Projects

EVALUATION OF GENETICALLY ENGINEERED CATTLE AND REFINING TECHNIQUES FOR PRODUCING THEM Appropriated (D)   Accession Number: 412303

TRIPLE ACTION CHIMERA: ERADICATION OF NASAL S. AUREUS BY CELL WALL HYDROLASES Reimbursable (R)   Accession Number: 414843

ENGINEERING BACTERIOPHAGE ENDOLYSINS: ANTIMICROBIALS FOR MASTITIS PATHOGENS THAT ARE REFRACTORY TO RESISTANCE DEVELOPMENT Reimbursable (R)   Accession Number: 412123

TRIPLE ACTION CHIMERA: ERADICATION OF NASAL S. AUREUS BY CELL WALL HYDROLASES Specific Cooperative Agreement (S)   Accession Number: 414971

Publications

LysK CHAP endopeptidase domain is required for lysis of live staphylococcal cells. - (Peer Reviewed Journal) - (29-Jan-09)

A Novel Use of a Bacteriophage Lysin, PlyC, as a Disinfectant against Streptococcus equi - (Peer Reviewed Journal) - (24-Dec-08)

Identification of Known Phage Endolysin Genes by Pcr - (Abstract) - (05-Aug-08)

SH3b Cell wall binding domains can enhance anti-staphylococcal activity of endolysin lytic domains. - (Proceedings/Symposium) - (10-Jul-08)

Engineering Antimicrobials that are Refractory to Resistance Development. - (Abstract) - (10-Jul-08)

Engineering MRSA antimicrobials that are refractory to resistance development - (Abstract) - (02-Apr-08)

Use of a bacteriophage lysin for barnyard decontamination of Streptococcus equi - (Abstract) - (20-Feb-08)

Genotyping Staphylococcus aureus allows one to identify bacteriophages harboring unknow endolysins. - (Abstract) - (10-Jan-08)

Chronic nicotine exposure regulates the mitochondrial electron transport system in multiple brain regions of rat - (Abstract) - (05-Aug-07)

Resolving the database sequence discrepancies for the Staphylococcus aureus bacteriophage phi 11 amidase. - (Peer Reviewed Journal)

Donovan D.M., Foster-Frey J., Garrett W.M., Blomberg L. Resolving the database sequence discrepancies for the Staphylococcus aureus bacteriophage phi 11 amidase. Journal of Basic Microbiology. 2008 Feb;48(1):48-52.

Assessment of the in vitro binding of JHW 007, a dopamine transport inhibitor that blocks the effects of cocaine - (Abstract) - (10-Jul-07)

A summary of staphylococcal C-terminal SH3b_5 cell wall binding domains. - (Abstract) - (10-Jun-07)

Bacteriophage and peptidoglycan degrading enzymes with antimicrobial applications. - (Review Article)

Donovan, D.M. 2007. Bacteriophage and peptidoglycan degrading enzymes with antimicrobial applications. Review Article. Recent Patents on Biotechnology. 1(2):113-122.

Designer Antimicrobials: Peptidoglycan Hydrolase Module Shuffling - (Abstract) - (30-Oct-06)

Bacteriophage Phi11 Endolysin Has Antimicrobial Activity Against the Mastitis Pathogens Staphylococcus Aureus and Coagulase Negative Staphylococcus - (Peer Reviewed Journal)

Donovan, D.M., Foster Frey, J.A. 2006. Bacteriophage phi11 endolysin has antimicrobial activity against the mastitis pathogens staphylococcus aureus and coagulase negative staphylococcus. Applied and Environmental Microbiology. 265(1):133-139.

The Cell Lysis Activity of the Streptococcus Agalactiae Bacteriophage B30 Endolysin Relies on the Chap Endopeptidase DOMAIN. - (Peer Reviewed Journal)

Donovan, D.M., Foster Frey, J.A., Dong, S., Rousseau, G., Moineau, S., Pritchard, D.G. 2006. The cell lysis activity of the streptococcus agalactiae bacteriophage b30 endolysin relies on the chap endopeptidase domain. Applied Environmental Microbiology. 72:5108-5112.

Designer Antimicrobials: Peptidoglycan Hydrolase Module Shuffling - (Abstract)

Donovan, D.M., Dong, S., Garrett, W.M., Foster Frey, J.A., Rousseau, G.M., Moineau, S., Pritchard, D.G. 2006. Designer Antimicrobials: Peptidoglycan Hydrolase Module Shuffling. American Society for Microbiology.

Engineering Disease Resistant Cattle - (Review Article)

Donovan, D.M., Kerr, D.E., Wall, R.J. 2005. Engineering disease resistant cattle. Transgenic Research. 14(5):563-567.

Follicular Expression of a Human Beta-Cell Leukemia/lymphoma-2 (Bcl-2)transgene Does Not Decrease Atresia Or Increase Ovulation Rate in Swine - (Peer Reviewed Journal)

Guthrie, H.D., Wall, R.J., Pursel, V.G., Foster Frey, J.A., Donovan, D.M., Dawson, H.D., Welch, G.R., Garrett, W.M. 2005. Follicular expression of a human B-cell leukemia/lymphoma-2 (Bcl-2)transgene does not decrease atresia or increase ovulation rate in swine. Journal Of Reproduction, Fertility And Development. 17(4):457-468.

Follicular Expression of a Human Beta-Cell Leukemia/lymphoma-2 (Bcl-2)transgene Does Not Decrease Atresia Or Increase Ovulation Rate in Swine - (Abstract)

Guthrie, H.D., Wall, R.J., Pursel, V.G., Donovan, D.M., Welch, G.R., Garrett, W.M. 2004. Follicular expression of a human beta-cell leukemia/lymphoma-2 (bcl-2)transgene does not decrease atresia or increase ovulation rate in swine [abstract]. Society for the Study of Reproduction Annual Meeting. p. 275.

Expression of a Group B Streptococcus Bacteriophage Lysin in Mammalian Cells. - (Abstract)

Donovan, D.M., Wall, R.J., Pritchard, D., Talbot, N.C. 2004. Expression of a group b streptococcus bacteriophage lysin in mammalian cells. [abstract]. American Society for Microbiology. No. M-035.

Identification and Characterization of Metallothionein-1 and 2 Gene Expression in the Context of (±)3,4-Methylenedioxymethamphetamine (Mdma)-Induced Toxicity to Brain Dopaminergic Neurons. - (Abstract)

Xie, T., Tong, L., Mccann, U., Yuan, J., Becker, K., Mechan, A., Cheadle, C., Donovan, D.M., Ricaurte, G. 2004. Identification and characterization of metallothionein-1 and 2 gene expression in the context of (±)3,4-methylenedioxymethamphetamine (mdma)-induced toxicity to brain dopaminergic neurons. Society for Neuroscience Abstracts and Proceedings. 24(32):7043-7050.

Identification and Annotation of 11,363 Clones from a Murine Dopamine Neuron-Specific Cdna Library Using Sequencing and Various Bioinformatics Approaches - (Abstract)

Li, M.D., Zhang, D., Taylor, W., Donovan, D.M., Becker, K.G. 2004. Identification and annotation of 11,363 clones from a murine dopamine neuron-specific cdna library using sequencing and various bioinformatics approaches. [abstract]. Society for Neuroscience Abstracts and Proceedings. 809.10.

Identification and Characterization of Metallothionein-1 and 2 Gene Expression in the Context of (±)3,4-Methylenedioxymethamphetamine (Mdma)-Induced Toxicity to Brain Dopaminergic Neurons - (Peer Reviewed Journal)

Xie, T., Tong, L., Mccann, U., Yuan, J., Becker, K., Mechan, A., Cheadle, C., Donovan, D.M., Ricaurte, A. 2004. Identification and characterization of metallothionein-1 and 2 gene expression in the context of (±)3,4-methylenedioxymethamphetamine (mdma)-induced toxicity to brain dopaminergic neurons. Journal of Neuroscience. 24(32):7043-7050.

Follicular Expression of a Human Beta-Cell Leukemia/lymphoma-2 (Bcl-2)transgene Does Not Decrease Atresia Or Increase Ovulation Rate in Swine. - (Abstract)

Guthrie, H.D., Wall, R.J., Pursel, V.G., Foster Frey, J.A., Donovan, D.M., Welch, G.R., Garrett, W.M. 2004. Follicular expression of a human beta-cell leukemia/lymphoma-2 (bcl-2)transgene does not decrease atresia or increase ovulation rate in swine. Society for the Study of Reproduction Annual Meeting. Abstract. p275.

Microsoft Excel Spread-Sheet Based Animal Colony Management for Genetically Altered Mouse Strains. - (Peer Reviewed Journal)

Donovan, D.M., Rowley, D.L., Williams, N.G. 2004. Microsoft excel spread-sheet based animal colony management for genetically altered mouse strains. Biotechniques. 37(1):50-56.

Role of U-Opioid Receptors in Formalin-Induced Pain Behavior in Mice - (Peer Reviewed Journal)

Zhao, C., Tao, Y., Tall, J.M., Donovan, D.M., Meyer, R.A., Raja, S.N. Role of u-opioid receptors in formalin-induced pain behavior in mice. Journal of Experimental Neurology. 2003. 184(2):839-45.

Microarray Analysis Reveals Interleukin-6 As a Novel Secretory Product of the Hypothalamo-Neurohypophyseal. - (Peer Reviewed Journal)

Ghorbel, M.T., Sharman, G., Leroux, M., Barrett, T., Donovan, D.M., Becker, K.G., Murphy, D. Microarray analysis reveals interleukin-6 as a novel secretory product of the hypothalamo-neurohypophyseal.. Journal of Biological Chemistry.2003 MAY 23; 278(21):19280-5. EPUB 2003 MARCH 14