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James Inglese, Ph.D.
Selected Publications
Inglese J., Samama P., Patel S., Stroke I.L., Burbaum J.J., Appell K.C.. Chemokine receptor-ligand interactions measured using time-resolved fluorescence. Biochemistry, 37:2372-2377. 1998. [PubMed]
Inglese J., Glickman J.F. Radiolabeling of receptor ligands by chemical incorporation of phosphorylation sites. Anal Biochem, 274:104-109. 1999. [PubMed]
Zuck P., Lao Z., Skwish S., Glickman J.F., Burbaum J., Inglese J.. Ligand-receptor binding measured by laser-scanning imaging. Proc Natl Acad Sci USA, 96:11122-11127. 1999. [PubMed]
Ferrer M., Hamilton A., Inglese J. A PDZ domain-based detection system for enzymatic assays. Anal Biochem, 301:207-216. 2002. [PubMed]
Inglese J. Engaging science and technology for drug development. Assay Drug Dev Technol, 1(1 Pt 1):1. 2002. [PubMed]
Inglese J. Expanding the HTS paradigm. Drug Discov Today 7:S105-S106. 2002. [PubMed]
Whitney M., Stack J.H., Darke P.L., Zheng W., Terzo J., Inglese J., Strulovici B., Kuo L.C., Pollock B.A. A collaborative screening program for the discovery of inhibitors of HCV NS2/3 cis-cleaving protease activity. J Biomol Screen, 7:149-154. 2002. [PubMed]
Ferrer M., Zuck P., Kolodin G., Mao S.S., Peltier R.R., Bailey C., Gardell S.J., Strulovici B., Inglese J.. Miniaturizable homogenous time-resolved fluorescence assay for carboxypeptidase B activity. Anal Biochem, 317:94-98. 2003. [PubMed]
Hamilton A., Inglese J., Ferrer M.. A PDZ domain-based assay for measuring HIV protease activity: assay design considerations. Protein Sci, 12:458-467. 2003.[PubMed]
Kunapuli P., Ransom R., Murphy K.L., Pettibone D., Kerby J., Grimwood S., Zuck P., Hodder P., Lacson R., Hoffman I., Inglese J., Strulovici B.. Development of an intact cell reporter gene beta-lactamase assay for G protein-coupled receptors for high-throughput screening. Anal Biochem, 314:16-29. 2003. [PubMed]
Kornienko O., Lacson R., Kunapuli P., Schneeweis J., Hoffman I., Smith T., Alberts M., Inglese J., Strulovici B. Miniaturization of whole live cell-based GPCR assays using microdispensing and detection systems. J Biomol Screen, 9:186-195. 2004. [PubMed]
Ferrer M., Maiolo J., Kratz P., Jackowski J.L., Murphy J.M., Delagrave S. and Inglese J., Directed Evolution of PDZ Variants to Generate High-affinity Detection Reagents. Protein Engineering, Design, and Selection, 18(4):165-73. 2005 [PubMed]
Inglese, J., Auld, D. S., Jadhav, A., Johnson, R. L., Simeonov, A., Yasgar, A., Zheng, W., Austin, C.P. Quantitative High-Throughput Screening (qHTS): A Titration-based Approach that Efficiently Identifies Biological Activities in Large Chemical Libraries. Proc Nat'l Acad Sci USA, 103: 11473-11478. 2006. [PubMed]
Auld, D. S., Johnson, R. L., Zhang, Y., Veith, H., Jadhav, A., Yasgar, A., Simeonov, A., Zheng,W., Martinez, E.D., Westwick, J.K., Austin, C.P., Inglese, J. Fluorescent Protein-based cellular assays analyzed by laser scanning microplate cytometry in 1536-well plate format. Methods in Enzymology, Measuring Biological Responses with Automated Microscopy, 414:566-589. 2006 [PubMed]
Davis, R.E., Zhang, Y.-Q., Southall, N., Staudt, L. M., Austin, C. P., Inglese, J., Auld, D. S. A cell-based assay for IkBa stabilization using a two-color dual luciferase-based sensor. Assay and Drug Development Technologies, 5: 85-103 2007.
Feng, B.Y, Simeonov, A., Jadhav, A., Babaoglu, K., Inglese, J., Shoichet, B. K.,
and Austin, C.P. A High-throughput Screen for Aggregation-based inhibition
in a Large Compound Library. J Med Chem, 50: 2385-2390. 2007. [PubMed]
Last Reviewed: December 8, 2008
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