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Julie A. Segre, Ph.D.

Senior Investigator, Genetics and Molecular Biology Branch
Head, Epithelial Biology Section

Selected Publications

Segre J.A, Nemhauser J.L, Taylor B.A., Nadeau J.H., Lander E.S.. Positional cloning of the nude locus: genetic, physical, and transcription maps of the region and mutations in the mouse and rat. Genomics, 28(3): 549-59. 1995. [PubMed]

Segre J.A., Bauer C., Fuchs E. Klf4 is a transcription factor required for establishing the barrier function of the skin. Nat Genet, 22(4): 356-60. 1999. [PubMed]

Fuchs E., Segre J.A. Stem cells: a new lease on life. Cell, 100(1): 143-55. 2000. [PubMed]

Jaubert J., Cheng J., Segre J.A. Ectopic expression of Kruppel like factor 4 (Klf4) accelerates formation of the epidermal permeability barrier. Development, (12):2767-77. 2003. [PubMed]

Segre J.A. Complex redundancy to build a simple epidermal permeability barrier. Current Opinion in Cell Biology, 15: 778-784. 2003. [PubMed]

Dai X., Segre J.A. Transcriptional control of epidermal specification and differentiation. Curr Opin Genet Dev, 14(5):485-91. 2004. [PubMed]

Jaubert J., Patel S., Cheng J., Segre J.A. Tetracycline-regulated transactivators driven by the involucrin promoter to achieve epidermal conditional gene expression. J Invest Dermatol, 123(2):313-8. 2004. [PubMed]

Martin, N., Patel, S. and Segre, J.A. Long-Range Comparison of Human and Mouse Sprr Loci to Identify Conserved Noncoding Sequences Involved in Coordinate Regulation. Genome Res, (12):2430-8. 2004. [PubMed]

Segre, J.A. Epidermal barrier formation and recovery in skin disorders. J. Clin. Invest. 2006; 116(5): 1150-8. [PubMed]

Segre, J.A. Epidermal Differentiation Complex yields a secret: Mutations in the cornification protein Filaggrin underlie ichthyosis vulgaris. J Invest Dermatol. 2006; 126(6):1202-4. [PubMed]

Patel, S., Xi, Z.F., Seo, E.Y., McGaughey, D., Segre, J.A. Klf4 and Corticosteroids Activate an Overlapping Set of Transcriptional Targets to Accelerate in utero Epidermal Barrier Acquisition. Proc Natl Acad Sci, 103(49):18668-73. 2006. [PubMed]

de Guzman Strong, C., Wertz, P.W., Wang, C., Yang, F. Meltzer, P.S., Andl, T., Millar, S.E., Ho, I.-C., Pai, S.-Y., and Segre, J.A. Defect Underlies Selective Barrier Deficiency of an Epidermal-specific Deletion of Gata-3. J Cell Biol, 175(4):661-70. 2006. [Full Text]

de Guzman Strong C, Segre JA. Navigating the genome. J Cell Sci, 1;121(Pt 7):921-3. 2008. [PubMed]

Scharschmidt TC, Segre JA. Modeling atopic dermatitis with increasingly complex mouse models. J Invest Dermatol, 128(5):1061-4. 2008. [PubMed]

Grice EA, Kong HH, Renaud G, Young AC; NISC Comparative Sequencing Program, Bouffard GG, Blakesley RW, Wolfsberg TG, Turner ML, Segre JA. A diversity profile of the human skin microbiota. Genome Res, 18(7):1043-50. 2008. [PubMed]

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Last Updated: March 23, 2009