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Center for Child Environmental Health Risks Research
EPA Grant Number: R826886Center: University of Washington
Center Director: Faustman, Elaine
Title: Center for Child Environmental Health Risks Research
Investigators: Faustman, Elaine
Institution: University of Washington
EPA Project Officer: Fields, Nigel
Project Period: August 1, 1998 through December 31, 2003
Project Amount: $3,545,396
RFA: Centers for Children's Environmental Health and Disease Prevention Research (1998)
Research Category: Children's Health , Health Effects
Description:
Objective:The theme of the University of Washington based Center for Child Environmental Health Risks Research (CHC) is understanding the biochemical, molecular and exposure mechanisms that define children's susceptibility to pesticides and the implications for assessing pesticide risks to normal development and learning. The CHC is a multi-disciplinary research center that takes advantage of the established landscape of risk research at the University of Washington; it is administratively housed within the Institute for Risk Analysis and Risk Communication that is in the UW's School of Public Health and Community Medicine..
To facilitate both basic and applied research on reducing the adverse effects of environmental pesticide exposures, center participants include members from multiple institutions, schools, and varied departments and clinics. To achieve tangible effects on the community, the CHC includes a partnership with an eastern Washington community within the Yakima Valley agricultural center of our state, to jointly accomplish pesticide intervention with reduced childhood pesticide exposures.
The CHC is comprised of two laboratory based research projects, two field based projects, and four facility cores. The specific objectives of the laboratory based research projects are to:
- identify cellular, biochemical and molecular mechanisms for the adverse developmental neurotoxicity of pesticides and
- identify the impact of genetic polymorphisms for paraoxonase on the developmental neurotoxicity of organophosphate pesticides.
The specific objectives of the two field based projects-a pesticide exposure pathways research project plus the related community based intervention study are to:
- identify critical pathways of pesticide exposure for children and
- to develop a culturally-appropriate intervention to break the take-home pathway that will ultimately result in reducing children's exposure to pesticides.
The four facility cores (Neurobehavioral Assessment, Exposure Assessment, Risk Characterization and Risk Communication) are designed to support the research agenda and to put the research into a child specific risk assessment context. Thus the scientific findings on pesticide toxicity and exposure can be directly incorporated into risk assessment models that are designed to protect child health. A diagram of the center's organizational structure follows.
Laboratory Based Projects
The laboratory based projects in this proposal will specifically address two aspects of children's susceptibility to pesticides. They will investigate molecular mechanisms of neurotoxicity for pesticides and evaluate the role of paraoxonase in defining sensitivity of children to organophosphate pesticides. Functional assessments for both studies will be performed in the Neurobehavioral Assessment Facility Core. These projects will be closely linked as common organophosphate pesticides will be examined in all projects, animals, and tissues and research results will be readily shared among these researchers.
Journal Articles: 47 Displayed | Download in RIS Format
| Other center views: | All 83 publications | 51 publications in selected types | All 47 journal articles |
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Brophy VH, Jampsa RL, Clendenning JB, McKinstry LA, Jarvik GP, Furlong CE. Effects of 5’ regulatory-region polymorphisms on paraoxonase-gene (PON1) expression. American Journal of Human Genetics 2001;68(6):1428-1436. |
R826886C002 (2001) R831709 (2005) |
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Brophy V H, Hastings MD, Clendenning JB, Richter RJ, Jarvik GP, Furlong CE. Polymorphisms in the human paraoxonase (PON1) promoter. Pharmacogenetics 2001;11(1):77-84. |
R826886C002 (2001) R831709 (2005) |
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Caughlan A, Newhouse K, Namgung U, Xia Z. Chlorpyrifos induces apoptosis in rat cortical neurons that is regulated by a balance between p38 and ERK/JNK MAP kinases. Toxicological Sciences 2004;78(1):125-134. |
R831709C001 (2004) |
not available |
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Costa LG, Li WF, Richter RJ, Shih DM, Lusis A, Furlong CE. The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polymorphism. Chemico-Biological Interactions 1999;119-120:429-438. |
R826886C002 (2000) R831709 (2005) |
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Costa LG. The emerging field of ecogenetics. NeuroToxicology 2000;21(1-2):85-89. |
R826886C002 (2000) R831709 (2005) |
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Costa LG, Cole TB, Jarvik GP, Furlong CE. Functional genomics of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism. Annual Review of Medicine 2003;54:371-392. |
R826886C002 (2002) |
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Costa LG, Richter RJ, Li W-F, Cole T, Guizzetti M, Furlong CE. Paraoxonase (PON1) as a biomarker of susceptibility for organophosphate toxicity. Biomarkers 2003;8(1):1-12. |
R826886C002 (2002) R831709 (2005) R831709C002 (2004) |
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Costa LG. Current issues in organophosphate toxicology. Clinica Chimica Acta 2006;366(1-2):1-13. |
R831709 (2005) R831709 (2006) R831709C001 (2006) |
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Costa LG, Cole TB, Furlong CE. Gene-environment interactions: paraoxonase (PON1) and sensitivity to organophosphate toxicity. Lab Medicine 2006;37(2):109-113. |
R831709 (2005) R831709C001 (2007) R831709C002 (2007) |
not available |
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Costa LG, Giordano G, Guizzetti M, Vitalone A. Neurotoxicity of pesticides: a brief review. Frontiers in Bioscience 2008;13(4):1240-1249. |
R831709 (2005) R831709 (2007) R831709C001 (2007) R831709C002 (2007) |
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Curl CL, Fenske RA, Kissel JC, Shirai JH, Moate TW, Griffith W, Coronado G, Thompson B. Evaluation of take-home organophosphorus pesticide exposure among agricultural workers and their children. Environmental Health Perspectives 2002;110(12):A787-A792. |
R826886C003 (2001) R826886C003 (2002) R826886C004 (2001) R826886C004 (2002) R831709 (2005) |
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Daston G, Faustman E, Ginsberg G, Fenner-Crisp P, Olin S, Sonawane B, Bruckner J, Breslin W. A framework for assessing risks to children from exposure to environmental agents. Environmental Health Perspectives 2004;112(2):238-256. |
R831709C001 (2004) |
not available |
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Elgethun K, Fenske RA, Yost MG, Palcisko GJ. Time-location analysis for exposure assessment studies of children using a novel global positioning system instrument. Environmental Health Perspectives 2003;111(1):115-122. |
R826886C004 (2002) R831709 (2005) |
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Elgethun K, Yost MG, Fitzpatrick CTE, NyergesTL, Fenske RA. Comparison of global positioning system (GPS) tracking and parent-report diaries to characterize children's time–location patterns. Journal of Exposure Science and Environmental Epidemiology 2007;17(2):196-206. |
R831709 (2005) R831709 (2006) R831709 (2007) R831709C004 (2006) R831709C004 (2007) |
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Eskenazi B, Gladstone EA, Berkowitz GS, Drew CH, Faustman EM, Holland NT, Lanphear B, Meisel SJ, Perera FP, Rauh VA, Sweeney A, Whyatt RM, Yolton K. Methodologic and logistic issues in conducting longitudinal birth cohort studies: lessons learned from the Centers for Children’s Environmental Health and Disease Prevention Research. Environmental Health Perspectives 2005;113(10):1419-1429. |
R831709 (2005) R831709C001 (2004) R827027 (2002) R829389 (2003) R829389 (2004) R829389 (2005) R829390 (2005) R831710 (2005) R831711 (2005) R831711 (2006) R831711C001 (2006) R831711C002 (2004) R831711C002 (2006) R831711C003 (2006) R832141 (2005) |
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Faustman EM, Silbernagel SM, Fenske RA, Burbacher TM, Ponce RA. Mechanisms underlying children’s susceptibility to environmental toxicants. Environmental Health Perspectives 2000;108(Suppl 1):13-21. |
R826886 (2000) R825173 (1999) R825173 (2000) R831709 (2005) |
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Faustman EM, Gohlke, JM, Judd NL, Lewandowski TA, Bartell SA, Griffith WC. Modeling developmental processes in animals: Applications in neurodevelopmental toxicology. Environmental Toxicology and Pharmacology 2005;19(3):615-624. |
R831709 (2005) R831709 (2006) R831709C001 (2004) R831709C001 (2005) R831709C001 (2006) |
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Fenske RA, Kissel JC, Lu C, Kalman DA, Simcox NJ, Allen EH, Keifer MC. Biologically based pesticide dose estimates for children in an agricultural community. Environmental Health Perspectives 2000;108(6):515-520. |
R826886C004 (2001) R831709 (2005) |
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Fenske RA, Lu C, Simcox NJ, Loewenherz C, Touchstone J, Moate TF, Allen EH, Kissel JC. Strategies for assessing children’s organophosphorus pesticide exposures in agricultural communities. Journal of Exposure Analysis and Environmental Epidemiology 2000;10(6 Suppl 2):662-671. |
R826886C004 (2001) R825171 (2000) R831709 (2005) |
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Furlong CE, Li WF, Richter RJ, Shih DM, Lusis AJ, Alleva E, Costa LG. Genetic and temporal determinants of pesticide sensitivity: role of paraoxonase (PON1). NeuroToxicology 2000;21(1-2):91-100. |
R826886C002 (2000) R826886C002 (2001) R831709 (2005) |
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Furlong CE, Li WF, Brophy VH, Jarvik GP, Richter RJ, Shih DM, Lusis AJ, Costa LG. The PON1 gene and detoxication. NeuroToxicology 2000;21(4):581-587. |
R826886C002 (2001) R831709 (2005) |
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Furlong CE, Li W-F, Shih DM, Lusis AJ, Richter RJ, Costa LG. Genetic factors in susceptibility:serum PON1 variation between individuals and species. Human and Ecological Risk Assessment 2002;8(1):31-43. |
R826886C002 (2002) R831709 (2005) |
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Furlong CE, Cole TB, Jarvik GP, Costa LG. Pharmacogenomic considerations of the paraoxonase polymorphisms. Pharmacogenomics 2002;3(3):341-348. |
R826886C002 (2002) R831709 (2005) |
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Giordano G, Afsharinejad Z, Guizzetti M, Vitalone A, Kavanagh TJ, Costa LG. Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency. Toxicology and Applied Pharmacology 2007;219(2-3):181-189. |
R831709 (2005) R831709 (2006) R831709 (2007) R831709C001 (2006) R831709C001 (2007) R831709C002 (2007) |
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Gohlke JM, Griffith WC, Faustman EM. The role of cell death during neocortical neurogenesis and synaptogenesis: implications from a computational model for the rat and mouse. Developmental Brain Research 2004;151(1-2):43-54. |
R831709 (2005) R831709C001 (2004) |
not available |
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Gohlke JM, Griffith WC, Faustman EM. A systems-based computational model for dose-response comparisons of two mode of action hypotheses for ethanol-induced neurodevelopmental toxicity. Toxicology Science 2005;86:470-84. |
R831709 (2004) R831709 (2005) R831709C001 (2005) |
not available |
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Guizzetti M, Pathak S, Giordano G, Costa LG. Effect of organophosphorus insecticides and their metabolites on astroglial cell proliferation. Toxicology 2005;215(3):182-190. |
R831709 (2005) R831709 (2006) R831709C001 (2005) R831709C001 (2006) R831709C002 (2006) |
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Lewandowski TA, Ponce RA, Charleston JS, Hong S, Faustman EM. Changes in cell cycle parameters and cell number in the rat midbrain during organogenesis. Developmental Brain Research 2003;141(1-2):117-128. |
R831709 (2005) R831709C001 (2004) |
not available |
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Lewandowski TA, Ponce RA, Charleston JS, Hong S, Faustman EM. Effect of methylmercury on midbrain cell proliferation during organogenesis: potential cross-species differences and implications for risk assessment. Toxicological Sciences 2003;75(1):124-133. |
R831709 (2005) R831709C001 (2004) |
not available |
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Li WF, Costa LG, Richter RJ, Hagen T, Shih DM, Tward A, Lusis AJ, Furlong CE. Catalytic efficiency determines the in- vivo efficacy of PON1 for detoxifying organophosphorus compounds. Pharmacogenetics 2000;10(9):767-779. |
R826886C002 (2000) R826886C002 (2001) R831709 (2005) |
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Lu C, Fenske RA. Dermal transfer of chlorpyrifos residues from residential surfaces: comparison of hand press, hand drag, wipe, and polyurethane foam roller measurements after broadcast and aerosol pesticide applications. Environmental Health Perspectives 1999;107(6):463-467. |
R826886C004 (2001) R831709 (2005) |
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Lu C, Fenske RA, Simcox NJ, Kalman D. Pesticide exposure of children in an agricultural community: evidence of household proximity to farmland and take home exposure pathways. Environmental Research 2000;84(3):290-302. |
R826886C004 (2001) R831709 (2005) |
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Mirkes PE, Little SA. Cytochrome c release from mitochondria of early postimplantation murine embryos exposed to 4-hydroperoxycyclophosphamide, heat shock, and staurosporine. Toxicology and Applied Pharmacology 2000;162(3):197-206. |
R826886C001 (2001) R831709 (2005) |
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Mirkes PE, Wilson KL, Cornel LM. Teratogen-induced activation of ERK, JNK, and p38 MAP kinases in early postimplantation murine embryos. Teratology 2000;62(1):14-25. |
R826886C001 (2001) R831709 (2005) |
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Moate TF, Lu C, Fenske RA, Hahne RMA, Kalman DA. Improved cleanup and determination of dialkyl phosphates in the urine of children exposed to organophosphorus insecticides. Journal of Analytical Toxicology 1999;23(4):230-236. |
R826886C004 (2001) R825171 (1999) R825171 (2000) R831709 (2005) |
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Moate TF, Furia M, Curl C, Muniz JF, Yu J, Fenske RA. Size exclusion chromatographic cleanup for GC/MS determination of organophosphorus pesticide residues in household and vehicle dust. Journal of AOAC International 2002;85(1):36-43. |
R826886C004 (2001) R826886C004 (2002) R831709 (2005) |
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Namgung U, Xia Z. Arsenic induces apoptosis in rat cerebellar neurons via activation of JNK3 and p38 MAP kinases. Toxicology and Applied Pharmacology 2001;174(2):130-138. |
R826886C001 (2002) R831709 (2005) |
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Ramaprasad J, Tsai M-Y, Elgethun K, Hebert VR, Felsot A, Yost MG, Fenske RA. The Washington aerial spray drift study: assessment of off-target organophosphorus insecticide atmospheric movement by plant surface volatilization. Atmospheric Environment 2004;38(33):5703-5713. |
R831709 (2005) R831709C004 (2004) |
not available |
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Sidhu JS, Ponce RA, Vredevoogd MA, Yu X, Gribble E, Hong S-W, Schneider E, Faustman EM. Cell cycle inhibition by sodium arsenite in primary embryonic rat midbrain neuroepithelial cells. Toxicological Sciences 2006;89(2):475-484. |
R831709 (2005) R831709 (2006) R831709C001 (2005) R831709C001 (2006) |
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Thompson B, Coronado G, Puschel K, Allen E. Identifying constituents to participate in a project to control pesticide exposure in children of farmworkers. Environmental Health Perspectives 2001;109(Suppl 3):443-448. |
R826886C003 (2001) R826886C003 (2002) R826886C004 (2001) R826886C004 (2002) R831709 (2005) |
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Thompson B, Coronado GD, Grossman JE, Puschel K, Solomon CC, Islas I, Curl CL, Shirai JH, Kissel JC, Fenske RA. Pesticide take-home pathway among children of agricultural workers: study design, methods, and baseline findings. Journal of Occupational and Environmental Medicine 2003;45(1):42-53. |
R826886C003 (2002) R831709 (2005) R831709C003 (2004) |
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Tsai M-Y, Elgethun K, Ramaprasad J, Yost MG, Felsot AS, Hebert VR, Fenske RA. The Washington aerial spray drift study:modeling pesticide spray drift deposition from an aerial application. Atmospheric Environment 2005;39(33):6194-6203. |
R831709 (2005) R831709C004 (2005) R831709C004 (2006) |
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Umpierre CC, Little SA, Mirkes PE. Co-localization of active caspase-3 and DNA fragmentation (TUNEL) in normal and hyperthermia-induced abnormal mouse development. Teratology 2001;63(3):134-143. |
R826886C001 (2001) R826886C001 (2002) R831709 (2005) |
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Vicini P, Pierce CH, Dills RL, Morgan MS, Kalman DA. Individual prior information in a physiological model of 2H8-toluene kinetics: an empirical Bayes estimation strategy. Risk Analysis 1999;19(6):1127-1134. |
R826886 (2000) |
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Weppner S, Elgethun K, Lu C, Herbert V, Yost MG, Fenske RA. The Washington aerial spray drift study: children's exposure to methamidophos in an agricultural community following fixed-wing aircraft applications. Journal of Exposure Science and Environmental Epidemiology 2006;16(5):387-396. |
R831709 (2005) R831709 (2006) R831709 (2007) R831709C004 (2006) R831709C004 (2007) |
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Yu X, Griffith WC, Hanspers K, Dillman III JF, Ong H, Vredevoogd MA, Faustman EM. A system-based approach to interpret dose-and time-dependent microarray data: quantitative integration of gene ontology analysis for risk assessment. Toxicological Sciences 2006;92(2):560-577. |
R831709 (2005) R831709 (2006) R831709C001 (2006) R832733 (2007) |
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Gribble EJ, Hong S-W, Faustman EM. The magnitude of methylmercury-induced cytotoxicity and cell cycle arrest is p53 dependent. Birth Defects Research Part A: Clinical and Molecular Teratology 2005;73(1):29-38. |
R831709 (2005) R831709C001 (2004) |
not available |
Geographic Area, Scientific Discipline, Health, RFA, Risk Assessments, Health Risk Assessment, Epidemiology, Children's Health, Biochemistry, Environmental Chemistry, State, exposure assessment, insecticides, developmental neurotoxicology, developmental disorders, health effects, Washington (WA), developmental effects, epidemelogy, developmental toxicity, children's environmental health, organophosphate pesticides, assessment of exposure, harmful environmental agents, human health risk, epidemeology, developmental neurotoxicity, agricultural community, pesticide exposure, environmental health, children, pesticides, exposure, growth & development, children's vulnerablity, environmental health hazard, human exposure, Human Health Risk Assessment, neurotoxicity
Progress and Final Reports:
2000 Progress Report
Subprojects under this Center:
(EPA does not fund or establish subprojects; EPA awards and manages the overall grant for this center).
R826886C001 Molecular Mechanisms of Pesticide-Induced Developmental Toxicity
R826886C002 Genetic Susceptibility to Pesticides (Paraoxonase Polymorphism or PON1 Study)
R826886C003 Community-Based Participatory Research Project
R826886C004 Pesticide Exposure Pathways Research Project