The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

Cellular Classification

Added text to state that having a molecular biology similar to Burkitt lymphoma occurs in as many as one-third of patients younger than 14 years with mature B-cell lymphoma (cited Klapper et al. as reference 12).

Added Miles et al. as reference 13 and level of evidence 3iiiDi.

Added text to state that peripheral T-cell lymphoma is very rare in children and that the United Kingdom Children's Cancer Study Group observed that the use of ALL-like therapy, instead of NHL therapy, produced a superior outcome (cited Windsor et al. as reference 45 and level of evidences 3iA, and Hutchison et al. as reference 46 and level of evidence 3iiiA).

Treatment Option Overview

Added text to state that the use of radiation therapy in children with NHL is limited (cited Link et al., Burkhardt et al, Seidemann et al., Cairo et al., and Bluhm et al., as references 9, 10, 11, 12, and 13, respectively).

Localized Non-Hodgkin Lymphoma in Children and Adolescents

Added Gerrard et al. as reference 6 and level of evidence 2A.

Recurrent Childhood Non-Hodgkin Lymphoma

Added text about a study using rituximab, ifosfamide, carboplatin, and etoposide to treat relapsed/refractory B-cell NHL that showed a complete remission/partial remission rate of 60% (cited Griffin et al. as reference 7 and level of evidence: 3iiA).

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