestion | | 1 2.0| Fatty Change, Diffuse | 2 1 2| 8 2.0| Fatty Change, Focal | 2 1 1 1 1 1 1 2 2 2 2 2 2 2 1 1 | 27 1.6| Hepatodiaphragmatic Nodule | X X| 3 | Mixed Cell Focus | X | 2 | Necrosis | | 1 2.0| Regeneration, Focal | | 1 2.0| Artery, Inflammation, Chronic Active | | 1 2.0| Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 35 2.0| __________________________________________________________________________|____________| Mesentery | + + + + | 9 | Artery, Necrosis, Fibrinoid | | 2 3.0| Fat, Necrosis | 4 | 4 3.8| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy | 2 | 2 2.0| Acinus, Hyperplasia | 2 2 2 2 2 | 7 2.1| Artery, Necrosis, Fibrinoid | | 2 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 | Acinus, Inflammation, Chronic Active | | 1 1.0| Artery, Necrosis, Fibrinoid | | 1 2.0| Duct, Inflammation, Chronic Active | | 3 1.3| Duct, Metaplasia, Squamous | 1 1 1 | 11 1.2| __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 2 | 2 2.0| Hyperkeratosis | 3 | 3 2.3| Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 32 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 4| 5| 3| 3| 3| 4| 5| 3| 3| 3| 3| 7| | | 8| 0| 7| 7| 7| 8| 8| 7| 7| 3| 8| 8| 8| 0| 1| 8| 8| 8| 0| 8| 8| 8| 0| 0| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Necrosis | | 2 2.5| Artery, Necrosis, Fibrinoid | | 1 3.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | Artery, Necrosis, Fibrinoid | | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | | 1 | Artery, Necrosis, Fibrinoid | | 1 1.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2| 37 2.0| Thrombosis | X | 1 | Artery, Necrosis, Fibrinoid | | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | Hemorrhage | | 1 2.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 | Hyperplasia | 2 2 1 2 1 | 9 1.6| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 2 2 | 4 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + M + + + + M + + + + +| 42 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Angiectasis | 2 2 2 2 | 9 2.2| Pars Distalis, Hemorrhage | | 1 2.0| Pars Distalis, Hyperplasia | 2 1 2 2 3 | 11 2.1| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 | C-Cell, Hyperplasia | 1 3 1 | 7 1.6| Capsule, Necrosis, Fibrinoid | | 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 33 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 4| 5| 3| 3| 3| 4| 5| 3| 3| 3| 3| 7| | | 8| 0| 7| 7| 7| 8| 8| 7| 7| 3| 8| 8| 8| 0| 1| 8| 8| 8| 0| 8| 8| 8| 0| 0| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Inflammation, Chronic Active | 2 | 2 2.0| Necrosis | 2 2 2 | 7 2.3| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 2 2 2 | 5 1.8| Artery, Necrosis, Fibrinoid | | 1 2.0| Epithelium, Hyperplasia | 2 2 | 2 2.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Testes | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | Interstitial Cell, Hyperplasia | 2 1 1 2 2 1 1 2 1 | 17 1.6| Seminiferous Tubule, Atrophy | 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 37 2.2| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + + + + + + + + + + + + + + + + | 31 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mediastinal, Angiectasis | | 1 2.0| Mediastinal, Infiltration Cellular, | | | Histiocyte | 3 2 2 | 5 2.2| Renal, Angiectasis | | 2 2.0| Renal, Depletion Lymphoid | | 1 2.0| Renal, Infiltration Cellular, | | | Histiocyte | 2 2| 4 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 2 | 1 2.0| Hemorrhage | | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Depletion Lymphoid | 2 | 1 2.0| Hematopoietic Cell Proliferation | 2 2 2 2 2 3 2 2 2 2 2 2 2 2| 27 2.0| Infiltration Cellular, Histiocyte | | 1 3.0| Necrosis | 2 | 2 2.0| Capsule, Fibrosis | | 1 2.0| Capsule, Inflammation, Chronic Active| | 1 2.0| __________________________________________________________________________|____________| Thymus | + + + M + + + M + + + + + + + + + + + + + M M + +| 46 | Atrophy | 3 | 1 3.0| Epithelial Cell, Hyperplasia | 2 | 2 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + M M + M M + M + + M M M M M M + M + M + + +| 26 | Galactocele | X | 7 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 34 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 4| 5| 3| 3| 3| 4| 5| 3| 3| 3| 3| 7| | | 8| 0| 7| 7| 7| 8| 8| 7| 7| 3| 8| 8| 8| 0| 1| 8| 8| 8| 0| 8| 8| 8| 0| 0| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst Epithelial Inclusion | X | 2 | Hyperkeratosis | 4 3 | 4 3.3| Necrosis | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | + | 2 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Artery, Necrosis, Fibrinoid | | 1 2.0| Brain Stem, Hemorrhage | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Bronchiectasis | | 1 2.0| Congestion | 2 | 3 2.0| Edema | 1 | 1 1.0| Infiltration Cellular, Histiocyte | 2 2 2 | 4 2.0| Inflammation, Chronic Active | 2 | 2 2.0| Alveolar Epithelium, Hyperplasia | 2 | 2 1.5| Artery, Necrosis, Fibrinoid | | 1 3.0| Bronchiole, Metaplasia, Squamous | | 1 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 | Inflammation, Chronic Active | 2 | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 1 | __________________________________________________________________________|____________| Eye | + + | 5 | Lens, Cataract | 3 | 1 3.0| Retina, Hemorrhage | 3 | 1 3.0| __________________________________________________________________________|____________| Harderian Gland | + + | 4 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Nephropathy | 2 2 3 2 2 2 2 1 2 2 2 2 2 2 1 2 3 2 3 1 2 2 1 2 2| 48 2.0| Artery, Inflammation | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 35 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 4| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 4| 5| 3| 3| 3| 4| 5| 3| 3| 3| 3| 7| | | 8| 0| 7| 7| 7| 8| 8| 7| 7| 3| 8| 8| 8| 0| 1| 8| 8| 8| 0| 8| 8| 8| 0| 0| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Cortex, Mineralization | | 2 1.0| Papilla, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 32 1.0| Pelvis, Mineralization | 1 | 4 1.0| Pelvis, Transitional Epithelium, | | | Hyperplasia | | 1 1.0| Renal Tubule, Hyperplasia | 1 | 3 1.0| Renal Tubule, Pigmentation | 1 1 1 1 1 3 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 46 1.1| __________________________________________________________________________|____________| Urinary Bladder | + + + + A + + + + + + + + + + + + + + A + + + + +| 48 | Calculus Gross Observation | X X | 2 | Calculus Micro Observation Only | X X | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 36 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| DAY ON TEST | 3| 3| 2| 6| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 5| 9| | 5| 5| 3| 7| 4| 5| 5| 5| 5| 2| 6| 6| 5| 5| 1| 6| 6| 6| 0| 6| 6| 6| 6| 0| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| .1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + +| Necrosis | 3| __________________________________________________________________________| Intestine Large | + + + + +| __________________________________________________________________________| Intestine Large, Cecum | A + + +| __________________________________________________________________________| Intestine Large, Colon | + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + +| Parasite | 1 | __________________________________________________________________________| Intestine Small | + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + +| Lymphoid Tissue, Hyperplasia | 2 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + +| Hemorrhage | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X X X X X X X X| Clear Cell Focus | X X X X X | Congestion | 3 | Cyst | X | Degeneration, Cystic | 1 | Degeneration | 1 | Fatty Change, Diffuse | 2 | Fatty Change, Focal | 2 2 2 2 1 2 2 1 2| Hepatodiaphragmatic Nodule | X X X | Mixed Cell Focus | X | Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 1| __________________________________________________________________________| Mesentery | + + | Fat, Necrosis | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + +| Acinus, Atrophy | 2 | Acinus, Hyperplasia | 3 | Artery, Mineralization | 2 | Artery, Necrosis, Fibrinoid | 3 | __________________________________________________________________________| Pharynx | + | Hyperplasia, Pseudoepitheliomatous | 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + +| Fibrosis | 2 | Hyperplasia | 2 | Duct, Inflammation, Acute | 1 | Duct, Metaplasia | | Duct, Metaplasia, Squamous | 1 1 1 2 | __________________________________________________________________________| Stomach | + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + +| Acanthosis | 2| Hyperkeratosis | 2 2| _____________________________________________________________________________________________________________________| Page 37 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| DAY ON TEST | 3| 3| 2| 6| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 5| 9| | 5| 5| 3| 7| 4| 5| 5| 5| 5| 2| 6| 6| 5| 5| 1| 6| 6| 6| 0| 6| 6| 6| 6| 0| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| .1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | Hyperplasia, Basal Cell | | Inflammation, Chronic Active | | Mineralization | | Necrosis | | __________________________________________________________________________| Stomach, Glandular | + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + +| Cardiomyopathy | 2 2 2 2| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | X | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 | Hyperplasia | 2 2 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 1 2 1 2 2 2 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 2 2 2 2 3 4 | Pars Distalis, Cyst | X | Pars Distalis, Hyperplasia | 2 2 2 | Pars Distalis, Pigmentation | 2 | Pars Intermedia, Angiectasis | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + +| C-Cell, Hyperplasia | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + +| Inflammation, Chronic Active | 2 | __________________________________________________________________________| Prostate | + + + + +| Inflammation, Chronic Active | 2 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + +| Concretion | 2 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Hyperplasia | 2 2 1 2 1 1 2 1 1| Seminiferous Tubule, Atrophy | 2 3 2 2 2 2 2 2 2 2 3 3 | _____________________________________________________________________________________________________________________| Page 38 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| DAY ON TEST | 3| 3| 2| 6| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 5| 9| | 5| 5| 3| 7| 4| 5| 5| 5| 5| 2| 6| 6| 5| 5| 1| 6| 6| 6| 0| 6| 6| 6| 6| 0| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| .1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | | __________________________________________________________________________| Bone Marrow | + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + +| Lumbar, Angiectasis | 2 | Lumbar, Infiltration Cellular, | | Histiocyte | | Lumbar, Pigmentation | | Mandibular, Angiectasis | 2 | Mediastinal, Angiectasis | | Mediastinal, Infiltration Cellular, | | Histiocyte | 2 2 | Mediastinal, Pigmentation | 2 2 2 | Pancreatic, Infiltration Cellular, | | Histiocyte | 2 | Pancreatic, Pigmentation | 2 2 2 1 2 | Renal, Angiectasis | 2 | Renal, Infiltration Cellular, | | Histiocyte | 3 | Renal, Pigmentation | 2 2 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + +| Angiectasis | 3 | Infiltration Cellular, Histiocyte | 2 2 | Pigmentation | 2 2 2 2 1 | __________________________________________________________________________| Spleen | + + + + + +| Congestion | | Depletion Lymphoid | 2 | Fibrosis | | Hematopoietic Cell Proliferation | 2 2 3 | Hemorrhage | | Necrosis | | __________________________________________________________________________| Thymus | + + + + + + +| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M + M + +| Galactocele | X | __________________________________________________________________________| Skin | + + + + + + + +| Cyst Epithelial Inclusion | | Hyperkeratosis | | Hyperplasia, Basal Cell | | Pigmentation | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 39 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| DAY ON TEST | 3| 3| 2| 6| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 5| 9| | 5| 5| 3| 7| 4| 5| 5| 5| 5| 2| 6| 6| 5| 5| 1| 6| 6| 6| 0| 6| 6| 6| 6| 0| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| .1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | __________________________________________________________________________| Bone | + + + +| __________________________________________________________________________| Skeletal Muscle | + | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + +| Cerebellum, Hemorrhage | 2| Cerebellum, Necrosis | 2| Cerebrum, Hemorrhage | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + +| Congestion | 2 2 1 | Edema | 1 2 | Hemorrhage | | Inflammation, Acute | | Alveolar Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Nose | + + + +| Congestion | | Inflammation, Chronic Active | 3| __________________________________________________________________________| Trachea | + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + + | __________________________________________________________________________| Eye | + + + + | Hemorrhage | | Synechia | 2 | Lens, Cataract | 2 | __________________________________________________________________________| Harderian Gland | + + + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | X | Hydronephrosis | 2 | Nephropathy | 1 2 2 3 2 2 2 1 3 2 2 2 1 2 3 2 3 1 1 2 1 1 1| Cortex, Mineralization | 2 1 2 1 1 1 | Papilla, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 | Pelvis, Mineralization | 1 1 1 1 1 1 1 | Renal Tubule, Degeneration | 1 | Renal Tubule, Pigmentation | 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 1 2 2 1 1 1| __________________________________________________________________________| Urinary Bladder | + + + + + +| Calculus Gross Observation | X | Calculus Micro Observation Only | X | Hemorrhage | 3 | Necrosis | 3 | _____________________________________________________________________________________________________________________| Page 40 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 5| 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 8| 6| 3| 3| 3| 9| 9| 3| 3| 3| 3| 7| | | 7| 1| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 2| 2| 7| 7| 7| 9| 4| 7| 7| 7| 0| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | .1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + +| 12 | Necrosis | | 1 3.0| __________________________________________________________________________|____________| Intestine Large | + + + + | 9 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + | 7 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + | 8 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + | 9 | Parasite | | 1 1.0| __________________________________________________________________________|____________| Intestine Small | + + + + | 9 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + | 9 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + | 8 | Lymphoid Tissue, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + M + + | 8 | Hemorrhage | 2 | 1 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + +| 41 | Basophilic Focus | X X X X X X X X X X X | 27 | Clear Cell Focus | X X X X X X | 11 | Congestion | | 1 3.0| Cyst | | 1 | Degeneration, Cystic | | 1 1.0| Degeneration | | 1 1.0| Fatty Change, Diffuse | 2 2 2 | 4 2.0| Fatty Change, Focal | 1 2 1 2 1 | 14 1.6| Hepatodiaphragmatic Nodule | X X X | 6 | Mixed Cell Focus | X | 2 | Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 | 25 2.0| __________________________________________________________________________|____________| Mesentery | + + | 4 | Fat, Necrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + | 20 | Acinus, Atrophy | | 1 2.0| Acinus, Hyperplasia | 3 | 2 3.0| Artery, Mineralization | | 1 2.0| Artery, Necrosis, Fibrinoid | | 1 3.0| __________________________________________________________________________|____________| Pharynx | | 1 | Hyperplasia, Pseudoepitheliomatous | | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + | 16 | Fibrosis | | 1 2.0| Hyperplasia | | 1 2.0| Duct, Inflammation, Acute | | 1 1.0| Duct, Metaplasia | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 41 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 5| 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 8| 6| 3| 3| 3| 9| 9| 3| 3| 3| 3| 7| | | 7| 1| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 2| 2| 7| 7| 7| 9| 4| 7| 7| 7| 0| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | .1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Duct, Metaplasia, Squamous | 1 | 5 1.2| __________________________________________________________________________|____________| Stomach | + + + + + + + + | 12 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + | 12 | Acanthosis | 3 2 | 3 2.3| Hyperkeratosis | 2 | 3 2.0| Hyperplasia, Basal Cell | 1 | 1 1.0| Inflammation, Chronic Active | 2 | 1 2.0| Mineralization | 2 | 1 2.0| Necrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + | 11 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + | 8 | Cardiomyopathy | 2 2 2 2 | 8 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | | 1 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 3.0| Hyperplasia | 2 | 3 2.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 2 2 2 2 1 2 2 | 15 1.7| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + | 19 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + M + + + +| 11 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + | 26 | Pars Distalis, Angiectasis | 3 2 3 3 2 | 11 2.5| Pars Distalis, Cyst | | 1 | Pars Distalis, Hyperplasia | 1 2 2 | 6 1.8| Pars Distalis, Pigmentation | | 1 2.0| Pars Intermedia, Angiectasis | 2 | 2 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + +| 12 | C-Cell, Hyperplasia | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 42 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 5| 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 8| 6| 3| 3| 3| 9| 9| 3| 3| 3| 3| 7| | | 7| 1| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 2| 2| 7| 7| 7| 9| 4| 7| 7| 7| 0| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | .1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + | 26 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + | 15 | Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Prostate | + + + + + | 10 | Inflammation, Chronic Active | 2 | 2 2.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + | 30 | Concretion | 2 3 | 3 2.3| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + +| 44 | Interstitial Cell, Hyperplasia | 1 1 1 1 2 1 2 2 1 2 1 | 20 1.4| Seminiferous Tubule, Atrophy | 2 3 2 2 2 3 2 3 3 3 2 2 3| 25 2.4| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + | 1 | __________________________________________________________________________|____________| Bone Marrow | + + + + | 8 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + +| 27 | Lumbar, Angiectasis | | 1 2.0| Lumbar, Infiltration Cellular, | | | Histiocyte | 2| 1 2.0| Lumbar, Pigmentation | 2| 1 2.0| Mandibular, Angiectasis | | 1 2.0| Mediastinal, Angiectasis | 2 | 1 2.0| Mediastinal, Infiltration Cellular, | | | Histiocyte | | 2 2.0| Mediastinal, Pigmentation | 2 | 4 2.0| Pancreatic, Infiltration Cellular, | | | Histiocyte | 2 | 2 2.0| Pancreatic, Pigmentation | 2 | 6 1.8| Renal, Angiectasis | | 1 2.0| Renal, Infiltration Cellular, | | | Histiocyte | 2 | 2 2.5| Renal, Pigmentation | 2 | 4 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + | 20 | Angiectasis | 3 | 2 3.0| Infiltration Cellular, Histiocyte | 2 2 | 4 2.0| Pigmentation | 1 2 2 2 | 9 1.8| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + +| 19 | Congestion | 3 | 1 3.0| Depletion Lymphoid | | 1 2.0| Fibrosis | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 43 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 5| 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 8| 6| 3| 3| 3| 9| 9| 3| 3| 3| 3| 7| | | 7| 1| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 2| 2| 7| 7| 7| 9| 4| 7| 7| 7| 0| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | .1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hematopoietic Cell Proliferation | 2 2 2 2 2 2 | 9 2.1| Hemorrhage | 2 | 1 2.0| Necrosis | 3| 1 3.0| __________________________________________________________________________|____________| Thymus | + + + + + + + | 14 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + M + + + + | 9 | Galactocele | X X | 3 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + | 20 | Cyst Epithelial Inclusion | X | 1 | Hyperkeratosis | 3 3 3 | 3 3.0| Hyperplasia, Basal Cell | 1 | 1 1.0| Pigmentation | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + | 8 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + | 8 | Cerebellum, Hemorrhage | | 1 2.0| Cerebellum, Necrosis | | 1 2.0| Cerebrum, Hemorrhage | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + | 18 | Congestion | 4 | 4 2.3| Edema | | 2 1.5| Hemorrhage | 2 1 2 | 3 1.7| Inflammation, Acute | 3 | 1 3.0| Alveolar Epithelium, Hyperplasia | 2 2 | 3 2.0| __________________________________________________________________________|____________| Nose | + + + + + | 9 | Congestion | 2 | 1 2.0| Inflammation, Chronic Active | | 1 3.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + | 18 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 3 | __________________________________________________________________________|____________| Eye | + + + + | 8 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 44 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 __________________________________________________________________________________________________________________________________ | 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| | DAY ON TEST | 3| 5| 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 8| 6| 3| 3| 3| 9| 9| 3| 3| 3| 3| 7| | | 7| 1| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 2| 2| 7| 7| 7| 9| 4| 7| 7| 7| 0| 2| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | .1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | Hemorrhage | 2 | 1 2.0| Synechia | | 1 2.0| Lens, Cataract | 2 3 | 3 2.3| __________________________________________________________________________|____________| Harderian Gland | + + + | 7 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | | 1 | Hydronephrosis | | 1 2.0| Nephropathy | 1 1 1 1 2 2 3 2 1 2 1 2 2 1 1 2 2 2 2 1 2 2 2 3 2| 48 1.8| Cortex, Mineralization | 1 1 1 | 9 1.2| Papilla, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 31 1.0| Pelvis, Mineralization | 1 1 1 1 1 | 12 1.0| Renal Tubule, Degeneration | | 1 1.0| Renal Tubule, Pigmentation | 1 2 1 2 2 2 1 2 1 3 2 2 1 2 2 2 2 3 3 2 2 2 2| 46 1.8| __________________________________________________________________________|____________| Urinary Bladder | + + + + | 10 | Calculus Gross Observation | X | 2 | Calculus Micro Observation Only | X | 2 | Hemorrhage | | 1 3.0| Necrosis | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 45 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| DAY ON TEST | 3| 3| 0| 9| 8| 3| 3| 2| 1| 5| 3| 2| 6| 0| 9| 3| 3| 3| 0| 0| 3| 1| 0| 0| 9| | 0| 0| 8| 5| 8| 0| 0| 7| 1| 7| 0| 3| 6| 0| 1| 5| 5| 0| 6| 3| 0| 3| 4| 4| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| .4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + M + + + + + + + + + + + + + + +| Hyperkeratosis | 2| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | Lymphoid Nodule, Hyperplasia | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + + + +| Parasite | 1 1 2 1 | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + + + + +| Parasite | | __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + +| Lymphoid Nodule, Hyperplasia | 3 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + +| Inflammation, Chronic Active | 2 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | X X X X X X X X X X X X X X X X | Clear Cell Focus | X | Eosinophilic Focus | | Fatty Change, Diffuse | 2 | Fatty Change, Focal | 1 2 1 1 1 1 2| Focal Cellular Change | X X | Hepatodiaphragmatic Nodule | X X | Mixed Cell Focus | X | Necrosis | 2 1 | Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | __________________________________________________________________________| Mesentery | + + + + + | Fat, Inflammation, Chronic Active | 1 2 | Fat, Necrosis | 3 | Fat, Pigmentation | 3 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy | 2 | Acinus, Hyperplasia | 3 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + M + +| Duct, Inflammation, Chronic Active | 1 | Duct, Metaplasia | | Duct, Metaplasia, Squamous | 2 1 1 1 1 1 | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Acanthosis | 2 1 | Hyperkeratosis | 2 | Inflammation, Chronic Active | | Necrosis | 1| _____________________________________________________________________________________________________________________| Page 46 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| DAY ON TEST | 3| 3| 0| 9| 8| 3| 3| 2| 1| 5| 3| 2| 6| 0| 9| 3| 3| 3| 0| 0| 3| 1| 0| 0| 9| | 0| 0| 8| 5| 8| 0| 0| 7| 1| 7| 0| 3| 6| 0| 1| 5| 5| 0| 6| 3| 0| 3| 4| 4| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| .4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | Mineralization | 2 | Necrosis | 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Cardiomyopathy | 2 2 2 2 2 3 2 2 2 3 3 2 2 2 2 2 2 2 2 2 2 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Vacuolization Cytoplasmic | 3 | __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 1 2 2 2 2 2 1 | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Parathyroid Gland | + + M M + + + + + + + + + M + M + + + + + + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Angiectasis | 2 3 2 | Pars Distalis, Hemorrhage | 4 | Pars Distalis, Hyperplasia | 2 2 2 2 2 | Pars Distalis, Necrosis | 3 | Pars Intermedia, Hyperplasia | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | C-Cell, Hyperplasia | 2 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + M + + + + + + + + + M +| Fibrosis | | Inflammation, Chronic Active | | Spermatocele | 2 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 3 | Necrosis | 2 2 2 3 3 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 1 2 2 | Epithelium, Hyperplasia | 2 1 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 47 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| DAY ON TEST | 3| 3| 0| 9| 8| 3| 3| 2| 1| 5| 3| 2| 6| 0| 9| 3| 3| 3| 0| 0| 3| 1| 0| 0| 9| | 0| 0| 8| 5| 8| 0| 0| 7| 1| 7| 0| 3| 6| 0| 1| 5| 5| 0| 6| 3| 0| 3| 4| 4| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| .4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Atrophy | 3 | Congestion | 1 | Interstitial Cell, Hyperplasia | 2 1 1 2 2 2 2 2 2 1 2 1 1 1| Seminiferous Tubule, Atrophy | 2 2 2 2 2 2 2 3 2 2 2 2 3 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + + + + + + + + + | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| Iliac, Infiltration Cellular, | | Histiocyte | 2 | Lumbar, Hematopoietic Cell | | Proliferation | 2 | Lumbar, Hemorrhage | 2 | Lumbar, Infiltration Cellular, | | Histiocyte | 2 | Mandibular, Necrosis | | Mediastinal, Angiectasis | 2 2 2 | Mediastinal, Depletion Lymphoid | | Mediastinal, Infiltration Cellular, | | Histiocyte | 3 2 | Pancreatic, Infiltration Cellular, | | Histiocyte | 2 | Renal, Angiectasis | 2 | Renal, Hemorrhage | 1 | Renal, Infiltration Cellular, | | Histiocyte | 2 2 2 2 2 3 3 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + M +| Angiectasis | 3 2 2 | Depletion Lymphoid | 2 | Infiltration Cellular, Mast Cell | 2 | Infiltration Cellular, Histiocyte | 2 2 2 2 2 2 2 2 2 2 1 | Renal, Angiectasis | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Lymphoid | 2 3 | Fibrosis | 2 | Hematopoietic Cell Proliferation | 2 2 3 2 2 2 2 3 2 1 2 3 3 2 2 2 2 1 3 2| Hemorrhage | | Infiltration Cellular, Histiocyte | 2 3 | Pigmentation | | __________________________________________________________________________| Thymus | + + + + + + + + + + + M + + + + + + + + + + + + +| Atrophy | | Depletion Lymphoid | | Epithelial Cell, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| Page 48 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| DAY ON TEST | 3| 3| 0| 9| 8| 3| 3| 2| 1| 5| 3| 2| 6| 0| 9| 3| 3| 3| 0| 0| 3| 1| 0| 0| 9| | 0| 0| 8| 5| 8| 0| 0| 7| 1| 7| 0| 3| 6| 0| 1| 5| 5| 0| 6| 3| 0| 3| 4| 4| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| .4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + M + M M + + M M + + + + M M M + + M + M + M +| Galactocele | X X X | Acinus, Hyperplasia | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Abscess | | Cyst Epithelial Inclusion | X | Fibrosis | | Hyperkeratosis | 3 3 4 | Hyperplasia, Basal Cell | 1 | Inflammation, Acute | | Necrosis | 2 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Cerebellum, Hemorrhage | | Cerebrum, Hemorrhage | 1 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Atelectasis | | Congestion | 2 2 | Edema | 2 2| Hemorrhage | 2 | Infiltration Cellular, Histiocyte | 1 2| Inflammation, Chronic Active | | Alveolar Epithelium, Hyperplasia | 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic Active | 2 2 3 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Erosion | 3 | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + + | Hemorrhage | 2 | Necrosis | 3 | __________________________________________________________________________| Eye | + + + + + + + + | Synechia | 2 3 | Lens, Cataract | 2 2 | _____________________________________________________________________________________________________________________| Page 49 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| DAY ON TEST | 3| 3| 0| 9| 8| 3| 3| 2| 1| 5| 3| 2| 6| 0| 9| 3| 3| 3| 0| 0| 3| 1| 0| 0| 9| | 0| 0| 8| 5| 8| 0| 0| 7| 1| 7| 0| 3| 6| 0| 1| 5| 5| 0| 6| 3| 0| 3| 4| 4| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| .4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | Retina, Atrophy | 2 3 2 | Sclera, Pigmentation | 1 | __________________________________________________________________________| Harderian Gland | + + + | Hyperplasia | 1 | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2| Cyst | X | Nephropathy | 2 2 2 2 2 3 2 1 1 3 3 1 2 2 2 2 1 2 1 2 2 1 1| Cortex, Mineralization | 1 | Papilla, Mineralization | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1| Pelvis, Mineralization | 1 1 1 1 1 1 1 1 | Renal Tubule, Mineralization | 1 | Renal Tubule, Pigmentation | 1 2 3 1 1 1 2 1 1 2 2 1 1 1 1 1 2 1 1 2 2 2 3 1| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + A + + + + + + + + + + + +| Calculus Micro Observation Only | X | _____________________________________________________________________________________________________________________| Page 50 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 6| 6| 3| 5| 7| 6| 5| 5| | DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 0| 6| 5| 7| 8| 3| 7| 6| 1| | | 5| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 0| 0| 6| 5| 7| 0| 2| 2| 0| 5| 0| 2| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | .4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 | Hyperkeratosis | | 1 2.0| __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | Inflammation, Chronic Active | | 1 2.0| Lymphoid Nodule, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | Parasite | 1 2 | 6 1.3| __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 | Parasite | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + M + A + + + + + + + + + + + + + + +| 47 | Lymphoid Nodule, Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + A| 47 | Inflammation, Chronic Active | | 1 2.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | X X X X X X X X X X X X X X X X X X | 34 | Clear Cell Focus | | 1 | Eosinophilic Focus | 1 | 1 1.0| Fatty Change, Diffuse | | 1 2.0| Fatty Change, Focal | 2 1 1 2 1 1 1| 14 1.3| Focal Cellular Change | | 2 | Hepatodiaphragmatic Nodule | X | 3 | Mixed Cell Focus | | 1 | Necrosis | | 2 1.5| Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 37 2.0| __________________________________________________________________________|____________| Mesentery | | 5 | Fat, Inflammation, Chronic Active | | 2 1.5| Fat, Necrosis | | 1 3.0| Fat, Pigmentation | | 1 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Acinus, Atrophy | | 1 2.0| Acinus, Hyperplasia | 2 2 2 2 | 6 2.2| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Duct, Inflammation, Chronic Active | | 1 1.0| Duct, Metaplasia | 1 | 1 1.0| Duct, Metaplasia, Squamous | 1 1 1 2 | 10 1.2| __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 51 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 6| 6| 3| 5| 7| 6| 5| 5| | DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 0| 6| 5| 7| 8| 3| 7| 6| 1| | | 5| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 0| 0| 6| 5| 7| 0| 2| 2| 0| 5| 0| 2| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | .4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acanthosis | 2 2 3 1| 6 1.8| Hyperkeratosis | 1 2 3 1| 5 1.8| Inflammation, Chronic Active | 2 | 1 2.0| Necrosis | 2 | 2 1.5| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Hyperplasia | | 1 2.0| Mineralization | | 1 2.0| Necrosis | | 1 1.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cardiomyopathy | 2 2 2 2 2 2 2 2 2 1 2 2 3 2 2 2 2 2 3 2 2 2| 44 2.1| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Vacuolization Cytoplasmic | | 1 3.0| __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 1 2 1 1 1 2 | 14 1.6| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + M + + + + + + + + + M + + + M + + + + +| 42 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Pars Distalis, Angiectasis | 2 2 2 4 2 2 | 9 2.3| Pars Distalis, Hemorrhage | | 1 4.0| Pars Distalis, Hyperplasia | 2 2 | 7 2.0| Pars Distalis, Necrosis | | 1 3.0| Pars Intermedia, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Hemorrhage | 2 | 1 2.0| C-Cell, Hyperplasia | 2 1 3 2 1 1 1 2 | 10 1.6| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Fibrosis | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 52 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 6| 6| 3| 5| 7| 6| 5| 5| | DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 0| 6| 5| 7| 8| 3| 7| 6| 1| | | 5| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 0| 0| 6| 5| 7| 0| 2| 2| 0| 5| 0| 2| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | .4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Inflammation, Chronic Active | 2 | 1 2.0| Spermatocele | X | 2 2.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 1 3.0| Necrosis | 3 2 | 7 2.4| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic Active | | 3 1.7| Epithelium, Hyperplasia | 1 | 3 1.3| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy | | 1 3.0| Congestion | | 1 1.0| Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2 1 2 1 2 2| 26 1.7| Seminiferous Tubule, Atrophy | 2 2 2 2 4 2 3 2 2 3 2 2 2 2 2 2 2 2 | 32 2.2| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + + + + + + + + + + + + | 21 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + A + + + + + + + + + + + + + M +| 48 | Iliac, Infiltration Cellular, | | | Histiocyte | | 1 2.0| Lumbar, Hematopoietic Cell | | | Proliferation | | 1 2.0| Lumbar, Hemorrhage | 2 | 2 2.0| Lumbar, Infiltration Cellular, | | | Histiocyte | 2 | 2 2.0| Mandibular, Necrosis | 2 | 1 2.0| Mediastinal, Angiectasis | 2 | 4 2.0| Mediastinal, Depletion Lymphoid | 2| 1 2.0| Mediastinal, Infiltration Cellular, | | | Histiocyte | 2 2 | 4 2.3| Pancreatic, Infiltration Cellular, | | | Histiocyte | | 1 2.0| Renal, Angiectasis | 3 | 2 2.5| Renal, Hemorrhage | | 1 1.0| Renal, Infiltration Cellular, | | | Histiocyte | 3 2 1| 11 2.3| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + A + + + + + + + + + + + + + M +| 47 | Angiectasis | 2 2 | 5 2.2| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 53 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 6| 6| 3| 5| 7| 6| 5| 5| | DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 0| 6| 5| 7| 8| 3| 7| 6| 1| | | 5| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 0| 0| 6| 5| 7| 0| 2| 2| 0| 5| 0| 2| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | .4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Depletion Lymphoid | 2| 2 2.0| Infiltration Cellular, Mast Cell | | 1 2.0| Infiltration Cellular, Histiocyte | 2 2 2 2 2 1 2 | 18 1.9| Renal, Angiectasis | | 1 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Depletion Lymphoid | | 2 2.5| Fibrosis | | 1 2.0| Hematopoietic Cell Proliferation | 2 2 2 2 1 2 2 2 2 3 2 2 2 2 1 2 3 2| 38 2.1| Hemorrhage | 2 | 1 2.0| Infiltration Cellular, Histiocyte | 2 | 3 2.3| Pigmentation | 2 | 1 2.0| __________________________________________________________________________|____________| Thymus | + + + + + + + + + A + + + + + + + + + + + M + M +| 46 | Atrophy | 3 | 1 3.0| Depletion Lymphoid | 4| 1 4.0| Epithelial Cell, Hyperplasia | | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M + + M + M M M + M M M + + M + + + M + + + M + M| 27 | Galactocele | X X | 5 | Acinus, Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Abscess | 4 | 1 4.0| Cyst Epithelial Inclusion | | 1 | Fibrosis | 2 | 1 2.0| Hyperkeratosis | 2 | 4 3.0| Hyperplasia, Basal Cell | | 1 1.0| Inflammation, Acute | 4 | 1 4.0| Necrosis | 3 3 | 3 2.7| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | | 3 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cerebellum, Hemorrhage | 1 | 1 1.0| Cerebrum, Hemorrhage | | 1 1.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 54 NTP Experiment-Test: 05030-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC PROBENECID Date: 04/29/97 Route: GAVAGE Time: 15:49:49 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 6| 6| 3| 5| 7| 6| 5| 5| | DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 0| 6| 5| 7| 8| 3| 7| 6| 1| | | 5| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 0| 0| 6| 5| 7| 0| 2| 2| 0| 5| 0| 2| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | .4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atelectasis | 2 | 1 2.0| Congestion | 2 2 | 4 2.0| Edema | 2 | 3 2.0| Hemorrhage | 1 1 1 1 1| 6 1.2| Infiltration Cellular, Histiocyte | 1 1 1 | 5 1.2| Inflammation, Chronic Active | 1 | 1 1.0| Alveolar Epithelium, Hyperplasia | 1 | 2 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic Active | 2 2 3 2 | 7 2.3| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Erosion | | 1 3.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | + | 3 | Hemorrhage | | 1 2.0| Necrosis | | 1 3.0| __________________________________________________________________________|____________| Eye | + + +| 11 | Synechia | | 2 2.5| Lens, Cataract | 2 | 3 2.0| Retina, Atrophy | | 3 2.3| Sclera, Pigmentation | | 1 1.0| __________________________________________________________________________|____________| Harderian Gland | + | 4 | Hyperplasia | | 1 1.0| _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 2 | 2 2.0| Cyst | | 1 | Nephropathy | 2 2 2 2 3 2 3 2 2 2 2 2 2 3 3 1 2 2 1 1 2 2 1 1| 47 1.9| Cortex, Mineralization | 1 | 2 1.0| Papilla, Mineralization | 1 1 2 1 1 2 1 1 1 1 1 1 1 1 1 1| 35 1.1| Pelvis, Mineralization | 1 1 1 1 1 | 13 1.0| Renal Tubule, Mineralization | 1 1 | 3 1.0| Renal Tubule, Pigmentation | 2 2 1 2 1 2 1 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1| 46 1.4| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + A + + + + + + + M + + + + + + +| 47 | Calculus Micro Observation Only | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 55 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------ --multipart-boundary Content-type: text/plain Range: bytes 517179-517179/517179 --multipart-boundary--
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The National Institute of Environmental Health Sciences is one of the National Institutes of Health within the U.S. Department of Health and Human Services. The National Toxicology Program is headquartered on the NIEHS campus in Research Triangle Park, NC.