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Links to NCI Materials
High-dose chemotherapy with bone marrow or stem cell transplantation for the treatment of advanced and early-stage breast cancer has been tested in several large, randomized clinical trials sponsored by the NCI, as well as in trials done in other countries. In all of the NCI-sponsored randomized trials, and in most of the international ones, high-dose chemotherapy with transplantation has not proven superior to treatment with more standard doses of chemotherapy. Therefore, at this time, high-dose chemotherapy is not recommended for the treatment of breast cancer outside of clinical trials.
High-Dose Chemotherapy with Stem Cell Transplantation: Still No Clear Benefit
(Posted: 07/14/2003, Reviewed: 04/12/2005) - Two studies published in the July 3, 2003, New England Journal of Medicine examined the benefits of high-dose chemotherapy with stem-cell transplantation for women at high risk of a breast cancer relapse. In both studies, a subgroup of women who underwent the experimental procedure experienced a significant delay in recurrence compared to women who received standard therapy, but they did not ultimately live any longer.
High-Dose Chemotherapy for Breast Cancer: Clinical Trials Overview
(Posted: 04/27/2001, Reviewed: 04/12/2005) - In the mid- to late-1990s, multiple clinical trials were begun around the world to compare the effectiveness of high-dose chemotherapy and blood cell transplant with a standard treatment for various stages of breast cancer.
High-Dose Chemotherapy for Breast Cancer: History
(Posted: 04/26/2001, Reviewed: 04/12/2005) - A background article summarizing the history and state of the science of the procedure.
Survey Shows Most Women Willing to Consider High-Dose Chemotherapy Studies
(Posted: 05/19/2000, Reviewed: 04/12/2005) - According to a spring 2000 survey, the public appears to be supportive of clinical trials examining high-dose chemotherapy with autologous bone marrow transplant as a treatment for breast cancer.
Don't Write Off High-Dose Chemotherapy with Bone Marrow Transplant for Breast Cancer, Experts Say
(Posted: 05/19/2000) - High-dose chemotherapy with bone marrow transplant may still prove to be a viable option for some breast cancer patients and needs to be tested in ongoing clinical trials, according to leading researchers at the National Cancer Institute (NCI) and elsewhere.
Breast Cancer Transplant Trials Continue to Show No Benefit
(Posted: 05/12/2000, Reviewed: 04/12/2005) - The final analysis of data from one of the major U.S. trials of high-dose chemotherapy with stem cell transplant for breast cancer shows that it holds no survival advantage over intermediate-dose therapy. The findings from the trial, known as CALGB 9082, were presented today at the annual meeting of the American Society of Clinical Oncology (ASCO) in San Francisco.
Interim Results of Large Trials of High-Dose Chemotherapy with Bone Marrow or Stem Cell Transplants for Breast Cancer
(Posted: 04/15/1999) - For the first time since the introduction of high-dose chemotherapy for breast cancer with bone marrow or stem cell transplants (HDC/BMT), patients and their physicians have data from large scientific studies comparing this treatment to standard therapies.
High-Dose Chemotherapy/ Bone Marrow Transplant Studies for Breast Cancer
(Posted: 03/10/1999) - The National Cancer Institute (NCI) is sponsoring studies of the effectiveness of high- dose chemotherapy and autologous bone marrow or stem cell transplantation in the treatment of breast cancer.
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