![Study Results & Research Projects Study Results & Research Projects](https://webarchive.library.unt.edu/eot2008/20090511054821im_/http://ntp-server.niehs.nih.gov/images/template/subMastHead_studyResults.gif)
Pathology Tables for Peer Review
Pathology Tables for Peer Review
Home » Study Results & Research Projects » Pathology Tables for Peer Review » TR395_TC.html » The National Toxicology Program
NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 Facility: TSI Mason Research Chemical CAS #: 000057669 Lock Date: None Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 _____________________________________________________________________________________________________________________ | 0| 7| 7| 7| 7| 7| 7| 7| 6| 6| 0| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| DAY ON TEST | 2| 3| 3| 2| 0| 3| 3| 3| 8| 1| 1| 3| 3| 4| 1| 3| 3| 3| 0| 6| 3| 3| 3| 3| 9| | 9| 6| 6| 2| 9| 2| 2| 2| 7| 2| 3| 2| 2| 8| 2| 5| 2| 6| 4| 0| 5| 5| 2| 2| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + M M + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + M + + + + + + + + A + + + + A| Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Intestine Large | + + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | X | Lymphoid Nodule, Lymphoma Malignant | | Undifferentiated Cell Type | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + A + + + + A| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + +| Lymphoid Nodule, Lymphoma Malignant | | Undifferentiated Cell Type | X | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + A| Lymphoid Nodule, Lymphoma Malignant | | Undifferentiated Cell Type | X X | __________________________________________________________________________| Liver | + + + + + + + + + A + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X | Hepatocellular Adenoma | X X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Mesentery | + + | __________________________________________________________________________| Pancreas | + + + + + + + + + A + + + + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + A + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Stomach | + + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + A + + + + + + + + + + + + + +| Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 _____________________________________________________________________________________________________________________ | 0| 7| 7| 7| 7| 7| 7| 7| 6| 6| 0| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| DAY ON TEST | 2| 3| 3| 2| 0| 3| 3| 3| 8| 1| 1| 3| 3| 4| 1| 3| 3| 3| 0| 6| 3| 3| 3| 3| 9| | 9| 6| 6| 2| 9| 2| 2| 2| 7| 2| 3| 2| 2| 8| 2| 5| 2| 6| 4| 0| 5| 5| 2| 2| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | __________________________________________________________________________| Heart | + + + + + + + + + A + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + A + + + + + + + + + + + + + +| Hepatocellular Carcinoma, Metastatic,| | Liver | X | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Adrenal Gland, Medulla | + + M + + + + + A + + M + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Parathyroid Gland | + + M M + + + M + M M + + + M + M + + + + + M +| __________________________________________________________________________| Pituitary Gland | + + M M + + + M + A + + + + + M + + + + + + + +| Pars Distalis, Adenoma | | Pars Distalis, Adenoma, Multiple | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + A + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | Sarcoma | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + + + + + + + + A + + + + + + + + + M + + + +| Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Uterus | + + + + + + + + + A + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + + + + + + + + + + + + + + | __________________________________________________________________________| Bone Marrow | + + + + + + + + + A + + + + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Lymph Node | + + + + + M + + + M + + + + + + + + + + + + + +| Axillary, Lymphoma Malignant | | Undifferentiated Cell Type | X | Iliac, Lymphoma Malignant | | Undifferentiated Cell Type | X | Inguinal, Lymphoma Malignant | | Undifferentiated Cell Type | X | Lumbar, Lymphoma Malignant | | Undifferentiated Cell Type | X | Mandibular, Lymphoma Malignant | | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 _____________________________________________________________________________________________________________________ | 0| 7| 7| 7| 7| 7| 7| 7| 6| 6| 0| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| DAY ON TEST | 2| 3| 3| 2| 0| 3| 3| 3| 8| 1| 1| 3| 3| 4| 1| 3| 3| 3| 0| 6| 3| 3| 3| 3| 9| | 9| 6| 6| 2| 9| 2| 2| 2| 7| 2| 3| 2| 2| 8| 2| 5| 2| 6| 4| 0| 5| 5| 2| 2| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Undifferentiated Cell Type | X | Mediastinal, Lymphoma Malignant | | Undifferentiated Cell Type | X | Pancreatic, Lymphoma Malignant Mixed | X | Pancreatic, Lymphoma Malignant | | Undifferentiated Cell Type | X | Renal, Lymphoma Malignant | | Undifferentiated Cell Type | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + M + + + M + + M + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | X X X | __________________________________________________________________________| Spleen | + + + + + + + + + M + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | X X X X | __________________________________________________________________________| Thymus | + + + + + + + + + A M + + + + + + M + + + + + +| Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | X X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + + M M M M M + M M + + + M + + + + M M M M +| __________________________________________________________________________| Skin | + + + + + + + + + A M + + + + + + + + + + + M +| Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + A + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + M + + + + + A + + + + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Carcinoma | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 _____________________________________________________________________________________________________________________ | 0| 7| 7| 7| 7| 7| 7| 7| 6| 6| 0| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| DAY ON TEST | 2| 3| 3| 2| 0| 3| 3| 3| 8| 1| 1| 3| 3| 4| 1| 3| 3| 3| 0| 6| 3| 3| 3| 3| 9| | 9| 6| 6| 2| 9| 2| 2| 2| 7| 2| 3| 2| 2| 8| 2| 5| 2| 6| 4| 0| 5| 5| 2| 2| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Nose | + + + M M + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + A + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + A + + + + + + + + + M + + + +| Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | X X X X | _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| | DAY ON TEST | 3| 2| 0| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| | | 5| 1| 9| 7| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| 0| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + A + + + + + + + + A +| 44 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + M + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | Lymphoid Nodule, Lymphoma Malignant | | | Undifferentiated Cell Type | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + M + M + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 | Lymphoid Nodule, Lymphoma Malignant | | | Undifferentiated Cell Type | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +| 46 | Lymphoid Nodule, Lymphoma Malignant | | | Undifferentiated Cell Type | | 2 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hepatocellular Carcinoma | | 2 | Hepatocellular Adenoma | X | 3 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 2 | __________________________________________________________________________|____________| Mesentery | +| 3 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 2 | __________________________________________________________________________|____________| Salivary Glands | + M + + + + + + M + + + + + M + + + + + + + + + +| 45 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 | Squamous Cell Papilloma | X X X | 3 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + M A + + + + + + + + + +| 46 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 6 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| | DAY ON TEST | 3| 2| 0| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| | | 5| 1| 9| 7| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| 0| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + M + +| 44 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Adenoma | | 1 | __________________________________________________________________________|____________| Parathyroid Gland | M + M + M M + M + + M M M + + + + + M + + M + M M| 29 | __________________________________________________________________________|____________| Pituitary Gland | + M M + M + + + + + + + + + + + + + + + + + + + +| 41 | Pars Distalis, Adenoma | X | 1 | Pars Distalis, Adenoma, Multiple | X | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + | 1 | Sarcoma | X | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 2 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + + + + + + + + + + + + + + + + | 30 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 7 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| | DAY ON TEST | 3| 2| 0| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| | | 5| 1| 9| 7| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| 0| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node | M + + M + + + + M + + + + + + + + + + + + + + + M| 43 | Axillary, Lymphoma Malignant | | | Undifferentiated Cell Type | | 1 | Iliac, Lymphoma Malignant | | | Undifferentiated Cell Type | | 1 | Inguinal, Lymphoma Malignant | | | Undifferentiated Cell Type | | 1 | Lumbar, Lymphoma Malignant | | | Undifferentiated Cell Type | X | 2 | Mandibular, Lymphoma Malignant | | | Undifferentiated Cell Type | | 1 | Mediastinal, Lymphoma Malignant | | | Undifferentiated Cell Type | | 1 | Pancreatic, Lymphoma Malignant Mixed | | 1 | Pancreatic, Lymphoma Malignant | | | Undifferentiated Cell Type | X X | 3 | Renal, Lymphoma Malignant | | | Undifferentiated Cell Type | X | 2 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | M + + M + + + M M + + + + + + + + + + + + + + + M| 41 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X X | 5 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | X | 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | X X | 6 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + M + + + M + + + + + + M + + + M| 42 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 4 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + M + M M M M M M + M + M M + + M + M M M + +| 22 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| | DAY ON TEST | 3| 2| 0| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| | | 5| 1| 9| 7| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| 0| 9| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Alveolar/Bronchiolar Adenoma | | 1 | Alveolar/Bronchiolar Carcinoma | X | 2 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 2 | __________________________________________________________________________|____________| Nose | + + + M + + + + + + + + + + M + + + + + + M M M +| 41 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + M + + + + + + + + + + + + + + A +| 44 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant Lymphocytic | | 2 | Lymphoma Malignant Mixed | X | 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | X X X | 7 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 9 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 4| 3| DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| 4| | 1| 1| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 6| 5| 2| 2| 2| 1| 7| 2| 2| 1| 8| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| .1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + M| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + M A + + + + A + + + + A| __________________________________________________________________________| Intestine Large | + + + + +| __________________________________________________________________________| Intestine Large, Cecum | M + + + +| Lymphoid Nodule, Lymphoma Malignant | | Undifferentiated Cell Type | | __________________________________________________________________________| Intestine Large, Colon | + + + + +| Histiocytic Sarcoma | | Lymphoid Nodule, Lymphoma Malignant | | Undifferentiated Cell Type | | __________________________________________________________________________| Intestine Large, Rectum | + M + M +| __________________________________________________________________________| Intestine Small | + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + A +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + A +| Histiocytic Sarcoma | | Lymphoid Nodule, Lymphoma Malignant | | Undifferentiated Cell Type | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X | Hepatocellular Adenoma | X | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | X X | __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Pancreas | + + + + + + + +| Histiocytic Sarcoma | | __________________________________________________________________________| Salivary Glands | + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | | Squamous Cell Carcinoma | | Squamous Cell Papilloma | X X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + M +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + M +| _____________________________________________________________________________________________________________________| Page 10 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 4| 3| DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| 4| | 1| 1| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 6| 5| 2| 2| 2| 1| 7| 2| 2| 1| 8| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| .1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Histiocytic Sarcoma | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Adrenal Gland, Medulla | + + + M +| __________________________________________________________________________| Islets, Pancreatic | + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + M M + + M + + + + M| __________________________________________________________________________| Pituitary Gland | + M + + + + + +| Pars Intermedia, Adenoma | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + + + + + + + + M + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Luteoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Oviduct | | __________________________________________________________________________| Uterus | + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Undifferentiated | | Cell Type | | Polyp Stromal | X | Endometrium, Histiocytic Sarcoma | X | __________________________________________________________________________| Vagina | + | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + + + + + + + + + + + + + + | __________________________________________________________________________| Bone Marrow | + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + +| Axillary, Lymphoma Malignant | | Lymphocytic | X | Axillary, Lymphoma Malignant Mixed | X | Deep Cervical, Lymphoma Malignant | | Mixed | X | Iliac, Lymphoma Malignant Lymphocytic| X | Inguinal, Lymphoma Malignant | | Lymphocytic | X | _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 4| 3| DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| 4| | 1| 1| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 6| 5| 2| 2| 2| 1| 7| 2| 2| 1| 8| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| .1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lumbar, Lymphoma Malignant | | Lymphocytic | X | Lumbar, Lymphoma Malignant | | Undifferentiated Cell Type | X | Mandibular, Lymphoma Malignant | | Lymphocytic | X | Mandibular, Lymphoma Malignant Mixed | X | Mandibular, Lymphoma Malignant | | Undifferentiated Cell Type | | Mediastinal, Lymphoma Malignant | | Lymphocytic | X | Mediastinal, Lymphoma Malignant Mixed| X X | Mediastinal, Lymphoma Malignant | | Undifferentiated Cell Type | X | Pancreatic, Lymphoma Malignant Mixed | X | Pancreatic, Lymphoma Malignant | | Undifferentiated Cell Type | X | Renal, Lymphoma Malignant Lymphocytic| X | Renal, Lymphoma Malignant Mixed | X X | Renal, Lymphoma Malignant | | Undifferentiated Cell Type | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | X X | __________________________________________________________________________| Spleen | + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | X X X | __________________________________________________________________________| Thymus | + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + M| __________________________________________________________________________| Skin | + + + + + +| Subcutaneous Tissue, Sarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 4| 3| DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| 4| | 1| 1| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 6| 5| 2| 2| 2| 1| 7| 2| 2| 1| 8| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| .1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM - cont | | | | | | __________________________________________________________________________| Brain | + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X | Carcinoma, Metastatic, Harderian | | Gland | | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Nose | + M + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | | Carcinoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Urinary Bladder | + M + + +| Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X X | Lymphoma Malignant Undifferentiated | | Cell Type | X X X | _____________________________________________________________________________________________________________________| Page 13 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 5| 0| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 1| | DAY ON TEST | 3| 3| 3| 7| 4| 2| 3| 3| 5| 3| 3| 3| 7| 4| 2| 3| 3| 3| 3| 8| 3| 3| 9| 4| 0| | | 2| 2| 2| 0| 7| 9| 2| 2| 0| 6| 2| 2| 4| 4| 7| 2| 2| 2| 2| 6| 2| 2| 4| 6| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | .1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + M + + + A +| 41 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + +| 15 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + +| 14 | Lymphoid Nodule, Lymphoma Malignant | | | Undifferentiated Cell Type | X | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + +| 15 | Histiocytic Sarcoma | X | 1 | Lymphoid Nodule, Lymphoma Malignant | | | Undifferentiated Cell Type | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + A + M + + + M + +| 10 | __________________________________________________________________________|____________| Intestine Small | + A + + + + + + + + +| 16 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + A + + + + + + + A +| 14 | __________________________________________________________________________|____________| Intestine Small, Ileum | + A + + + + + + + + +| 16 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + A + + + + + + + A +| 14 | Histiocytic Sarcoma | X | 1 | Lymphoid Nodule, Lymphoma Malignant | | | Undifferentiated Cell Type | | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hepatocellular Carcinoma | | 2 | Hepatocellular Adenoma | X | 2 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X X X | 5 | __________________________________________________________________________|____________| Mesentery | + + + + | 5 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + +| 19 | Histiocytic Sarcoma | X | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + +| 15 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | Squamous Cell Carcinoma | X | 1 | Squamous Cell Papilloma | | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + +| 48 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 14 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 5| 0| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 1| | DAY ON TEST | 3| 3| 3| 7| 4| 2| 3| 3| 5| 3| 3| 3| 7| 4| 2| 3| 3| 3| 3| 8| 3| 3| 9| 4| 0| | | 2| 2| 2| 0| 7| 9| 2| 2| 0| 6| 2| 2| 4| 4| 7| 2| 2| 2| 2| 6| 2| 2| 4| 6| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | .1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + +| 15 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + +| 14 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + +| 14 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + + +| 13 | __________________________________________________________________________|____________| Islets, Pancreatic | + A + + + + + + + +| 15 | __________________________________________________________________________|____________| Parathyroid Gland | + + + M + M + + M + + + M + + + + +| 29 | __________________________________________________________________________|____________| Pituitary Gland | M + M M + + + + +| 13 | Pars Intermedia, Adenoma | | 1 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Follicular Cell, Adenoma | X X | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | + | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Histiocytic Sarcoma | X | 1 | Luteoma | X | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 2 | __________________________________________________________________________|____________| Oviduct | + | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + +| 30 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | Polyp Stromal | | 1 | Endometrium, Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Vagina | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + + + + + + + + + + + + | 26 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 15 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 5| 0| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 1| | DAY ON TEST | 3| 3| 3| 7| 4| 2| 3| 3| 5| 3| 3| 3| 7| 4| 2| 3| 3| 3| 3| 8| 3| 3| 9| 4| 0| | | 2| 2| 2| 0| 7| 9| 2| 2| 0| 6| 2| 2| 4| 4| 7| 2| 2| 2| 2| 6| 2| 2| 4| 6| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | .1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + +| 14 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + +| 26 | Axillary, Lymphoma Malignant | | | Lymphocytic | | 1 | Axillary, Lymphoma Malignant Mixed | | 1 | Deep Cervical, Lymphoma Malignant | | | Mixed | | 1 | Iliac, Lymphoma Malignant Lymphocytic| | 1 | Inguinal, Lymphoma Malignant | | | Lymphocytic | | 1 | Lumbar, Lymphoma Malignant | | | Lymphocytic | | 1 | Lumbar, Lymphoma Malignant | | | Undifferentiated Cell Type | X X | 3 | Mandibular, Lymphoma Malignant | | | Lymphocytic | | 1 | Mandibular, Lymphoma Malignant Mixed | | 1 | Mandibular, Lymphoma Malignant | | | Undifferentiated Cell Type | X X | 2 | Mediastinal, Lymphoma Malignant | | | Lymphocytic | | 1 | Mediastinal, Lymphoma Malignant Mixed| | 2 | Mediastinal, Lymphoma Malignant | | | Undifferentiated Cell Type | X X | 3 | Pancreatic, Lymphoma Malignant Mixed | | 1 | Pancreatic, Lymphoma Malignant | | | Undifferentiated Cell Type | X X | 3 | Renal, Lymphoma Malignant Lymphocytic| | 1 | Renal, Lymphoma Malignant Mixed | | 2 | Renal, Lymphoma Malignant | | | Undifferentiated Cell Type | X | 2 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + +| 20 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X X | 4 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + +| 25 | Hemangiosarcoma | X | 1 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 16 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 5| 0| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 1| | DAY ON TEST | 3| 3| 3| 7| 4| 2| 3| 3| 5| 3| 3| 3| 7| 4| 2| 3| 3| 3| 3| 8| 3| 3| 9| 4| 0| | | 2| 2| 2| 0| 7| 9| 2| 2| 0| 6| 2| 2| 4| 4| 7| 2| 2| 2| 2| 6| 2| 2| 4| 6| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | .1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 4 | __________________________________________________________________________|____________| Thymus | + + M + + + +| 12 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + M| 14 | __________________________________________________________________________|____________| Skin | + + + + + + + + + +| 16 | Subcutaneous Tissue, Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + +| 14 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + +| 15 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + +| 23 | Alveolar/Bronchiolar Adenoma | | 4 | Carcinoma, Metastatic, Harderian | | | Gland | X | 1 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + +| 13 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + +| 43 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 1 | __________________________________________________________________________|____________| Harderian Gland | + | 1 | Carcinoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + +| 19 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 17 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 5| 0| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 1| | DAY ON TEST | 3| 3| 3| 7| 4| 2| 3| 3| 5| 3| 3| 3| 7| 4| 2| 3| 3| 3| 3| 8| 3| 3| 9| 4| 0| | | 2| 2| 2| 0| 7| 9| 2| 2| 0| 6| 2| 2| 4| 4| 7| 2| 2| 2| 2| 6| 2| 2| 4| 6| 8| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A | .1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + +| 13 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | X | 2 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | X X X | 6 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 18 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 7| 0| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 3| 3| 3| 1| 6| | 0| 0| 0| 0| 0| 0| 0| 6| 5| 8| 0| 0| 0| 6| 5| 0| 0| 0| 3| 6| 0| 0| 0| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| .4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + M M + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + M + + + M A + + M + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +| Sarcoma | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + M + + + + + + + + + A + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + A + + + + + + A + + + A A + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | | Lymphoid Nodule, Lymphoma Malignant | | Mixed | X | __________________________________________________________________________| Intestine Small, Jejunum | + + + M + + + A + + + + + + + + + + A A + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + M + + + + + +| Hemangiosarcoma | | Hemangiosarcoma, Metastatic | X | Hepatocellular Carcinoma | X X | Hepatocellular Adenoma | X X X X X X X | Hepatocellular Adenoma, Multiple | X | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Mesentery | + + + + + +| __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + M M + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + M + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + M + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + M + + + + + +| Squamous Cell Papilloma | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + M + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + M + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 7| 0| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 3| 3| 3| 1| 6| | 0| 0| 0| 0| 0| 0| 0| 6| 5| 8| 0| 0| 0| 6| 5| 0| 0| 0| 3| 6| 0| 0| 0| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| .4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| Capsule, Adenoma | X | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + M + + + + + +| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + M + + + M + + + + + + M M + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + M M + + + + +| __________________________________________________________________________| Parathyroid Gland | + + M + + + + + M M + + + M M M M M M M + + M + M| __________________________________________________________________________| Pituitary Gland | + + + M + + + + + + + + + + + M + + M + + + + + M| Pars Distalis, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + M + + + M + + + + + +| Follicular Cell, Adenoma | X X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystadenoma | X | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | Sarcoma | X | __________________________________________________________________________| Vagina | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + + + + + + + + + + + + + + | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + M + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Lymph Node | + + + M + + + + + + + + + + + M + + M + + + + + +| Axillary, Lymphoma Malignant | | Undifferentiated Cell Type | | Lumbar, Lymphoma Malignant | | Lymphocytic | X | Lumbar, Lymphoma Malignant | | Undifferentiated Cell Type | | Mandibular, Lymphoma Malignant | | Lymphocytic | X | Mandibular, Lymphoma Malignant | | Undifferentiated Cell Type | | Mediastinal, Lymphoma Malignant | | Undifferentiated Cell Type | | _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 7| 0| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 3| 3| 3| 1| 6| | 0| 0| 0| 0| 0| 0| 0| 6| 5| 8| 0| 0| 0| 6| 5| 0| 0| 0| 3| 6| 0| 0| 0| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| .4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Pancreatic, Lymphoma Malignant | | Undifferentiated Cell Type | | Renal, Lymphoma Malignant Lymphocytic| X | Renal, Lymphoma Malignant | | Undifferentiated Cell Type | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + M + + + + + + + + + + + M + + M + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + M + + + + + +| Hemangiosarcoma, Metastatic | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Thymus | + + + + + + + M + + + + + + + + + + M M + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M + + M M M + M + M + M M M + + + + M + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Subcutaneous Tissue, Fibrosarcoma | X | Subcutaneous Tissue, Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + M + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + M + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + M + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Carcinoma | X | Fibrosarcoma, Metastatic, Skin | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 7| 0| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 3| 3| 3| 1| 6| | 0| 0| 0| 0| 0| 0| 0| 6| 5| 8| 0| 0| 0| 6| 5| 0| 0| 0| 3| 6| 0| 0| 0| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| .4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + M + + M + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + M + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | +| __________________________________________________________________________| Harderian Gland | +| Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + M + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X X X | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| Page 22 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 4| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 5| 3| 3| | DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 2| 0| 3| 3| 3| 3| 2| 3| 3| 3| 0| 1| 3| 3| 8| 4| 4| | | 0| 0| 0| 0| 2| 1| 1| 1| 2| 3| 1| 1| 1| 0| 7| 1| 1| 1| 5| 4| 1| 1| 3| 3| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | .4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + A| 45 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + A| 47 | Sarcoma | X | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + A| 46 | __________________________________________________________________________|____________| Intestine Small | + + + + A + + + + + + + + + + + + + + + + + + + A| 47 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + A| 44 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + M + A + + + + + + + + + + + + + + + + + + + A| 46 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | Lymphoid Nodule, Lymphoma Malignant | | | Mixed | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + A| 44 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma | X | 1 | Hemangiosarcoma, Metastatic | | 1 | Hepatocellular Carcinoma | X | 3 | Hepatocellular Adenoma | X X X | 10 | Hepatocellular Adenoma, Multiple | X X X | 4 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant Lymphocytic | X | 2 | Lymphoma Malignant Mixed | | 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | X X | 2 | __________________________________________________________________________|____________| Mesentery | + + + | 9 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + M +| 47 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Squamous Cell Papilloma | X | 2 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 23 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 4| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 5| 3| 3| | DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 2| 0| 3| 3| 3| 3| 2| 3| 3| 3| 0| 1| 3| 3| 8| 4| 4| | | 0| 0| 0| 0| 2| 1| 1| 1| 2| 3| 1| 1| 1| 0| 7| 1| 1| 1| 5| 4| 1| 1| 3| 3| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | .4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Capsule, Adenoma | | 1 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + M + M + + + + + + + + + + + + + + + + + + + +| 44 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + M + + M +| 46 | __________________________________________________________________________|____________| Parathyroid Gland | + M M + M M + + + M M + M + M + + + + M + + M + +| 28 | __________________________________________________________________________|____________| Pituitary Gland | + + + + M M + + + M + + + + + + + + M M + + M M M| 38 | Pars Distalis, Adenoma | X X X X | 4 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Follicular Cell, Adenoma | | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + | 1 | __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cystadenoma | | 1 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X X | 2 | Lymphoma Malignant Lymphocytic | | 1 | Sarcoma | | 1 | __________________________________________________________________________|____________| Vagina | + | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + + + + + + + + | 22 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Lymph Node | + + + + + + + + + + + + + + + M + + + + + + + + A| 45 | Axillary, Lymphoma Malignant | | | Undifferentiated Cell Type | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 24 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 4| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 5| 3| 3| | DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 2| 0| 3| 3| 3| 3| 2| 3| 3| 3| 0| 1| 3| 3| 8| 4| 4| | | 0| 0| 0| 0| 2| 1| 1| 1| 2| 3| 1| 1| 1| 0| 7| 1| 1| 1| 5| 4| 1| 1| 3| 3| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | .4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Lumbar, Lymphoma Malignant | | | Lymphocytic | | 1 | Lumbar, Lymphoma Malignant | | | Undifferentiated Cell Type | X X | 2 | Mandibular, Lymphoma Malignant | | | Lymphocytic | | 1 | Mandibular, Lymphoma Malignant | | | Undifferentiated Cell Type | X | 1 | Mediastinal, Lymphoma Malignant | | | Undifferentiated Cell Type | X | 1 | Pancreatic, Lymphoma Malignant | | | Undifferentiated Cell Type | X | 1 | Renal, Lymphoma Malignant Lymphocytic| | 1 | Renal, Lymphoma Malignant | | | Undifferentiated Cell Type | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + M + + + A| 44 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemangiosarcoma, Metastatic | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | X X | 2 | __________________________________________________________________________|____________| Thymus | + + + + M + + + M + + + + + + + + + + M + + M M +| 42 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M + + + + + + + + + M + + + + M M + + M + + M M| 32 | __________________________________________________________________________|____________| Skin | M + + + + + + + + + + + + + M + + + + + + + + + +| 48 | Lymphoma Malignant Lymphocytic | | 1 | Subcutaneous Tissue, Fibrosarcoma | | 1 | Subcutaneous Tissue, Hemangiosarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 25 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 4| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 5| 3| 3| | DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 2| 0| 3| 3| 3| 3| 2| 3| 3| 3| 0| 1| 3| 3| 8| 4| 4| | | 0| 0| 0| 0| 2| 1| 1| 1| 2| 3| 1| 1| 1| 0| 7| 1| 1| 1| 5| 4| 1| 1| 3| 3| 3| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A | .4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Alveolar/Bronchiolar Adenoma | X X X | 5 | Alveolar/Bronchiolar Carcinoma | | 1 | Fibrosarcoma, Metastatic, Skin | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + M + + + + + M + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 2 | __________________________________________________________________________|____________| Harderian Gland | + | 2 | Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + A| 47 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X X X | 3 | Lymphoma Malignant Lymphocytic | X | 2 | Lymphoma Malignant Mixed | | 3 | Lymphoma Malignant Undifferentiated | | | Cell Type | X X | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 26 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 5| 3| 7| 7| 7| 7| 3| 7| 7| 7| 6| 5| DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 3| 0| 3| 3| 3| 3| 4| 9| 3| 3| 3| 3| 1| 3| 3| 3| 8| 2| | 3| 2| 2| 2| 3| 3| 2| 2| 6| 2| 2| 2| 2| 1| 0| 2| 2| 2| 3| 0| 2| 2| 2| 0| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + M + + + + + + + + + M + + + + + + + + + M| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + M| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + M + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X X X| Hepatocellular Adenoma | X X X | __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Pancreas | + M + + + + + + + + + + + + + + + + + + + + + + M| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + M + + + + + + + + + + + + + + + + + + + + + + M| __________________________________________________________________________| Parathyroid Gland | + + M + + M + + + + + + M M M M M + + + + + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + M + + + + + + M M M M M M + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +| Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + +| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Adenoma | | _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 5| 3| 7| 7| 7| 7| 3| 7| 7| 7| 6| 5| DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 3| 0| 3| 3| 3| 3| 4| 9| 3| 3| 3| 3| 1| 3| 3| 3| 8| 2| | 3| 2| 2| 2| 3| 3| 2| 2| 6| 2| 2| 2| 2| 1| 0| 2| 2| 2| 3| 0| 2| 2| 2| 0| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + + + + + + + + + + M + + + + + + M + + M| Axillary, Lymphoma Malignant | | Undifferentiated Cell Type | X | Inguinal, Lymphoma Malignant | | Undifferentiated Cell Type | X | Lumbar, Lymphoma Malignant | | Undifferentiated Cell Type | X | Mandibular, Lymphoma Malignant | | Undifferentiated Cell Type | X | Mediastinal, Lymphoma Malignant | | Undifferentiated Cell Type | X | Renal, Lymphoma Malignant | | Undifferentiated Cell Type | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + + M + + M| Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | X X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + M + + + + + +| Subcutaneous Tissue, Fibrosarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Alveolar/Bronchiolar Carcinoma | X | Carcinoma, Metastatic, Harderian | | _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 5| 3| 7| 7| 7| 7| 3| 7| 7| 7| 6| 5| DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 3| 0| 3| 3| 3| 3| 4| 9| 3| 3| 3| 3| 1| 3| 3| 3| 8| 2| | 3| 2| 2| 2| 3| 3| 2| 2| 6| 2| 2| 2| 2| 1| 0| 2| 2| 2| 3| 0| 2| 2| 2| 0| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | Gland | X | Hepatocellular Carcinoma, Metastatic,| | Liver | | __________________________________________________________________________| Nose | + + + + M + M + + + + + M + + + M + + + + + M + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | __________________________________________________________________________| Harderian Gland | + + | Adenoma | | Carcinoma | X X | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + M| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | X X | _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| | DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 1| | | 2| 2| 3| 3| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 3| 3| 2| 3| 2| 3| 3| 3| 6| 0| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + M + + + + M + + + M +| 44 | __________________________________________________________________________|____________| Gallbladder | + + + + + M + + + + + + + + + + + + + M + + + + M| 46 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hepatocellular Carcinoma | X X X | 7 | Hepatocellular Adenoma | X X X X X X X X X | 12 | __________________________________________________________________________|____________| Mesentery | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + A + + + + +| 47 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A M + + + +| 47 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + M + + + + + + + + + + + + + + A + + + + +| 48 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + M + + + + + + + + + + + + + + A + + + + +| 48 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + M + + + + + + + + + + + + + + A + + + + +| 48 | Pheochromocytoma Benign | X | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + M + + + + +| 47 | __________________________________________________________________________|____________| Parathyroid Gland | M M M M + M + M + + + M + M + + + + M M + + + M +| 31 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + M + M + + + + + + + + + M M M + + + +| 38 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | Follicular Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 30 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| | DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 1| | | 2| 2| 3| 3| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 3| 3| 2| 3| 2| 3| 3| 3| 6| 0| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Preputial Gland | + + + + + + | 12 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + M + + + + + + + + + A + + + + +| 48 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | Interstitial Cell, Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 | __________________________________________________________________________|____________| Lymph Node | + + + M + + + + + + + + + + + + + M + M + + + + +| 44 | Axillary, Lymphoma Malignant | | | Undifferentiated Cell Type | | 1 | Inguinal, Lymphoma Malignant | | | Undifferentiated Cell Type | | 1 | Lumbar, Lymphoma Malignant | | | Undifferentiated Cell Type | | 1 | Mandibular, Lymphoma Malignant | | | Undifferentiated Cell Type | | 1 | Mediastinal, Lymphoma Malignant | | | Undifferentiated Cell Type | | 1 | Renal, Lymphoma Malignant | | | Undifferentiated Cell Type | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + M + M + + + + +| 44 | Lymphoma Malignant Mixed | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 | Lymphoma Malignant Mixed | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 2 | __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + M + + + + M + + M + +| 47 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M + M M M M M + M M M M M M M + M + M M| 4 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + M + + + + + A + + + + +| 47 | Subcutaneous Tissue, Fibrosarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 31 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| | DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 1| | | 2| 2| 3| 3| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 3| 3| 2| 3| 2| 3| 3| 3| 6| 0| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A | VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | Alveolar/Bronchiolar Adenoma | X | 3 | Alveolar/Bronchiolar Carcinoma | X | 2 | Carcinoma, Metastatic, Harderian | | | Gland | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + M + + + + + + M + M + + M + M + + +| 40 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | + | 3 | __________________________________________________________________________|____________| Harderian Gland | + + | 4 | Adenoma | X X | 2 | Carcinoma | | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Mixed | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 32 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 4| 2| 1| 0| 7| 7| 6| 5| 0| 7| 7| 4| 3| 7| 7| 7| 4| 3| DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 0| 4| 0| 3| 3| 8| 6| 0| 3| 0| 6| 9| 3| 3| 3| 2| 0| | 1| 1| 1| 1| 5| 1| 5| 1| 8| 3| 3| 1| 1| 3| 1| 3| 1| 7| 3| 0| 1| 1| 1| 6| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| .1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + M M + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + A + + + A M A + + + + A + + + + + + + A M| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + A + + + + + + + + + + M + + + + + + + A +| Sarcoma | X | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + A + + + + + + + + + + M + + M + + + + M +| __________________________________________________________________________| Intestine Small | + + + + + + + + A + + + + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + A + A + + + + M + + + + + + + A +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Intestine Small, Ileum | + + + + A + + + A + M + + + + + + + + + + + + A +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + A + + + A M A + + + + M + + + + + + + A +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hemangiosarcoma, Multiple | | Hepatocellular Carcinoma | X X X X | Hepatocellular Adenoma | X | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Medulla | M + + + M + + + + + M M + + + + + + + + + + + + +| Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + M + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + M M M M + M + + M + M + + + M M + + + + M + + +| __________________________________________________________________________| Pituitary Gland | + + + + M + + + + + + + + + + + M + + + + + + + M| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | _____________________________________________________________________________________________________________________| Page 33 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 4| 2| 1| 0| 7| 7| 6| 5| 0| 7| 7| 4| 3| 7| 7| 7| 4| 3| DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 0| 4| 0| 3| 3| 8| 6| 0| 3| 0| 6| 9| 3| 3| 3| 2| 0| | 1| 1| 1| 1| 5| 1| 5| 1| 8| 3| 3| 1| 1| 3| 1| 3| 1| 7| 3| 0| 1| 1| 1| 6| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| .1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + | __________________________________________________________________________| Prostate | M + + + + M + + + + + + + + + + + + + + + + + M +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Blood | + + + + + + | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | __________________________________________________________________________| Lymph Node | + + + + + + + + M M + + + + + + + + + + + + + M +| Axillary, Lymphoma Malignant | | Lymphocytic | | Lumbar, Histiocytic Sarcoma | | Lumbar, Lymphoma Malignant | | Lymphocytic | | Mandibular, Histiocytic Sarcoma | | Mediastinal, Histiocytic Sarcoma | | Pancreatic, Lymphoma Malignant | | Lymphocytic | | Pancreatic, Lymphoma Malignant | | Undifferentiated Cell Type | | Renal, Histiocytic Sarcoma | | Renal, Lymphoma Malignant Lymphocytic| | Renal, Lymphoma Malignant | | Undifferentiated Cell Type | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + M M + + + + + + + + + + + + + M +| Histiocytic Sarcoma | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Thymus | + + + M M M + + + M A + + + M + + + + + + + + M M| Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M + M M M + M M + M M M M M M + M M +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X | Subcutaneous Tissue, Fibrosarcoma | X X | Subcutaneous Tissue, Hemangiosarcoma | | _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 6| 4| 2| 1| 0| 7| 7| 6| 5| 0| 7| 7| 4| 3| 7| 7| 7| 4| 3| DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 0| 4| 0| 3| 3| 8| 6| 0| 3| 0| 6| 9| 3| 3| 3| 2| 0| | 1| 1| 1| 1| 5| 1| 5| 1| 8| 3| 3| 1| 1| 3| 1| 3| 1| 7| 3| 0| 1| 1| 1| 6| 5| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| .1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Subcutaneous Tissue, Neurofibroma | X | Subcutaneous Tissue, | | Neurofibrosarcoma | | Subcutaneous Tissue, Sarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | X X | Mediastinum, Fibrosarcoma, Early | | Invasion | X | __________________________________________________________________________| Nose | M + + + + + + + + M + + + M + + + + + + + + + M +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | | Adenoma | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| Page 35 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 6| 4| 2| 7| 7| 7| 6| 4| 7| 6| 5| 5| 4| 7| 7| 7| 6| 4| | DAY ON TEST | 3| 3| 3| 1| 4| 3| 3| 4| 4| 3| 3| 3| 3| 4| 1| 3| 5| 8| 1| 9| 3| 3| 3| 4| 5| | | 1| 1| 1| 7| 5| 1| 1| 6| 3| 9| 1| 1| 1| 5| 6| 1| 9| 9| 5| 2| 2| 2| 1| 5| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | .1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Gallbladder | + + + + A + + + + + + + + + + + + + M A + + + + +| 40 | __________________________________________________________________________|____________| Intestine Large | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A + + + + +| 46 | Sarcoma | | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +| 45 | __________________________________________________________________________|____________| Intestine Small | + + + + + + + + + + + + + + + + + + + A + + + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + +| 45 | Lymphoma Malignant Lymphocytic | X | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + + +| 44 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + + +| 43 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X | 2 | Hemangiosarcoma, Multiple | X | 1 | Hepatocellular Carcinoma | X X X X X X X X | 12 | Hepatocellular Adenoma | X | 2 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant Lymphocytic | X | 1 | __________________________________________________________________________|____________| Mesentery | + | 2 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + + M + + + + + + + + + + + + + + M + +| 44 | Pheochromocytoma Benign | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + M M + M + + + + M + + + + + + + + + + + M + +| 35 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + M + M + M + + + + + +| 44 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 36 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 6| 4| 2| 7| 7| 7| 6| 4| 7| 6| 5| 5| 4| 7| 7| 7| 6| 4| | DAY ON TEST | 3| 3| 3| 1| 4| 3| 3| 4| 4| 3| 3| 3| 3| 4| 1| 3| 5| 8| 1| 9| 3| 3| 3| 4| 5| | | 1| 1| 1| 7| 5| 1| 1| 6| 3| 9| 1| 1| 1| 5| 6| 1| 9| 9| 5| 2| 2| 2| 1| 5| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | .1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + A + +| 15 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + M + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Blood | + + + + + + + + | 14 | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | __________________________________________________________________________|____________| Lymph Node | + + + + M + + M + + + + + + + + + + + + + + + + +| 45 | Axillary, Lymphoma Malignant | | | Lymphocytic | X | 1 | Lumbar, Histiocytic Sarcoma | X | 1 | Lumbar, Lymphoma Malignant | | | Lymphocytic | X | 1 | Mandibular, Histiocytic Sarcoma | X | 1 | Mediastinal, Histiocytic Sarcoma | X | 1 | Pancreatic, Lymphoma Malignant | | | Lymphocytic | X | 1 | Pancreatic, Lymphoma Malignant | | | Undifferentiated Cell Type | X | 1 | Renal, Histiocytic Sarcoma | X | 1 | Renal, Lymphoma Malignant Lymphocytic| X | 1 | Renal, Lymphoma Malignant | | | Undifferentiated Cell Type | X | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + M + + M + M + + + + + + M M + + + + + + +| 42 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangiosarcoma | X | 1 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant Lymphocytic | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 37 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 6| 4| 2| 7| 7| 7| 6| 4| 7| 6| 5| 5| 4| 7| 7| 7| 6| 4| | DAY ON TEST | 3| 3| 3| 1| 4| 3| 3| 4| 4| 3| 3| 3| 3| 4| 1| 3| 5| 8| 1| 9| 3| 3| 3| 4| 5| | | 1| 1| 1| 7| 5| 1| 1| 6| 3| 9| 1| 1| 1| 5| 6| 1| 9| 9| 5| 2| 2| 2| 1| 5| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | .1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Thymus | + + + + A + + + M M + + + + + + M M M + + + + + +| 36 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M + M M + M M M M M M M M M M + M M M M M M| 8 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Squamous Cell Papilloma | | 1 | Subcutaneous Tissue, Fibrosarcoma | X X | 4 | Subcutaneous Tissue, Hemangiosarcoma | X | 1 | Subcutaneous Tissue, Neurofibroma | | 1 | Subcutaneous Tissue, | | | Neurofibrosarcoma | X | 1 | Subcutaneous Tissue, Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Spinal Cord | + | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X X X X | 4 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X | 3 | Mediastinum, Fibrosarcoma, Early | | | Invasion | | 1 | __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + M + + +| 45 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + | 1 | Adenoma | X | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 38 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 6| 4| 2| 7| 7| 7| 6| 4| 7| 6| 5| 5| 4| 7| 7| 7| 6| 4| | DAY ON TEST | 3| 3| 3| 1| 4| 3| 3| 4| 4| 3| 3| 3| 3| 4| 1| 3| 5| 8| 1| 9| 3| 3| 3| 4| 5| | | 1| 1| 1| 7| 5| 1| 1| 6| 3| 9| 1| 1| 1| 5| 6| 1| 9| 9| 5| 2| 2| 2| 1| 5| 2| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A | .1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Histiocytic Sarcoma | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Mixed | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 39 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 7| 5| 3| DAY ON TEST | 3| 3| 3| 3| 4| 3| 3| 3| 2| 6| 3| 3| 2| 2| 3| 3| 3| 3| 3| 0| 3| 1| 3| 1| 0| | 1| 1| 1| 1| 6| 1| 1| 1| 2| 7| 1| 1| 5| 0| 8| 1| 1| 1| 4| 8| 1| 7| 1| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| .4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + M M + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + M + + + + + A A + + + + +| __________________________________________________________________________| Intestine Large | + + + + + + + + + + + + + + + + + + A + + + + + +| Anus, Squamous Cell Carcinoma | X | __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + M M + + + + + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Intestine Small | + + + + + + + + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A A + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + M + + + + + + + + + + + + + A + + + + + +| Lymphoid Nodule, Lymphoma Malignant | | Undifferentiated Cell Type | X | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Uncertain | | Primary Site | | Hemangiosarcoma, Multiple | X | Hepatocellular Carcinoma | X X X X | Hepatocellular Adenoma | X X X | Hepatocellular Adenoma, Multiple | X X | Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | | Sarcoma, Metastatic, Uncertain | | Primary Site | X | __________________________________________________________________________| Mesentery | | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Uncertain | | Primary Site | | Lymphoma Malignant Lymphocytic | | Acinus, Adenoma | X | __________________________________________________________________________| Salivary Glands | + + + + + + M + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach | + + + + + + + + + + + + + + M + + + M + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + M + + + M + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + M + + + M + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Sarcoma, Metastatic, Uncertain | | Primary Site | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 40 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 7| 5| 3| DAY ON TEST | 3| 3| 3| 3| 4| 3| 3| 3| 2| 6| 3| 3| 2| 2| 3| 3| 3| 3| 3| 0| 3| 1| 3| 1| 0| | 1| 1| 1| 1| 6| 1| 1| 1| 2| 7| 1| 1| 5| 0| 8| 1| 1| 1| 4| 8| 1| 7| 1| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| .4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M M + + + + M M + + M + + + + M + M M M M + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + M + M + + + + + + + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + M M + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Preputial Gland | + + + + + + +| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | X | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Lymph Node | + + M + M + + + + + + + M + + + + + M + + + + M +| Axillary, Lymphoma Malignant | | Lymphocytic | | Lumbar, Lymphoma Malignant | | Lymphocytic | | Mandibular, Lymphoma Malignant | | Lymphocytic | | Mediastinal, Lymphoma Malignant | | Lymphocytic | | Pancreatic, Lymphoma Malignant Mixed | | Renal, Lymphoma Malignant Lymphocytic| | Renal, Sarcoma, Metastatic, | | Uncertain Primary Site | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + M + M + + + + M + + M + + + + + M + + + + M +| Carcinoma, Metastatic, Uncertain | | Primary Site | | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 7| 5| 3| DAY ON TEST | 3| 3| 3| 3| 4| 3| 3| 3| 2| 6| 3| 3| 2| 2| 3| 3| 3| 3| 3| 0| 3| 1| 3| 1| 0| | 1| 1| 1| 1| 6| 1| 1| 1| 2| 7| 1| 1| 5| 0| 8| 1| 1| 1| 4| 8| 1| 7| 1| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| .4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphoma Malignant Undifferentiated | | Cell Type | X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | Sarcoma | X | __________________________________________________________________________| Thymus | + + + + M + + + + + + + + + M + + + M + M + + + M| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M + M M M M M + M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + M + + + + + + + + + +| Subcutaneous Tissue, Fibroma | X X | Subcutaneous Tissue, Fibrosarcoma | X X X | Subcutaneous Tissue, Hemangiosarcoma | X | Subcutaneous Tissue, Neurofibroma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | Carcinoma, Metastatic, Uncertain | | Primary Site | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Meninges, Lymphoma Malignant Mixed | | __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X | Alveolar/Bronchiolar Carcinoma | X | Carcinoma, Metastatic, Uncertain | | Primary Site | X | Hemangiosarcoma, Metastatic, Skin | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | | Sarcoma, Metastatic, Uncertain | | Primary Site | X | __________________________________________________________________________| Nose | + + + + + + + + M M + + + + + + + + M + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 42 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 7| 5| 3| DAY ON TEST | 3| 3| 3| 3| 4| 3| 3| 3| 2| 6| 3| 3| 2| 2| 3| 3| 3| 3| 3| 0| 3| 1| 3| 1| 0| | 1| 1| 1| 1| 6| 1| 1| 1| 2| 7| 1| 1| 5| 0| 8| 1| 1| 1| 4| 8| 1| 7| 1| 5| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| .4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma, Metastatic, Uncertain | | Primary Site | X | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + M +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | X X | _____________________________________________________________________________________________________________________| Page 43 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 3| 7| 6| 6| 5| 3| 7| 7| 6| 6| 6| 7| 7| 7| 5| 5| 0| 0| 7| 6| 7| | DAY ON TEST | 3| 3| 3| 8| 5| 3| 8| 2| 0| 0| 3| 3| 4| 3| 1| 3| 3| 2| 6| 6| 2| 3| 3| 1| 3| | | 1| 1| 1| 9| 5| 1| 6| 6| 9| 6| 1| 1| 0| 5| 1| 1| 1| 7| 8| 8| 0| 1| 1| 1| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | .4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Gallbladder | + + + M M + A + + + + + + + + + + A + M M A + + +| 40 | __________________________________________________________________________|____________| Intestine Large | + + + + A + + + + + + + + + + + + + + + + A + + +| 47 | Anus, Squamous Cell Carcinoma | | 1 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + A + A + + A + + + + + + + A + M + A + + +| 43 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + A + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + A + A + M A + + + + + + + A + M + A + + +| 40 | __________________________________________________________________________|____________| Intestine Small | + + + + A + + + A A + + + + + + + A + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + A + + + A A + + + + + + + A + M + A + + +| 42 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + A + A + A A + + + + + + + A + + + + + + +| 43 | Lymphoid Nodule, Lymphoma Malignant | | | Undifferentiated Cell Type | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + M A + A + A A + + + + M + + A + M + A M + +| 39 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Uncertain | | | Primary Site | X | 1 | Hemangiosarcoma, Multiple | | 1 | Hepatocellular Carcinoma | X X X X X X X | 11 | Hepatocellular Adenoma | X X X X| 7 | Hepatocellular Adenoma, Multiple | X | 3 | Histiocytic Sarcoma | X | 2 | Lymphoma Malignant Lymphocytic | X | 1 | Sarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | __________________________________________________________________________|____________| Mesentery | + | 1 | Lymphoma Malignant Lymphocytic | X | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Uncertain | | | Primary Site | X | 1 | Lymphoma Malignant Lymphocytic | X | 1 | Acinus, Adenoma | | 1 | __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Stomach, Glandular | + + + + A + + + A A + + + + + + + + + + + + + + +| 45 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Lymphocytic | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 44 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 3| 7| 6| 6| 5| 3| 7| 7| 6| 6| 6| 7| 7| 7| 5| 5| 0| 0| 7| 6| 7| | DAY ON TEST | 3| 3| 3| 8| 5| 3| 8| 2| 0| 0| 3| 3| 4| 3| 1| 3| 3| 2| 6| 6| 2| 3| 3| 1| 3| | | 1| 1| 1| 9| 5| 1| 6| 6| 9| 6| 1| 1| 0| 5| 1| 1| 1| 7| 8| 8| 0| 1| 1| 1| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | .4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Sarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Adrenal Gland, Cortex | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Adrenal Gland, Medulla | + + + + + + M + + + + M + + + + + + M + + + + M +| 46 | Pheochromocytoma Benign | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + + + + M M M + + M M + + M M + M + + + M + M M +| 28 | __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + M + + + M M + + + + + + M + + + + +| 44 | __________________________________________________________________________|____________| Thyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 47 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Lymphocytic | X | 1 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + | 21 | __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Lymphocytic | X | 1 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Lymphocytic | X | 1 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Lymphocytic | X | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemangioma | | 1 | Lymphoma Malignant Lymphocytic | X | 1 | __________________________________________________________________________|____________| Lymph Node | M + + + + + + M M + + + + + + + + + + + + + + + +| 42 | Axillary, Lymphoma Malignant | | | Lymphocytic | X | 1 | Lumbar, Lymphoma Malignant | | | Lymphocytic | X X | 2 | Mandibular, Lymphoma Malignant | | | Lymphocytic | X | 1 | Mediastinal, Lymphoma Malignant | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 45 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 3| 7| 6| 6| 5| 3| 7| 7| 6| 6| 6| 7| 7| 7| 5| 5| 0| 0| 7| 6| 7| | DAY ON TEST | 3| 3| 3| 8| 5| 3| 8| 2| 0| 0| 3| 3| 4| 3| 1| 3| 3| 2| 6| 6| 2| 3| 3| 1| 3| | | 1| 1| 1| 9| 5| 1| 6| 6| 9| 6| 1| 1| 0| 5| 1| 1| 1| 7| 8| 8| 0| 1| 1| 1| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | .4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Lymphocytic | X | 1 | Pancreatic, Lymphoma Malignant Mixed | X | 1 | Renal, Lymphoma Malignant Lymphocytic| X | 1 | Renal, Sarcoma, Metastatic, | | | Uncertain Primary Site | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | M + + M + + + M M M + M + + + + + + + + + + + + +| 38 | Carcinoma, Metastatic, Uncertain | | | Primary Site | X | 1 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant Lymphocytic | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 2 | __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + M + + + A + + +| 48 | Histiocytic Sarcoma | X | 1 | Lymphoma Malignant Lymphocytic | X X | 2 | Lymphoma Malignant Mixed | X | 1 | Sarcoma | | 1 | __________________________________________________________________________|____________| Thymus | + + + + M + M M M M + + + M + + + + + + M + M + M| 36 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M + M M M M M M + M M M M M M M M M M M M M M| 4 | __________________________________________________________________________|____________| Skin | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 | Subcutaneous Tissue, Fibroma | X | 3 | Subcutaneous Tissue, Fibrosarcoma | | 3 | Subcutaneous Tissue, Hemangiosarcoma | | 1 | Subcutaneous Tissue, Neurofibroma | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Skeletal Muscle | + | 1 | Carcinoma, Metastatic, Uncertain | | | Primary Site | X | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Lymphoma Malignant Lymphocytic | X | 1 | Meninges, Lymphoma Malignant Mixed | X | 1 | __________________________________________________________________________|____________| Spinal Cord | + + | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 46 NTP Experiment-Test: 05030-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC PROBENECID Date: 04/10/97 Route: GAVAGE Time: 09:28:08 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 3| 7| 6| 6| 5| 3| 7| 7| 6| 6| 6| 7| 7| 7| 5| 5| 0| 0| 7| 6| 7| | DAY ON TEST | 3| 3| 3| 8| 5| 3| 8| 2| 0| 0| 3| 3| 4| 3| 1| 3| 3| 2| 6| 6| 2| 3| 3| 1| 3| | | 1| 1| 1| 9| 5| 1| 6| 6| 9| 6| 1| 1| 0| 5| 1| 1| 1| 7| 8| 8| 0| 1| 1| 1| 1| | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A | .4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L | HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Alveolar/Bronchiolar Adenoma | X | 4 | Alveolar/Bronchiolar Carcinoma | X | 2 | Carcinoma, Metastatic, Uncertain | | | Primary Site | X | 2 | Hemangiosarcoma, Metastatic, Skin | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | X X X X X X | 7 | Histiocytic Sarcoma | X | 2 | Lymphoma Malignant Lymphocytic | X X | 2 | Sarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | __________________________________________________________________________|____________| Nose | M + + + + + M + + + + + M + + + M + + + + + + + +| 43 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Carcinoma, Metastatic, Uncertain | | | Primary Site | X | 2 | Lymphoma Malignant Lymphocytic | X | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 | Lymphoma Malignant Lymphocytic | X | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Histiocytic Sarcoma | X | 2 | Lymphoma Malignant Lymphocytic | X X | 2 | Lymphoma Malignant Mixed | X | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 47 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------ --multipart-boundary Content-type: text/plain Range: bytes 453521-453521/453521 --multipart-boundary--
Web page last updated on October 03, 2004
The National Institute of Environmental Health Sciences is one of the National Institutes of Health within the U.S. Department of Health and Human Services. The National Toxicology Program is headquartered on the NIEHS campus in Research Triangle Park, NC.