Project Number: 3625-32000-086-04
Project Type: Specific Cooperative Agreement

Start Date: Sep 01, 2004
End Date: Aug 31, 2009

Objective:
The objective of this cooperative research project is to obtain material from an oral bovine spongiform encephalopathy (BSE) pathogenesis study performed at the Veterinary Laboratories Agency (VLA)-Weybridge in the United Kingdom. These BSE materials will be used to identify PrPd tissue distribution and migration in BSE infected cattle.

Approach:
We will obtain various materials from the bovine spongiform encephalophathy (BSE) oral pathogenesis study. These materials will be used to identify PrPd tissue distribution and migration employing validated and non-validated PrPd detecting methods developed at the NADC for use with CWD and scrapie. At necropsy, approximately 80 samples were taken from the animals at various time points post infection. This study also included ante mortem sampling of body fluids like blood, cerebrospinal fluid, urine, saliva, nasal secretions, feces and milk at determined intervals.