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Treatment Options for Childhood Acute Lymphoblastic
Leukemia
Untreated Childhood Acute Lymphoblastic Leukemia
Childhood Acute Lymphoblastic Leukemia Subgroups
Recurrent Childhood Acute Lymphoblastic
Leukemia
A link to a list of current clinical trials is included for each treatment section. For some types or stages of cancer, there may not be any trials listed. Check with your doctor for clinical trials that are not listed here but may be right for you.
Untreated Childhood Acute Lymphoblastic Leukemia
Standard treatment of childhood acute lymphoblastic leukemia (ALL) during the induction, consolidation /intensification, and maintenance phases may include the following:
Some of the treatments being studied in clinical trials for childhood ALL include the following:
Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with untreated childhood acute lymphoblastic leukemia. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.
Childhood Acute Lymphoblastic Leukemia Subgroups
Standard treatment of T-cell childhood acute lymphoblastic leukemia (ALL) is usually combination chemotherapy. CNS sanctuary therapy with intrathecal chemotherapy and/or radiation therapy to the brain may also be given. One of the treatments being studied in clinical trials for T-cell childhood ALL is a new kind of anticancer drug.
Treatment of infants with ALL is usually a clinical trial of systemic chemotherapy with intrathecal chemotherapy or chemotherapy followed by a donor stem cell transplant.
Treatment of ALL in older children and adolescents usually involves more aggressive therapy (stronger treatments and higher doses) than that given to children aged 1-9 years.
Standard treatment of Philadelphia chromosome -positive childhood ALL is usually a stem cell transplant using stem cells donated by a brother or sister. One of the treatments being studied in clinical trials for Philadelphia chromosome-positive childhood ALL is imatinib mesylate (Gleevec).
Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with T-cell childhood acute lymphoblastic leukemia and Philadelphia chromosome positive childhood precursor acute lymphoblastic leukemia. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.
Recurrent Childhood Acute Lymphoblastic
Leukemia
Standard treatment of recurrent childhood acute lymphoblastic leukemia (ALL) may include the following:
Some of the treatments being studied in clinical trials for recurrent childhood ALL include the following:
- A clinical trial of chemotherapy with stem cell transplant, using stem cells from a donor who is not related to the patient, with or without total-body irradiation.
- A clinical trial of new anticancer drugs and new combination chemotherapy treatments.
Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with recurrent childhood acute lymphoblastic leukemia. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.
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