Types of Grants Supported by NIDDK
The NIDDK supports research under a variety of grant,
contract, and cooperative agreement activities or mechanisms. This
list identifies the major activities and does not preclude the funding of others
in the future.
Application Types
See table of receipt dates.
- New
- Competing continuation
- Supplemental
- Extension
- Non-competing continuation (annual)
- Change of Institute or Division (new, training)
- Change of Grantee or Training Institution
- Change of Institute or Division (noncompeting continuation)
- Change of Institute or Division (competing continuation)
Research Project Grants
- P01 Research
Program Project (See guidelines.)
- R01 Investigator Research
Project
- R37 Method to Extend
Research in Time (MERIT) Award
- U01 Research Project
(Cooperative Agreement)
- U10 Cooperative Clinical
Research (Cooperative Agreement)
Small Business Innovation Research Grants (SBIR) and Small Business Technology
Transfer (STTR)
(See NIH SBIR
and NIDDK SBIR pages.)
- R41 Small Business
Technology Transfer (STTR) - Phase I
- R42 Small Business
Technology Transfer (STTR) - Phase II
- R43 Small Business
Innovative Research Grant - Phase I (SBIR)
- R44 Small Business
Innovative Research Grant - Phase II (SBIR)
Centers
(See funded NIDDK Centers.)
- P20 Exploratory Grants
- P30 Center Core Grants
- P50 Specialized Centers
- P60 Comprehensive Centers
Careers
(See Training page.)
Other Research
- R03 Small Research Grants
- R13 Conference Award
- R15 Academic Research
Enhancement Awards (AREA)
- R18 Research Demonstration and Dissemination Projects
- R21 Exploratory/Developmental
Grants
- R24 Resource-Related
Research Project
- R25 Education Projects
- R33 Exploratory/Developmental Grants Phase II
- S06 Minority Biomedical
Research Support (MBRS)
- U13 Conference Award
(Cooperative Agreement)
- U19 Research Programs (Cooperative
Agreements)
- U24 Resource-Related
Research Project (Cooperative Agreements)
Training
(See Training page.)
Contracts
(See Contracts page.)
- N01 Research and
Development Contracts
- N02 Resource and Support Contracts - Awarded in the ICD
- N41 Small
Business Technology Transfer (STTR) - Phase I
- N42 Small
Business Technology Transfer (STTR) - Phase II
- N43 Small Business Innovation Research - Phase I (contract)
- N44 Small Business Innovation Research - Phase II (contract)
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Major Funding Categories
Research Project Grants
- P01 Research Program Project
Program projects generally involve the organized efforts of three
or more investigators who conduct projects with a central research
focus or objective, or are focussed in on a range of problems
that share a central research focus. Although each project
has a well-defined research goal, they must be interdependent.
A program project is usually under the overall leadership of a
recognized senior investigator. The individual cores and
subprojects will also each have a principal investigator.
The important concept that distinguishes a program project from
a collection of R01s is demonstrated synergy between the investigators,
research resources, and research goals. A program project
must be seen as greater than the sum of its parts.
The P01 grant can support certain shared basic resources used
by the research team, including clinical components that facilitate
the total research effort. Eligibility criteria are the
same as for the traditional Research Project Grant. In
general, they are reviewed by a special committee during a site
visit.
A letter of intent is required for P01s, and potential applicants
may be asked to present their proposal to NIDDK staff prior to
obtaining approval for submission (often via videoconference).
NIDDK guidelines for preparation of
a P01 application should be consulted. Program
projects, like other large grants, may be subject to a lower payline
than other regular research grants.
- R01 Investigator Research Project
The R01 grant is the most widely used NIH mechanism for research
support (>70% of all NIDDK support). The R01is an investigator-initiated
research grant awarded to public and private organizations and
institutions, governments and their agencies (including other
Federal institutions), foreign institutions, and international
organizations, to provide support for a discrete, specified research
project to be performed by a named principal investigator.
The individual, or principal investigator (P.I.) is responsible
for conceptualizing, originating, and completing the proposed research.
Clinical trials may be supported using this mechanism.
Detailed information and eligibility criteria may be found in
the Grants
Policy Statement. Prospective applicants should be
aware that all R01s (new or competing continuations) that request
$250,000 or less in direct costs for each year must be submitted
using a Modular
Grant format. Although applicants using this format
must request between 1 and 10 $25,000 modules each year, the requested
budget must be reasonable for the proposed work. All budgets
greater than $250,000 must be detailed. An applicant planning
to request $500,000 or more in direct costs for any year (including
indirect costs on subcontracts) is advised that he or she must contact
NIDDK program staff for permission several weeks before submission.
- R03 Small Research Grants
To provide limited research support for studies that meet specific
program needs. They are typically 1-3 year, nonrenewable
awards used to support pilot projects, to test new techniques,
or perform feasibility studies of innovative and high-risk research.
R03 applications can only be received in response to an RFA or
PA. They have been used particularly for planning grants
for clinical trials and for additional support for NIDDK investigators
holding a K08 award.
- R15 Academic Research Enhancement
Awards (AREA)
To support small-scale research projects conducted by faculty
in primarily baccalaureate-degree-granting domestic institutions.
Awards are for up to $75,000 for direct costs (plus applicable
indirect costs) for up to a 36-month period. See NIH
Guide for general information and receipt dates.
- R21 Exploratory/Development Grants
The R21 is an exploratory/developmental grant mechanism used
to foster the development of high-risk pilot and feasibility research
by established or newly independent investigators to develop new
ideas sufficiently to allow for submission of a full R01 application.
These grants are not intended to support or supplement ongoing
funded research of an established investigator. R21 applications
can be submitted only in response to specific RFA or program announcements,
and are not renewable. Continuation of projects developed
under this program is through the regular research grant program
(R01). Although the duration and amount of R21 awards may
vary depending on the announcement, typical caps are $100,000/year
and 2 years.
- R24/U24 Resource-Related Research Project
The R24 is used to support research projects that will enhance
the capability of resources to serve biomedical research.
An R24 can only be submitted in response to a specific RFA or
PA, which then defines the type of projects,
duration, and funds that can be requested. An applicant planning
to request $500,000 or more in direct costs (including indirect
costs on subcontracts) for any year is advised that he or she
must contact NIDDK program staff for permission several weeks
before submission.
- R37 Method to Extend Research in Time (MERIT)
Award
Investigators who have demonstrated superior competence and outstanding
productivity during their research careers, and who are highly
likely to continue to perform in an outstanding manner, may be
selected to extend an initial 5-year R01 award for an additional
5 years based on an expedited review. Program staff
and/or members of the NIDDK National Advisory Council/Board will
identify candidates for the MERIT award during the course of review
of competing research grant applications prepared and submitted
in accordance with regular PHS requirements. Investigators
may not apply for a MERIT award.
-
U01 Research Project (Cooperative Agreement)
Like grants, Cooperative Agreements support research and related
activities but they also provide for substantial Division staff
involvement in organizing and managing the project. This
mechanism is often used to fund clinical trials or Centers.
Applications for Cooperative Agreements are accepted only in response
to a specific RFA.
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Small Business Research Grants
- R41/R42 Small Business Technology Transfer (STTR)
These grants support cooperative research and development
projects between small business concerns and not-for-profit research institutions
that have potential for commercialization. The Phase I award (R41) allows up to $100,000
for 1 year to establish the technical merit and feasibility of ideas. The Phase II award
(R42) provides up to $500,000 and 2 years support for in-depth development of ideas with
feasibility that has already been established in Phase I. Awards are made to small
business concerns only. Applicants can also choose the Fast-Track option, which
allows for submission and review of Phase I and Phase II applications
simultaneously. Guidance and information on preparing STTR
applications can be found on the NIH
grants page. STTR topics of special interest to the Division can be found
in the Omnibus
Solicitation. (pdf-1.1mb)
- R43/R44 Small Business Innovation Research (SBIR)
Under the Small Business Research and Development
Enhancement Act of 1992, NIH must target funds to promote technological innovation within
the American small business community. This law gives small businesses a larger role
in Federal research and development projects and attracts private capital to market
resulting products or services.
There are three phases of an SBIR grant or contract.
In phase I, a small business is allowed up to $100,000 and 6 months to establish the
technical merit and feasibility of a biomedical research product or service that has
commercialization potential. During phase II, the company is allowed up to $750,000
and 2 years to fully develop the product or service begun in phase I. In phase III,
the small business markets the product or service with capital from non-Federal
sources. These amounts and durations are provided as guidelines and may be exceeded
with appropriate justification.
Guidance and information on preparing SBIR
applications can be found at the NIH
SBIR page.
SBIR topics of particular interest to NIDDK can be
found in the Omnibus Solicitation. (pdf-1.1mb)
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Research Centers
- P20 Exploratory Grants
P20 grants are used to support planning for a new program, expansion
or modification of existing resources, and feasibility studies to explore various
approaches to the development of interdisciplinary projects that offer potential solutions
to problems of special significance to the mission of NIDDK. These exploratory
studies may lead to specialized or comprehensive centers.
- P30 Center Core Grants (See list of active NIDDK Centers.)
Core Centers provide shared resources to a group of
investigators to foster a coordinated interdisciplinary clinical and basic research
approach. The core center grant is designed to enhance and extend the effectiveness
of a group of related projects and investigators already funded through other mechanisms
such as research project or program project grants. In this respect, the core center
mechanism builds upon an established base of research excellence.
A Core Center, by providing more accessible resources, is expected to assure
a greater productivity than from the separate projects and program projects. The research activities of a center should focus on
research that is relevant to the underlying cause, mechanism, diagnosis, early detection,
prevention, control, or treatment of diseases of interest to NIDDK.
Core Centers provide funds for
1. Shared resources (cores), such as tissue
culture, immunoassay, nutritional assessment, or other central research service
facilities.
2. Pilot and feasibility projects.
3. Program enrichment funds for small conferences or symposia,
and special consultants for the centers.
4. A named new investigator.
NIDDK uses the P30 mechanism for support of Diabetes Endocrinology Research
Centers (DERC), Gene Therapy Centers, Cystic Fibrosis Centers, Digestive
Diseases Centers, Clinical Nutrition Research Units, and Obesity/Nutrition
Research Units. Applications for Center Grants are accepted
only in response to a specific RFA.
Before submitting an application, please consult the appropriate
program director and obtain specific administrative guidelines for
these applications.
- P50 Specialized Centers (See
list of active NIDDK Centers.)
The Specialized Center of Research Grant (P50)
supports an interdisciplinary clinical and basic research approach to understanding and
treating disease. These centers support both research projects and shared basic
resources.Centers may support any part of the
full range of research and development from very basic to clinical and may involve ancillary
supportive activities such as protracted patient care necessary to the primary research or
R&D effort. The spectrum of activities comprises a multidisciplinary attack on a
specific disease entity or biomedical problem area. These grants differ from program
project grants in that they are usually developed in response to an announcement of the
programmatic needs of an Institute or Division and subsequently receive continuous
attention from its staff. Centers may also serve as regional or national resources for
special research purposes. Applications
for Center Grants are accepted only in response to a specific RFA.
- P60 Comprehensive Centers (See list of active NIDDK Centers.)
Comprehensive Centers support a multipurpose unit designed to
bring together into a common focus divergent but related facilities within a given
community. It may be based in a university or may involve other locally available
resources, such as hospitals, computer facilities, regional centers, and primate colonies.
It may include specialized centers, program projects, and projects as integral
components. Regardless of the facilities available to a program, it usually includes the
following objectives: to foster biomedical research and development at both the
fundamental and clinical levels; to initiate and expand community education, screening,
and counseling programs; and to educate medical and allied health professionals concerning
the problems of diagnosis and treatment of a specific disease. NIDDK currently uses this mechanism to support Diabetes Research
and Training Centers (DRTCs). Like Core Center Grants, the DRTCs support core resources and
pilot and feasibility studies. They also provide support for a Demonstration and
Evaluation component focusing on training and translation of diabetes research. Applications
for Center Grants are accepted only in response to a specific RFA.
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Other Research
- R13/U13 Conference Award
Conference Grants/Cooperative Agreements are awarded to
institutions and organizations (not individuals) to provide partial support for
international or domestic meetings, conferences, and workshops to coordinate, exchange,
and disseminate research information. NIDDK is especially interested in conference
grants used to cover travel expenses for young and minority investigators, although
meeting publications, salaries, consultant services, equipment rental, and supplies may be
requested. Indirect costs normally are not allowed. Conference grants will
not be accepted unless permission is received from program staff before submission.
- R18 Research Demonstration and Dissemination Projects
To provide support designed to develop, test, and evaluate health service activities, and to foster the application of existing knowledge for the control of categorical diseases.
- R25 Education Projects
For support to develop and/or implement a program as
it relates to a category in one or more of the areas of education, information, training,
technical assistance, coordination, or evaluation. It can be used for research in
how to develop better information dissemination to specific target groups.
- R33 Exploratory/Developmental Grants Phase II
The R33 award is to provide a second phase for the support for innovative exploratory and development research activities initiated under the R21 mechanism. Although only R21 awardees are generally eligible to apply for R33 support, specific program initiatives may establish eligibility criteria under which applications could be accepted from applicants demonstrating progress equivalent to that expected under the R33 mechanism.
- S06 Minority Biomedical Research Support (MBRS)
To strengthen the biomedical research and research training
capability of ethnic minority institutions, and thus establish a more favorable milieu for
increasing the involvement of minority faculty and students in biomedical research.
- U10 Cooperative Clinical Research (Cooperative Agreement)
The purpose of these awards is to support clinical evaluation
of various methods of therapy and/or prevention in specific disease areas. These represent
cooperative programs between sponsoring institutions and participating principal
investigators, and are usually conducted under established protocols.
- U19 Research Programs (Cooperative Agreements)
To support a research program of multiple projects directed toward a specific major objective, basic theme or program goal, requiring a broadly based, multidisciplinary and often long-term approach. A cooperative agreement research program generally involves the organized efforts of large groups, members of which are conducting research projects designed to elucidate the various aspects of a specific objective. Substantial Federal programmatic staff involvement is intended to assist investigators during performance of the research activities, as defined in the terms and conditions of award. The investigators have primary authorities and responsibilities to define research objectives and approaches, and to plan, conduct, analyze, and publish results, interpretations and conclusions of their studies. Each research project is usually under the leadership of an established investigator in an area representing his/her special interest and competencies. Each project supported through this mechanism should contribute to or be directly related to the common theme of the total research effort. The award can provide support for certain basic shared resources, including clinical components, which facilitate the total research effort. These scientifically meritorious projects should demonstrate an essential element of unity and interdependence.
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Research Contracts
- N01 Research and Development Contracts
To develop and/or apply new knowledge or to test, screen, or
evaluate a product, material, device, or component for use by the scientific community.
- N02 Resource and Support Contracts - Awarded in the ICD
To develop and/or apply new knowledge or to test, screen, or evaluate a product, material, device, or component for use by the scientific community.
- N43 Small Business Innovation Research - Phase I (contract)
To support a project, limited in time and amount, to establish the technical merit and feasibility of R&D ideas which may ultimately lead to a commercial product(s) or service(s). These contracts may be made only with small businesses.
- N44 Small Business Innovation Research - Phase II (contract)
To support in-depth development of R&D ideas whose feasibility has been established in Phase I and which are likely to result in commercial products or services. These contracts may be made only to small businesses.
- SBIR/STTR CONTRACTS (Phase I & II)
- N41 Small
Business Technology Transfer (STTR) - Phase I
- N42 Small
Business Technology Transfer (STTR) - Phase II
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