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Pathology Tables for Peer Review
Pathology Tables for Peer Review
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NTP Experiment-Test: 89006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC AZT Date: 05/31/96 Route: GAVAGE Time: 12:30:48 TWO-YEAR CHRONIC Facility: Southern Research Institute Chemical CAS #: 30516-87-1 Lock Date: 06/04/93 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 89006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC AZT Date: 05/31/96 Route: GAVAGE Time: 12:30:48 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE 30 MG/KG 60 MG/KG 120 CONTROL MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 50 Early Deaths Moribund Sacrifice 5 5 9 7 Natural Death 11 6 7 11 Dosing Accident 2 1 Accidently Killed 1 Survivors Terminal Sacrifice 34 38 31 31 Natural Death 1 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Esophagus (50) (49) (50) (50) Necrosis 1 (2%) Muscularis, Inflammation, Chronic 1 (2%) 1 (2%) Intestine Large, Colon (46) (48) (46) (45) Inflammation, Chronic 1 (2%) Intestine Large, Cecum (46) (47) (46) (45) Hemorrhage 1 (2%) Inflammation, Chronic 1 (2%) Intestine Small, Duodenum (46) (45) (46) (44) Erosion 1 (2%) Intestine Small, Jejunum (46) (46) (44) (42) Peyer's Patch, Hyperplasia, Lymphoid 1 (2%) Intestine Small, Ileum (46) (44) (45) (42) Peyer's Patch, Hyperplasia, Lymphoid 1 (2%) Liver (50) (50) (50) (50) Angiectasis 1 (2%) Basophilic Focus 1 (2%) 3 (6%) Clear Cell Focus 1 (2%) 3 (6%) 1 (2%) Eosinophilic Focus 6 (12%) 16 (32%) 7 (14%) 7 (14%) Fibrosis, Focal 1 (2%) Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 1 (2%) Hepatodiaphragmatic Nodule 1 (2%) Inflammation, Chronic 1 (2%) 2 (4%) 2 (4%) 1 (2%) Mixed Cell Focus 1 (2%) 1 (2%) 5 (10%) Necrosis, Focal 3 (6%) 3 (6%) 2 (4%) 10 (20%) Vacuolization Cytoplasmic 3 (6%) 4 (8%) 3 (6%) 3 (6%) Hepatocyte, Karyomegaly 1 (2%) 1 (2%) Mesentery (13) (17) (8) (11) Inflammation, Chronic 1 (8%) 1 (9%) Fat, Necrosis 8 (62%) 16 (94%) 5 (63%) 10 (91%) Pancreas (50) (49) (49) (48) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 89006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC AZT Date: 05/31/96 Route: GAVAGE Time: 12:30:48 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE 30 MG/KG 60 MG/KG 120 CONTROL MG/KG ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Atrophy 1 (2%) 1 (2%) 2 (4%) 1 (2%) Atrophy, Diffuse 1 (2%) Inflammation, Chronic 2 (4%) Necrosis 1 (2%) Duct, Cyst 2 (4%) 1 (2%) 1 (2%) 1 (2%) Stomach, Forestomach (49) (49) (49) (49) Cyst 1 (2%) Erosion 1 (2%) Hemorrhage 1 (2%) Inflammation, Chronic 1 (2%) 2 (4%) Ulcer 1 (2%) 1 (2%) Epithelium, Hyperplasia 4 (8%) 9 (18%) 7 (14%) 3 (6%) Stomach, Glandular (49) (49) (48) (49) Erosion 1 (2%) 2 (4%) 1 (2%) 1 (2%) Mineralization 1 (2%) 1 (2%) Necrosis 1 (2%) Glands, Degeneration, Cystic, Focal 1 (2%) 1 (2%) 4 (8%) 4 (8%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (49) (50) (50) (50) Inflammation, Chronic, Focal 1 (2%) 4 (8%) 3 (6%) 3 (6%) Mineralization 1 (2%) 1 (2%) Thrombosis 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (49) (50) (50) Accessory Adrenal Cortical Nodule 1 (2%) Cyst 1 (2%) Cytoplasmic Alteration, Focal 4 (8%) 4 (8%) 2 (4%) Hematopoietic Cell Proliferation 1 (2%) Hyperplasia, Focal 1 (2%) 1 (2%) Hypertrophy, Focal 2 (4%) 1 (2%) 4 (8%) Islets, Pancreatic (49) (49) (50) (47) Hyperplasia 2 (4%) Parathyroid Gland (47) (45) (48) (50) Cyst 1 (2%) 1 (2%) Pituitary Gland (46) (49) (46) (46) Angiectasis 1 (2%) 2 (4%) 1 (2%) Pars Distalis, Cyst 1 (2%) Pars Distalis, Cytoplasmic Alteration, Focal 7 (15%) 1 (2%) 3 (7%) Pars Distalis, Hyperplasia, Focal 4 (9%) 7 (14%) 6 (13%) 5 (11%) Pars Intermedia, Hyperplasia, Focal 2 (4%) Thyroid Gland (49) (50) (50) (50) a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 89006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC AZT Date: 05/31/96 Route: GAVAGE Time: 12:30:48 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE 30 MG/KG 60 MG/KG 120 CONTROL MG/KG ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Degeneration, Cystic, Focal 25 (51%) 19 (38%) 23 (46%) 20 (40%) Follicle, Cyst 2 (4%) 6 (12%) 2 (4%) 7 (14%) Follicular Cell, Hyperplasia 6 (12%) 11 (22%) 5 (10%) 11 (22%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (49) (49) (49) (48) Degeneration, Cystic 35 (71%) 46 (94%) 33 (67%) 43 (90%) Inflammation, Chronic 1 (2%) 1 (2%) Ovary (50) (50) (47) (48) Angiectasis 1 (2%) Cyst 10 (20%) 10 (20%) 5 (11%) 10 (21%) Hemorrhage 3 (6%) 1 (2%) 1 (2%) Hyperplasia, Tubular 1 (2%) Thrombosis 1 (2%) 1 (2%) Bilateral, Cyst 1 (2%) Uterus (50) (50) (49) (50) Cyst 3 (6%) Hemorrhage 1 (2%) 2 (4%) 2 (4%) 1 (2%) Hydrometra 11 (22%) 20 (40%) 22 (45%) 13 (26%) Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%) 1 (2%) Thrombosis 1 (2%) 2 (4%) Endometrium, Hyperplasia, Cystic 45 (90%) 45 (90%) 36 (73%) 42 (84%) Vagina (50) (49) (45) (49) Cyst 1 (2%) Fibrosis 1 (2%) Inflammation, Suppurative 1 (2%) Epithelium, Hyperplasia 3 (6%) 2 (4%) 7 (14%) Epithelium, Hyperplasia, Atypical 2 (4%) 4 (8%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (49) (50) (50) Angiectasis 1 (2%) 1 (2%) Hyperplasia 1 (2%) 3 (6%) 3 (6%) 7 (14%) Necrosis 1 (2%) Lymph Node (7) (5) (7) (10) Bronchial, Hyperplasia 1 (14%) Iliac, Ectasia 1 (10%) Iliac, Hematopoietic Cell Proliferation 1 (14%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 89006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC AZT Date: 05/31/96 Route: GAVAGE Time: 12:30:48 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE 30 MG/KG 60 MG/KG 120 CONTROL MG/KG ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Iliac, Hemorrhage 1 (20%) Iliac, Hyperplasia, Histiocytic 1 (14%) Inguinal, Hyperplasia, Histiocytic 1 (10%) Inguinal, Hyperplasia, Lymphoid 1 (20%) 1 (14%) 2 (20%) Mediastinal, Hemorrhage 1 (14%) 1 (20%) Mediastinal, Hyperplasia, Histiocytic 1 (10%) Mediastinal, Hyperplasia, Lymphoid 1 (10%) Renal, Hyperplasia, Lymphoid 1 (10%) Lymph Node, Mandibular (50) (46) (48) (48) Hemorrhage 1 (2%) 1 (2%) Hyperplasia, Lymphoid 2 (4%) 3 (6%) 6 (13%) Infiltration Cellular, Mast Cell 1 (2%) 1 (2%) Lymph Node, Mesenteric (50) (47) (48) (47) Ectasia 1 (2%) 2 (4%) Hematopoietic Cell Proliferation 1 (2%) Hemorrhage 3 (6%) 5 (11%) 2 (4%) 5 (11%) Hyperplasia, Lymphoid 5 (11%) 3 (6%) 5 (11%) Spleen (49) (48) (49) (50) Congestion 1 (2%) 2 (4%) Depletion Cellular 1 (2%) 3 (6%) 1 (2%) Hematopoietic Cell Proliferation 13 (27%) 12 (25%) 10 (20%) 14 (28%) Hyperplasia, Lymphoid 8 (16%) 6 (13%) 2 (4%) 6 (12%) Thymus (48) (46) (49) (46) Angiectasis 1 (2%) Cyst 3 (6%) 1 (2%) Hyperplasia, Lymphoid 4 (8%) 1 (2%) 1 (2%) 4 (9%) Necrosis 2 (4%) 2 (4%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (47) (47) (48) (47) Hyperplasia 3 (6%) 1 (2%) Skin (50) (49) (50) (50) Inflammation, Chronic, Focal 1 (2%) 1 (2%) Subcutaneous Tissue, Cyst Epithelial Inclusion 1 (2%) Subcutaneous Tissue, Edema 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Fibrous Osteodystrophy 4 (8%) Hyperostosis 37 (74%) 35 (70%) 33 (66%) 37 (74%) Cranium, Fibrous Osteodystrophy 1 (2%) Skeletal Muscle (50) (50) (50) (50) a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 89006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC AZT Date: 05/31/96 Route: GAVAGE Time: 12:30:48 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE 30 MG/KG 60 MG/KG 120 CONTROL MG/KG ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - CONT Hyperplasia, Focal, Lymphoid 1 (2%) Inflammation, Suppurative 1 (2%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) Atrophy, Focal 1 (2%) 3 (6%) Hemorrhage 1 (2%) Vacuolization Cytoplasmic 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (49) (50) (50) (50) Congestion 2 (4%) 1 (2%) Foreign Body 1 (2%) 1 (2%) Hemorrhage 3 (6%) 3 (6%) 1 (2%) Hyperplasia, Histiocytic 2 (4%) 1 (2%) 2 (4%) Infiltration Cellular, Mixed Cell 1 (2%) Pigmentation 1 (2%) 1 (2%) Alveolar Epithelium, Hyperplasia 2 (4%) 4 (8%) 1 (2%) Mediastinum, Hemorrhage 1 (2%) 1 (2%) Mediastinum, Inflammation, Chronic 2 (4%) 1 (2%) Mediastinum, Necrosis 1 (2%) Nose (50) (50) (50) (50) Hemorrhage 1 (2%) Mucosa, Glands, Dilatation, Focal 1 (2%) 2 (4%) 2 (4%) Nasolacrimal Duct, Cyst 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (3) (1) Cataract 1 (33%) Fibrosis 2 (67%) Cornea, Inflammation, Chronic 1 (100%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (50) (50) Cyst 1 (2%) Fibrosis, Focal 1 (2%) Infarct 1 (2%) 2 (4%) Metaplasia, Focal, Osseous 1 (2%) 2 (4%) Nephropathy 29 (58%) 30 (60%) 31 (62%) 35 (70%) a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 89006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC AZT Date: 05/31/96 Route: GAVAGE Time: 12:30:48 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE VEHICLE 30 MG/KG 60 MG/KG 120 CONTROL MG/KG ____________________________________________________________________________________________________________________________________ URINARY SYSTEM - CONT Pelvis, Dilatation 3 (6%) 3 (6%) Renal Tubule, Accumulation, Hyaline Droplet 1 (2%) 1 (2%) Renal Tubule, Dilatation 1 (2%) 1 (2%) 3 (6%) Renal Tubule, Necrosis 1 (2%) Renal Tubule, Pigmentation 2 (4%) 1 (2%) 2 (4%) Transitional Epithelium, Hyperplasia 1 (2%) Urinary Bladder (50) (50) (49) (49) Hyperplasia, Lymphoid 1 (2%) 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 7 NTP Experiment-Test: 89006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC AZT Date: 05/31/96 Route: GAVAGE Time: 12:30:48 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE 30 MG/KG 60 MG/KG 120 CONTROL MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 50 Early Deaths Natural Death 12 6 9 4 Moribund Sacrifice 6 9 9 4 Accidently Killed 2 Dosing Accident 1 Survivors Terminal Sacrifice 32 35 29 42 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Esophagus (50) (50) (49) (50) Necrosis 1 (2%) Muscularis, Inflammation, Chronic 1 (2%) Gallbladder (41) (42) (46) (44) Cyst 1 (2%) Intestine Large, Cecum (47) (48) (45) (49) Hyperplasia, Lymphoid 1 (2%) Intestine Small, Duodenum (48) (48) (47) (47) Cyst 1 (2%) Inflammation, Chronic, Focal 1 (2%) Intestine Small, Jejunum (47) (48) (45) (47) Hyperplasia, Adenomatous 1 (2%) Intestine Small, Ileum (47) (48) (45) (47) Peyer's Patch, Hyperplasia, Lymphoid 1 (2%) 1 (2%) Liver (50) (50) (50) (50) Angiectasis 3 (6%) 1 (2%) Basophilic Focus 5 (10%) 1 (2%) 3 (6%) 3 (6%) Clear Cell Focus 4 (8%) 3 (6%) 4 (8%) Eosinophilic Focus 12 (24%) 12 (24%) 7 (14%) 12 (24%) Inflammation, Chronic 17 (34%) 24 (48%) 24 (48%) 16 (32%) Mixed Cell Focus 2 (4%) 4 (8%) 7 (14%) 4 (8%) Necrosis, Focal 8 (16%) 8 (16%) 9 (18%) 3 (6%) Vacuolization Cytoplasmic 3 (6%) 1 (2%) 4 (8%) 3 (6%) Bile Duct, Cyst 1 (2%) 1 (2%) Bile Duct, Hyperplasia 1 (2%) 9 (18%) 4 (8%) 3 (6%) Hepatocyte, Karyomegaly 7 (14%) 10 (20%) 15 (30%) 5 (10%) Mesentery (1) (4) (5) (2) Hemorrhage 1 (20%) Inflammation, Chronic 1 (20%) Inflammation, Granulomatous 1 (100%) Thrombosis 1 (25%) Artery, Inflammation, Chronic 1 (25%) a Number of animals examined microscopically at site and number of animals with lesion Page 8 NTP Experiment-Test: 89006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC AZT Date: 05/31/96 Route: GAVAGE Time: 12:30:48 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE 30 MG/KG 60 MG/KG 120 CONTROL MG/KG ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Fat, Necrosis 2 (50%) 2 (40%) 2 (100%) Pancreas (50) (49) (49) (50) Atrophy 1 (2%) 3 (6%) 3 (6%) Inflammation, Granulomatous 1 (2%) Necrosis 1 (2%) Thrombosis 1 (2%) Artery, Inflammation, Chronic 1 (2%) Duct, Cyst 1 (2%) 1 (2%) Stomach, Forestomach (50) (48) (49) (50) Erosion 1 (2%) 1 (2%) 1 (2%) Inflammation, Chronic 2 (4%) 1 (2%) Ulcer 2 (4%) 1 (2%) Epithelium, Hyperplasia 7 (14%) 4 (8%) 3 (6%) 1 (2%) Stomach, Glandular (50) (48) (49) (50) Erosion 1 (2%) 4 (8%) Mineralization 1 (2%) 1 (2%) 2 (4%) 2 (4%) Pigmentation, Focal 1 (2%) Glands, Degeneration, Cystic, Focal 2 (4%) 1 (2%) 2 (4%) Tooth (2) (2) (7) (1) Developmental Malformation 2 (100%) 2 (100%) 7 (100%) 1 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (50) (48) (50) (50) Inflammation, Chronic 1 (2%) 2 (4%) Heart (50) (50) (50) (50) Fibrosis 1 (2%) Inflammation, Chronic, Focal 2 (4%) 4 (8%) 1 (2%) Mineralization 1 (2%) Thrombosis 1 (2%) 2 (4%) 1 (2%) Artery, Inflammation, Chronic 1 (2%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (49) (49) (49) Accessory Adrenal Cortical Nodule 1 (2%) 1 (2%) Cyst 1 (2%) 1 (2%) Cytoplasmic Alteration, Focal 5 (10%) 11 (22%) 8 (16%) 18 (37%) Hyperplasia, Focal 3 (6%) 1 (2%) 3 (6%) 5 (10%) Hypertrophy, Focal 10 (20%) 17 (35%) 8 (16%) 7 (14%) Inflammation, Chronic, Focal 1 (2%) Capsule, Hyperplasia, Focal 3 (6%) 2 (4%) 1 (2%) Adrenal Medulla (50) (49) (48) (49) Hyperplasia 1 (2%) 1 (2%) Parathyroid Gland (46) (45) (45) (49) a Number of animals examined microscopically at site and number of animals with lesion Page 9 NTP Experiment-Test: 89006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC AZT Date: 05/31/96 Route: GAVAGE Time: 12:30:48 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE 30 MG/KG 60 MG/KG 120 CONTROL MG/KG ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Cyst 1 (2%) 1 (2%) 1 (2%) Pituitary Gland (40) (46) (42) (47) Pars Distalis, Cyst 1 (3%) 2 (4%) 1 (2%) 3 (6%) Pars Distalis, Cytoplasmic Alteration, Focal 1 (2%) Pars Distalis, Hyperplasia, Focal 1 (2%) Thyroid Gland (50) (49) (48) (50) Degeneration, Cystic, Focal 15 (30%) 18 (37%) 11 (23%) 16 (32%) Follicle, Cyst 8 (16%) 4 (8%) 2 (4%) 5 (10%) Follicular Cell, Hyperplasia 8 (16%) 10 (20%) 11 (23%) 9 (18%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (50) (49) (50) (50) Granuloma Sperm 1 (2%) Spermatocele 1 (2%) 1 (2%) Preputial Gland (48) (50) (50) (49) Degeneration, Cystic 39 (81%) 46 (92%) 44 (88%) 45 (92%) Inflammation, Chronic 4 (8%) 5 (10%) 2 (4%) Prostate (50) (49) (50) (50) Inflammation, Chronic 3 (6%) Inflammation, Chronic, Focal 3 (6%) 2 (4%) Epithelium, Hyperplasia, Focal 2 (4%) 1 (2%) Seminal Vesicle (50) (49) (50) (50) Angiectasis 1 (2%) 1 (2%) 4 (8%) Congestion 1 (2%) Inflammation, Chronic 1 (2%) 1 (2%) Testes (50) (49) (50) (50) Germinal Epithelium, Degeneration 1 (2%) 1 (2%) 1 (2%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (49) (50) Angiectasis 1 (2%) 1 (2%) 1 (2%) Hyperplasia 2 (4%) 6 (12%) 6 (12%) 1 (2%) Lymph Node (6) (7) (5) (1) Inguinal, Hyperplasia, Lymphoid 1 (20%) Inguinal, Pigmentation 1 (17%) 2 (29%) 1 (20%) Mediastinal, Hyperplasia, Lymphoid 1 (17%) 1 (20%) Mediastinal, Inflammation, Granulomatous 1 (17%) Pancreatic, Hyperplasia, Lymphoid 1 (17%) a Number of animals examined microscopically at site and number of animals with lesion Page 10 NTP Experiment-Test: 89006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC AZT Date: 05/31/96 Route: GAVAGE Time: 12:30:48 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE 30 MG/KG 60 MG/KG 120 CONTROL MG/KG ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Lymph Node, Mandibular (49) (48) (49) (50) Hemorrhage 1 (2%) Hyperplasia, Histiocytic 1 (2%) Hyperplasia, Lymphoid 1 (2%) 1 (2%) 1 (2%) Infiltration Cellular, Mast Cell 1 (2%) Lymph Node, Mesenteric (48) (49) (49) (49) Ectasia 5 (10%) 4 (8%) 1 (2%) 3 (6%) Fibrosis 1 (2%) Hemorrhage 20 (42%) 31 (63%) 21 (43%) 25 (51%) Hyperplasia, Lymphoid 3 (6%) 3 (6%) 3 (6%) 4 (8%) Inflammation, Granulomatous 1 (2%) Spleen (50) (49) (48) (50) Angiectasis 1 (2%) Depletion Cellular 1 (2%) 1 (2%) 6 (12%) Hematopoietic Cell Proliferation 18 (36%) 16 (33%) 14 (29%) 11 (22%) Hyperplasia, Lymphoid 2 (4%) 1 (2%) 2 (4%) 2 (4%) Necrosis, Focal 1 (2%) Thymus (41) (44) (41) (35) Cyst 6 (15%) 11 (25%) 5 (12%) 4 (11%) Mineralization 1 (2%) Necrosis 1 (2%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (15) (10) (15) (5) Inflammation, Chronic 1 (10%) Skin (50) (50) (50) (50) Subcutaneous Tissue, Edema 1 (2%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Hyperostosis 30 (60%) 36 (72%) 28 (56%) 41 (82%) Skeletal Muscle (50) (50) (50) (50) Necrosis 1 (2%) ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (49) (50) Hemorrhage 1 (2%) Spinal Cord (1) (1) Degeneration 1 (100%) Hemorrhage, Focal 1 (100%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 11 NTP Experiment-Test: 89006-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: CHRONIC AZT Date: 05/31/96 Route: GAVAGE Time: 12:30:48 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE VEHICLE 30 MG/KG 60 MG/KG 120 CONTROL MG/KG ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (50) (50) (50) (50) Hemorrhage 2 (4%) 1 (2%) 2 (4%) 3 (6%) Hyperplasia, Histiocytic 2 (4%) 2 (4%) 1 (2%) Hyperplasia, Lymphoid 1 (2%) Infiltration Cellular, Mixed Cell 1 (2%) 1 (2%) 1 (2%) Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%) Alveolar Epithelium, Hyperplasia 6 (12%) 3 (6%) 1 (2%) 8 (16%) Nose (50) (50) (49) (50) Nasolacrimal Duct, Inflammation, Suppurative 1 (2%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (1) Cornea, Inflammation, Chronic 1 (100%) Harderian Gland (3) (7) (2) (10) Hyperplasia, Focal 1 (14%) ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (48) (49) (50) Cyst 2 (4%) 1 (2%) Infarct 1 (2%) 2 (4%) 1 (2%) 2 (4%) Metaplasia, Focal, Osseous 1 (2%) 3 (6%) 1 (2%) Nephropathy 45 (90%) 44 (92%) 44 (90%) 49 (98%) Thrombosis 1 (2%) Papilla, Necrosis 1 (2%) Pelvis, Dilatation 1 (2%) Renal Tubule, Accumulation, Hyaline Droplet 1 (2%) Renal Tubule, Dilatation 1 (2%) 1 (2%) Renal Tubule, Hyperplasia, Focal 1 (2%) Renal Tubule, Pigmentation 2 (4%) 1 (2%) 1 (2%) Urethra (1) (1) (1) Inflammation, Chronic 1 (100%) 1 (100%) 1 (100%) Urinary Bladder (50) (50) (50) (50) Hemorrhage 1 (2%) a Number of animals examined microscopically at site and number of animals with lesion Page 12 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------
Web page last updated on November 11, 2004
The National Institute of Environmental Health Sciences is one of the National Institutes of Health within the U.S. Department of Health and Human Services. The National Toxicology Program is headquartered on the NIEHS campus in Research Triangle Park, NC.