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• Department of Defense (DOD) provides technical assistance and, in emergency situations, provides facilities for storage, treatment, and disposal of hazardous substances;
• Department of Energy (DOE) provides technical guidance and support services for incidents involving radioactive releases;
• Department of Labor (DOL) provides guidance on worker health and safety through the Occupational Safety and Health Administration (OSHA);
• Federal Emergency Management Agency (FEMA) coordinates temporary relocation of individuals; and
• Health and Human Services (HHS) provides site-specific health threat advisories for removal actions through the Agency for Toxic Substance and Disease Registry (ATSDR), and technical guidance regarding worker health and safety through the National Institute for Occupational Safety and Health (NIOSH).
• The National Pollution Funds Center (NPFC) manages funds for the Oil Spill Liability Trust Fund (OSLTF) and the portion of the Superfund used by the U.S. for response to hazardous substance released in the coastal zone. The NPFC is an independent unit of the U.S. Coast Guard.
• Scientific Support Coordinators The National Oceanic and Atmospheric Administration (NOAA) Office of Response and Restoration works to remediate damage to coastline and marine resources caused by oil and hazardous substance releases. Their scientists analyze and identify solutions to environmental contamination.
• The U.S. Coast Guard District Response Group (DRG) provides a framework for the Coast Guard districts to organize their response operations. The DRG consists of all Coast Guard units, personnel and equipment within a district's boundary, all pre-positioned response equipment strategically located in the district, and the District Response Advisory Team (DRAT).
• The U.S. Coast Guard National Strike Force provides specialized materials and staff to assist other organizations in responding to hazardous substance emergencies. Their services include communications, technical advice and assistance, specialized equipment, training, and contingency planning.
• The U.S. Navy Superintendent of Salvage and Diving (SUPSALV) has extensive equipment and expertise for supporting responses to open-sea pollution incidents. Specialized capabilities include salvage, firefighting, and petroleum, oil and lubricants offloading.

Other federal agencies may also provide support when the National Response Team is activated.