HomeResearchIntramural ResearchResearch Branches at NHGRIGenome Technology BranchChandrasekharappa Lab Chandrasekharappa Publications

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Settara C. Chandrasekharappa, Ph.D.

Associate Investigator, Genome Technology Branch
Head, Gene Identification Unit

Selected Publications

Chandrasekharappa S.C., Guru S.C., Manickam P., Olufemi S.E., Collins F.S., Emmert-Buck M.R., Debelenko L.V., Zhuang Z., Lubensky I.A., Liotta L.A., Crabtree J.S., Wang Y., Roe B.A., Weisemann J., Boguski M.S., Agarwal S.K., Kester M.B., Kim Y.S., Heppner C., Dong Q., Spiegel A.M., Burns A.L., Marx S.J. Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science, 276:404-407. 1997. [PubMed]

Oda T., Elkahloun A.G., Pike B.L., Okajima K., Krantz I.D., Gennin A., Piccoli D.A., Meltzer P.S., Spinner N.B., Collins F.S., Chandrasekharappa S.C. Mutations in the human Jagged1 gene are responsible for Alagille syndrome. Nat Genet, 16:235-242. 1997. [PubMed]

Guru S.C., Goldsmith P.K., Burns A.L., Marx S.J., Spiegel A.M., Collins F.S., Chandrasekharappa S.C. Menin, the product of the MEN1 gene, is a nuclear protein. Proc Natl Acad Sci U S A, 95:1630-4. 1998. [PubMed]

Agarwal S.K., Guru S.C., Heppner C., Erdos M.R., Collins R.M., Park S.Y., Saggar S., Chandrasekharappa S.C., Collins F.S., Spiegel A.M., Marx S.J., Burns A.L. Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. Cell, 96:143-52. 1999. [PubMed]

Itoh, M., Kim, C.H., Palardy, G., Oda, T., Jiang, Y.J., Maust, D., Yeo, S-Y., Lorick, K., Kenworthy, A., Lippincott-Schwartz, J., Weissman, A.M., Lewis, J., Chandrasekharappa, S.C. and Chitnis, A.B. Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. Developmental Cell, 4:67-8. 2003. [PubMed]

Cerrato, A., Parisi, M., Santa Anna, S., Missirlis, F., Guru, S., Agarwal, S., Sturgill, D., Talbot, T., Spiegel, A., Collins, F., Chandrasekharappa, S., Marx, S., and Oliver, B. Genetic interactions between Drosophila melanogaster menin and Jun/Fos. Dev Biol, 298:59-70. 2006. [PubMed]
 
Rodriguez, V., Chen, Y., Elkahloun, A., Dutra, A., Pak, E., Chandrasekharappa, S. Chromosome 8 BAC array comparative genomic hybridization and expression analysis identify amplification and overexpression of TRMT12 in breast cancer. Genes Chromosomes and Cancer, 46:694-707. 2007. [PubMed]

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Last Reviewed: December 8, 2008