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thymidine kinase-deleted vaccinia-hGM-CSF JX-594
A thymidine kinase-deleted vaccinia virus expressing human GM-CSF (hGM-CSF) with oncolytic activity. Upon intratumoral or intravenous administration, thymidine kinase-deleted vaccinia-hGM-CSF JX-594 may selectively infect and lyse tumor cells. While vaccinia displays a natural tumor cell tropism, deletion of the thymidine kinase gene increases the tumor selectivity of vaccinia by limiting viral replication to transformed cells. hGM-CSF expression by this agent may help recruit antigen processing cells (APCs), such as denritic cells and macrophages, to virally infected tumor cells, initiating a systemic antitumoral immune response.
Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Code name: | | JX-594 | | |
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