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vandetanib
An orally bioavailable 4-anilinoquinazoline. Vandetanib
selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGF2), thereby blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability. This agent also blocks the tyrosine kinase activity of epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that mediates tumor cell proliferation and migration and angiogenesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| US brand name: | | Zactima | | | | Code names: | | AZD6474
ZD6474 | | |
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