Biomarker Distinguishes Between Cell Death and DNA Damage

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News Note: Biomarker Can Distinguish Between Cell Death and DNA Damage

National Cancer Institute (NCI) researchers have identified a molecular ring pattern that could be used as a biomarker to identify and distinguish between cells that are programmed for death from cells that have a particular type of DNA damage. Such biomarkers could provide new tools for basic cellular biology research, but also help to mark cell death in clinical samples and monitor the efficacy of anticancer regimens.

The research was done at NCI's Center for Cancer Research's laboratory of molecular pharmacology, headed up by Yves Pommier, M.D., Ph.D, and Stéphanie Solier, Ph.D. The findings appeared online in Cell Cycle in May 2009 at http://www.landesbioscience.com/journals/cc/article/8865 and will appear in the June 15, 2009 print edition (Volume 8, Issue 12).