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Genome Informatics and Computational Biology Program
Genome Informatics and Computational Biology Program OverviewIn 1911, Alfred Sturtevant, an undergraduate research assistant of Thomas Hunt Morgan, realized that he could map the locations of Drosophila genes followed over generations. Indeed, the map was Sturtevant's solution to the problem of managing the data generated by the Morgan laboratory. Data management remains a challenge for genome researchers to this day: one of the major responsibilities of the National Human Genome Research Institute (NHGRI) is the development of new computational approaches to analyze and understand the enormous amount of data generated by the Human Genome Project (HGP). The Genome Informatics program supports research in computational biology that will enable the development of tools for sequence analysis, gene mapping, complex trait mapping and genetic variation. These tools include mathematical and statistical methods for the identification of functional elements in complex genomes; the identification of patterns in large datasets (for example, microarray data); and the mapping of complex traits and genetic variations (for example, single nucleotide polymorphisms, or SNPs). The program also encourages development and maintenance of databases of genomic and genetic data. This emphasis includes new tools for annotating complex genomes so as to expand their utility. The program also supports the production of robust, exportable software that can be widely shared among different databases in order to facilitate database interoperability. These bioinformatics resources will allow the scientific community efficient access to genomic data, which will enable new types of analyses. The analyses, in turn, will allow for the computer modeling and subsequent experimental validation of the complex pathways and networks that ultimately determine the phenotype of a cell or the causes of many human diseases.
Genome Informatics and Computational Biology Program Model Organism Databases and Human Genome Resources
Genome Informatics and Computational Biology Program Reports and Related Program InformationNIH/NIAID/Wellcome Trust Workshop Report on Model Organism Databases April 29-30, 2002 Report of the NIH Model Organism Database Workshop [nhlbi.nih.gov] December 7-8, 1998 Report on DOE/NIH Genome Informatics Workshop April 2-3, 1998 The Biomedical Information Science and Technology Initiative Report [bisti.nih.gov] June 1999
Genome Informatics and Computational Biology Program Funding OpportunitiesBioinformatics Initiatives at NIH - BISTI [bisti.nih.gov] PA-06-181 [grants.nih.gov]: NIH Exploratory/Developmental Research Grant Program (Parent R21) PA-07-070 [grants.nih.gov]: Research Project Grant (Parent R01) PAR-07-425 [grants.nih.gov]: Data Ontologies for Biomedical Research (R01) PAR-08-010 [grants.nih.gov]: Continued Development and Maintenance of Software (R01) Small Business Funding Opportunities [grants.nih.gov]
NHGRI-Sponsored TrainingThe Genome Informatics and Computational Biology Program Web page sponsors the following courses: Cold Spring Harbor Laboratory Course: Programming for Biology : October 15 - 28, 2008 Computational and Comparative Genomics: November 5 - 11, 2008
Genome Informatics and Computational Biology Program StaffProgram Directors Vivien Bonazzi, Ph.D. Address Phone: (301) 496-7531
Last Reviewed: October 28, 2008 |
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