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PEP-3-KLH conjugate vaccine A cancer vaccine consisting of PEP-3, a synthetic peptide encompassing a tumor-specific mutated segment of the epidermal growth factor receptor type vIII (EGFRvIII), conjugated to the naturally-occuring immunoadjuvant keyhole limpet hemocyanin (KLH) with potential immunostimulating and antineoplastic activities. Upon administration, PEP-3-KLH conjugate vaccine may induce a cytotoxic immune response against tumor cells that overexpress EGFRvIII; this antitumoral immune response may involve antibody-dependent cellular cytotoxicity (ADCC).
Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20090509192230im_/http://www.cancer.gov/images/spacer.gif) | PEPvIII-KLH conjugate vaccine | | ![](https://webarchive.library.unt.edu/eot2008/20090509192230im_/http://www.cancer.gov/images/spacer.gif) | Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20090509192230im_/http://www.cancer.gov/images/spacer.gif) | PEP-3-KLH | | ![](https://webarchive.library.unt.edu/eot2008/20090509192230im_/http://www.cancer.gov/images/spacer.gif) |
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