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Yingzi Yang, Ph.D.
Selected Publications
Topol L, Chen W, Song H, Day TF, Yang Y. Sox9 Inhibits Wnt Signaling by Promoting {beta}-Catenin Phosphorylation in the Nucleus. J Biol Chem, 30;284(5):3323-33. 2009. [PubMed]
Yang Y. Growth and patterning in the limb: signaling gradients make the decision. Sci Signal, 13;2(53):pe3. 2009. [PubMed]
Kinglun Kingston Mak, Henry M. Kronenberg, Pao-Tien Chuang, Susan Meckem and Yingzi Yang. Indian Hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy. Development, 135(11):1947-56. 2008. [PubMed]
Mak KK, Bi y, Wan C, Chuang PT, Clemens T, Young M and Yang Y. Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression. Dev Cell, 14(5):674-88. 2008. [PubMed]
Day TF and Yang Y. Wnt and Hedgehog Signaling Pathways in Bone Development. J Bone Joint Surg Am, 90(Supp 1):19-24. 2008. [Abstract]
Nemeth MJ, Topol L, Anderson SM, Yang Y, Bodine DM. Wnt5a inhibits canonical Wnt signaling in hematopoietic stem cells and enhances repopulation. Proc Natl Acad Sci U S A, 104(39):15436-41. 2007. [PubMed]
Yang Y. Xom as a novel partner of Lef/Tcfs during dorsal-ventral patterning of the Xenopus embryo. Cell Res, 17(4):307-8. 2007. [PubMed]
Mak, K.K., Chen, M.H., Day, T.F., Chuang, P.T. and Yang, Y. Wnt/b-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation. Development, 133(18): 3695-707. 2006. [PubMed]
Kobayashi T, Soegiarto DW, Yang Y, Lanske B, Schipani E, McMahon AP, Kronenberg HM. Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP. J Clin Invest, 115(7):1734-42. 2005. [PubMed]
Day T., Guo X., Garrett-Beal L., Yang Y.
Wnt/b-Catenin Signaling in Mesenchymal Progenitors Controls Osteoblast
and Chondrocyte Differentiation during Vertebrate Skeletogenesis.
Dev Cell, 8(5): 739-750. 2005. [PubMed]
Guo X., Day T.F., Jiang X., Garrett-Beal L., Topol L., Yang Y.
Wnt/"-catenin signaling is sufficient and necessary for synovial joint formation.
Genes & development, 18(19). 2004. [PubMed]
Yang Y. Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis. Birth Defects Res Part C Embryo Today, 69(4):305-17. 2003. [PubMed]
Topol L., Jiang X., Choi H., Garrett-Beal L., Carolan P.J, Yang Y. Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent {beta}-catenin degradation. J Cell Biol, 162(5):899-908. 2003. [PubMed]
Yang Y., Topol L., Lee H., Wu J. Wnt5a and Wnt5b exhibit distinct activities in coordinating hondrocyte proliferation and differentiation. Development, (5):1003-15. 2003. [PubMed]
Kundu M., Javed A., Jeon J.P., Horner A., Eckhaus M., Muenke M., Lian J.B., Yang Y., Nuckolls GH, Stein GS, Liu PP. Cbfbeta interacts with Runx2 and has a critical role in bone development. Nat Genet, 32(4):639-44. 2002." [PubMed]
Long F., Zhang X.M., Karp S., Yang Y., and McMahon A.P. Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development, 128:5099-5108. 2001. [PubMed]
Yang Y., Guillot P., Boyd Y., Lyon M.F., and McMahon A.P. Evidence that preaxial polydactyly in Double Foot mutant is due to ectopic Indian Hedgehog signaling. Development, 125(16):3123-3132. 1998. [PubMed]
Yang Y., Drossopoulou G., Chuang P-T., Duprez D., Marti E., Bumcrot D., Vargesson N., Clarke J., Niswander L., McMahon A and Tickle C. Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb. Development, 124(21):4393-4404. 1997. [PubMed]
Yang Y. and Niswander L. Interaction between the signaling molecules WNT and SHH during vertebrate limb development: the role of dorsal ectoderm signals in anteroposterior patterning. Cell, 80:939-947. 1995. [PubMed]
Last Updated: February 10, 2009
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