![](https://webarchive.library.unt.edu/eot2008/20090509151355im_/http://www.cancer.gov/images/spacer.gif) |
|
![](https://webarchive.library.unt.edu/eot2008/20090509151355im_/http://www.cancer.gov/images/spacer.gif)
alvocidib A synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of cyclin-dependent kinases (CDKs) and by down-regulating cyclin D1 and D3 expression, resulting in G1 cell cycle arrest and apoptosis. This agent is also a competitive inhibitor of adenosine triphosphate activity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
![](https://webarchive.library.unt.edu/eot2008/20090509151355im_/http://www.cancer.gov/images/spacer.gif)
Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20090509151355im_/http://www.cancer.gov/images/spacer.gif) | flavopiridol | | ![](https://webarchive.library.unt.edu/eot2008/20090509151355im_/http://www.cancer.gov/images/spacer.gif) | Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20090509151355im_/http://www.cancer.gov/images/spacer.gif) | FLAVO | | ![](https://webarchive.library.unt.edu/eot2008/20090509151355im_/http://www.cancer.gov/images/spacer.gif) | Code names: | ![](https://webarchive.library.unt.edu/eot2008/20090509151355im_/http://www.cancer.gov/images/spacer.gif) | HMR 1275 L-868275 | | ![](https://webarchive.library.unt.edu/eot2008/20090509151355im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure name: | ![](https://webarchive.library.unt.edu/eot2008/20090509151355im_/http://www.cancer.gov/images/spacer.gif) | (-)-2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3R,4S)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride | | ![](https://webarchive.library.unt.edu/eot2008/20090509151355im_/http://www.cancer.gov/images/spacer.gif) |
![](https://webarchive.library.unt.edu/eot2008/20090509151355im_/http://www.cancer.gov/images/spacer.gif)
![](https://webarchive.library.unt.edu/eot2008/20090509151355im_/http://www.cancer.gov/images/gray_spacer.gif)
![](https://webarchive.library.unt.edu/eot2008/20090509151355im_/http://www.cancer.gov/images/spacer.gif)
|
![](https://webarchive.library.unt.edu/eot2008/20090509151355im_/http://www.cancer.gov/images/spacer.gif) |