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Pathology Tables for Peer Review
Pathology Tables for Peer Review
Home » Study Results & Research Projects » Pathology Tables for Peer Review » TR395_TC.html » The National Toxicology Program
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: Mason DATE: 09/04/94 EXP: 05030 PROBENECID TIME: 15:19:33 TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1 TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 56097 CONT: N01CP9561903 CAS: 000057669 PATHOLOGIST: K. MURTHY S. EUSTIS -------------------------------------------------------------------------------- REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE ALL NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: Mason DATE: 09/04/94 EXP: 05030 PROBENECID TIME: 15:19:33 TEST: 02 CAGES FROM 0000 TO LAST CAGE TEST TYPE: CHRONIC ROUTE: GAVAGE NTP C#: 56097 CONT: N01CP9561903 CAS: 000057669 PATHOLOGIST: K. MURTHY S. EUSTIS PROBENECID STATISTICAL ANALYSIS OF SURVIVAL DATA MALE MICE FIRST TERMINAL SACRIFICE AT 731 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = VEHICLE | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 0 TERMINAL 38 | | | | UNCENSORED DEATHS | | 3 310 390 410 522 541 576 582 606 614 | | 680 682 | | CENSORED DEATHS | | NONE | | | |--------------------------------------------------------------------------------| | DOSE = .1G/KG | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 25 CENSORED DEATHS 2 TERMINAL 23 | | | | UNCENSORED DEATHS | | 143 208 239 305 390 416 426 431 443 452 | | 463 492 515 561 589 635 645 645 645 646 | | 659 683 707 717 725 | | CENSORED DEATHS | | 3 3 | | | |--------------------------------------------------------------------------------| | DOSE = .4G/KG | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 26 CENSORED DEATHS 0 TERMINAL 24 | | | | UNCENSORED DEATHS | | 20 31 304 306 355 408 438 509 515 568 | | 568 589 611 611 620 626 634 635 640 646 | | 667 686 717 722 725 727 | | CENSORED DEATHS | | NONE | | | ================================================================================== PROBENECID STATISTICAL ANALYSIS OF SURVIVAL DATA MALE MICE FIRST TERMINAL SACRIFICE AT 731 DAYS ================================================================================== | KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) | | | |--------------------------------------------------------------------------------| | DOSE TIME (DAYS) | | 90 180 270 365 425 485 545 605 665 731 (A) | | | |--------------------------------------------------------------------------------| | | | |VEHICLE | 98.0 98.0 98.0 96.0 92.0 92.0 88.0 84.0 80.0 76.0 | | | | | | | |.1G/KG | 100.0 97.9 93.8 91.7 87.5 77.1 72.9 68.8 56.3 47.9 | | | | | | | |.4G/KG | 96.0 96.0 96.0 90.0 88.0 86.0 82.0 76.0 60.0 48.0 | | | | | | | ================================================================================== ================================================================================== | SURVIVAL SUMMARY STATISTICS | | | | | |--------------------------------------------------------------------------------| | DOSE | | | | VEHICLE .1G/KG .4G/KG | | | |--------------------------------------------------------------------------------| |SURVIVAL AT END OF STUDY| 76.0% 47.9% 48.0% | |(KAPLAN-MEIER) | | | | | |SIGNIFICANCE (B) | P=0.050 P=0.009 P=0.011 | |(LIFE TABLE) | | | | | |MEAN DAY OF | 493.0 511.2 533.8 | |NATURAL DEATHS (C) | (55.5) (33.3) (38.0) | |(STANDARD ERROR) | | | | | |MEAN LIFE SPAN (D) | 673.9 592.0 628.4 | |(STANDARD ERROR) | (19.4) (28.3) (24.1) | | | | ================================================================================== (A) FIRST TERMINAL SACRIFICE (B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT. SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS (COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N". (C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE (D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE) PROBENECID STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE MICE FIRST TERMINAL SACRIFICE AT 730 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = VEHICLE | | --------------------- | | | | TOTAL 49 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 32 | | | | UNCENSORED DEATHS | | 13 539 580 596 603 612 612 648 655 660 | | 687 687 704 709 709 721 722 | | CENSORED DEATHS | | NONE | | | |--------------------------------------------------------------------------------| | DOSE = .1G/KG | | --------------------- | | | | TOTAL 49 UNCENSORED DEATHS 16 CENSORED DEATHS 1 TERMINAL 32 | | | | UNCENSORED DEATHS | | 337 347 488 536 547 550 570 595 606 627 | | 644 646 674 686 694 717 | | CENSORED DEATHS | | 108 | | | |--------------------------------------------------------------------------------| | DOSE = .4G/KG | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 | | | | UNCENSORED DEATHS | | 303 343 343 408 422 475 486 514 527 567 | | 583 585 586 605 643 672 716 717 | | CENSORED DEATHS | | NONE | | | ================================================================================== PROBENECID STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE MICE FIRST TERMINAL SACRIFICE AT 730 DAYS ================================================================================== | KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) | | | |--------------------------------------------------------------------------------| | DOSE TIME (DAYS) | | 90 180 270 365 425 485 545 605 665 730 (A) | | | |--------------------------------------------------------------------------------| | | | |VEHICLE | 98.0 98.0 98.0 98.0 98.0 98.0 95.9 89.8 79.6 65.3 | | | | | | | |.1G/KG | 100.0 100.0 100.0 95.8 95.8 95.8 91.7 83.3 75.0 66.7 | | | | | | | |.4G/KG | 100.0 100.0 100.0 94.0 90.0 88.0 82.0 72.0 70.0 64.0 | | | | | | | ================================================================================== ================================================================================== | SURVIVAL SUMMARY STATISTICS | | | | | |--------------------------------------------------------------------------------| | DOSE | | | | VEHICLE .1G/KG .4G/KG | | | |--------------------------------------------------------------------------------| |SURVIVAL AT END OF STUDY| 65.3% 66.7% 64.0% | |(KAPLAN-MEIER) | | | | | |SIGNIFICANCE (B) | P=0.679 P=1.000 P=0.759 | |(LIFE TABLE) | | | | | |MEAN DAY OF | 615.1 579.0 527.5 | |NATURAL DEATHS (C) | (39.9) (28.1) (29.8) | |(STANDARD ERROR) | | | | | |MEAN LIFE SPAN (D) | 690.1 668.0 657.1 | |(STANDARD ERROR) | (15.7) (17.9) (17.4) | | | | ================================================================================== (A) FIRST TERMINAL SACRIFICE (B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT. SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS (COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N". (C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE (D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE) PROBENECID KAPLAN-MEIER SURVIVAL CURVES VEHICLE = 1 .1G/KG = 2 .4G/KG = 3 ------------------------------------------------------ SPECIES=MICE SEX=MALE ------------------------------------------------------- Plot of SURVIVAL*WEEK. Symbol is value of DOSE. | | 100 + 11 3 2 | 1 3 3 2 2 1 | 3 2 2 2 1 1 1 | 2 3 2 1 1 P 90 + 3 2 32 1 1 E | 322 3 1 1 R | 223 33 11 1 C | 2 2 2 3 3 11 E 80 + 2 2 1 1 N | 2 2 3 3 T | 2 2 3 3 1 1 | 2 2 33 S 70 + 2 2 332 U | 32 2 R | 33 V | 33 I 60 + 3 3 V | 2 23 2 A | 2 2 33 L | 2 2 50 + 22 | 2 2 | | 40 + | --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-- 0 10 20 30 40 50 60 70 80 90 100 110 WEEK NOTE: 17 obs hidden. PROBENECID KAPLAN-MEIER SURVIVAL CURVES VEHICLE = 1 .1G/KG = 2 .4G/KG = 3 ----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------ Plot of SURVIVAL*WEEK. Symbol is value of DOSE. | | 100 + 1 1 3 2 | | 1 3 22 1 | 2 2 1 1 95 + | 3 3 2 2 1 1 | 3 3 | 2 2 11 P 90 + 3 3 11 E | R | 3 3 2 2 C | 3 3 1 1 E 85 + 2 2 N | 3 3 2 2 11 T | 3 3 | 2 2 1 1 S 80 + 3 3 1 1 U | 2 2 R | 22 V | I 75 + 2 2 1 1 V | 3 3 11 A | 3 3 22 L | 2 2 70 + 3 3 11 | 2 2 | 3 11 | 2 2 65 + 1 1 | 3 3 | | 60 + | --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-- 0 10 20 30 40 50 60 70 80 90 100 110 WEEK NOTE: 4 obs hidden. --multipart-boundary Content-type: text/plain Range: bytes 25157-25157/25157 --multipart-boundary--
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The National Institute of Environmental Health Sciences is one of the National Institutes of Health within the U.S. Department of Health and Human Services. The National Toxicology Program is headquartered on the NIEHS campus in Research Triangle Park, NC.