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Eosinophilia-Myalgia
Syndrome
A complex systemic
syndrome with
inflammatory and
autoimmune
components that
affect the skin,
fascia, muscle,
nerve, blood
vessels, lung,
and heart. The
varied symptoms
include severe
muscle pain and
abnormally high
numbers of
eosinophils. This
disease has
presented itself
only in people
taking the amino
acid l-tryptophan
and it is believed
that a specific
impurity (probably
stemming from a
genetically
engineered bacterial
strain) in lots of
l-tryptophan made by
a single
manufacturer may be
the cause of the
syndrome.
©
On-line Medical
Dictionary
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Initial Symptoms
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Acute pain
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Elevated eosinophil count
(a type of white blood cell that is usually found when a toxin or parasitic infection is present).
-
Severe myalgias
(muscle cramps and muscle pain)
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Myofascial pain syndrome
(a condition characterized by chronic pain in the muscle tissues, similar to fibromyalgia)
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Neuropathy
(a problem with functioning of the nerves.Symptoms include numbness, weakness, burning pain especially at night and loss of reflexes)
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Neurologic pain in joints
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Tremor, Myoclonus
(abnormal repetitive shaking and contraction of muscles or portions of muscles)
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Peripheral edema
(the swelling of soft tissues as the result of excess water accumulation in the extremities)
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Paresthesias
(an abnormal sensation of the body, such as numbness, tingling, or burning)
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Fasciitis
(a tenderness & swelling of the extremities which occurs when eosinophils infiltrate the fibrous layer surrounding the muscle and the muscle itself)
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Morphia
(patches of yellow or ivory colored rigid dry skin which become hard and slightly depressed. When generalized can cause underlying muscles to tighten & atrophy)
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Low grade fever
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Pulmonary disorders
(having to do with the lungs)
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Rashes
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Weakness & severe fatigue
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Gastro-intestinal disorders
(referring to the stomach and intestines)
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Cardiac arrhythmias
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Hair loss
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Despnea or cough
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Headache
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Later
Symptoms
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Neurocognitive
Dysfunction
(short term
memory loss,
concentration &
communication
problems)
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Chronic Myalgias
& Arthralgias
(muscle & joint
pain)
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Severe Axonal
Neuropathies
(pain along the
long fiber of a
nerve cell (a
neuron) that
acts somewhat
like a
fiber-optic
cable carrying
outgoing
messages to the
body)
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Cardiomyopathy
(disease of the
heart muscle)
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Chronic liver
disease-
Cirrhosis
(irreversible
scarring of the
liver)
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Internal
Fibrosis
(excessive
growth of hard,
fibrous tissue
that replaces
normal bone
tissue in a
single
bone.Symptoms
include pain and
bone fracturing)
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Pulmonary
Hypertension
(high blood
pressure)
-
Desmoid Tumor
(benign soft
tissue tumors
which intertwine
extensively with
the surrounding
tissues)
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Malignant
Fibrous
Histiocytoma
(a rare disorder
in which
histiocytes
start to
multiply &
attack the
person's own
tissue or organs
resulting in
tissue damage,
fatigue and
other symptoms)
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Scleroderma-like
Syndrome
(a disease of
connective
tissue
(fibrosis) in
the skin and
sometimes also
in other organs
of the body)
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Fibromyalgia
Syndrome
(chronically
causes pain,
stiffness, and
tenderness of
muscles,
tendons, and
joints without
detectable
inflammation)
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Chronic Fatigue
Syndrome
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Post Traumatic
Stress Disorder
(a psychological
disorder that
develops in
individuals who
have had major
traumatic
experiences)
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Depression
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Visual & Dental
problems
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Sleeping
Disorders
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