fr88 protats ryatsatlr.


-2-

   Althwgh tke base map?mltfaa ef lW4A cedsrr aad may proprrtirrs of the

geuetfa rro$s uers crlarillrsd wit& the ure af ryath+tlrr pelymucbetfdes, tke requsnst

of the bases ritbia docB aodea remained nrctaown.  i&we remntly, a #mIsr*l wethod

of great sfsplletty uaa fsuad by #rrrabq o d w+-worimrt fer detsrmMug the base

aeqnesaccb ef cadout.  With tbfr it was dsilrraartratwi directly that strma tri- but

aQt dltwl8otirkS aerw 11s tmplat#S i@ thiS SySttra, a trdplat ati exists.

   The oeqwwm of virtually all cedons have am Mm Jatartniaed by br,

Mrsabergvr laboratory.  Tt has badn SAara that ma potterns of rymmyrtl C&dO#S

diffur aprkadly la betb  t  late estirity oab sjmuifieity. `Eke biologhl @t911s6-

queueot of these and stlrcrr ffndiqe remaria tu be assessed. It wotrld sum hgical,

hmrer, that mm sgmmym sodoar must play sped81 roles ia protein ryatbsrir,

swb II sgecffylag t&e beqiaWg or md of the quadtie massage; otkmrs umy Lrs

meerrswy forr the tyatksis of osrtailt prsteiar er my sslsetirely infltmcc! t&w

rate ef protein syatlwir,

   Studier am aaiu fr pragrm~ ia Dr. NirecbtrBsrg'r labaratury to define perribh

toarequeaces af oefectira AodiPicatioR of ~~nsntr reqrrlred for mdeR reclkgeitierb

Particular attmtiea is baiq foeused upsr mwhaakmr ubicb may ralectltely eontral

the ?8t6 of protafn syPth!ksit dfirriag 9ir81 iafectioul and sabryeaie differeatiation.


   Dr. Nirunbt+rg has deciphered tbe genetic wde. His work ha8 given US

understaftding of RIUC~ of the StJrsterieus way information is eodaQ into the

nuoleio aoidr and used to direct the facorpwatien a2 rpeeific a&no acids into

pratafail.  It represents a atojor contribution toward understanding en a wolaaular

basis hopr the chmiaalr of the call suclaus carry the hereditary massage from

eaa ganaratfon to the next.