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fotemustine A chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Foreign brand name: | ![](https://webarchive.library.unt.edu/eot2008/20090509171807im_/http://www.cancer.gov/images/spacer.gif) | Muphoran | | ![](https://webarchive.library.unt.edu/eot2008/20090509171807im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/eot2008/20090509171807im_/http://www.cancer.gov/images/spacer.gif) | S 10036 | | ![](https://webarchive.library.unt.edu/eot2008/20090509171807im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure names: | ![](https://webarchive.library.unt.edu/eot2008/20090509171807im_/http://www.cancer.gov/images/spacer.gif) | - [1-[[[(2-chloroethyl)nitrosamino]-carbonyl]amino]ethyl]phosphonic acid diethyl ester
- 1-[N-(2-chloroethyl)-N-nitrosoureido]ethylphosphonic acid diethyl ester
- diethyl[1-[3-(2-chloroethyl)-3-nitrosoureido]ethyl]phosphonate
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