National Toxicology Program

CASRN: 106-47-8

Related: 20265-96-7, 108-42-9, & 95-51-2

Formula: C6-H6-CL-N

Synonyms/Common Names:

• 4-CHLOROBENZENAMINE

Known Uses:

DYES; INTERMEDIATE FOR PHARMACEUTICALS AND AGRICULTURAL CHEMICALS

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C02039A) Completed 
  • NTIS No. PB295896  (Peer Review 10/25/1978)
    Citation: Bioassay of p-Chloroaniline for Possible Carcinogenicity (CAS No. 106-47-8)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C02039A) Completed 
  • NTIS No. PB295896  (Peer Review 10/25/1978)
    Citation: Bioassay of p-Chloroaniline for Possible Carcinogenicity (CAS No. 106-47-8)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,70,1465, M: 0,255,17380 PPM/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C02039A) Report Complete 
  • TR-189 (NTIS No. PB295896)  (Peer Review 10/25/1978)
    Bioassay of p-Chloroaniline for Possible Carcinogenicity (CAS No. 106-47-8)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Equivocal 
  • Female Rats Negative 
  • Male Mice Equivocal 
  • Female Mice Equivocal 
  • Dose: R: 0,250,500, M: 0,2500,5000 PPM/50 PER GROUP

Special Studies

• Absorption Disposition Metabolism Elimination (Intravenous; Gavage)  (S0135) Completed 
  • Citation: PHARMACOKINETICS OF XENOBIOTICS
  • M Rats; M Rats
  • Dose: PO: 0.3,3,30 IV:3 MG/KG

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (096094) Completed 
  • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• In Vitro Cytogenetics (CA/SCE)  (883820) Completed 
  • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Weakly Positive 
• Mouse Lymphoma (NCI)  (G13922) Completed 
  • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
  • Mouse Lymphoma-NCI  Positive 
• Mouse Lymphoma (NCI)  (G75586) Completed 
  • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
  • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
  • Mouse Lymphoma-NCI  Positive 
• Mouse Lymphoma  (147947) Completed 
  • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
  •  Positive 
• Mouse Lymphoma  (845528) Completed 
  •  Positive 
• Salmonella (NCI)  (N-9081) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
  • Salmonella-NCI  Positive 
• Salmonella  (260964) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  • Citation: Zeiger, E. Mutagenicity of 42 chemicals in Salmonella Environ. Molec. Mutagen. Vol. 16(Suppl 18) (1990) 32-54
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  •  Positive 
• Salmonella  (417641) Completed 
  • Citation: Zeiger, E. Mutagenicity of 42 chemicals in Salmonella Environ. Molec. Mutagen. Vol. 16(Suppl 18) (1990) 32-54
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  •  Weakly Positive 
• Salmonella  (619172) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  • Citation: Zeiger, E. Mutagenicity of 42 chemicals in Salmonella Environ. Molec. Mutagen. Vol. 16(Suppl 18) (1990) 32-54
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  •  Negative