FYI from the NHLBI Index

January 2004: Vol. 4, Issue 3
Research and Resources

Animal Models of Organ-specific Tolerance for Heart and Lung Transplantation
Biological Basis of Hutchinson-Gilford Syndrome: Relationship to Mutations in the Lamin A/C Gene and to Other Known Laminopathies
Chemical Screens for New Inducers of Fetal Hemoglobin (SBIR/STTR)
Chronic Illness Self-Management in Children
Exploratory and Developmental Research Grants for Investigations in Rare Diseases (R21)
Innovative Exploratory Studies and Technology Development in Neuroinformatics Research (R21)
Inter-Relationships of Sleep, Fatigue, and HIV/AIDS
Molecular Mechanisms Underlying Diamond-Blackfan Anemia and Other Congenital Bone Marrow Failure Syndromes
NIH Support for Conferences and Scientific Meetings
Overweight and Obesity Control at Worksites
Progression of Cardiovascular Disease in Type 1 Diabetes
Sleep Disturbance in Parkinson's Disease and Parkinson-like Conditions

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Modified 1/21/04
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NHLBI Research Initiatives

From time to time, the NHLBI invites investigators to submit grant applications or contract proposals for specific research programs. We are currently soliciting applications for the programs described below. For a full details of these and other research initiatives, visit www.nhlbi.nih.gov/funding/inits/index.htm or the Web page that is linked to each initiative number.

Animal Models of Organ-specific Tolerance for Heart and Lung Transplantation

Initiative Number: PA-02-044
Applications are accepted for February 1, June 1, and October 1 deadlines each year.
Objective: To encourage development of organ-specific tolerance protocols using large animal models for heart transplantation and both large and small animal models for lung transplantation.

Biological Basis of Hutchinson-Gilford Syndrome: Relationship to Mutations in the Lamin A/C Gene and to Other Known Laminopathies

Initiative Number: PA-03-069
Applications are accepted for February 1, June 1, and October 1 deadlines each year.
Objective: To understand how mutations in the gene for lamin A/C affect nuclear structure, thus leading to both dysfunction of the nuclear envelope, and depending on the mutation, Hutchinson-Gilford syndrome.

Chemical Screens for New Inducers of Fetal Hemoglobin (SBIR/STTR)

Initiative Number: PA-03-049
Applications are accepted for April 1, August 1, and December 1 deadlines each year.
Objective: To develop drugs that increase fetal hemoglobin levels for the treatment of beta-chain hemoglobinopathies such as sickle cell disease and Cooley's anemia (beta-thalassemia).

Chronic Illness Self-Management in Children

Initiative Number: PA-03-159
Applications are accepted for February 1, June 1, and October 1 deadlines each year.
Objective: To support research related to sociocultural, environmental, and behavioral mechanisms as well as biological/technological factors that improve self-management and quality of life in children and adolescents with chronic diseases.

Exploratory and Developmental Research Grants for Investigations in Rare Diseases (R21)

Initiative Number: PA-03-171
Applications are accepted for February 1, June 1, and October 1 deadlines each year.
Objective: To encourage new approaches to understanding, treating, and preventing rare diseases in the areas of heart, lung, and blood disease, as well as sleep disorders.

Innovative Exploratory Studies and Technology Development in Neuroinformatics Research (R21)

Initiative Number: PAR-03-036
Applications are accepted for January 21, 2004; May 21, 2004; September 22, 2004; January 21, 2005; May 20, 2005; and September 22, 2005 deadlines.
Objective: To encourage exploratory research pilot studies having the potential for significant advances in neuroscience research through the creation of neuroscience databases, knowledge management systems, and analytic tools to integrate vast, complex data and information about the nervous system.

Inter-Relationships of Sleep, Fatigue, and HIV/AIDS

Initiative Number: RFA-HL-04-010
Applications due: March 15, 2004
Objective: To elucidate the etiology of sleep disturbances and fatigue associated with human immunodeficiency virus (HIV) infection and acquired immunodeficiency disease syndrome (AIDS).

Molecular Mechanisms Underlying Diamond-Blackfan Anemia and Other Congenital Bone Marrow Failure Syndromes

Initiative Number: RFA-HL-04-008
Applications due: March 17, 2004.
Objective: To encourage research into the genetics and basic mechanisms of inherited bone marrow failure syndromes such as, Diamond-Blackfan Aniema, dyskeratosis congenita, Pearson syndrome, severe congenital neutropenia (Kostmann syndrome), Shwachman-Diamond syndrome, and congenital amegakaryocytic thrombocytopenia.

NIH Support for Conferences and Scientific Meetings

Initiative Number: PAR-03-176
Applications are accepted for April 15, August 15, and December 15 deadlines each year.
Objective: To encourage the exchange and dissemination of information related to research on heart, lung, blood or sleep disorders or blood resources.

Overweight and Obesity Control at Worksites

Initiative Number: RFA-HL-04-006
Applications are due March 12, 2004.
Objective: To support worksite interventions that include environmental strategies (programs, policies or organizational practices to influence health behaviors) for the prevention or treatment of obesity in adults.

Progression of Cardiovascular Disease in Type 1 Diabetes

Initiative Number: RFA-HL-04-013
Applications are due March 24, 2004.
Objectives: To support basic and clinical studies on the effects of type 1 diabetes and its metabolic complications on the early development and fast progression of cardiovascular disease.

Sleep Disturbance in Parkinson's Disease and Parkinson-like Conditions

Initiative Number: PAS-03-131
Applications are accepted for February 1, June 1, and October 1 deadlines each year.
Objectives: To stimulate research on sleep disorders in Parkinson’s disease and Parkinson’s related neurological conditions, and on associated sleep disorders such as Restless Legs Syndrome and sleep-disordered breathing.