FYI from the NHLBI Index

January 2009: Vol. 9, Issue 3
Research and Resources

NHLBI Research Initiatives

• Summer Institute for Training in Biostatistics (SIBS) II
• Translating Basic Behavioral and Social Science Discoveries into Interventions to Reduce Obesity: Centers for Behavioral Intervention Development (U01)
• Airway Smooth Muscle Function and Targeted Therapeutics in Human Asthma (R01)
• The Role of Cardiomyocyte Mitochondria in Heart Disease: An Integrated Approach (R01)
• Innovative Toxicity Assays of Pollutants, Therapeutics, and Drugs (STTR [R41/R42])
• Circadian-Coupled Cellular Function in Heart, Lung, and Blood Tissue (R01)
• NHLBI Cardiac Development Consortium (U01)
• NHLBI Pediatric Cardiac Genomics Consortium (U01)
• NHLBI Pediatric Translational Consortium Administrative Coordinating Center (U01)
• Characterizing the Blood Stem Cell Niche (R01)
• Cardiac Translational Research Implementation Program (C-TRIP) (P20)
• Microbiome of the Lung and Respiratory Tract in HIV-Infected Individuals and HIV-Uninfected Controls (U01)
• Exploratory Studies in the Neurobiology of Pain in Sickle Cell Disease (R01)

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NHLBI Research Initiatives

From time to time, the NHLBI invites investigators to submit grant applications or contract proposals for specific research programs. We are soliciting applications for the new programs described below. Please visit the URL listed with each program to obtain information about important application dates and deadlines. For full details of these and other current research initiatives, visit www.nhlbi.nih.gov/funding/inits/index.htm.

Summer Institute for Training in Biostatistics (SIBS) II

• Initiative Number: HL-09-009
• Objective: Develop, conduct, and evaluate six-week summer training courses in biostatistics using data from recent, highly visible studies of heart, lung, and blood diseases.

Translating Basic Behavioral and Social Science Discoveries into Interventions to Reduce Obesity: Centers for Behavioral Intervention Development (U01)

• Initiative Number: HL-08-013
• Objective: Establish up to eight research centers to translate findings from basic research on human behavior into more effective interventions to reduce obesity and promote cardiovascular health.

Airway Smooth Muscle Function and Targeted Therapeutics in Human Asthma (R01)

• Initiative Number: HL-09-007
• Objective: Investigate the complex role that airway smooth muscle plays in the development of human asthma and identify new therapeutic targets.

The Role of Cardiomyocyte Mitochondria in Heart Disease: An Integrated Approach (R01)

• Initiative Number: HL-10-002
• Objective: Develop an integrated understanding of cardiomyocyte mitochondria and their contributions to myocardial adaptations and heart disease progression.

Innovative Toxicity Assays of Pollutants, Therapeutics, and Drugs (STTR [R41/R42])

• Initiative Number: PA-09-006/007
• Objective: Develop, standardize, and validate new and innovative assays that determine or predict cardiotoxicity, pulmonary toxicity, or hematotoxicity resulting from exposures to chemicals, environmental pollutants, biologics, and drugs.

Circadian-Coupled Cellular Function in Heart, Lung, and Blood Tissue (R01)

• Initiative Number: HL-09-012
• Objective: Elucidate the molecular basis of circadian cycles in cellular function and gene expression, and determine the role of circadian timing in the organization of cellular pathways.

NHLBI Cardiac Development Consortium (U01)

• Initiative Number: HL-09-002
• Objective: Conduct collaborative basic research leading to a comprehensive understanding of the regulatory networks controlling cardiovascular development.

NHLBI Pediatric Cardiac Genomics Consortium (U01)

• Initiative Number: HL-09-003
• Objective: Conduct clinical and translational research on the genetic causes of congenital heart disease and on genetic contributions to outcome in individuals with congenital heart disease.

NHLBI Pediatric Translational Consortium Administrative Coordinating Center (U01)

• Initiative Number: HL-09-011
• Objective: Operate an Administrative Coordinating Center to serve the NHLBI Cardiac Development Consortium and the NHLBI Pediatric Cardiac Genomics Consortium.

Characterizing the Blood Stem Cell Niche (R01)

• Initiative Number: HL-09-010
• Objective: Characterize the cellular components and factors involved in the microenvironment that interacts with blood stem cells to regulate their fate.

Cardiac Translational Research Implementation Program (C-TRIP) (P20)

• Initiative Number: HL-10-001
• Objective: Accelerate the translation of recent research discoveries for the treatment and prevention of heart failure and arrhythmias into well-designed clinical trials that demonstrate the efficacy and safety of new therapeutic interventions.

Microbiome of the Lung and Respiratory Tract in HIV-Infected Individuals and HIV-Uninfected Controls (U01)

• Initiative Number: RFA-HL-09-006
• Objective: Characterize the microbiome in the lung of HIV-infected individuals and matched uninfected controls.

Exploratory Studies in the Neurobiology of Pain in Sickle Cell Disease (R01)

• Initiative Number: HL-09-008
• Objective: Apply investigative modalities used by neuroscientists in the field of pain research to the understanding of pain in sickle cell disease.

Need More Information?

We are always interested in receiving comments and suggestions from the community. If you or your organizations have questions for me or for the Institute, please contact me at nabele@nhlbi.nih.gov or Dr. Carl Roth at rothc@nhlbi.nih.gov.

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