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Pathology Tables for Peer Review
Pathology Tables for Peer Review
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NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 Facility: Southern Research Institute Chemical CAS #: 30516-871 Lock Date: 11/01/93 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 8| 3| 8| 5| 3| 0| 3| 3| 3| 3| 3| 3| 3| | 3| 0| 3| 0| 0| 0| 3| 9| 0| 0| 3| 0| 6| 3| 0| 1| 3| 1| 0| 0| 0| 0| 0| 3| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + A + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +| Hyperplasia, Adenomatous | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Amyloid Deposition | 2 | Hyperplasia, Adenomatous | 3 | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Eosinophilic Focus | 3 4 2 | Hematopoietic Cell Proliferation | | Hyperplasia, Focal, Lymphoid | | Inflammation, Chronic | 1 1 | Mixed Cell Focus | 3 | Necrosis, Focal | | Vacuolization Cytoplasmic | | Centrilobular, Necrosis | | Hepatocyte, Karyomegaly | | __________________________________________________________________________| Mesentery | + + + + | Hemorrhage | | Inflammation, Chronic | 3 | Fat, Necrosis | 3 3 2 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Hyperplasia | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | Glands, Degeneration, Cystic, Focal | 2 2 2 | __________________________________________________________________________| Tongue | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + M + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic, Focal | | Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 8| 3| 8| 5| 3| 0| 3| 3| 3| 3| 3| 3| 3| | 3| 0| 3| 0| 0| 0| 3| 9| 0| 0| 3| 0| 6| 3| 0| 1| 3| 1| 0| 0| 0| 0| 0| 3| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Accessory Adrenal Cortical Nodule | | Cyst | | Hyperplasia, Focal | 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + M M + + + + + M + M + + + + M M| Cyst | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| Angiectasis | 2 2 | Pars Distalis, Hyperplasia, Focal | 2 2 2 2 2 2 4| Rathke's Cleft, Cyst | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + I + + + + + + + + + + + + + +| Degeneration, Cystic, Focal | 2 1 1 2 1 1 1 1 2 2 1 | Inflammation, Chronic, Focal | | Follicle, Cyst | 2 3 2| Follicular Cell, Hyperplasia | 3 1 2 1 1 2 1 3 3| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Peritoneum | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic | 2 2 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 3 2 3 | Mineralization | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Hydrometra | 3 2 2 3 2 2 2 2 2 | Thrombosis | 3 | Endometrium, Hyperplasia, Cystic | 2 2 2 2 3 2 2 2 3 2 2 2 2 3 3 2 2 2 2 2 1 2 2| __________________________________________________________________________| Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Hyperplasia | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | __________________________________________________________________________| Lymph Node | + + | Iliac, Hemorrhage | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + M + + M + + + + + + + + M M + + + + +| Hemorrhage | | Hyperplasia, Lymphoid | 2 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 8| 3| 8| 5| 3| 0| 3| 3| 3| 3| 3| 3| 3| | 3| 0| 3| 0| 0| 0| 3| 9| 0| 0| 3| 0| 6| 3| 0| 1| 3| 1| 0| 0| 0| 0| 0| 3| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hemorrhage | 1 | Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 2 3 1 3 3 2 2 1 | Hyperplasia, Lymphoid | 2 2 3 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 1 2 3| Hyperplasia, Lymphoid | 3 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Fibrous Osteodystrophy | 2 | Hyperostosis | 2 2 1 1 2 1 1 2 1 2 2 2 1 2 2 2 2 3 1 3 2 2 2 2| __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + +| Regeneration | 1 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy, Focal | 3 | Meninges, Inflammation, Chronic | | __________________________________________________________________________| Peripheral Nerve | + | __________________________________________________________________________| Spinal Cord | + | Cyst Epithelial Inclusion | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 | Hyperplasia, Histiocytic | 2 2 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Mucosa, Glands, Dilatation, Focal | 2 2 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | Fibrosis | 2 | __________________________________________________________________________| Harderian Gland | + + +| Hyperplasia, Focal | 2| Inflammation, Chronic, Focal | 3 | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 8| 3| 8| 5| 3| 0| 3| 3| 3| 3| 3| 3| 3| | 3| 0| 3| 0| 0| 0| 3| 9| 0| 0| 3| 0| 6| 3| 0| 1| 3| 1| 0| 0| 0| 0| 0| 3| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | __________________________________________________________________________| Lacrimal Gland | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | | Nephropathy | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | Renal Tubule, Dilatation | | Renal Tubule, Pigmentation | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| | DAY ON TEST | 3| 9| 3| 3| 8| 3| 3| 3| 1| 7| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 1| 3| 3| 2| 7| | | 0| 6| 0| 0| 2| 0| 0| 3| 8| 2| 3| 0| 0| 0| 3| 3| 1| 3| 3| 3| 0| 3| 3| 5| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + A + + + + + + A + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + A + + + + + + A + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | + A + + + + + + A + + + + + + + + + + + + + + + A| 47 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + A + + + + + + A + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + A + + + + + + A + + + + + + + + + + + + + + + +| 47 | Hyperplasia, Adenomatous | 2 | 1 2.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + A + + + + + + A + + + + + + + + + + + + + + + A| 47 | Amyloid Deposition | | 1 2.0| Hyperplasia, Adenomatous | | 1 3.0| __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 2| 1 2.0| Eosinophilic Focus | 2 | 4 2.8| Hematopoietic Cell Proliferation | 2 2| 2 2.0| Hyperplasia, Focal, Lymphoid | 2 | 1 2.0| Inflammation, Chronic | 2 1 1 2 2 1 2 3| 10 1.6| Mixed Cell Focus | 2 | 2 2.5| Necrosis, Focal | 1 2| 2 1.5| Vacuolization Cytoplasmic | 1 1 | 2 1.0| Centrilobular, Necrosis | 3 | 1 3.0| Hepatocyte, Karyomegaly | 1 | 1 1.0| __________________________________________________________________________|____________| Mesentery | + + + + + + | 10 | Hemorrhage | 3 | 1 3.0| Inflammation, Chronic | | 1 3.0| Fat, Necrosis | 3 3 2 | 7 2.6| __________________________________________________________________________|____________| Pancreas | + M + + + + + + A + + + + + + + + + + + + + + + +| 48 | Necrosis | | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epithelium, Hyperplasia | 3 1 2| 3 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 | Edema | 2 | 1 2.0| Glands, Degeneration, Cystic, Focal | 1 2 | 5 1.8| __________________________________________________________________________|____________| Tongue | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + M +| 48 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| | DAY ON TEST | 3| 9| 3| 3| 8| 3| 3| 3| 1| 7| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 1| 3| 3| 2| 7| | | 0| 6| 0| 0| 2| 0| 0| 3| 8| 2| 3| 0| 0| 0| 3| 3| 1| 3| 3| 3| 0| 3| 3| 5| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Inflammation, Chronic, Focal | 1 3| 2 2.0| Thrombosis | 4| 1 4.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | 2 | 1 2.0| Cyst | 3 | 1 3.0| Hyperplasia, Focal | 1 2 | 3 1.7| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Islets, Pancreatic | + M + + + + + + A + + + + + + + + + + + + + + + +| 48 | Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 43 | Cyst | 2 | 1 2.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | 3 2| 4 2.3| Pars Distalis, Hyperplasia, Focal | 2 | 8 2.3| Rathke's Cleft, Cyst | 3 | 1 3.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Degeneration, Cystic, Focal | 2 1 2 2 2 2 1 2 | 19 1.5| Inflammation, Chronic, Focal | 2 | 1 2.0| Follicle, Cyst | 3 2 2 3 | 7 2.4| Follicular Cell, Hyperplasia | 1 1 2 3 1 1 1 2 1 1 1 1 | 21 1.6| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Peritoneum | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Cystic | | 3 2.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 2 2 2 3 2 | 10 2.4| Mineralization | 3 | 1 3.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 | 1 3.0| Hydrometra | 2 2 2 3 3 2 2 2 2 3| 19 2.3| Thrombosis | | 1 3.0| Endometrium, Hyperplasia, Cystic | 2 2 2 2 2 3 2 2 2 3 3 3 2 1 2 2 2 2 2| 42 2.1| __________________________________________________________________________|____________| Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epithelium, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| | DAY ON TEST | 3| 9| 3| 3| 8| 3| 3| 3| 1| 7| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 1| 3| 3| 2| 7| | | 0| 6| 0| 0| 2| 0| 0| 3| 8| 2| 3| 0| 0| 0| 3| 3| 1| 3| 3| 3| 0| 3| 3| 5| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Lymph Node | + + + + + + | 8 | Iliac, Hemorrhage | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 | Hemorrhage | 1 | 1 1.0| Hyperplasia, Lymphoid | | 2 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + I + + + A + + + + + + + + + + + + + + + +| 48 | Hemorrhage | 2 1 3 | 4 1.8| Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + A + + + + + + + + + + + + + + + +| 49 | Hematopoietic Cell Proliferation | 3 2 3 2 1 3 1 1 3 3 2 2 3 3 3| 23 2.3| Hyperplasia, Lymphoid | 3 2 | 5 2.4| __________________________________________________________________________|____________| Thymus | + + + + + + + + I + + + + + + + + M + + + I + + +| 47 | Cyst | | 3 2.0| Hyperplasia, Lymphoid | 2 | 2 2.5| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | | 1 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst Epithelial Inclusion | X | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Fibrous Osteodystrophy | 2 | 2 2.0| Hyperostosis | 2 2 2 2 3 3 2 1 1 1 3 2 2 2 2 2 1 2 2 2 2 2 2 2| 48 1.9| __________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Regeneration | 1 | 2 1.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy, Focal | 2 | 2 2.5| Meninges, Inflammation, Chronic | 2 | 1 2.0| __________________________________________________________________________|____________| Peripheral Nerve | | 1 | __________________________________________________________________________|____________| Spinal Cord | + | 2 | Cyst Epithelial Inclusion | X | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 5| | DAY ON TEST | 3| 9| 3| 3| 8| 3| 3| 3| 1| 7| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 1| 3| 3| 2| 7| | | 0| 6| 0| 0| 2| 0| 0| 3| 8| 2| 3| 0| 0| 0| 3| 3| 1| 3| 3| 3| 0| 3| 3| 5| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A | VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | | 1 3.0| Hyperplasia, Histiocytic | | 2 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mucosa, Glands, Dilatation, Focal | | 3 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | Fibrosis | | 1 2.0| __________________________________________________________________________|____________| Harderian Gland | + + | 5 | Hyperplasia, Focal | | 1 2.0| Inflammation, Chronic, Focal | | 1 3.0| __________________________________________________________________________|____________| Lacrimal Gland | + | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infarct | 3 | 1 3.0| Nephropathy | 1 3 2 1 2 1 1 1 1 1 2 1 1 2 2 1 1| 35 1.2| Renal Tubule, Dilatation | 2 | 1 2.0| Renal Tubule, Pigmentation | | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 5| DAY ON TEST | 3| 3| 3| 3| 3| 2| 3| 4| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 9| 3| 7| 9| | 3| 0| 0| 0| 3| 1| 3| 0| 3| 0| 0| 3| 0| 0| 3| 7| 3| 2| 2| 3| 3| 2| 3| 4| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5000 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + A + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + A +| Peyer's Patch, Hyperplasia, Lymphoid | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 2 | Basophilic Focus | | Clear Cell Focus | 3 | Eosinophilic Focus | 3 3 | Hematopoietic Cell Proliferation | 3 | Hemorrhage | | Inflammation, Chronic | 3 1 1 1 | Mixed Cell Focus | 4 4 4 | Necrosis, Focal | | Vacuolization Cytoplasmic | 2 | __________________________________________________________________________| Mesentery | + + + + + | Hemorrhage | | Inflammation, Chronic | | Fat, Necrosis | 3 2 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy, Diffuse | | Duct, Cyst | 3 | __________________________________________________________________________| Salivary Glands | + + + + + A + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | Mineralization | | Glands, Degeneration, Cystic, Focal | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + M + + + + + + + + + + + M + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Thrombosis | 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + M + + + + + + + + + + + + + + + + + + +| Cyst | | _____________________________________________________________________________________________________________________| Page 10 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 5| DAY ON TEST | 3| 3| 3| 3| 3| 2| 3| 4| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 9| 3| 7| 9| | 3| 0| 0| 0| 3| 1| 3| 0| 3| 0| 0| 3| 0| 0| 3| 7| 3| 2| 2| 3| 3| 2| 3| 4| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5000 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Hyperplasia, Focal | 1 2 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + M + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + A +| __________________________________________________________________________| Parathyroid Gland | + + + + + + M + + + + M + + + + + M + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + I + + + + + + + + + +| Angiectasis | 1 | Pars Distalis, Cyst | | Pars Distalis, Cytoplasmic | | Alteration, Focal | 1 1 | Pars Distalis, Hyperplasia, Focal | 1 3 4 1 1 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic, Focal | 2 2 2 2 2 2 1 2 1 | Follicle, Cyst | 2 2 | Follicular Cell, Hyperplasia | 2 2 1 2 1 2 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic | 2 | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 2 3 2 1 | Hemorrhage | 3 | Mineralization | 2 | Thrombosis | 4 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 | Hemorrhage | 3 | Hydrometra | 2 2 3 2 2 2 3 3 | Thrombosis | 2 | Endometrium, Hyperplasia, Cystic | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3| __________________________________________________________________________| Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Hyperplasia, Atypical | 3 | Epithelium, Hyperplasia | 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 3 | __________________________________________________________________________| Lymph Node | + + + + +| __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + M| Hyperplasia, Lymphoid | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | | _____________________________________________________________________________________________________________________| Page 11 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 5| DAY ON TEST | 3| 3| 3| 3| 3| 2| 3| 4| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 9| 3| 7| 9| | 3| 0| 0| 0| 3| 1| 3| 0| 3| 0| 0| 3| 0| 0| 3| 7| 3| 2| 2| 3| 3| 2| 3| 4| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5000 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hemorrhage | 1 | Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Spleen | + + + + + A + + + + + + + + + + + + + + + + + + +| Hematopoietic Cell Proliferation | 4 2 2 3 4 1 1 3 | Hyperplasia, Lymphoid | 3 3 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + M| Atrophy | | Cyst | 2 2 2 | Inflammation, Granulomatous | 4 | Necrosis | 4 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 3 3 2 | Inflammation, Chronic, Focal | 1 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 2 1 1 2 1 2 2 2 2 2 2 2 2 1 2 2 2 2 2| Femur, Fibrous Osteodystrophy | | Femur, Osteopetrosis | 3 | __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy, Focal | 3 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 3 3 1 | Hyperplasia, Histiocytic | 2 2| Pigmentation | 2 | Alveolar Epithelium, Hyperplasia | 1 1 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 6| 5| DAY ON TEST | 3| 3| 3| 3| 3| 2| 3| 4| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 9| 3| 7| 9| | 3| 0| 0| 0| 3| 1| 3| 0| 3| 0| 0| 3| 0| 0| 3| 7| 3| 2| 2| 3| 3| 2| 3| 4| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 30 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5000 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Metaplasia, Focal, Osseous | 1 1 | Nephropathy | 2 2 1 1 1 1 1 1 2 1 1 1 2 1 1 2 | Renal Tubule, Accumulation, Hyaline | | Droplet | 3 | Renal Tubule, Mineralization | | Renal Tubule, Necrosis | | __________________________________________________________________________| Ureter | + | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 2 | _____________________________________________________________________________________________________________________| Page 13 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 5| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 5| 3| 8| | | 2| 2| 2| 2| 2| 2| 3| 6| 8| 8| 3| 2| 3| 2| 2| 2| 2| 2| 3| 2| 2| 3| 4| 3| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 30 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | 5000 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + + + M + + + + + + A + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + A + + + +| 46 | Peyer's Patch, Hyperplasia, Lymphoid | 3 | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + A + + + +| 46 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 1 2.0| Basophilic Focus | 2 | 1 2.0| Clear Cell Focus | 2 | 2 2.5| Eosinophilic Focus | 3 3 2 2 | 6 2.7| Hematopoietic Cell Proliferation | 2 | 2 2.5| Hemorrhage | 3 | 1 3.0| Inflammation, Chronic | 2 1| 6 1.5| Mixed Cell Focus | | 3 4.0| Necrosis, Focal | 1 1 | 2 1.0| Vacuolization Cytoplasmic | 1 2 2 2 4 | 6 2.2| __________________________________________________________________________|____________| Mesentery | + + + + + + + | 12 | Hemorrhage | 3 2 | 2 2.5| Inflammation, Chronic | 2 | 1 2.0| Fat, Necrosis | 2 2 2 3 3 2 | 9 2.3| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy, Diffuse | 3 | 1 3.0| Duct, Cyst | | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 2 | 1 2.0| Epithelium, Hyperplasia | 2 | 2 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | 2 | 1 2.0| Mineralization | 1 | 1 1.0| Glands, Degeneration, Cystic, Focal | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + M + + + + + + + + +| 47 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 5| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 5| 3| 8| | | 2| 2| 2| 2| 2| 2| 3| 6| 8| 8| 3| 2| 3| 2| 2| 2| 2| 2| 3| 2| 2| 3| 4| 3| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 30 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | 5000 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Thrombosis | | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | 3 | 1 3.0| Hyperplasia, Focal | 1 | 4 1.5| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Parathyroid Gland | + M M + + + + + + + + + + + + + + + + + + M I + +| 43 | __________________________________________________________________________|____________| Pituitary Gland | + + + + M + + + + + + + + + + + + + M + M + I M +| 44 | Angiectasis | | 1 1.0| Pars Distalis, Cyst | 2 | 1 2.0| Pars Distalis, Cytoplasmic | | | Alteration, Focal | | 2 1.0| Pars Distalis, Hyperplasia, Focal | 2 4 | 7 2.3| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Cystic, Focal | 1 2 2 1 2 1 1| 16 1.6| Follicle, Cyst | 2 2 4 2 | 6 2.3| Follicular Cell, Hyperplasia | 2 1 2 1 1 2 1 1 1 2 1 2 | 19 1.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Cystic | | 1 2.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + M + + + + + + + + + + + + +| 49 | Cyst | 3 | 6 2.3| Hemorrhage | 3 | 2 3.0| Mineralization | | 1 2.0| Thrombosis | | 1 4.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 3 | 2 3.0| Hemorrhage | | 1 3.0| Hydrometra | 2 2 3 3 3 3 3 2 3 2 3 3 2 | 21 2.5| Thrombosis | | 1 2.0| Endometrium, Hyperplasia, Cystic | 2 2 3 3 3 2 3 1 2 2 2 2 2 2 2 1 2 2 2| 37 2.1| __________________________________________________________________________|____________| Vagina | + + + + M + + + + + M + + + + + + + + + + + + + +| 48 | Epithelium, Hyperplasia, Atypical | | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 5| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 5| 3| 8| | | 2| 2| 2| 2| 2| 2| 3| 6| 8| 8| 3| 2| 3| 2| 2| 2| 2| 2| 3| 2| 2| 3| 4| 3| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 30 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | 5000 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Epithelium, Hyperplasia | 2 2 | 3 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 3 | 4 2.5| __________________________________________________________________________|____________| Lymph Node | + + | 7 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + M + M + + + + + + + + + + + + + + + M + + + + +| 46 | Hyperplasia, Lymphoid | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 | Ectasia | 2 | 1 2.0| Hemorrhage | 3 | 2 2.0| Hyperplasia, Lymphoid | 3 | 2 2.5| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hematopoietic Cell Proliferation | 2 3 2 2 2 3 4 | 15 2.5| Hyperplasia, Lymphoid | 3 2 | 4 2.8| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + M + + M + + + + + + + M + + +| 46 | Atrophy | 2 3 2| 3 2.3| Cyst | 2 | 4 2.0| Inflammation, Granulomatous | | 1 4.0| Necrosis | | 1 4.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | | 3 2.7| Inflammation, Chronic, Focal | | 1 1.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperostosis | 2 1 1 2 2 2 2 2 2 1 2 1 2 2 2 2 2 3 2 1 2| 40 1.8| Femur, Fibrous Osteodystrophy | 2 | 1 2.0| Femur, Osteopetrosis | | 1 3.0| __________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy, Focal | 3 2 2 | 4 2.5| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 16 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 5| | DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 5| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 5| 3| 8| | | 2| 2| 2| 2| 2| 2| 3| 6| 8| 8| 3| 2| 3| 2| 2| 2| 2| 2| 3| 2| 2| 3| 4| 3| 6| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A | 30 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | 5000 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 3 2.3| Hyperplasia, Histiocytic | 2 | 3 2.0| Pigmentation | | 1 2.0| Alveolar Epithelium, Hyperplasia | | 2 1.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 2| 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Harderian Gland | + | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Metaplasia, Focal, Osseous | 1 | 3 1.0| Nephropathy | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2 1 1| 33 1.2| Renal Tubule, Accumulation, Hyaline | | | Droplet | | 1 3.0| Renal Tubule, Mineralization | 2 | 1 2.0| Renal Tubule, Necrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Ureter | | 1 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 17 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 3| 1| 7| 7| 7| 7| 7| 7| 4| 7| 3| 7| 7| 7| DAY ON TEST | 3| 3| 2| 4| 9| 3| 3| 3| 3| 3| 3| 4| 9| 3| 3| 3| 3| 2| 3| 9| 3| 1| 3| 3| 3| | 3| 3| 0| 8| 4| 3| 2| 3| 2| 2| 3| 4| 9| 2| 2| 3| 3| 2| 3| 4| 3| 8| 3| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 60 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 5000 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + M + + +| Necrosis | 3 | Perforation | X | Muscularis, Inflammation, Chronic | 3 | Periesophageal Tissue, Inflammation, | | Chronic | | __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + +| Peyer's Patch, Hyperplasia, Lymphoid | | __________________________________________________________________________| Intestine Small, Ileum | + + + A A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 3 | Basophilic Focus | | Clear Cell Focus | 2 | Eosinophilic Focus | 2 2 | Hyperplasia, Focal, Lymphoid | | Inflammation, Chronic | 2 2 1 2 1 1 | Mixed Cell Focus | | Necrosis, Focal | 1 | Vacuolization Cytoplasmic | 1 | Hepatocyte, Karyomegaly | 3 | __________________________________________________________________________| Mesentery | + + + | Fat, Necrosis | 2 2 | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 3 | Acinus, Atrophy, Focal | | Duct, Cyst | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 3 | __________________________________________________________________________| Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +| Cyst | | Inflammation, Chronic | 2 | Epithelium, Hyperplasia | | __________________________________________________________________________| Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +| Glands, Degeneration, Cystic, Focal | 3 2 2 1 2 1 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic, Focal | | _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 3| 1| 7| 7| 7| 7| 7| 7| 4| 7| 3| 7| 7| 7| DAY ON TEST | 3| 3| 2| 4| 9| 3| 3| 3| 3| 3| 3| 4| 9| 3| 3| 3| 3| 2| 3| 9| 3| 1| 3| 3| 3| | 3| 3| 0| 8| 4| 3| 2| 3| 2| 2| 3| 4| 9| 2| 2| 3| 3| 2| 3| 4| 3| 8| 3| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 60 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 5000 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Accessory Adrenal Cortical Nodule | 2 | Hyperplasia, Focal | | Hypertrophy, Focal | 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + M + + + + M + + + + + + M + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + M + + + + + + + + + + + + + + + + +| Angiectasis | 3 | Pars Distalis, Cyst | 1 | Pars Distalis, Cytoplasmic | | Alteration, Focal | 2 | Pars Distalis, Hyperplasia, Focal | 1 1 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic, Focal | 2 2 2 1 | Follicle, Cyst | 2 3 2 2 | Follicular Cell, Hyperplasia | 2 1 2 1 2 2 1 2 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic | 2 1 2 | __________________________________________________________________________| Ovary | + + + + M + + + + + + + + + + + + + + + + + + + +| Cyst | 2 2 2 | Hemorrhage | 3 | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Hydrometra | 2 2 3 2 2 3 2 2| Endometrium, Hyperplasia, Cystic | 1 2 2 2 2 3 3 3 2 1 2 2 2 2 2 3 2 2 2 3 3| __________________________________________________________________________| Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Hyperplasia, Atypical | | Epithelium, Hyperplasia | 2 2 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | __________________________________________________________________________| Lymph Node | | __________________________________________________________________________| Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 1 | _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 3| 1| 7| 7| 7| 7| 7| 7| 4| 7| 3| 7| 7| 7| DAY ON TEST | 3| 3| 2| 4| 9| 3| 3| 3| 3| 3| 3| 4| 9| 3| 3| 3| 3| 2| 3| 9| 3| 1| 3| 3| 3| | 3| 3| 0| 8| 4| 3| 2| 3| 2| 2| 3| 4| 9| 2| 2| 3| 3| 2| 3| 4| 3| 8| 3| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 60 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 5000 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hyperplasia, Lymphoid | 3 3 3 | Infiltration Cellular, Mast Cell | 4 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + A + + + + + + + + + + + + M + + + + + + +| Hemorrhage | 2 2 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Cellular | | Hematopoietic Cell Proliferation | 2 3 3 4 | Hyperplasia, Lymphoid | 3 3 2 3 2 | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + M + + +| Atrophy | 2 | Cyst | 2 2 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| Hyperplasia | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 2 3 2 | Inflammation, Chronic, Focal | 3 | Subcutaneous Tissue, Inflammation, | | Chronic Active | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 2 2 1 2 1 2 2 2 1 1 2 1 2 2 2 2 1| Cranium, Fibrous Osteodystrophy | | Femur, Fibrous Osteodystrophy | 3 | __________________________________________________________________________| Skeletal Muscle | + + + M + + + + + + + + + + + + + + + + + + + + +| Hemorrhage, Focal | 2 | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Atrophy, Focal | | __________________________________________________________________________| Peripheral Nerve | + | __________________________________________________________________________| Spinal Cord | + | Hemorrhage, Focal | 2 | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 3 | Hemorrhage | 1| Hyperplasia, Histiocytic | 3 | Pigmentation | | Alveolar Epithelium, Hyperplasia | | Mediastinum, Inflammation, Chronic | | _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 3| 1| 7| 7| 7| 7| 7| 7| 4| 7| 3| 7| 7| 7| DAY ON TEST | 3| 3| 2| 4| 9| 3| 3| 3| 3| 3| 3| 4| 9| 3| 3| 3| 3| 2| 3| 9| 3| 1| 3| 3| 3| | 3| 3| 0| 8| 4| 3| 2| 3| 2| 2| 3| 4| 9| 2| 2| 3| 3| 2| 3| 4| 3| 8| 3| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 60 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 5000 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM - cont | | | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | Cornea, Inflammation, Chronic | 3 | __________________________________________________________________________| Harderian Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | | Metaplasia, Focal, Osseous | 1| Nephropathy | 1 2 3 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1 1| Pelvis, Dilatation | 2 | Renal Tubule, Accumulation, Hyaline | | Droplet | 3 | Renal Tubule, Dilatation | 3 | Renal Tubule, Mineralization | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Lymphoid | 2 | _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 7| | DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 0| 1| 3| | | 2| 1| 3| 2| 2| 2| 3| 2| 8| 2| 2| 3| 9| 2| 3| 2| 3| 2| 2| 2| 3| 3| 4| 4| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 60 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | 5000 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Necrosis | 3 | 2 3.0| Perforation | X | 2 | Muscularis, Inflammation, Chronic | 3 | 2 3.0| Periesophageal Tissue, Inflammation, | | | Chronic | 3 | 1 3.0| __________________________________________________________________________|____________| Gallbladder | + + + + + + + + + + + M + + + + + + + + + + + A +| 48 | __________________________________________________________________________|____________| Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + + + + A +| 47 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + A + + + + + + + + + + A + + + + + + + + + + A +| 46 | Peyer's Patch, Hyperplasia, Lymphoid | 3 3 | 2 3.0| __________________________________________________________________________|____________| Intestine Small, Ileum | + A + + + + + + + + + + + + + + + + + + + + + A +| 46 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 1 3.0| Basophilic Focus | 2 | 1 2.0| Clear Cell Focus | | 1 2.0| Eosinophilic Focus | 2 1 2 | 5 1.8| Hyperplasia, Focal, Lymphoid | 2 | 1 2.0| Inflammation, Chronic | | 6 1.5| Mixed Cell Focus | 3 4 | 2 3.5| Necrosis, Focal | 2 | 2 1.5| Vacuolization Cytoplasmic | 2 | 2 1.5| Hepatocyte, Karyomegaly | | 1 3.0| __________________________________________________________________________|____________| Mesentery | + + + + + + | 9 | Fat, Necrosis | 2 2 2 | 5 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | | 1 3.0| Acinus, Atrophy, Focal | 3 1 | 2 2.0| Duct, Cyst | 2 | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | | 1 3.0| __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | 2 | 1 2.0| Inflammation, Chronic | | 1 2.0| Epithelium, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + + + + + +| 48 | Glands, Degeneration, Cystic, Focal | 2 2 | 8 1.9| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 22 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 7| | DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 0| 1| 3| | | 2| 1| 3| 2| 2| 2| 3| 2| 8| 2| 2| 3| 9| 2| 3| 2| 3| 2| 2| 2| 3| 3| 4| 4| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 60 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | 5000 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic, Focal | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Accessory Adrenal Cortical Nodule | 2 2 | 3 2.0| Hyperplasia, Focal | 2 | 1 2.0| Hypertrophy, Focal | 2 | 2 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + M + + + + M + + + + + + +| 45 | __________________________________________________________________________|____________| Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 48 | Angiectasis | 2 2 1 | 4 2.0| Pars Distalis, Cyst | | 1 1.0| Pars Distalis, Cytoplasmic | | | Alteration, Focal | | 1 2.0| Pars Distalis, Hyperplasia, Focal | 1 2 2 1 2| 8 1.5| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Cystic, Focal | 2 1 2 1 1 1 2 1 2 2 | 14 1.6| Follicle, Cyst | 3 2 3 2 2 | 9 2.3| Follicular Cell, Hyperplasia | 1 2 1 1 1 2 1 2| 17 1.5| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Cystic | | 3 1.7| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | 3 3 | 5 2.4| Hemorrhage | | 1 3.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | 3 3 | 2 3.0| Hydrometra | 3 3 2 3 3 | 13 2.5| Endometrium, Hyperplasia, Cystic | 2 1 2 2 3 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2| 41 2.1| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 23 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 7| | DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 0| 1| 3| | | 2| 1| 3| 2| 2| 2| 3| 2| 8| 2| 2| 3| 9| 2| 3| 2| 3| 2| 2| 2| 3| 3| 4| 4| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 60 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | 5000 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Vagina | + + + + + + + + + + + + + + + + M + + + + + M + +| 48 | Epithelium, Hyperplasia, Atypical | 3 | 1 3.0| Epithelium, Hyperplasia | 2 2 2 2 | 7 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | 3 2 4| 4 3.0| __________________________________________________________________________|____________| Lymph Node | + + + +| 4 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + + + +| 48 | Hemorrhage | 2 | 2 1.5| Hyperplasia, Lymphoid | | 3 3.0| Infiltration Cellular, Mast Cell | | 1 4.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hemorrhage | 3 2 2 1 3 | 7 2.1| __________________________________________________________________________|____________| Spleen | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 | Depletion Cellular | 3 | 1 3.0| Hematopoietic Cell Proliferation | 4 2 3 3 3 2 2 3| 12 2.8| Hyperplasia, Lymphoid | 2 2 3 | 8 2.5| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + I + + + + + + + +| 48 | Atrophy | | 1 2.0| Cyst | 2| 4 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | | 3 2.3| Inflammation, Chronic, Focal | | 1 3.0| Subcutaneous Tissue, Inflammation, | | | Chronic Active | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperostosis | 2 1 2 2 2 1 2 2 2 2 2 2 2 2 2 1 2 2 2| 36 1.8| Cranium, Fibrous Osteodystrophy | 3 | 1 3.0| Femur, Fibrous Osteodystrophy | 2 | 2 2.5| __________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hemorrhage, Focal | | 1 2.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 24 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 7| 5| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 7| | DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 0| 3| 3| 3| 3| 3| 0| 1| 3| | | 2| 1| 3| 2| 2| 2| 3| 2| 8| 2| 2| 3| 9| 2| 3| 2| 3| 2| 2| 2| 3| 3| 4| 4| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A | 60 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | 5000 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Atrophy, Focal | 2 | 1 2.0| __________________________________________________________________________|____________| Peripheral Nerve | | 1 | __________________________________________________________________________|____________| Spinal Cord | | 1 | Hemorrhage, Focal | | 1 2.0| _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 2 | 2 2.5| Hemorrhage | 2 | 2 1.5| Hyperplasia, Histiocytic | | 1 3.0| Pigmentation | 1 | 1 1.0| Alveolar Epithelium, Hyperplasia | 3 | 1 3.0| Mediastinum, Inflammation, Chronic | 3 | 1 3.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 2 | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | Cornea, Inflammation, Chronic | | 1 3.0| __________________________________________________________________________|____________| Harderian Gland | + | 2 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infarct | 2 | 1 2.0| Metaplasia, Focal, Osseous | 1 | 2 1.0| Nephropathy | 1 2 2 1 1 1 2 1 1 1 1 2 1 1 2 1 2 1 | 39 1.3| Pelvis, Dilatation | | 1 2.0| Renal Tubule, Accumulation, Hyaline | | | Droplet | | 1 3.0| Renal Tubule, Dilatation | | 1 3.0| Renal Tubule, Mineralization | | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 25 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 6| 6| DAY ON TEST | 8| 3| 3| 3| 1| 3| 3| 3| 3| 7| 6| 3| 1| 3| 9| 3| 3| 5| 3| 3| 2| 3| 3| 3| 8| | 2| 3| 2| 2| 3| 2| 2| 2| 3| 1| 1| 3| 6| 3| 3| 3| 2| 7| 3| 2| 8| 3| 2| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 120MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5000 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + M + + + + + + + + + + + + + + + + A + + + M| __________________________________________________________________________| Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + + + + A| __________________________________________________________________________| Intestine Large, Rectum | + + + + A + + + + + + + A + + + + + + + + + + + A| __________________________________________________________________________| Intestine Large, Cecum | + + + + A + + + + + + + A + + + + + + + + + + + A| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + + A| Hyperplasia, Adenomatous | 3 | __________________________________________________________________________| Intestine Small, Jejunum | + + + + A + + + + + + + A + + + + + + + + + + + A| __________________________________________________________________________| Intestine Small, Ileum | + + + + A + + + + + + + A + + + + + + + + + + + A| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Eosinophilic Focus | 2 | Inflammation, Chronic | 2 2 | Mixed Cell Focus | 4 2 | Necrosis, Focal | 1 | Vacuolization Cytoplasmic | 2 2 2 | Bile Duct, Hyperplasia | | Hepatocyte, Karyomegaly | | __________________________________________________________________________| Mesentery | + + + + + +| Fat, Necrosis | 3 2 3| __________________________________________________________________________| Oral Mucosa | + | __________________________________________________________________________| Pancreas | + + + + A + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy, Diffuse | 1 | Acinus, Atrophy, Focal | | Duct, Cyst | 3 | __________________________________________________________________________| Salivary Glands | + + + + M + + + + + + + + + M + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +| Cyst | | Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Glands, Degeneration, Cystic, Focal | 1 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Thrombosis | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + A + + + + + + + + + + + + + + + + + + + +| Hyperplasia, Focal | 2 2 3| Hypertrophy, Focal | 2 2 | __________________________________________________________________________| Adrenal Medulla | + + + + A + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 26 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 6| 6| DAY ON TEST | 8| 3| 3| 3| 1| 3| 3| 3| 3| 7| 6| 3| 1| 3| 9| 3| 3| 5| 3| 3| 2| 3| 3| 3| 8| | 2| 3| 2| 2| 3| 2| 2| 2| 3| 1| 1| 3| 6| 3| 3| 3| 2| 7| 3| 2| 8| 3| 2| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 120MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5000 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Pituitary Gland | + + + + I + + + + + + + + + + + + M + + M + + + +| Angiectasis | | Pars Distalis, Cyst | 1 2 1 | Pars Distalis, Hyperplasia, Focal | 2 2 2 1 2 | Rathke's Cleft, Cyst | 3 2 3 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic, Focal | 2 3 2 2 1 | Follicle, Cyst | 1 2 3 2 | Follicular Cell, Hyperplasia | 2 1 1 1 3 1 1 2 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic | 2 | Inflammation, Chronic | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 2 3 3 2 2 | Hemorrhage | | Thrombosis | 4 | Bilateral, Cyst | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Hydrometra | 2 3 2 3 2 3 3 2 | Endometrium, Hyperplasia, Cystic | 2 2 3 2 2 1 2 3 3 2 2 3 2 2 2 2 3 2 3 3 2 2 2 2 2| __________________________________________________________________________| Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +| Epithelium, Hyperplasia, Atypical | 3 | Epithelium, Hyperplasia | 2 1 2 3 1 1 2 2 | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + A + + + + + + + + + + + + + + + I + + + +| Angiectasis | 2 | Depletion Cellular | 3 2 | Hyperplasia | 2 2 | __________________________________________________________________________| Lymph Node | + + + | Renal, Hemorrhage | 2 | __________________________________________________________________________| Lymph Node, Mandibular | M + + + M + + M + + + + + + M + + + + + M + + + +| Hyperplasia, Lymphoid | 3 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + + +| Ectasia | 3 2 | Hemorrhage | 2 1 1 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Depletion Cellular | 2 | _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 6| 6| DAY ON TEST | 8| 3| 3| 3| 1| 3| 3| 3| 3| 7| 6| 3| 1| 3| 9| 3| 3| 5| 3| 3| 2| 3| 3| 3| 8| | 2| 3| 2| 2| 3| 2| 2| 2| 3| 1| 1| 3| 6| 3| 3| 3| 2| 7| 3| 2| 8| 3| 2| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 120MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5000 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Fibrosis, Focal | 2 | Hematopoietic Cell Proliferation | 1 2 2 2 2 3 1 3 1 2 2| Hyperplasia, Lymphoid | 3 | __________________________________________________________________________| Thymus | + + + + A + + + + + + + + + + + + + + + M + + + +| Atrophy | 3 2 | Cyst | 2 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | Inflammation, Chronic, Focal | | Ulcer | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 1 2 2 2 2 2 2 1| Femur, Fibrous Osteodystrophy | | __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Vacuolization Cytoplasmic | 2 | Meninges, Inflammation, Chronic | 2 | __________________________________________________________________________| Peripheral Nerve | + + + | __________________________________________________________________________| Spinal Cord | + + + | Cyst Epithelial Inclusion | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | Hyperplasia, Histiocytic | 2 | Metaplasia, Osseous | 2 | Alveolar Epithelium, Hyperplasia | 3 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | __________________________________________________________________________| Harderian Gland | + | __________________________________________________________________________| Lacrimal Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 5| 7| 7| 5| 7| 7| 6| 7| 7| 6| 6| DAY ON TEST | 8| 3| 3| 3| 1| 3| 3| 3| 3| 7| 6| 3| 1| 3| 9| 3| 3| 5| 3| 3| 2| 3| 3| 3| 8| | 2| 3| 2| 2| 3| 2| 2| 2| 3| 1| 1| 3| 6| 3| 3| 3| 2| 7| 3| 2| 8| 3| 2| 0| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 120MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5000 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | | | __________________________________________________________________________| Kidney | + + + + A + + + + + + + + + + + + + + + + + + + +| Congestion | | Infarct | | Nephropathy | 1 1 2 1 2 1 1 1 1 1 2 1 1 1 1 1 | Pelvis, Dilatation | 3 | Renal Tubule, Atrophy | 3 | Renal Tubule, Dilatation | 2 1 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 0| 3| 2| 3| 5| 3| 3| 8| 2| 7| 3| 3| 3| 3| 7| 2| 3| 3| 3| 3| 3| 3| | | 3| 2| 2| 1| 2| 1| 2| 8| 2| 3| 7| 7| 6| 3| 2| 3| 2| 1| 6| 3| 2| 3| 3| 3| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 120MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | 5000 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Gallbladder | + + + + + A + M + + + + + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + A + + + + + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + A + A + + + + + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + + + + + + + +| 47 | Hyperplasia, Adenomatous | | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + A + A + + + + + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + A + A + + + + + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Eosinophilic Focus | 3 | 2 2.5| Inflammation, Chronic | 2 1 1 1| 6 1.5| Mixed Cell Focus | | 2 3.0| Necrosis, Focal | 3 2 | 3 2.0| Vacuolization Cytoplasmic | | 3 2.0| Bile Duct, Hyperplasia | 1 | 1 1.0| Hepatocyte, Karyomegaly | 2 | 1 2.0| __________________________________________________________________________|____________| Mesentery | + + + +| 10 | Fat, Necrosis | 2 2| 5 2.4| __________________________________________________________________________|____________| Oral Mucosa | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Acinus, Atrophy, Diffuse | | 1 1.0| Acinus, Atrophy, Focal | 2 | 1 2.0| Duct, Cyst | 3 3 | 3 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 | Cyst | 2 | 1 2.0| Epithelium, Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 | Glands, Degeneration, Cystic, Focal | 1 1 1 2 2 1 | 8 1.4| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + M + M + + + + + + + + + + M + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Thrombosis | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Hyperplasia, Focal | 2 | 4 2.3| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 30 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 0| 3| 2| 3| 5| 3| 3| 8| 2| 7| 3| 3| 3| 3| 7| 2| 3| 3| 3| 3| 3| 3| | | 3| 2| 2| 1| 2| 1| 2| 8| 2| 3| 7| 7| 6| 3| 2| 3| 2| 1| 6| 3| 2| 3| 3| 3| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 120MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | 5000 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Hypertrophy, Focal | | 2 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + M + M + + + + + + + M + + + + + M + + + +| 46 | __________________________________________________________________________|____________| Pituitary Gland | + + I + + I + + + + + + + + + + + M + + + + + + +| 44 | Angiectasis | 1 2 2| 3 1.7| Pars Distalis, Cyst | | 3 1.3| Pars Distalis, Hyperplasia, Focal | 2 1 1 | 8 1.6| Rathke's Cleft, Cyst | | 3 2.7| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Cystic, Focal | 1 2 1 1 1 1 2 | 12 1.6| Follicle, Cyst | 2 2 2 | 7 2.0| Follicular Cell, Hyperplasia | 1 1 2 2 2 1 1 1 1 | 17 1.4| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 | Degeneration, Cystic | 3 2 | 3 2.3| Inflammation, Chronic | 3 | 1 3.0| __________________________________________________________________________|____________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 2 2 2 3 3 2 | 13 2.3| Hemorrhage | 3 3 4 2 | 4 3.0| Thrombosis | | 1 4.0| Bilateral, Cyst | 3 | 1 3.0| __________________________________________________________________________|____________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 3 | 1 3.0| Hydrometra | 2 2 3 3 3 3 2 | 15 2.5| Endometrium, Hyperplasia, Cystic | 2 2 2 1 2 2 3 2 2 2 3 2 1 3 2 2 2 2 2 2| 45 2.2| __________________________________________________________________________|____________| Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Epithelium, Hyperplasia, Atypical | 3 1 | 3 2.3| Epithelium, Hyperplasia | 2 2 2 1 | 12 1.8| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Angiectasis | | 1 2.0| Depletion Cellular | | 2 2.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 31 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 0| 3| 2| 3| 5| 3| 3| 8| 2| 7| 3| 3| 3| 3| 7| 2| 3| 3| 3| 3| 3| 3| | | 3| 2| 2| 1| 2| 1| 2| 8| 2| 3| 7| 7| 6| 3| 2| 3| 2| 1| 6| 3| 2| 3| 3| 3| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 120MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | 5000 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hyperplasia | 3 3 | 4 2.5| __________________________________________________________________________|____________| Lymph Node | + + + | 6 | Renal, Hemorrhage | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + M + + + + + + + + + +| 44 | Hyperplasia, Lymphoid | | 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Ectasia | | 2 2.5| Hemorrhage | 3 2 | 6 2.0| __________________________________________________________________________|____________| Spleen | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | Depletion Cellular | | 1 2.0| Fibrosis, Focal | | 1 2.0| Hematopoietic Cell Proliferation | 2 2 3 2 2 2 | 17 2.0| Hyperplasia, Lymphoid | 2 2 | 3 2.3| __________________________________________________________________________|____________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Atrophy | | 2 2.5| Cyst | | 2 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | 2 | 1 2.0| Inflammation, Chronic, Focal | 1 3 | 2 2.0| Ulcer | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperostosis | 1 2 2 2 2 2 1 2 2 2 2 1 2 2 2 3 2 2| 43 1.9| Femur, Fibrous Osteodystrophy | 2 2 | 2 2.0| __________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Vacuolization Cytoplasmic | | 1 2.0| Meninges, Inflammation, Chronic | | 1 2.0| __________________________________________________________________________|____________| Peripheral Nerve | | 3 | __________________________________________________________________________|____________| Spinal Cord | +| 4 | Cyst Epithelial Inclusion | X| 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 32 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 3| 3| 0| 3| 2| 3| 5| 3| 3| 8| 2| 7| 3| 3| 3| 3| 7| 2| 3| 3| 3| 3| 3| 3| | | 3| 2| 2| 1| 2| 1| 2| 8| 2| 3| 7| 7| 6| 3| 2| 3| 2| 1| 6| 3| 2| 3| 3| 3| 3| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A | 120MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | 5000 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ NERVOUS SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 1 3 | 3 2.0| Hyperplasia, Histiocytic | | 1 2.0| Metaplasia, Osseous | | 1 2.0| Alveolar Epithelium, Hyperplasia | 2 | 2 2.5| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 1 | __________________________________________________________________________|____________| Harderian Gland | | 1 | __________________________________________________________________________|____________| Lacrimal Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Congestion | 2 | 1 2.0| Infarct | 2 | 1 2.0| Nephropathy | 1 1 1 2 1 1 1 1 1 1 1 2 2 1 1 1 1 | 33 1.2| Pelvis, Dilatation | | 1 3.0| Renal Tubule, Atrophy | | 1 3.0| Renal Tubule, Dilatation | | 2 1.5| __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 33 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 7| 4| 5| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 7| 7| 7| 3| 2| 2| 1| 3| 9| 2| 5| 2| 3| 9| 1| 3| 2| 1| 3| 2| 2| 3| 2| 2| | 1| 4| 6| 7| 1| 9| 9| 2| 1| 1| 9| 4| 9| 1| 3| 4| 1| 9| 3| 1| 9| 9| 1| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + A + + + A + + + + + + + + + M + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + A + + + A + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + A + + + A + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + A + + + A + + + + + + + A + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + A + + + A + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + A + + + A + + + + + + + A + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + A + + + A + + + + + + + A + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | | Clear Cell Focus | | Eosinophilic Focus | 2 3 2 2 3| Hemorrhage | | Inflammation, Chronic | 2 3 2 1 2 2 2 2 2 2 3 2 3 2 3 2 2 2 2 2 3 2| Mixed Cell Focus | 2 | Necrosis, Focal | 3 1 | Pigmentation, Focal | | Vacuolization Cytoplasmic | 2 2 | Bile Duct, Cyst | | Bile Duct, Hyperplasia | 2 2 2 2 2 2 3 2 3 2 2 2 2 2| Hepatocyte, Karyomegaly | 2 3 2 2 2 2 2 3 2 2 3 2 2 2 3 3 3| __________________________________________________________________________| Mesentery | + | Artery, Inflammation, Chronic | | Fat, Necrosis | 2 | __________________________________________________________________________| Pancreas | + + + + + + + A + + + + + + + + + + + + + + + + +| Duct, Cyst | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + A + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 2 | Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + A + + + + + + + + + + + + + + + + +| Mineralization | | __________________________________________________________________________| Tooth | + | Developmental Malformation | 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Thrombosis | | Artery, Inflammation, Chronic | 2 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + A + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 34 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 7| 4| 5| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 7| 7| 7| 3| 2| 2| 1| 3| 9| 2| 5| 2| 3| 9| 1| 3| 2| 1| 3| 2| 2| 3| 2| 2| | 1| 4| 6| 7| 1| 9| 9| 2| 1| 1| 9| 4| 9| 1| 3| 4| 1| 9| 3| 1| 9| 9| 1| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Cytoplasmic Alteration, Focal | 1 | Hypertrophy, Focal | 1 2 | Capsule, Hyperplasia, Focal | | __________________________________________________________________________| Adrenal Medulla | + + + M + + + A + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + A + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 2 | __________________________________________________________________________| Pituitary Gland | + + + + + + + M + + + + + + + + + + + + + I + + +| Pars Distalis, Hyperplasia, Focal | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic, Focal | 2 2 | Follicle, Cyst | 2 3 2 | Follicular Cell, Hyperplasia | 2 1 2 2 2 2| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 3 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic | 4 4 4 3 2 2 4 1 2 2 2 4 3 2 4 4 3 3 4 4 2 4| Inflammation, Chronic | 3 | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 2 | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 2 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Germinal Epithelium, Degeneration | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | | __________________________________________________________________________| Lymph Node | | __________________________________________________________________________| Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + M + + + + +| Hyperplasia, Lymphoid | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + A + + + + + + + + + + + + + + + + +| Hemorrhage | 2 1 1 2 2 1| Hyperplasia, Histiocytic | 2 | Hyperplasia, Lymphoid | 2 2 | Inflammation, Chronic | 3 | __________________________________________________________________________| Spleen | + + + A + + + A + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 35 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 7| 4| 5| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 7| 7| 7| 3| 2| 2| 1| 3| 9| 2| 5| 2| 3| 9| 1| 3| 2| 1| 3| 2| 2| 3| 2| 2| | 1| 4| 6| 7| 1| 9| 9| 2| 1| 1| 9| 4| 9| 1| 3| 4| 1| 9| 3| 1| 9| 9| 1| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Congestion | 2 2 | Hematopoietic Cell Proliferation | 2 2 2 2 3 2 2 | Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Thymus | + + M + + + + + + + + + + M + + M + + + + + + + +| Atrophy | 2 | Cyst | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M + M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst Epithelial Inclusion | X | Edema | | Inflammation, Chronic, Focal | | Subcutaneous Tissue, Hemorrhage | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 2 2 1 1 2 2 2 1 1 2 2 2 2 1 2 3 2 1| __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | | __________________________________________________________________________| Peripheral Nerve | + | __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 | Hemorrhage | | Hyperplasia, Histiocytic | 3 | Alveolar Epithelium, Hyperplasia | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | __________________________________________________________________________| Eye | + | Cornea, Inflammation, Chronic | 2 | __________________________________________________________________________| Harderian Gland | + +| Hyperplasia, Focal | 2| __________________________________________________________________________| Zymbal's Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | _____________________________________________________________________________________________________________________| Page 36 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 7| 4| 5| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 7| 7| 7| 3| 2| 2| 1| 3| 9| 2| 5| 2| 3| 9| 1| 3| 2| 1| 3| 2| 2| 3| 2| 2| | 1| 4| 6| 7| 1| 9| 9| 2| 1| 1| 9| 4| 9| 1| 3| 4| 1| 9| 3| 1| 9| 9| 1| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| VEHICLE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | | | __________________________________________________________________________| Kidney | + + + + + + + A + + + + + + + + + + + + + + + + +| Cyst | 3 2| Infarct | | Nephropathy | 2 1 2 1 2 2 1 2 1 2 1 2 2 1 1 2 2 2 1 2 1 1 1 2| Renal Tubule, Accumulation, Hyaline | | Droplet | | Renal Tubule, Pigmentation | | __________________________________________________________________________| Urethra | + + + | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 37 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| | DAY ON TEST | 3| 3| 9| 9| 2| 2| 2| 6| 2| 3| 2| 2| 3| 2| 2| 3| 3| 1| 3| 3| 7| 7| 3| 9| 3| | | 8| 1| 0| 7| 9| 9| 9| 2| 9| 1| 9| 7| 1| 9| 4| 1| 1| 0| 1| 1| 6| 0| 1| 4| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + + + + M + + + + + + M + + + M + + + + + +| 44 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + + + + + + + +| 47 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + A + + + A + + + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + A + + + A + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + A + + + A + + + + + + + + + + + + +| 45 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | 2 | 1 2.0| Clear Cell Focus | 2 | 1 2.0| Eosinophilic Focus | 2 | 6 2.3| Hemorrhage | 3 2 | 2 2.5| Inflammation, Chronic | 3 3 3 3 2 3 2 2 2 2 3 2 2 1 3 2 3 3 2 3 2 3 3| 45 2.3| Mixed Cell Focus | 3 2 | 3 2.3| Necrosis, Focal | | 2 2.0| Pigmentation, Focal | 2 | 1 2.0| Vacuolization Cytoplasmic | 2 3 1 2 | 6 2.0| Bile Duct, Cyst | 2 | 1 2.0| Bile Duct, Hyperplasia | 3 3 2 2 3 2 1 2 2 3 3 2 2 2 2| 29 2.2| Hepatocyte, Karyomegaly | 3 2 2 3 2 2 3 2 2 3 3 2 3 3 3 3 3 2 2 3| 37 2.5| __________________________________________________________________________|____________| Mesentery | + + | 3 | Artery, Inflammation, Chronic | 3 | 1 3.0| Fat, Necrosis | | 1 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 | Duct, Cyst | 3| 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Inflammation, Chronic | | 1 2.0| Epithelium, Hyperplasia | 2 2 | 3 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Mineralization | 2 | 1 2.0| __________________________________________________________________________|____________| Tooth | + | 2 | Developmental Malformation | 3 | 2 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | 4 | 1 4.0| __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 38 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| | DAY ON TEST | 3| 3| 9| 9| 2| 2| 2| 6| 2| 3| 2| 2| 3| 2| 2| 3| 3| 1| 3| 3| 7| 7| 3| 9| 3| | | 8| 1| 0| 7| 9| 9| 9| 2| 9| 1| 9| 7| 1| 9| 4| 1| 1| 0| 1| 1| 6| 0| 1| 4| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | Thrombosis | 3 | 1 3.0| Artery, Inflammation, Chronic | | 1 2.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cytoplasmic Alteration, Focal | 1 2 | 3 1.3| Hypertrophy, Focal | 2 2 1 2 2 | 7 1.7| Capsule, Hyperplasia, Focal | 2 2 | 2 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 | Hyperplasia | 2 | 2 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 2 | 3 2.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 | Pars Distalis, Hyperplasia, Focal | | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Cystic, Focal | 2 2 2 2 1 | 7 1.9| Follicle, Cyst | 2 2 | 5 2.2| Follicular Cell, Hyperplasia | 1 2 2 2 1 2 1 | 13 1.7| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | | 1 3.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Cystic | 4 2 3 2 3 2 4 3 4 2 2 2 4 4 4 3 4 4 3 4 4 4| 44 3.1| Inflammation, Chronic | 3 | 2 3.0| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 | Inflammation, Chronic | | 1 2.0| __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | | 1 2.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Germinal Epithelium, Degeneration | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 39 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| | DAY ON TEST | 3| 3| 9| 9| 2| 2| 2| 6| 2| 3| 2| 2| 3| 2| 2| 3| 3| 1| 3| 3| 7| 7| 3| 9| 3| | | 8| 1| 0| 7| 9| 9| 9| 2| 9| 1| 9| 7| 1| 9| 4| 1| 1| 0| 1| 1| 6| 0| 1| 4| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hyperplasia | 3 | 1 3.0| __________________________________________________________________________|____________| Lymph Node | + +| 2 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + M + + + + + + + + + + + + + M + + M + + + + + +| 45 | Hyperplasia, Lymphoid | 2 | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | I + M + + + + + + + + + + + + + + + + + M + + + +| 46 | Hemorrhage | 2 2 2 2 2 2 3 2 2 1 2| 17 1.8| Hyperplasia, Histiocytic | | 1 2.0| Hyperplasia, Lymphoid | 3 | 3 2.3| Inflammation, Chronic | 3 | 2 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 | Congestion | 3 | 3 2.3| Hematopoietic Cell Proliferation | 2 2 2 3 2 3 3 3 3 3 3 | 18 2.4| Hyperplasia, Lymphoid | 2 2| 3 2.0| __________________________________________________________________________|____________| Thymus | + + I M + + + M + + + + + + M + + + + + M + + + +| 42 | Atrophy | 3 3 | 3 2.7| Cyst | 2 2 | 2 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| 1 | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst Epithelial Inclusion | X | 2 | Edema | 3 | 1 3.0| Inflammation, Chronic, Focal | 3 | 1 3.0| Subcutaneous Tissue, Hemorrhage | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperostosis | 2 1 1 2 1 1 2 2 2 2 2 2 2 2 1 2 2 1 1 1 2 2| 40 1.7| __________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis | 3 | 1 3.0| __________________________________________________________________________|____________| Peripheral Nerve | | 1 | __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 3 | 2 2.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 40 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 6| 7| 6| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 6| 7| | DAY ON TEST | 3| 3| 9| 9| 2| 2| 2| 6| 2| 3| 2| 2| 3| 2| 2| 3| 3| 1| 3| 3| 7| 7| 3| 9| 3| | | 8| 1| 0| 7| 9| 9| 9| 2| 9| 1| 9| 7| 1| 9| 4| 1| 1| 0| 1| 1| 6| 0| 1| 4| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A | VEHICLE | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Hemorrhage | 2 | 1 2.0| Hyperplasia, Histiocytic | 2 2 2 | 4 2.3| Alveolar Epithelium, Hyperplasia | 1 3 | 2 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | 2 | 2 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 1 | __________________________________________________________________________|____________| Eye | | 1 | Cornea, Inflammation, Chronic | | 1 2.0| __________________________________________________________________________|____________| Harderian Gland | + + | 4 | Hyperplasia, Focal | | 1 2.0| __________________________________________________________________________|____________| Zymbal's Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Cyst | 3 | 3 2.7| Infarct | 2 | 1 2.0| Nephropathy | 2 2 1 3 2 2 2 1 2 2 1 1 2 2 2 2 2 2 2 2 2 1 3 1 2| 49 1.7| Renal Tubule, Accumulation, Hyaline | | | Droplet | 2 | 1 2.0| Renal Tubule, Pigmentation | 3 | 1 3.0| __________________________________________________________________________|____________| Urethra | | 3 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 41 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 4| 3| 7| 7| 6| 5| 7| 5| 6| DAY ON TEST | 3| 2| 2| 2| 2| 6| 1| 2| 2| 3| 2| 7| 5| 3| 2| 3| 3| 3| 2| 3| 8| 5| 3| 2| 8| | 1| 9| 9| 9| 9| 3| 5| 9| 9| 1| 9| 3| 4| 1| 9| 1| 9| 9| 9| 1| 3| 7| 1| 8| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 30 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5000 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Perforation | X | Muscularis, Inflammation, Chronic | 2 | __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + M +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + M +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Basophilic Focus | 3 | Clear Cell Focus | 2 2 | Congestion | 1 | Eosinophilic Focus | 3 2 2 2 2 | Inflammation, Chronic | 1 3 2 2 3 2 3 3 4 2 3 2 2 1 1 1 2 3 3 1 3| Inflammation, Focal | | Mixed Cell Focus | | Necrosis, Focal | 1 | Vacuolization Cytoplasmic | 2 1 | Bile Duct, Cyst | | Bile Duct, Hyperplasia | 3 1 2 3 2 3 2 3 3 3 2 2 2 2 3| Centrilobular, Necrosis | | Hepatocyte, Karyomegaly | 3 3 3 2 3 3 3 3 3 2 2 2 3 2 3| __________________________________________________________________________| Mesentery | + + | Inflammation, Chronic | 3 | Thrombosis | 3 | Artery, Inflammation, Chronic | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic | 3 | Duct, Cyst | 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Ulcer | 2 2 | Epithelium, Hyperplasia | 2 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Mineralization | 1 | Glands, Degeneration, Cystic, Focal | 1 | __________________________________________________________________________| Tooth | + | Developmental Malformation | 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 42 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 4| 3| 7| 7| 6| 5| 7| 5| 6| DAY ON TEST | 3| 2| 2| 2| 2| 6| 1| 2| 2| 3| 2| 7| 5| 3| 2| 3| 3| 3| 2| 3| 8| 5| 3| 2| 8| | 1| 9| 9| 9| 9| 3| 5| 9| 9| 1| 9| 3| 4| 1| 9| 1| 9| 9| 9| 1| 3| 7| 1| 8| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 30 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5000 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM - cont | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Artery, Inflammation, Chronic | 3 | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Cytoplasmic Alteration, Focal | 2 2 | Hyperplasia, Focal | 2 | Hypertrophy, Focal | 2 2 2 1 2 | Capsule, Hyperplasia, Focal | 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Parathyroid Gland | + M + + + M + + + + + + M M + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + M + + + + + + + + + + + + + M + + + M| Pars Distalis, Cyst | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic, Focal | 1 2 2 | Follicle, Cyst | 2 2 3 1| Follicular Cell, Hyperplasia | 1 2 1 2 2 3 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + M + + + + +| Degeneration, Cystic | 4 4 3 4 3 4 4 3 3 3 4 4 4 1 4 4 3 3 3 3 4 4| Inflammation, Chronic | 3 2| __________________________________________________________________________| Prostate | + M + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 3 3 2 3 3 | __________________________________________________________________________| Lymph Node | + + + | Pancreatic, Hyperplasia, Lymphoid | 2 | __________________________________________________________________________| Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 4 2| Hemorrhage | 3 1 3 2 2 2 2 2 2 4 1 2 1| Hyperplasia, Lymphoid | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | _____________________________________________________________________________________________________________________| Page 43 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 4| 3| 7| 7| 6| 5| 7| 5| 6| DAY ON TEST | 3| 2| 2| 2| 2| 6| 1| 2| 2| 3| 2| 7| 5| 3| 2| 3| 3| 3| 2| 3| 8| 5| 3| 2| 8| | 1| 9| 9| 9| 9| 3| 5| 9| 9| 1| 9| 3| 4| 1| 9| 1| 9| 9| 9| 1| 3| 7| 1| 8| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 30 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5000 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hematopoietic Cell Proliferation | 3 2 3 3 3 4 3 2 | Necrosis, Focal | | Capsule, Fibrosis | 2 | __________________________________________________________________________| Thymus | M + + + M + + + + + + M + + + + + + + + + + + M +| Cyst | 2 1 2 | Necrosis | 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | Inflammation, Chronic, Focal | 3 2 | Ulcer | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 2 1 1 2 1 1 2 1 2| __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Peripheral Nerve | + + | __________________________________________________________________________| Spinal Cord | + + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | | Foreign Body | | Hyperplasia, Histiocytic | | Pigmentation | | Alveolar Epithelium, Hyperplasia | | Mediastinum, Inflammation, Chronic | 3 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Suppurative | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | External Ear, Inflammation, Chronic | 3 | __________________________________________________________________________| Eye | + + + + | Cataract | 3 3 | Fibrosis | | Cornea, Inflammation, Chronic | 3 3 2 | __________________________________________________________________________| Harderian Gland | + + + + + | _____________________________________________________________________________________________________________________| Page 44 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 4| 5| 7| 7| 7| 4| 3| 7| 7| 6| 5| 7| 5| 6| DAY ON TEST | 3| 2| 2| 2| 2| 6| 1| 2| 2| 3| 2| 7| 5| 3| 2| 3| 3| 3| 2| 3| 8| 5| 3| 2| 8| | 1| 9| 9| 9| 9| 3| 5| 9| 9| 1| 9| 3| 4| 1| 9| 1| 9| 9| 9| 1| 3| 7| 1| 8| 0| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 30 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5000 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | 3 | Infarct | 3 2 3 2 2| Metaplasia, Focal, Osseous | | Nephropathy | 2 1 3 1 2 1 1 2 2 2 2 1 1 2 2 2 2 1 2 1 1 1 1 2 2| __________________________________________________________________________| Urethra | + | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 45 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 2| 8| 3| 5| 2| 3| 3| 6| 3| 2| 8| 3| 2| 3| 2| 2| 2| 2| 3| 2| 2| 3| 3| 1| | | 1| 9| 9| 1| 7| 9| 1| 1| 1| 1| 9| 8| 1| 9| 1| 9| 9| 9| 9| 1| 9| 9| 1| 1| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 30 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | 5000 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Perforation | | 1 | Muscularis, Inflammation, Chronic | | 1 2.0| __________________________________________________________________________|____________| Gallbladder | + + M + + + + + M + + M + M + + + + + + + + + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Basophilic Focus | | 1 3.0| Clear Cell Focus | 3 2 3 2 | 6 2.3| Congestion | | 1 1.0| Eosinophilic Focus | 2 2 | 7 2.1| Inflammation, Chronic | 1 1 2 2 2 3 3 2 2 2 3 3 2 2 2 3 3 1 3 2 2 2| 43 2.2| Inflammation, Focal | 4 | 1 4.0| Mixed Cell Focus | 2 2 3| 3 2.3| Necrosis, Focal | 3 | 2 2.0| Vacuolization Cytoplasmic | 3 2 2 2 3 | 7 2.1| Bile Duct, Cyst | 3 | 1 3.0| Bile Duct, Hyperplasia | 2 2 2 2 2 1 3 2 2 2 2 2 3 2 2 2 | 31 2.2| Centrilobular, Necrosis | 3 | 1 3.0| Hepatocyte, Karyomegaly | 2 2 2 3 2 3 3 3 3 3 2 2 3 3 3 3 3| 32 2.7| __________________________________________________________________________|____________| Mesentery | + + + | 5 | Inflammation, Chronic | | 1 3.0| Thrombosis | | 1 3.0| Artery, Inflammation, Chronic | 3 | 1 3.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic | | 1 3.0| Duct, Cyst | | 1 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 1 | 1 1.0| Ulcer | 2 | 3 2.0| Epithelium, Hyperplasia | 2 | 2 2.0| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Mineralization | | 1 1.0| Glands, Degeneration, Cystic, Focal | 2 1 2 | 4 1.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 46 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 2| 8| 3| 5| 2| 3| 3| 6| 3| 2| 8| 3| 2| 3| 2| 2| 2| 2| 3| 2| 2| 3| 3| 1| | | 1| 9| 9| 1| 7| 9| 1| 1| 1| 1| 9| 8| 1| 9| 1| 9| 9| 9| 9| 1| 9| 9| 1| 1| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 30 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | 5000 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Tooth | + | 2 | Developmental Malformation | 2 | 2 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Artery, Inflammation, Chronic | | 1 3.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cytoplasmic Alteration, Focal | 2 2 1 2 1 2 2 2| 10 1.8| Hyperplasia, Focal | 2 | 2 2.0| Hypertrophy, Focal | 2 2 1 2 2 1 | 11 1.7| Capsule, Hyperplasia, Focal | 1 | 2 1.5| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + +| 45 | __________________________________________________________________________|____________| Pituitary Gland | + + M + + + + M M + + + + I + + + + + + + + + + +| 43 | Pars Distalis, Cyst | 2 | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Cystic, Focal | 2 1 2 2 2 2 3 2| 11 1.9| Follicle, Cyst | 2 | 5 2.0| Follicular Cell, Hyperplasia | 2 2 1 1 1 2 2 2 | 14 1.7| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Degeneration, Cystic | 3 3 4 4 2 3 3 2 4 3 2 2 2 4 4 3 4 4 4| 41 3.3| Inflammation, Chronic | | 2 2.5| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 47 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 2| 8| 3| 5| 2| 3| 3| 6| 3| 2| 8| 3| 2| 3| 2| 2| 2| 2| 3| 2| 2| 3| 3| 1| | | 1| 9| 9| 1| 7| 9| 1| 1| 1| 1| 9| 8| 1| 9| 1| 9| 9| 9| 9| 1| 9| 9| 1| 1| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 30 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | 5000 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hyperplasia | 2 | 7 2.7| __________________________________________________________________________|____________| Lymph Node | + | 4 | Pancreatic, Hyperplasia, Lymphoid | | 1 2.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + + M + + M + + + + + + + + + + + + + + + + M + +| 46 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 2 | 3 2.7| Hemorrhage | 2 2 1 1 2 3 1 2 | 21 2.0| Hyperplasia, Lymphoid | 2 | 1 2.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 2 | 1 2.0| Hematopoietic Cell Proliferation | 3 2 2 2 3 3 3 3 | 16 2.8| Necrosis, Focal | 3 | 1 3.0| Capsule, Fibrosis | | 1 2.0| __________________________________________________________________________|____________| Thymus | + + + + M + + + + + + + + + + + + + + + + + + + +| 45 | Cyst | 2 2 2 | 6 1.8| Necrosis | | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + | 49 | Edema | 3 | 1 3.0| Inflammation, Chronic, Focal | 3 | 3 2.7| Ulcer | 3 | 2 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperostosis | 2 2 2 2 2 2 2 1 2 2 2 1 1 1 2 1 2| 26 1.6| __________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Peripheral Nerve | | 2 | __________________________________________________________________________|____________| Spinal Cord | | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Congestion | 3 | 1 3.0| Foreign Body | 1 1 | 2 1.0| Hyperplasia, Histiocytic | 3 | 1 3.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 48 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | DAY ON TEST | 3| 2| 8| 3| 5| 2| 3| 3| 6| 3| 2| 8| 3| 2| 3| 2| 2| 2| 2| 3| 2| 2| 3| 3| 1| | | 1| 9| 9| 1| 7| 9| 1| 1| 1| 1| 9| 8| 1| 9| 1| 9| 9| 9| 9| 1| 9| 9| 1| 1| 5| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A | 30 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | 5000 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Pigmentation | 1 | 1 1.0| Alveolar Epithelium, Hyperplasia | 1 3 | 2 2.0| Mediastinum, Inflammation, Chronic | | 1 3.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Suppurative | | 1 2.0| __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 1 | External Ear, Inflammation, Chronic | | 1 3.0| __________________________________________________________________________|____________| Eye | + +| 6 | Cataract | | 2 3.0| Fibrosis | 2 | 1 2.0| Cornea, Inflammation, Chronic | 3 3| 5 2.8| __________________________________________________________________________|____________| Harderian Gland | + + + + | 9 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 2 | 3 2.3| Infarct | | 5 2.4| Metaplasia, Focal, Osseous | 1 | 1 1.0| Nephropathy | 2 1 1 2 2 1 1 1 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 1| 50 1.7| __________________________________________________________________________|____________| Urethra | + | 2 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 49 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 4| 7| 7| 1| 7| 7| 4| 3| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 2| 2| 3| 2| 8| 3| 2| 6| 3| 3| 8| 8| 2| 2| 4| 3| 0| 3| 2| 2| 2| 3| 2| | 1| 1| 9| 9| 1| 9| 8| 1| 9| 9| 1| 1| 0| 6| 9| 9| 3| 1| 5| 1| 9| 9| 9| 1| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 60 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 5000 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| Necrosis | | Muscularis, Inflammation, Chronic | | __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + M + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Clear Cell Focus | 2 3 | Eosinophilic Focus | 2 3 | Inflammation, Chronic | 3 2 3 3 3 3 3 1 2 3 2 3 3 3 3 2| Mixed Cell Focus | 2 3 3 3 | Necrosis, Focal | 2 2 2 | Vacuolization Cytoplasmic | 2 | Bile Duct, Cyst | | Bile Duct, Hyperplasia | 2 3 3 2 2 2 2 2 1 2 2 3 2 3| Hepatocyte, Karyomegaly | 3 3 3 3 3 2 2 3 3 3 3 3 | __________________________________________________________________________| Mesentery | | Fat, Necrosis | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy, Focal | 2 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Diverticulum | | Edema | | Epithelium, Hyperplasia | 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | | Hyperplasia, Adenomatous | 2 | Inflammation, Chronic | 2 | Mineralization | 1 | Glands, Degeneration, Cystic, Focal | 2 1 2 | __________________________________________________________________________| Tooth | + + | Developmental Malformation | 2 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 50 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 4| 7| 7| 1| 7| 7| 4| 3| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 2| 2| 3| 2| 8| 3| 2| 6| 3| 3| 8| 8| 2| 2| 4| 3| 0| 3| 2| 2| 2| 3| 2| | 1| 1| 9| 9| 1| 9| 8| 1| 9| 9| 1| 1| 0| 6| 9| 9| 3| 1| 5| 1| 9| 9| 9| 1| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 60 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 5000 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Cytoplasmic Alteration, Focal | 2 1 | Hyperplasia, Focal | 1 1 2 2 2| Hypertrophy, Focal | 2 2 2 2 1 1 | Capsule, Hyperplasia, Focal | 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| Cyst | | __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| Pars Distalis, Cyst | 2 2 | Pars Distalis, Hyperplasia, Focal | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic, Focal | 2 2 1 2 2| Inflammation, Chronic, Focal | | Follicle, Cyst | 2 | Follicular Cell, Hyperplasia | 1 2 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Granuloma Sperm | 2 3 | Spermatocele | 3 | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + I + M + M + + + + +| Degeneration, Cystic | 3 4 3 3 2 1 3 4 4 4 4 3 4 4 3 4 4 3 3 3| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 3 | __________________________________________________________________________| Lymph Node | + + | Mediastinal, Hyperplasia, Lymphoid | 3 | Mediastinal, Necrosis | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | | Hemorrhage | 2 3 1 1 2 3 | Hyperplasia, Lymphoid | 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | 1 | Depletion Cellular | 2 | _____________________________________________________________________________________________________________________| Page 51 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 4| 7| 7| 1| 7| 7| 4| 3| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 2| 2| 3| 2| 8| 3| 2| 6| 3| 3| 8| 8| 2| 2| 4| 3| 0| 3| 2| 2| 2| 3| 2| | 1| 1| 9| 9| 1| 9| 8| 1| 9| 9| 1| 1| 0| 6| 9| 9| 3| 1| 5| 1| 9| 9| 9| 1| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 60 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 5000 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Fibrosis, Focal | | Hematopoietic Cell Proliferation | 2 3 2 2 3 2 3| Hyperplasia, Lymphoid | 3 2 2 | __________________________________________________________________________| Thymus | I + + + + + I + + + + + + + + + + + + + + + + + I| Atrophy | 3 | Cyst | 2 2 1 | Necrosis | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 3 2 3 | Infiltration Cellular, Mast Cell | 3 | Inflammation, Chronic, Focal | 1 | Subcutaneous Tissue, Foreign Body | X | Subcutaneous Tissue, Inflammation, | | Focal, Suppurative | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 1 2 1 2 2 2 2 2 2 1 1 2 1 2 2 1| __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | Hyperplasia, Histiocytic | | Alveolar Epithelium, Hyperplasia | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | __________________________________________________________________________| Harderian Gland | + + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Infarct | 2 2 2 | Nephropathy | 2 2 2 2 1 2 2 2 2 2 2 2 1 1 2 1 2 3 2 2 2 2 2 1| Renal Tubule, Dilatation | 2 | Renal Tubule, Necrosis | | _____________________________________________________________________________________________________________________| Page 52 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 4| 7| 7| 1| 7| 7| 4| 3| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 2| 2| 3| 2| 8| 3| 2| 6| 3| 3| 8| 8| 2| 2| 4| 3| 0| 3| 2| 2| 2| 3| 2| | 1| 1| 9| 9| 1| 9| 8| 1| 9| 9| 1| 1| 0| 6| 9| 9| 3| 1| 5| 1| 9| 9| 9| 1| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 60 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 5000 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | __________________________________________________________________________| Urethra | + + | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 53 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 2| 7| 5| 7| 7| 7| 3| | DAY ON TEST | 2| 2| 3| 6| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 5| 6| 1| 3| 8| 1| 3| 3| 4| | | 9| 6| 1| 2| 1| 0| 0| 0| 1| 0| 6| 0| 0| 0| 0| 1| 2| 5| 5| 1| 1| 7| 1| 1| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 60 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | 5000 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Necrosis | 3| 1 3.0| Muscularis, Inflammation, Chronic | 3| 1 3.0| __________________________________________________________________________|____________| Gallbladder | + M + + + + M + + + + + + + + + + A + + M + + + +| 45 | __________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + A + + + + + + +| 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + A + + + +| 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | + A + + + + + + + + + + + + + + + A + + A + + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + A + + + + + + + + + + + + + + + + + + A + + + +| 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | + A + + + + + + + + + + + + + + + A + + A + + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Ileum | + A + + + + + + + + + + + + + + + A + + A + + + +| 46 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Clear Cell Focus | | 2 2.5| Eosinophilic Focus | 2 | 3 2.3| Inflammation, Chronic | 2 1 2 2 3 3 1 3 3 3 3 3 1 2 3 3 2 3 3 2 2 2| 38 2.5| Mixed Cell Focus | 2 2 | 6 2.5| Necrosis, Focal | | 3 2.0| Vacuolization Cytoplasmic | 2 | 2 2.0| Bile Duct, Cyst | 3 3 | 2 3.0| Bile Duct, Hyperplasia | 2 2 1 3 2 3 2 3 2 2 3 2 2 2 3 2 2 2 2| 33 2.2| Hepatocyte, Karyomegaly | 2 2 2 2 3 3 3 3 3 2 3 3 3 3 3 3 2 3 3| 31 2.7| __________________________________________________________________________|____________| Mesentery | + | 1 | Fat, Necrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy, Focal | 2 | 2 2.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Diverticulum | X | 1 | Edema | 2 | 1 2.0| Epithelium, Hyperplasia | 2 2 2 2 | 5 1.8| __________________________________________________________________________|____________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | 2 | 1 2.0| Hyperplasia, Adenomatous | | 1 2.0| Inflammation, Chronic | | 1 2.0| Mineralization | 1 1 | 3 1.0| Glands, Degeneration, Cystic, Focal | 2 | 4 1.8| __________________________________________________________________________|____________| Tooth | | 2 | Developmental Malformation | | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 54 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 2| 7| 5| 7| 7| 7| 3| | DAY ON TEST | 2| 2| 3| 6| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 5| 6| 1| 3| 8| 1| 3| 3| 4| | | 9| 6| 1| 2| 1| 0| 0| 0| 1| 0| 6| 0| 0| 0| 0| 1| 2| 5| 5| 1| 1| 7| 1| 1| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 60 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | 5000 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cytoplasmic Alteration, Focal | 2 2 2 2 | 6 1.8| Hyperplasia, Focal | 2 2 | 7 1.7| Hypertrophy, Focal | 2 2 2 | 9 1.8| Capsule, Hyperplasia, Focal | 3 2 | 3 2.3| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 48 | Cyst | 2 | 1 2.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + I + + + + + + + + + + + + + +| 48 | Pars Distalis, Cyst | 1 | 3 1.7| Pars Distalis, Hyperplasia, Focal | 1 | 1 1.0| __________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Cystic, Focal | 2 2 1 2 2 2 2 2 3| 14 1.9| Inflammation, Chronic, Focal | 3| 1 3.0| Follicle, Cyst | 3 2 1 2 1 | 6 1.8| Follicular Cell, Hyperplasia | 2 2 1 1 | 7 1.4| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Granuloma Sperm | | 2 2.5| Spermatocele | | 1 3.0| __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Degeneration, Cystic | 4 4 3 4 1 4 1 4 1 3 4 3 4 3 4 2 4 4 4 3 3 3| 42 3.2| __________________________________________________________________________|____________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 3.0| __________________________________________________________________________|____________| Lymph Node | + + +| 5 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 55 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 2| 7| 5| 7| 7| 7| 3| | DAY ON TEST | 2| 2| 3| 6| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 5| 6| 1| 3| 8| 1| 3| 3| 4| | | 9| 6| 1| 2| 1| 0| 0| 0| 1| 0| 6| 0| 0| 0| 0| 1| 2| 5| 5| 1| 1| 7| 1| 1| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 60 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | 5000 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Mediastinal, Hyperplasia, Lymphoid | | 1 3.0| Mediastinal, Necrosis | 3| 1 3.0| __________________________________________________________________________|____________| Lymph Node, Mandibular | + M + M + + + + + + + + + + + + M + + + M + + + M| 44 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 2 | 1 2.0| Hemorrhage | 3 2 3 2 3 2| 12 2.3| Hyperplasia, Lymphoid | | 1 3.0| __________________________________________________________________________|____________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Angiectasis | | 1 1.0| Depletion Cellular | 2| 2 2.0| Fibrosis, Focal | 2| 1 2.0| Hematopoietic Cell Proliferation | 2 2 3 2 3 | 12 2.4| Hyperplasia, Lymphoid | | 3 2.3| __________________________________________________________________________|____________| Thymus | + + + + + + + M + + + + + + + + + + + + + + + + +| 46 | Atrophy | 3| 2 3.0| Cyst | 2 2 2 2 2 | 8 1.9| Necrosis | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | 2 2 2 2 | 7 2.3| Infiltration Cellular, Mast Cell | | 1 3.0| Inflammation, Chronic, Focal | | 1 1.0| Subcutaneous Tissue, Foreign Body | | 1 | Subcutaneous Tissue, Inflammation, | | | Focal, Suppurative | | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperostosis | 2 1 2 2 1 2 2 1 2 2 2 2 2 2 2 1 1 2 2 2 | 36 1.7| __________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 56 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 2| 7| 5| 7| 7| 7| 3| | DAY ON TEST | 2| 2| 3| 6| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 5| 6| 1| 3| 8| 1| 3| 3| 4| | | 9| 6| 1| 2| 1| 0| 0| 0| 1| 0| 6| 0| 0| 0| 0| 1| 2| 5| 5| 1| 1| 7| 1| 1| 0| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A | 60 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L | 5000 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | Hyperplasia, Histiocytic | 2 | 1 2.0| Alveolar Epithelium, Hyperplasia | 2 | 1 2.0| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 1 | __________________________________________________________________________|____________| Harderian Gland | + + | 4 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Infarct | 1 | 4 1.8| Nephropathy | 2 1 2 1 2 3 2 2 1 2 1 2 1 2 2 2 1 2 1 2 3 1 1| 47 1.8| Renal Tubule, Dilatation | | 1 2.0| Renal Tubule, Necrosis | 2 | 1 2.0| __________________________________________________________________________|____________| Urethra | | 2 | __________________________________________________________________________|____________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 57 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| DAY ON TEST | 2| 3| 3| 6| 3| 1| 0| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| | 6| 1| 0| 5| 1| 7| 7| 0| 1| 0| 0| 0| 0| 0| 8| 1| 0| 0| 1| 0| 0| 5| 0| 1| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 120MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5000 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + A + + + + + + + A + + + + + + + + + +| Inflammation, Chronic | 3| __________________________________________________________________________| Intestine Large, Colon | + + + + + + A + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + A + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + A + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + A + + + + + + + A + + + + + + + + + +| Hyperplasia, Adenomatous | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + A + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Clear Cell Focus | 3 | Degeneration, Cystic | 3 | Eosinophilic Focus | 3 2 | Hemorrhage | | Inflammation, Chronic | 2 3 3 3 3 2 3 2 2 2 4 3 2 2 1 1 2 3 2 1| Mixed Cell Focus | 2 3 | Necrosis, Focal | 2 | Vacuolization Cytoplasmic | 2 1 | Bile Duct, Hyperplasia | 3 3 3 3 2 2 2 1 4 2 2 3 2 3 | Hepatocyte, Karyomegaly | 2 3 3 3 2 2 2 2 2 2 3 3 2 3 2 3 | __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Oral Mucosa | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Acinus, Atrophy, Diffuse | 3 | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + + + + + + +| Cyst | | Epithelium, Hyperplasia | 1 2 1 | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + A + + + + + + + + + +| Erosion | 2 | Mineralization | 1 | Necrosis | 3 | Glands, Degeneration, Cystic, Focal | 1 | __________________________________________________________________________| Tooth | + | Developmental Malformation | 3 | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Blood Vessel | + + + + + M + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Inflammation, Chronic, Focal | | Mineralization | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 58 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| DAY ON TEST | 2| 3| 3| 6| 3| 1| 0| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| | 6| 1| 0| 5| 1| 7| 7| 0| 1| 0| 0| 0| 0| 0| 8| 1| 0| 0| 1| 0| 0| 5| 0| 1| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 120MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5000 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Cytoplasmic Alteration, Focal | 2 2 2 2 2 4 2 1 1 | Hyperplasia, Focal | 1 | Hypertrophy, Focal | 1 2 1 2 1 2 2 2 1 | Capsule, Hyperplasia, Focal | 2 | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | __________________________________________________________________________| Pituitary Gland | + + + + + + M + + + + M + + M + + + I + + + + + I| Pars Distalis, Cyst | 2 | Pars Distalis, Hyperplasia, Focal | 2 | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic, Focal | 2 2 1 2 1 2 2 | C-Cell, Hyperplasia | 2 | Follicle, Cyst | 2 2 1 1 | Follicular Cell, Hyperplasia | 1 1 1 1 | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Degeneration, Cystic | 2 4 2 3 4 4 4 3 4 2 4 3 4 2 2 3 4 2 4 3 3 4 4 4 4| __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Angiectasis | | Inflammation, Chronic | 3 | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperplasia | 2 | __________________________________________________________________________| Lymph Node | + | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + M + + + + I + + + + + + M + + +| Hyperplasia, Lymphoid | 2 2 | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Ectasia | 2 | Hemorrhage | 1 2 1 2 2 2 3 | Hyperplasia, Lymphoid | 2 3 | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Congestion | 2 2 | _____________________________________________________________________________________________________________________| Page 59 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| DAY ON TEST | 2| 3| 3| 6| 3| 1| 0| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| | 6| 1| 0| 5| 1| 7| 7| 0| 1| 0| 0| 0| 0| 0| 8| 1| 0| 0| 1| 0| 0| 5| 0| 1| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 120MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5000 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Hematopoietic Cell Proliferation | 2 3 3 3 2 2 3 3| __________________________________________________________________________| Thymus | + + + + + + I + + + + + + + M M + + + I + + I + +| Atrophy | 3 | Cyst | 1 2 2 | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Edema | 2 2 | Inflammation, Chronic, Focal | 2 | Subcutaneous Tissue, Edema | 3 | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Hyperostosis | 2 2 3 1 2 2 2 1 2 1 1 2 2 2 2 1 1| __________________________________________________________________________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + A + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | | Hyperplasia, Histiocytic | 3 2 | Thrombosis | 2 | Alveolar Epithelium, Hyperplasia | 4 | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemorrhage | 2 | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | Cataract | 3 | Cornea, Inflammation, Chronic | 2 3 | __________________________________________________________________________| Harderian Gland | + + + + | __________________________________________________________________________| Lacrimal Gland | + | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Cyst | | Nephropathy | 3 2 2 2 2 2 1 2 2 1 1 1 1 1 2 1 2 3 2 1 1 1 2| Renal Tubule, Hyperplasia, Focal | 1 | __________________________________________________________________________| Urethra | + A + + | _____________________________________________________________________________________________________________________| Page 60 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 _____________________________________________________________________________________________________________________ | 7| 7| 7| 5| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| DAY ON TEST | 2| 3| 3| 6| 3| 1| 0| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| | 6| 1| 0| 5| 1| 7| 7| 0| 1| 0| 0| 0| 0| 0| 8| 1| 0| 0| 1| 0| 0| 5| 0| 1| 6| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 120MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 5000 U | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Inflammation, Chronic | 2 | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + A + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 61 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 6| 7| 5| 5| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| | DAY ON TEST | 2| 3| 8| 6| 1| 3| 3| 3| 3| 3| 3| 6| 3| 0| 3| 3| 3| 3| 3| 3| 3| 9| 5| 3| 3| | | 5| 1| 6| 2| 3| 1| 0| 0| 0| 0| 1| 6| 1| 0| 1| 2| 1| 0| 1| 0| 1| 7| 7| 1| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 120MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | 5000 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Gallbladder | + + + + M + + + + + + I + M + M M + + + + M + + +| 42 | Inflammation, Chronic | | 1 3.0| __________________________________________________________________________|____________| Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + A + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + A + + +| 46 | __________________________________________________________________________|____________| Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + A + + +| 46 | __________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + A + + +| 46 | Hyperplasia, Adenomatous | 3 | 1 3.0| __________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + A + + +| 47 | __________________________________________________________________________|____________| Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + + + A + + +| 46 | __________________________________________________________________________|____________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Clear Cell Focus | 2 | 2 2.5| Degeneration, Cystic | | 1 3.0| Eosinophilic Focus | 2 | 3 2.3| Hemorrhage | 4 | 1 4.0| Inflammation, Chronic | 3 3 1 2 3 3 3 2 2 2 2 3 3 2 3 2 2 2 2 3 3| 41 2.4| Mixed Cell Focus | 2 2 | 4 2.3| Necrosis, Focal | 2 2 1 2 4 1 1 | 8 1.9| Vacuolization Cytoplasmic | 2 2 2 2 | 6 1.8| Bile Duct, Hyperplasia | 3 3 2 3 3 2 2 3 2 2 2 2 3 2 2| 29 2.4| Hepatocyte, Karyomegaly | 2 3 3 3 3 3 3 2 2 3 3 3 3 3 2 3| 32 2.6| __________________________________________________________________________|____________| Mesentery | | 1 | __________________________________________________________________________|____________| Oral Mucosa | | 1 | __________________________________________________________________________|____________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Acinus, Atrophy, Diffuse | | 1 3.0| __________________________________________________________________________|____________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + A + + +| 47 | Cyst | 2 | 1 2.0| Epithelium, Hyperplasia | | 3 1.3| __________________________________________________________________________|____________| Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + A + + +| 47 | Erosion | | 1 2.0| Mineralization | 1 | 2 1.0| Necrosis | | 1 3.0| Glands, Degeneration, Cystic, Focal | | 1 1.0| __________________________________________________________________________|____________| Tooth | | 1 | Developmental Malformation | | 1 3.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 62 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 6| 7| 5| 5| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| | DAY ON TEST | 2| 3| 8| 6| 1| 3| 3| 3| 3| 3| 3| 6| 3| 0| 3| 3| 3| 3| 3| 3| 3| 9| 5| 3| 3| | | 5| 1| 6| 2| 3| 1| 0| 0| 0| 0| 1| 6| 1| 0| 1| 2| 1| 0| 1| 0| 1| 7| 7| 1| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 120MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | 5000 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Inflammation, Chronic, Focal | 2 | 1 2.0| Mineralization | 1 1 | 2 1.0| _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cytoplasmic Alteration, Focal | 2 2 3 3 1 2 2 2 2 | 18 2.1| Hyperplasia, Focal | 2 2 | 3 1.7| Hypertrophy, Focal | 2 2| 11 1.6| Capsule, Hyperplasia, Focal | 2 | 2 2.0| __________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Parathyroid Gland | M + + + + + + + M + M + M + + + + + + + + + + + +| 46 | Cyst | 2 | 1 2.0| __________________________________________________________________________|____________| Pituitary Gland | + + + + I + + + + + + + + + + M + + + + + + + + +| 43 | Pars Distalis, Cyst | 2 | 2 2.0| Pars Distalis, Hyperplasia, Focal | | 1 2.0| __________________________________________________________________________|____________| Thyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 | Degeneration, Cystic, Focal | 1 1 1 | 10 1.5| C-Cell, Hyperplasia | | 1 2.0| Follicle, Cyst | 2 3 | 6 1.8| Follicular Cell, Hyperplasia | 1 1 2 1 1 1 | 10 1.1| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________|____________| Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Degeneration, Cystic | 4 3 4 1 3 1 3 4 4 4 2 3 1 4 1 4 4 4 4 4 4 3 2| 48 3.2| __________________________________________________________________________|____________| Prostate | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Seminal Vesicle | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 | Angiectasis | 2 | 1 2.0| Inflammation, Chronic | | 1 3.0| __________________________________________________________________________|____________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 63 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 6| 7| 5| 5| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| | DAY ON TEST | 2| 3| 8| 6| 1| 3| 3| 3| 3| 3| 3| 6| 3| 0| 3| 3| 3| 3| 3| 3| 3| 9| 5| 3| 3| | | 5| 1| 6| 2| 3| 1| 0| 0| 0| 0| 1| 6| 1| 0| 1| 2| 1| 0| 1| 0| 1| 7| 7| 1| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 120MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | 5000 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hyperplasia | | 1 2.0| __________________________________________________________________________|____________| Lymph Node | + | 2 | __________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 | Hyperplasia, Lymphoid | | 2 2.0| __________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Ectasia | 2 | 2 2.0| Hemorrhage | 3 2 2 1 2 1 | 13 1.8| Hyperplasia, Lymphoid | 2 | 3 2.3| __________________________________________________________________________|____________| Spleen | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 | Congestion | | 2 2.0| Hematopoietic Cell Proliferation | 3 3 3 3 2 3 | 14 2.7| __________________________________________________________________________|____________| Thymus | M + + + A + + + + + + + + + + M + + + + + + + + +| 42 | Atrophy | 3 3 | 3 3.0| Cyst | 2 1 2 2| 7 1.7| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| | __________________________________________________________________________|____________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Edema | 2 | 3 2.0| Inflammation, Chronic, Focal | 2 | 2 2.0| Subcutaneous Tissue, Edema | | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hyperostosis | 1 2 2 1 1 2 2 1 2 2 2 2 2 1 | 31 1.7| __________________________________________________________________________|____________| Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 | __________________________________________________________________________|____________| Spinal Cord | + + | 2 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | 1 | 1 1.0| Hyperplasia, Histiocytic | | 2 2.5| Thrombosis | | 1 2.0| Alveolar Epithelium, Hyperplasia | 2 2| 3 2.7| __________________________________________________________________________|____________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Hemorrhage | | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 64 NTP Experiment-Test: 89006-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC AZT/INTERFERON A/INTERFERON AD Date: 08/14/96 Route: GAVAGE Time: 09:06:20 __________________________________________________________________________________________________________________________________ | 6| 7| 5| 5| 4| 7| 7| 7| 7| 7| 7| 4| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 5| 7| 7| | DAY ON TEST | 2| 3| 8| 6| 1| 3| 3| 3| 3| 3| 3| 6| 3| 0| 3| 3| 3| 3| 3| 3| 3| 9| 5| 3| 3| | | 5| 1| 6| 2| 3| 1| 0| 0| 0| 0| 1| 6| 1| 0| 1| 2| 1| 0| 1| 0| 1| 7| 7| 1| 1| T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O | B6C3F1 MICE MALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A | 120MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L | 5000 U | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | Cataract | | 1 3.0| Cornea, Inflammation, Chronic | | 2 2.5| __________________________________________________________________________|____________| Harderian Gland | | 4 | __________________________________________________________________________|____________| Lacrimal Gland | | 1 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 | Cyst | 2 2 | 2 2.0| Nephropathy | 1 2 2 2 2 2 2 2 1 2 2 2 1 2 1 1 1 1 1 1 2| 44 1.6| Renal Tubule, Hyperplasia, Focal | 1 | 2 1.0| __________________________________________________________________________|____________| Urethra | + + + | 6 | Inflammation, Chronic | | 1 2.0| __________________________________________________________________________|____________| Urinary Bladder | M + + + A + + + + + + + + + + + + + + + + + + + +| 47 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 65 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------
Web page last updated on November 11, 2004
The National Institute of Environmental Health Sciences is one of the National Institutes of Health within the U.S. Department of Health and Human Services. The National Toxicology Program is headquartered on the NIEHS campus in Research Triangle Park, NC.