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Elaine A. Ostrander, Ph.D.

Chief & Senior Investigator, Cancer Genetics Branch
Head, Comparative Genetics Section

Selected Publications:

Chase K, Carrier DR, Adler FR, Jarvik T, Ostrander EA, Lorentzen TD, Lark KG. Genetic basis for systems of skeletal quantitative traits: principal component analysis of the canid skeleton. Proc Natl Acad Sci USA, 99:9930-9935. 2002. [PubMed]

Fleming MA, Potter JD, Ramirez CJ, Ostrander GK, Ostrander EA. Understanding missense mutations in the BRCA1 gene: an evolutionary approach. Proc Natl Acad Sci USA, 4:1151-1156. 2003. [PubMed]

Janer M, Fredrichsen D, Stanford JL, Badzioch MD, Kolb SK, Deutsch K, Peters MA, Goode EL, Welti R, DeFrance HB, Iwasaki L, Li S, Hood L, Ostrander EA, Jarvik GP. A genomic scan of 254 hereditary prostate cancer families. Prostate, 57:309-319. 2003. [PubMed]

Lingaas FL, Comstock KE, Kirkness EF, Sørensen A, Aarskaug T, Hitte C, Nickerson ML, Moe L, Schmidt LS, Thomas R, Breen M, Galibert F, Zbar B, Ostrander EA. A mutation in the canine BHD gene is associated with hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis in the German shepherd dog. Hum Mol Genet, 12:3043-3053. 2003. [PubMed]

Ostrander, E.A., Comstock K. The domestic dog genome. Current Biology, 14: 98-99. 2004.

Chase, K., Lawler, D.F., Adler, F.R., Ostrander, E.A. Lark, K.G. Bilaterally asymmetric effects of Quantitative Trait Loci on the right versus left coxofemoral (hip) joints of the dog (C. familiaris). Am J Med Genet, 124:239-47. 2004. [PubMed]

Friedrichsen DM, Stanford JL, Isaacs SD, Janer M, Chang BL, Deutsch K, Gillander E, Kolb S, Wiley KE, Badzioch MS, Zheng L, Walsh PC, Jarvik GP, Hood L, Trent JM, Isaacs W, Ostrander EA, Xu JF. Identification of a prostate cancer susceptibility locus on chromosome 7q11-21 in Jewish families. Proc Natl Acad Sci USA, 101:1939-1944. 2004. [PubMed]

Suter NM, Ray RM, Hu YW, Lin MG, Porter P, Gao DL, Zaucha RE, Iwasaki LM, Sabacan LP, Thomas DB, Ostrander EA. BRCA1 and BRCA2 mutations in a cohort of women from Shanghai China. Cancer Epidemiol Biomarkers, 13:181-189. 2004. [PubMed]

Ramirez, C.J., Fleming, M.A.,  Potter, J.D., Ostrander, G.K., Ostrander, E.A. Marsupial BRCA1: Conserved regions in mammals and the potential effect of missense changes.  Oncogene, 23: 1780-1788. 2004. [PubMed]

Cheteri, M.B., Stanford, J.L., Friedrichsen, D.M., Iwasaki, L., Langlois, M.C., Feng, Z., Ostrander, E.A. Vitamin D receptor gene polymorphisms and prostate cancer risk.  Prostate, 59: 409-418. 2004. [PubMed]

Lubieniecka, J.M., Cheteri, M.K., Stanford, J.L., Ostrander, E.A. The Met160Val polymorphism in the TRMPSS2 gene and risk of prostate cancer in a population based case-control study.  Prostate, 59:357-9.  2004 [PubMed]

Guyon R., Kirkness E. F., Lorentzen T. D., Hitte C., Comstock K. E., Quignon P., Derrien T., Andréa C., Fraser C. M., Galibert F., and Ostrander E. A. Comparative mapping of human chromosome 1p and the canine genome.  The Genome of Homo sapiens. The 68th Cold Spring Harbor Symposium, 68:171-177. 2004.

Wayne R.K., Ostrander E.A. Out of the Dog House: The emergence of the canine genome.  J of Hered, 92:273-4.  2004. [PubMed]

Comstock, K.E., Lingaas, F., Kirkness, E.F., Hitte, C., Thomas, R., Breen, M., Galibert, F., Ostrander E.A. A high resolution comparative map of canine chromosome 5q14.3-q33 constructed utilizing the 1.5 x canine genome sequence. Mammalian Genome, 15: 544-51. 2004. [PubMed]

Clark, L.A., Tsai, K.L., Steiner, J.M., Williams, D.A., Guerra, T., Ostrander, E.A., Galibert, F., Murphy, K.E.  Chromosome-specific microsatellite multiplex sets for linkage studies in the domestic dog. Genomics, 84:550-554. 2004. [PubMed]

Werner, P., Raducha, M.G., Shin, D., Ostrander, E.A., Kirkness, E., Patterson, D.F., Henthorn, P.S. Assignment of 10 canine genes to the canine linkage and comparative maps. Anim Genet, 35:249-51. 2004. [PubMed]

Parker HG, Kim LV, Sutter NB, Carlson S, Lorentzen TD, Malek TB, Johnson GS, DeFrance HB, Ostrander EA, Kryglyak L. Genetic structure of the purebred domestic dog. Science, 304:1160-1164. 2004. [PubMed]

Zuhlke, K.A., Madeoy, J.J., Beebe-Dimmer, J., White, K.A., Griffin, A., Lange, E.M., Gruber, S.B., Ostrander, E.A., Cooney, K.A.  Truncating BRCA1 mutations are uncommon in a cohort of hereditary prostate cancer families with strong suggestive evidence of linkage to 17q markers. Clin Cancer Res, 10:5975-80. 2004. [PubMed]

Hitte, C., Derrien, T., Andre, C., Ostrander, E.A., Galibert F.  CRH_Server : An online comparative and radiation hybrid mapping server for the canine genome. Bioinformatics, 20:3665-7. 2004. [PubMed]

Friedrichsen, D.M., Malone K.E., Dooty, D., Daling J.R., Ostrander E.A. Frequency of CHEK2 mutations in a population-based, case control study of young women and breast cancer.  Breast Cancer Research, 6: 629-35.  2004. [PubMed]

Lee, J-H., Joo, Y-D., Yim, D., Lee, R., Storb, R., Ostrander E.A., Little M.-T., Kuhr, C.S.  Molecular cloning and characterization of canine ICOS. Genomics, 84:730-6. 2004. [PubMed]

Wasser, S.K., Shedlock, A. M., Comstock, K., Ostrander, E. A., Mutayoba, B., Stephens, M.  Assigning isolated African elephant DNA to a geographic region of origin:  Applications to monitoring the ivory trade. Proc. Natl. Acad.Sci USA, 101:14847-52. 2004. [PubMed]

Breen, M., Hitte, C., Lorentzen, T. D., Thomas, R., Cadieu, E., Sabacan, L., Scott, A., Evanno, G., Parker, H. G., Kirkness, E., Hudson, R., Guyon, R., Mahairas, G. G, Gelfenbeyn, B., Fraser, C. M, André, C.,  Galibert, F.,  Ostrander, E. A. An integrated 4249 marker FISH/RH map of the canine genome.  BMC Genomics, 65:1-11. 2004. [PubMed]

Sutter, N.S., Eberle, M.A., Parker, H.G., Pullar, B. J., Kirkness, E.F., Kruglyak, L., Ostrander E.A.  Extensive and breed specific linkage disequilibrium in Canis familiaris. Genome Res, 12:2388-96. 2004. [PubMed]

Sutter, N.S., Ostrander, E.A.  Dog star rising:  The canine genetic system. Nature Rev Genet, 5:900-10. 2004. [PubMed]

Lohi L., Young E.J., Fitzmaurice S.N., Rusbridge C., Chan E.M., Vervoort M., Turnbull J., Ianzano L., Paterson A.D., Sutter N.B., Ostrander E.A., Andre C., Shelton G.D., Ackerley C.A., Scherer S.W., Minassian B.A. Expanded repeat in canine epilepsy. Science, 307:81. 2005. [PubMed]

Seddon, J.M., Parker, H.G., Ostrander, E.A., Ellegren, H. SNPs in ecological and conservation studies: A test in the Scandinavian wolf population.  Molec. Ecol, 14:503-511. 2005. [PubMed]

Green, S.L., Westendorf, J.M., Jaffe, H., Pant, H.C., Cork, L.C., Ostrander, E.A., Vigneaux, F., Ferrell, J.E. Allelic Variants of the canine heavy neurofilament (NFH) subunit and extensive phosphorylation in dogs with motor neuron disease.  Comparative Pathology, 132:33-50. 2005. [PubMed]

Narla, G., DiFeo A., Reeves H.L., Schaid D.J., Hirshfeld J., Hod E., Katz A., Isaacs W.B., Hebrring S., Komiya A., McDonnell S.K., Wiley K.E., Jacobsen S.J., Isaacs S.D., Walsh P.C.,  Zheng S. L., Chang B-L., Friedrichsen D.M., Stanford J. L., Ostrander E.A., Chinnaiyan A.M., Rubin M.A., Xu J., Thibodeau S.N., Friedman S.L., Martignetti J.A. A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk. Cancer Research, 65:1213-22. [PubMed]

Werner P.,  Raducha, M., Prociuk U., Ostrander E.A., Spielman R.S., Kirkness E.F.,  Patterson D.F., Henthorn, P.S.  The keeshond defect in cardiac conotruncal development is oligoneic.  Human Genetics, 116:368-77. 2005. [PubMed]

Schaid, D.J., Chang, B.L., and The International Consortium for Prostate Cancer Genetics.  Description of the International Consortium for Prostate Cancer Genetics, and failure to replicate linkage of hereditary prostate cancer to 20q13. Prostate, 5:276-90. 2005. [PubMed]

Salinas, C. A., Austin, M., Ostrander, E.A., Stanford, J.L.  Polymorphisms in the androgen receptor and prostate specific antigen gene and prostate cancer risk. Prostate, 15;58-65. 2005.

Friedrichsen, D.M., Hawley, S., Shu J., Humphrey, M., Sabacan, L., Iwasaki, L., Etzioni, R., Ostrander, E.A., Stanford, J.L. IGF-1  and IGFBP-3 polymorphisms and risk of prostate cancer.  Prostate, 65:44-51. 2005. [PubMed]

Thomas R., Scott, A., Langford C., Forsmire, S.P.,  Jubala, C.M.,  Lorentzen, T.D., Hitte, C., Karlsson, E., Kirkness, E. F.,  Ostrander, E.A., Galibert, F., Lindblad-Toh, K., Modiano, J.F.,  Breen, M.  Construction of a 2Mb resolution BAC-microarray for CGH analysis of canine tumors. Genome Res, 15:1831-1837.  2005. [PubMed]

Ewart-Toland, A., Dai, Q., Gao, Y.T., Nagase, H., Dunlop, M.G., Farrington, S.M., Barnetson, R.A., Anton-Culver, H., Peel, D., Ziogas, A., Lin, D., Miao, X., Sun, T., Ostrander, E.A., Stanford, J.L., Langlois, M, Chan, JM, Yuan, J, Harris, C, Bowman, E, Clayman, GL, Lippman, S.M., Lee, JJ, Zheng, W.,  Balmain, A. Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types. Carcinogenesis, 26: 1368-1373. 2005. [PubMed]

Xu, J., Dimitrov, L., Chang, B.L., Adams, T.S., Turner, A.R., Meyers, D.A., Eeles, R.A., Easton, D.F., Foulkes, W.D., Simard, J., Giles, G.G., Hopper, J.L., Mahle, L., Moller, P., Bishop, T., Evans, C., Edwards, S., Meitz, J., Bullock, S., Hope, Q., The Actane Consortium, Hsieh, C.L., Halpern, J., Balise, R.N., Oakley-Girvan, I., Whittemore, A.S., Ewing, C.M., Gielzak, M., Isaacs, S.D., Walsh, P.C., Wiley, K.E., Isaacs, W.B., Thibodeau, S.N., McDonnell, S.K., Cunningham, J.M., Zarfas, K.E., Hebbring, S., Schaid, D.J., Friedrichsen, D.M., Deutsch, K., Kolb, S., Badzioch, M., Jarvik, G.P., Janer, M., Hood, L., Ostrander, E.A., Stanford, J.L., Lange, E.M., Beebe-Dimmer, J.L., Mohai, C., Cooney, K.A, Ikonen, T., Baffoe-Bonnie, A., Fredriksson, H., Matikainen, M.P., Tammela, T.L., Bailey-Wilson, J., Schleutker, J., Maier, C., Herkommer, K., Hoegel, J., Vogel, W., Paiss, T., Wiklund, F., Emanuelsson, M., Stenman, E., Jonsson, B.A., Gronberg, H., Camp, N.J., Farnham, J., Cannon Albright L., Seminara, D. A combined genomewide linkage scan, of 1,233 families, for prostate cancer-susceptibility genes conducted by the International Consortium for Prostate Cancer Genetics. Am. J. Hum. Gen, 77: 219-229. 2005. [PubMed]

Parker, H.G., Ostrander, E.A. The canine genome: Running with the pack. PLOS Genetics, 1: 507-53. 2005. [PubMed]

Stanford, J.L., McDonnell, S.K., Friedrichsen, D.M., Carlson, E.E., Kolb, S., Deutsch, K., Janer, M., Hood, L., Ostrander, E.A., Schaid, D.L. Prostate cancer and genetic susceptibility: a genome scan incorporating disease aggressiveness.  Prostate, 66:317-25. 2006.   [PubMed]

Kukekova, A.V., Nelson, J., Kuchtey, R.W., Lowe, J.K.,  Johnson, J.L., Ostrander, E.A.,  Aguirre, G.D., Acland G.M.  Linkage mapping of canine rod cone dysplasia type 2 (rcd2) to CFA7, the canine ortholog of human 1q31. Invest Optholmol Vis Sci, 47:1210-5. 2006. [PubMed]

Parker, H., Kruglyak, L., Ostrander, E.A. Molecular genetics: DNA analysis of a putative dog clone. Nature, 440(7081):E1-2. 2006. [PubMed]

Malone, K.E., Daling, J.R., Doody, D.R., Hsu, L., Bernstein, L., Coates, R.J, Marchbanks, P.A., Simon, M.S., McDonald, J.A. Norman, S.A. Strom, B.L., Burkman, R.T., Ursin, G., Deapen, D., Weiss, L.K., Folger, S.F., Madeoy J.J., Friedrichsen, D.F., Suter, N.M., Humphrey, M.C,. Spirtas R., Ostrander E.A. Prevalence and predictors of BRCA1 and BRCA2 mutations in a population-based study of breast cancer in white and black American women ages 35 to 64 years.  Cancer Research, 66:8297-308. 2006. [PubMed]

Chase, K., Sargan, D., Miller K., Ostrander E.A., Lark, K.G. Understanding the genetics of autoimmune disease: two loci that regulate late onset Addison's disease in Portuguese Water Dogs.  Int J Immunogenet, 33:179-84. 2006. [PubMed]

Parker, H.G., Meurs, K., Ostrander E.A. , Finding cardiovascular disease genes in the dog. J.Vet.Cardiol, 8:2:115-127. 2006. [Full Text]. 

Schaid  D.J., McDonnell S.K., Zarfas, K.E. Cunningham, J.M., Hebbring S., Thibodeau S.N. Eeles, R.A., Easton, D.F., Foulkes W.D., Simard J., Giles, G.G., Hopper J.L. Mahle L., Moller P.,  Bishop, D.T., Evans, C., Edwards S., Meitz, J., Bullock S., Hope Q., The ACTANE Consortium, Hsieh, C-l, Halpern J., Balise R.R., Oakley-Girvan I., Whittemore Å.S., Xu J., Dimitrov, L., Chang, B.-L, Adams T.S., Turner A.R., Meyers, D.A., Friedrichsen, D.M, Deutsch, K, Kolb, S., Janer, M., Hood, L., Ostrander E.A., Stanford J.L., Ewing, C.M., Gielzak, M., Isaacs, S.D., Walsh, P.C., Wiley, K.E., Isaacs, W.B., Lange, E.M., Ho L.A., Beebe-Dimmer J.L., Wood, D.P., Cooney K.A., Seminara D., Ikonen T., Baffoe-Bonnie, A.,  Fredriksson, H., Matikainen, M.P.,  Tammela,, TLK,  Bailey-Wilson, J., Schleutker J.  Maier, C., Herkommer K., Hoegel J.J., Vogel W., Paiss T., Wiklund F., Emanuelsson, M., Stenman, E., Jonsson, B-A, Gronberg, H. , Camp N.J. ,Farnham J., Cannon-Albright L.A., Catalona W.J., Suarez B.K., Roehl K.A.  Pooled genome linkage scan of aggressive prostate cancer: Results from the International Consortium for Prostate Cancer Genetics.  Human Genetics, 120:471-85. 2006. [PubMed]

Kohn, M.H., Murphy, W., Morin, P., Ostrander E.A., Wayne, R.K.  Conservation genetics and the genomic tool box.  Trends in Ecol and Evol, 21: 629-37. 2006.

VonHoldt, B. M, Ostrander, E.A.  The singular history of a canine transmissible tumor.  Cell, 126: 445-447. 2006.[Full Text]

Ostrander, E.A., Kwon, E.M., Stanford, J.L. Genetic susceptibility to aggressive prostate cancer.  Cancer Epi. Bio Markers, 5:1761-4. 2006. [PubMed]

Khanna, C., Lindblad-Toh, L., Vail, D., London, C., Bergman, P., Barber, L., Breen, M., Kitchell, B., McNeil, E., Modiano, J.F., Niemi, S.,  Comstock, K.E.,  Ostrander, E.,  Westmoreland, S.,  Withrow S. The dog as a cancer model. Nature Biotechnol,  24:1065-6. 2006. [PubMed]

Abecasis, G., Tam, P.K., Bustamante, C.D., Ostrander, E.A., Scherer, S.W., Chanock, S.J., Kwok, P.Y., Brookes, A.J. Human Genome Variation 2006: emerging views on structural variation and large-scale SNP analysis. Nature Genetics, 39:153-5.  2007. [PubMed]

Pierce, B.L., Friedrichsen-Karyadi, D.M., McIntosh, L., Deutsch, K., Hood, L., Ostrander, E.A.,  Austin M.A.,  Stanford, J.L.  Genomic scan of 12 hereditary prostate cancer families having an occurrence of pancreas cancer. Prostate, 67:410-5.  2007. [PubMed]

Johanneson, B., Deutsch, K., McIntosh, L., Friedrichsen-Karyadi, D.M.,  Janer, M., Kwon, E.M.,  Iwasaki, L., Hood, L, Ostrander E.A., Stanford  J.L. Suggestive genetic linkage to chromosome 11q12.1 in hereditary prostate cancer families with primary kidney cancer. 2007. [In Press]

Agalliu I., Kwon E., Zadory D., Thompson J., Stanford J.L., Ostrander E.A.,  Germline mutations in the BRCA2 gene and susceptibility to hereditary prostate cancer. Clinical Cancer Research, 13(3):839-43.  2007. [PubMed]

Parmigiani G., Friebel T., Iversen E.A., Chen S., Finkelstein D., Culver H.A., Ziogas A., Weber B.L., Eisen A., Malone K.E., Daling J.R., Hsu L., Osrtander E.A., Peterson L.E., Schildkraut J.M.,  Isaacs C., Peshkin B.N., Corio C., Leondaridis L., Tomlinson G., Amos C.I., Strong L.C., Berry D.A.  Weitzel J.N., Sand S., Dutson D., Kerber R., Euhus D.M.  (2007).   Validity of models for prediction of BRCA1 and BRCA2 mutations.  Annals of Internal Medicine (In Press). 

Sargan D.S., Aguirre-Hernandez, J., Galibert F., Ostrander E.A.  An extended microsatellite set for linkage mapping in the domestic dog.  J. Heredity, 98(3):221-31. 2007. [PubMed]

Spady, T. C., Ostrander E.A. Candid genomics: Mapping genes for domestication in the silver fox.  Genome Research, 7:259-63.  2007. [PubMed]

Suuriniemi, M., Aaliu I., Schaid D.J., Johanesson, B., McDonell, S.K., Iwasaki L., Stanford J.L., Ostrander E.A.  Confirmation of a positive association between prostate cancer risk and a locus at chromosome 8q24.  Cancer Epi Biomarkers, 16(4):809-14. 2007. [PubMed]

Schaid, D.J., Mcdonnell S.K., Carlson E.F., Thibodeau, S.N. Ostrander E.A., Stanford J.L.  Affected relative pairs and simultaneous search for two-locus linkage  in the presence of epistasis.  Genetic. Epidemiology, 31(5):431-49. 2007. [PubMed]

Books

Parker, H.G., Sutter, N.B., Ostrander E.A.: Understanding genetic relationship among purebred dogs: The PhyDo Project. In: E.A. Ostrander, K. Lindbland-Toh, Urs Giger, (eds). The Dog and Its Genome. Cold Spring Harbor Press. 2006.

Hitte C., Kirkness E.F., Ostrander, E.A. Galibert, F.: Survey sequencing and radiation hybrid mapping to construct comparative maps. In: W. Murphy (ed). Methods in Molecular Biology: Phylogenomics. Humana Press, 2006.

Ostrander E.A., and Wayne R.K. The Canine Genome. In: H. Sussman and M.A. Smit, (eds.) Genomes. Cold Spring Harbor Press. 275 pp. 2006.

Every dog has its day: An overview of the recent advances in canine genetics. In: C. Kole & Noelle E. Cockett (eds.). Genome Mapping in Animals. Springer-Verlag. [In Press]

Ostrander E.A., Parker, H.G., and Sutter N.B. Canine Genetics Facilitates Understanding of Human Biology. In: 2006 Stadler Symposium. St. Louis. 2006. [In Press].

Ostrander E.A. and Parker H.G. Human genetics and the canine system. In: F. Vogel, A. Motulsky, S, Antonarakis and M. Speicher. (eds.) Human Genetics: Principals and Approaches. 4th Edition. Springer Publishing. 2007 [In Press].

Ostrander, E.A., and Johannesson, B. Hormonal Carcinogenesis III. In: Li, J.J., and Li, S.A. (eds.) Springer-Verlag. 2007. [In Press].

Lindblad-Toh, K. and Ostrander, E.A. Canine genetics and genome variation. In: S. Gabriel, J.C. Stephens and M. Weiner (eds.) Genetic Variation: A Laboratory Manual. Cold Spring Harbor Press. 2007. [In Press].

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Last Reviewed: April 29, 2009