In this article, Jones and Nirenberg provide a progress report on code translation efforts. They find that almost every amino acid tested can be coded by a polymer containing only two bases. The article includes approximations of nineteen triplet codewords and suggests that any theory concerning the physical basis of the code must explain the available data revealing the high coding efficiency of polynucleotides, marked codeword specificity, and degenerate codewords. The degeneracy model of Gamov and Watson-Crick pairing are among some of the ideas discussed.
Item is a photocopy.
Number of Image Pages:
9 (899,526 Bytes)
Date:
1962
Creator:
Jones, Oliver W. Jr
Nirenberg, Marshall W.
Source:
Periodical: Jones, Oliver W. Jr., and Marshall W. Nirenberg. "Qualitative Survey of RNA Codewords." Proceedings of the National Academy of Sciences 48, (1962): 2115-2123. Article. 9 Images.
Publisher:
National Academy of Sciences
Rights:
Reproduced with permission of Marshall W. Nirenberg.
Subject:
Medical Subject Headings (MeSH):
Amino Acids
RNA
Codon
Polynucleotides
Exhibit Categories:
Synthetic RNA and the Poly-U Experiments, 1959-1962
Translating the Code of Life and the Nobel Prize, 1962-1968
Relation:
The Current Status of the RNA Code (1963)
Letter from Marshall W. Nirenberg to Francis Crick (November 16, 1962) (in The Francis Crick Papers)
Letter from Francis Crick to Marshall W. Nirenberg (December 5, 1962) (in The Francis Crick Papers)