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padeliporfin A vascular-acting photosensitizer consisting of a water-soluble, palladium-substituted bacteriochlorophyll derivative with potential antineoplastic activity. Upon administration, paldeliporfin is activated locally when the tumor bed is exposed to low-power laser light; reactive oxygen species (ROS) are formed upon activation and ROS-mediated necrosis may occur at the site of interaction between the photosensitizer, light and oxygen. Vascular-targeted photodynamic therapy (VTP) with padeliporfin may allow tumor-site specific cytotoxicity while sparing adjacent normal tissues. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20090509175809im_/http://www.cancer.gov/images/spacer.gif) | palladium-bacteriochlorophyll derivative WST11 | | ![](https://webarchive.library.unt.edu/eot2008/20090509175809im_/http://www.cancer.gov/images/spacer.gif) | US brand name: | ![](https://webarchive.library.unt.edu/eot2008/20090509175809im_/http://www.cancer.gov/images/spacer.gif) | Stakel | | ![](https://webarchive.library.unt.edu/eot2008/20090509175809im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20090509175809im_/http://www.cancer.gov/images/spacer.gif) | WST11 | | ![](https://webarchive.library.unt.edu/eot2008/20090509175809im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure name: | ![](https://webarchive.library.unt.edu/eot2008/20090509175809im_/http://www.cancer.gov/images/spacer.gif) | (SP-4-2)-[(7S,8S,17R,18R)-13-acetyl-18-ethyl-5-(2-methoxy-2-oxoethyl)-2,8,12,17-tetramethyl-3-[[(2-sulfoethyl)amino]carbonyl]-21H,23H-porphine-7-propanoato(4-)-kN21,kN22,kN23,kN24]palladate(2-) | | ![](https://webarchive.library.unt.edu/eot2008/20090509175809im_/http://www.cancer.gov/images/spacer.gif) |
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