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Lawrence C. Brody, Ph.D.

Senior Investigator, Genome Technology Branch
Head, Molecular Pathogenesis Section

Selected Publications

Brody LC, Conley M, Cox C, Kirke PN, McKeever MP, Mills JL, Molloy AM, O'Leary VB, Parle-McDermott A, Scott JM, Swanson DA. A Polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: Report of the birth defects research group. Am J Hum Genet, 71(5):1207-15. 2002. [PubMed]

Brody LC. CHEKs and balances: Accounting for breast cancer. Nat Genet, 31(1):3-4. 2002. [PubMed]

Yarden RI, Pardo-Reoyo S, Sgagias M, Cowan KH and Brody LC. BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage. Nat Genet, 30(3):285-9. 2002. [PubMed]

Kanaan Y, Kpenu E, Utley K, Adams-Campbell L, Dunston GM, Brody LC, Broome C. Inherited BRCA2 mutations in African Americans with breast and/or ovarian cancer: a study of familial and early onset cases. Hum Genet, 113(5):452-60. 2003. [PubMed]

Coyne RS, McDonald HB, Edgemon K and Brody LC. Functional characterization of BRCA1 sequence variants using a yeast small colony phenotype assay. Cancer Biology and Therapy, 3:453-7. 2004. [PubMed]

Parle-McDermott A, Pangilinan FJ, Mills JL, Signore CC, Molloy AM, Cotter A, Conley M, Cox C, Kirke PN, Scott JM and Brody LC. A polymorphism in the MTHFD1 gene increases a mother's risk of having an unexplained second trimester pregnancy loss. Molecular Human Reproduction, 11:477-480. 2005. [PubMed]

Brody LC. Treating cancer by targeting a weakness. N Engl J Med, 353(9):949-50. 2005. [PubMed]

Parle-McDermott A, Kirke PN, Mills JL, Molloy AM, Cox C, O'leary VB, Pangilinan F, Conley M, Cleary L, Brody LC. Confirmation of the R653Q polymorphism of the trifunctional C1-synthase enzyme as a maternal risk for neural tube defects in the Irish population. Eur J Hum Genet, 14:768-772. 2006. [PubMed]

Parle-McDermott A, Mills JL, Molloy AM, Carroll N, Kirke PN, Cox C, Conley MR, Pangilinan FJ, Brody LC, Scott JM. The MTHFR 1298CC and 677TT genotypes have opposite associations with red cell folate levels. Mol Genet Metab, 88:290-294. 2006. [PubMed]

Alter BP, Rosenberg PS, Brody LC. Clinical and molecular features associated with biallelic mutations in FANCD1/BRCA2. J Med Genet, 44(1):1-9. 2007. [PubMed]

Parle-McDermott A, Pangilinan F, Mills JL, Kirke PN, Gibney ER, Troendle J, O'Leary VB, Molloy AM, Conley M, Scott JM, Brody LC. The 19-bp deletion polymorphism in intron-1 of dihydrofolate reductase (DHFR) may decrease rather than increase risk for spina bifida in the Irish population. Am J Med Genet A, 143A(11):1174-80. 2007. [PubMed]

Pangilinan F, Geiler K, Dolle J, Troendle J, Swanson DA, Molloy AM, Sutton M, Conley M, Kirke PN, Scott JM, Mills JL, Brody LC. Construction of a high resolution linkage disequilibrium map to evaluate common genetic variation in TP53 and neural tube defect risk in an Irish population. Am J Med Genet A, 146A(20):2617-25. 2008. [PubMed]

McBride CM, Alford SH, Reid RJ, Larson EB, Baxevanis AD, Brody LC. Putting science over supposition in the arena of personalized genomics. Nat Genet, 40(8):939-42. 2008. [PubMed]

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Last Reviewed: December 4, 2008