Jump to main content.

Source Apportionment of Fine Particulate Matter in the U.S. and Associations with Lung Inflammatory Markers IL-8, COX-2, and HO-1

R.M. Duvall1, G.A. Norris1, J.M. Burke1, J.K. McGee2, M.I. Gilmour2, and R.B. Devlin2

1 - National Exposure Research Laboratory
U.S. Environmental Protection Agency
Research Triangle Park, NC, 27711

2 - National Health and Environmental Effects Laboratory
U.S. Environmental Protection Agency
Research Triangle Park, NC 27711

 

Associations are well established between particulate matter (PM) mass concentrations and increased human mortality and morbidity. Fine particulate matter (particle diameter < 2.5 mm) is most strongly linked to adverse health impacts. The toxicity of PM may depend on the PM source (e.g. vehicle exhaust, coal combustion, etc.) and composition of PM which will vary by location. While a number of epidemiological studies have shown that certain PM sources are associated with specific health outcomes, the mechanisms are still unclear.


In this study, the association between fine PM sources and three lung inflammatory markers (interleukin-8, cyclooxygenase-2, and heme oxygenase-1) was evaluated in multiple cities with contrasting PM sources as part of the Multiple Pollutant Study (MAPS).

Disclaimer:  Although this work was reviewed by EPA and approved for publication, it may not necessarily reflect official Agency policy.


 

Exposure Research Home

Atmospheric Modeling | Ecological Exposure Research | Ecosystems Research | Environmental Sciences
Human Exposure & Atmospheric Sciences | Microbiological & Chemical Exposure Assessment Research

Local Navigation

Jump to main content.