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lutetium Lu 177-capromab A radioimmunoconjugate consisting of capromab linked to lutetium Lu 177 via the bifunctional macrocyclic chelator methoxy-tetraazacyclododecane-tetraacetic acid (MeO-DOTA) with potential antineoplastic activity. Lutetium Lu 177-capromab binds to human prostate specific membrane antigen (PSMA) expressed on tumor cell surfaces via its capromab moiety and, upon internalization, delivers cytotoxic beta radiation directly to PSMA-expressing tumor cells. PSMA is a cell surface glycoprotein abundantly expressed by prostate epithelium and is typically overexpressed by prostate cancer cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20090509211700im_/http://www.cancer.gov/images/spacer.gif) | 177Lu-meO-DOTA-7E11 | | ![](https://webarchive.library.unt.edu/eot2008/20090509211700im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20090509211700im_/http://www.cancer.gov/images/spacer.gif) | CYT-500 | | ![](https://webarchive.library.unt.edu/eot2008/20090509211700im_/http://www.cancer.gov/images/spacer.gif) |
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