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pirfenidone An orally active synthetic antifibrotic agent structurally similar to pyridine 2,4-dicarboxylate. Pirfenidone inhibits fibroblast, epidermal, platelet-derived, and transforming beta-1 growth factors, thereby slowing tumor cell proliferation. This agent also inhibits DNA synthesis and the production of mRNA for collagen types I and III, resulting in a reduction in radiation-induced fibrosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20090509194529im_/http://www.cancer.gov/images/spacer.gif) | Deskar | | ![](https://webarchive.library.unt.edu/eot2008/20090509194529im_/http://www.cancer.gov/images/spacer.gif) |
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