Pathology Tables for Peer Review
The National Toxicology Program
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
PROBENECID
NTP Experiment-Test: 05030-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/04/94
Route: GAVAGE Time: 13:40:33
Facility: TSI Mason Research
Chemical CAS #: 57-66-9
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05030-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 13:40:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE .1G/KG .4G/KG
FEMALE LF HF
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund 25 15 20
Dead 1 10
Gavage Death 1
Survivors
Terminal Sacrifice 23 35 19
Moribund 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (50) (30) (50)
Histiocytic Sarcoma 1 (3%) 1 (2%)
Neoplastic Nodule 1 (3%) 2 (4%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Mesentery (6) (2) (6)
Histiocytic Sarcoma 1 (17%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (17%)
Sarcoma Stromal, Metastatic 1 (17%)
Pancreas (50) (14) (50)
Histiocytic Sarcoma 1 (2%)
Salivary Glands (50) (10) (48)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Stomach, Forestomach (49) (9) (49)
Histiocytic Sarcoma 1 (2%)
Stomach, Glandular (50) (9) (47)
Histiocytic Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (9) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (13) (49)
Adenoma 1 (2%) 1 (2%)
Carcinoma, Metastatic 1 (2%)
Histiocytic Sarcoma 1 (2%)
Adrenal Gland, Medulla (48) (13) (45)
Histiocytic Sarcoma 1 (2%)
Page 2
NTP Experiment-Test: 05030-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 13:40:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE .1G/KG .4G/KG
FEMALE LF HF
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Pheochromocytoma Benign 1 (2%) 1 (8%) 1 (2%)
Bilateral, Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (50) (11) (50)
Adenoma 1 (9%) 2 (4%)
Pituitary Gland (50) (50) (50)
Pars Distalis, Adenoma 20 (40%) 25 (50%) 15 (30%)
Pars Distalis, Adenoma, Multiple 2 (4%) 1 (2%) 1 (2%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (49) (50) (47)
Bilateral, C-Cell, Carcinoma 1 (2%)
C-Cell, Adenoma 9 (18%) 3 (6%) 1 (2%)
C-Cell, Carcinoma 3 (6%) 1 (2%) 1 (2%)
Follicular Cell, Adenoma 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (36) (16) (45)
Adenoma 3 (8%) 7 (44%) 1 (2%)
Carcinoma 1 (6%)
Ovary (50) (16) (50)
Arrhenoblastoma Benign 1 (2%)
Granulosa Cell Tumor Benign 2 (4%) 1 (6%) 1 (2%)
Histiocytic Sarcoma 1 (6%) 1 (2%)
Uterus (50) (16) (49)
Adenoma 1 (2%)
Deciduoma NOS 1 (2%)
Leiomyosarcoma 1 (2%)
Polyp Stromal 6 (12%) 10 (63%) 9 (18%)
Sarcoma Stromal 1 (2%) 2 (4%)
Bilateral, Polyp Stromal 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (23) (18)
Bone Marrow (50) (8) (50)
Lymph Node (49) (21) (50)
Mandibular, Carcinoma, Metastatic, Thyroid
Gland 1 (2%) 1 (2%)
Lymph Node, Mesenteric (49) (20) (50)
Spleen (50) (23) (50)
Page 3
NTP Experiment-Test: 05030-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 13:40:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE .1G/KG .4G/KG
FEMALE LF HF
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Sarcoma 1 (2%)
Thymus (49) (10) (46)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (47) (28) (36)
Adenocarcinoma 3 (6%) 1 (4%)
Fibroadenoma 14 (30%) 17 (61%) 5 (14%)
Fibroadenoma, Multiple 10 (21%) 6 (21%)
Skin (50) (12) (49)
Basal Cell Carcinoma 1 (8%)
Histiocytic Sarcoma 1 (2%)
Neurofibroma 1 (2%)
Sarcoma 2 (4%) 1 (8%)
Squamous Cell Carcinoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (10) (50)
Astrocytoma Benign 1 (10%)
Cerebrum, Oligodendroglioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (26) (50)
Alveolar/Bronchiolar Adenoma 2 (4%) 2 (8%) 1 (2%)
Carcinoma, Metastatic, Thyroid Gland 2 (4%) 1 (2%)
Histiocytic Sarcoma 1 (2%)
Sarcoma, Metastatic, Uncertain Primary Site 1 (2%)
Trachea (50) (46) (50)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05030-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 13:40:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE .1G/KG .4G/KG
FEMALE LF HF
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Urinary Bladder (50) (8) (47)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%) 1 (2%)
Leukemia Mononuclear 15 (30%) 17 (34%) 17 (34%)
Lymphoma Malignant Histiocytic 1 (2%)
Lymphoma Malignant Undifferentiated Cell 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05030-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 13:40:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE .1G/KG .4G/KG
FEMALE LF HF
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 48 46 37
Total Primary Neoplasms 102 100 70
Total Animals with Benign Neoplasms 41 39 29
Total Benign Neoplasms 75 77 44
Total Animals with Malignant Neoplasms 26 21 24
Total Malignant Neoplasms 26 23 26
Total Animals with Metastatic Neoplasms 3 2
Total Metastatic Neoplasm 9 3
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05030-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 13:40:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE .1G/KG .4G/KG
MALE LM HM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Moribund 10 11 22
Dead 3 4 5
Gavage Death 1 1
Survivors
Terminal Sacrifice 34 32 21
Moribund 2 2 1
Dead 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (47) (8) (48)
Intestine Small, Duodenum (48) (9) (49)
Adenocarcinoma 1 (2%)
Intestine Small, Jejunum (46) (8) (47)
Adenocarcinoma 1 (13%)
Leiomyoma 1 (2%)
Liver (50) (41) (50)
Fibrous Histiocytoma, Metastatic, Skin 1 (2%)
Hepatocellular Carcinoma 1 (2%)
Neoplastic Nodule 1 (2%) 1 (2%)
Mesentery (9) (4) (5)
Hepatocellular Carcinoma, Metastatic, Liver 1 (25%)
Pancreas (50) (20) (49)
Acinus, Adenoma 1 (2%)
Salivary Glands (49) (16) (49)
Stomach, Forestomach (50) (12) (50)
Squamous Cell Papilloma 1 (8%)
Stomach, Glandular (49) (11) (49)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (8) (50)
Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 05030-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 13:40:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE .1G/KG .4G/KG
MALE LM HM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (49) (50) (50)
Adenoma 2 (4%)
Adrenal Gland, Medulla (49) (50) (50)
Pheochromocytoma Malignant 1 (2%) 1 (2%)
Pheochromocytoma Benign 14 (29%) 16 (32%) 6 (12%)
Bilateral, Pheochromocytoma Benign 5 (10%) 2 (4%) 2 (4%)
Islets, Pancreatic (49) (19) (49)
Adenoma 2 (4%) 2 (11%) 3 (6%)
Carcinoma 1 (5%) 1 (2%)
Pituitary Gland (50) (26) (50)
Pars Distalis, Adenoma 15 (30%) 12 (46%) 17 (34%)
Pars Distalis, Adenoma, Multiple 2 (8%)
Thyroid Gland (49) (12) (49)
Carcinoma 1 (2%)
C-Cell, Adenoma 9 (18%) 3 (25%) 10 (20%)
C-Cell, Carcinoma 1 (2%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (26) (48)
Preputial Gland (49) (15) (50)
Adenoma 6 (12%) 2 (13%) 7 (14%)
Carcinoma 2 (13%) 1 (2%)
Bilateral, Adenoma 1 (7%) 2 (4%)
Seminal Vesicle (49) (30) (50)
Testes (49) (44) (50)
Bilateral, Interstitial Cell, Adenoma 42 (86%) 33 (75%) 37 (74%)
Bilateral, Interstitial Tissue, Adenoma 1 (2%)
Interstitial Cell, Adenoma 3 (6%) 5 (11%) 7 (14%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Blood (31) (1) (21)
Bone Marrow (50) (8) (49)
Lymph Node (50) (27) (48)
Bronchial, Mediastinal, Fibrosarcoma,
Metastatic, Skin 1 (2%)
Page 8
NTP Experiment-Test: 05030-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 13:40:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE .1G/KG .4G/KG
MALE LM HM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Mediastinal, Fibrous Histiocytoma,
Metastatic, Skin 1 (4%)
Lymph Node, Mesenteric (50) (20) (47)
Mediastinal, Hepatocellular Carcinoma,
Metastatic, Liver 1 (5%)
Spleen (50) (19) (49)
Thymus (46) (14) (46)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Epithelial Cell, Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (26) (9) (27)
Fibroadenoma 3 (12%) 2 (22%)
Skin (49) (20) (50)
Basal Cell Adenoma 1 (2%) 1 (5%)
Basal Cell Carcinoma 1 (5%) 1 (2%)
Fibrous Histiocytoma 1 (5%)
Keratoacanthoma 2 (4%) 1 (5%)
Squamous Cell Carcinoma 1 (5%)
Squamous Cell Papilloma 1 (5%) 1 (2%)
Trichoepithelioma 1 (2%) 1 (5%)
Subcutaneous Tissue, Fibroma 5 (10%) 3 (15%) 3 (6%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%) 1 (5%)
Subcutaneous Tissue, Sarcoma 1 (5%) 2 (4%)
Subcutaneous Tissue, Schwannoma Malignant 1 (5%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (2) (1) (3)
Fibrosarcoma, Metastatic, Skin 1 (50%)
Fibrous Histiocytoma, Metastatic, Skin 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (8) (50)
Astrocytoma Malignant 1 (2%)
Granular Cell Tumor Benign 1 (2%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05030-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 13:40:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE .1G/KG .4G/KG
MALE LM HM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (18) (50)
Alveolar/Bronchiolar Adenoma 3 (6%) 2 (11%) 6 (12%)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Fibrous Histiocytoma, Metastatic, Skin 1 (6%)
Hepatocellular Carcinoma, Metastatic, Liver 1 (6%)
Nose (49) (9) (49)
Basosquamous Tumor Benign 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (3) (3)
Fibrosarcoma 1 (100%) 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Fibrosarcoma, Metastatic, Skin 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Urinary Bladder (48) (10) (47)
Fibrous Histiocytoma, Metastatic, Skin 1 (10%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Leukemia Mononuclear 6 (12%) 10 (20%) 7 (14%)
Lymphoma Malignant Undifferentiated Cell 1 (2%)
Mesothelioma Benign 1 (2%)
Mesothelioma Malignant 4 (8%) 2 (4%) 5 (10%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05030-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 13:40:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE .1G/KG .4G/KG
MALE LM HM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 48 48 48
Total Primary Neoplasms 132 118 128
Total Animals with Benign Neoplasms 47 46 47
Total Benign Neoplasms 117 93 105
Total Animals with Malignant Neoplasms 15 23 21
Total Malignant Neoplasms 15 25 23
Total Animals with Metastatic Neoplasms 1 2 1
Total Metastatic Neoplasm 5 8 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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